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Case Study
- Combined Adenosquamous and Large Cell Neuroendocrine Carcinoma of the Gallbladder
- Jiyoon Jung, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
- J Pathol Transl Med. 2018;52(2):121-125. Published online October 5, 2017
- DOI: https://doi.org/10.4132/jptm.2017.08.20
- 7,561 View
- 153 Download
- 11 Web of Science
- 9 Crossref
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Abstract
PDF - Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3×4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.
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Citations
Citations to this article as recorded by
- Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Ya-Fei Hu, Jun-Ke Wang, Wen-Jie Ma, Hai-Jie Hu, Han-Fei Gu, Fei Liu, Tian-Run Lv, Si-Qi Yang, Yu-Shi Dai, Rui-Qi Zou, Yan-Wen Jin, Fu-Yu Li
Frontiers in Endocrinology.2024;[Epub] CrossRef - Az epehólyag adenosquamosus daganata
Fanni Hegedűs, Anita Sejben
Orvosi Hetilap.2024; 165(49): 1945. CrossRef - Comparison of Metastatic Patterns Among Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Nonneuroendocrine Carcinomas of Various Primary Organs
Hyung Kyu Park, Ghee Young Kwon
Journal of Korean Medical Science.2023;[Epub] CrossRef - Clinical features and outcomes analysis of Gallbladder neuroendocrine carcinoma
Man Jiang, Yijing Zhang
Journal of Cancer Research and Therapeutics.2023; 19(4): 910. CrossRef - Primary mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: A case report and literature review
Tingting Yu, Shike Li, Zhuo Zhang
Asian Journal of Surgery.2022; 45(11): 2336. CrossRef - Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder: case report and literature review
Xu Ren, Hong Jiang, Kan Sun, Xufu Qin, Yongping Qu, Tian Xia, Yan Chen
Diagnostic Pathology.2022;[Epub] CrossRef - Neuroendocrine Neoplasms of the Gallbladder: A Clinicopathological Analysis of 13 Patients and a Review of the Literature
Pengyan Wang, Jingci Chen, Ying Jiang, Congwei Jia, Junyi Pang, Shan Wang, Xiaoyan Chang, Oronzo Brunetti
Gastroenterology Research and Practice.2021; 2021: 1. CrossRef - Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature
Amedeo Sciarra, Edoardo Missiaglia, Mounir Trimech, Emmanuel Melloul, Jean-Philippe Brouland, Christine Sempoux, Stefano La Rosa
Endocrine Pathology.2020; 31(1): 84. CrossRef - Mixed neuroendocrine-non-neuroendocrine carcinoma of gallbladder: case report
Adam Skalický, Lucie Vištejnová, Magdaléna Dubová, Tomáš Malkus, Tomáš Skalický, Ondřej Troup
World Journal of Surgical Oncology.2019;[Epub] CrossRef
- Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Brief Case Report
- Hyalinizing Cholecystitis and Associated Carcinoma: A Case Report
- Youngjin Kang, Yang-Seok Chae, Chul Hwan Kim, Youngseok Lee, Dong-Sik Kim, Young-Dong Yu, Joo Young Kim
- J Pathol Transl Med. 2018;52(1):64-66. Published online April 4, 2017
- DOI: https://doi.org/10.4132/jptm.2016.11.04
- 9,708 View
- 211 Download
- 4 Web of Science
- 5 Crossref
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Citations
Citations to this article as recorded by- Unexpected intraoperative finding of a hyalinizing cholecystitis in a patient with gallbladder calculi
Klaudia Gjinoska, Andrej Nikolovski, Emil Stoicovski, Zan Mitrev
Journal of Surgical Case Reports.2024;[Epub] CrossRef - 18F-FDG PET/CT in Hyalinized Cholecystitis
Esra Arslan, Aytül Hande Yardimci, Enver Yarikkaya, Göksel Alçin, Tevfik Fikret Çermik
Clinical Nuclear Medicine.2021; 46(4): e228. CrossRef - Gallbladder Carcinoma and Its Differential Diagnosis at MRI: What Radiologists Should Know
Camila Lopes Vendrami, Michael J. Magnetta, Pardeep K. Mittal, Courtney C. Moreno, Frank H. Miller
RadioGraphics.2021; 41(1): 78. CrossRef - A simple method for diagnosing gallbladder malignant tumors with subserosa invasion by endoscopic ultrasonography
Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi, Hiromasa Ohi
BMC Cancer.2021;[Epub] CrossRef - KRONİK KOLESİSTİTİN NADİR VE MALİGNİTE POTANSİYELİ YÜKSEK OLAN ALT TİPİ; HYALİNİZE KOLESİSTİT: OLGU SUNUMU
Leymune PARLAK, Bahar MEMİŞ
Balıkesir Medical Journal.2019; 3(3): 129. CrossRef
- Unexpected intraoperative finding of a hyalinizing cholecystitis in a patient with gallbladder calculi
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