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- Intravascular NK/T-cell lymphoma: a case report and literature review
- Ji Min Na, Wookjae Jung, Minhye Kim, Yun-Hong Cheon, Jong Sil Lee, Dae Hyun Song, Jung Wook Yang
- J Pathol Transl Med. 2023;57(6):332-336. Published online November 14, 2023
- DOI: https://doi.org/10.4132/jptm.2023.10.30
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- 4 Crossref
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Abstract
PDF - Intravascular lymphoma is characterized by an exclusively intravascular distribution of tumor cells. Intravascular natural killer/T-cell lymphoma (IVNKTL) is extremely rare, highly aggressive, commonly Epstein-Barr virus (EBV)–positive, and predominantly affects the skin and central nervous system. Here we report a case of IVNKTL diagnosed in a 67-year-old female, presenting with persistent intermittent fever and skin rashes throughout the body. Incisional biopsy of an erythematous lesion on the chest exhibited aggregation of medium to large-sized atypical lymphoid cells confined to the lumen of small vessels that were positive for CD3, granzyme B, and CD56 on immunohistochemistry and EBV-encoded RNA in situ hybridization. EBV DNA was also detected in serum after diagnosis. With a review of 26 cases of IVNKTL to date, we suggest that active biopsy based on EBV DNA detection may facilitate early diagnosis of IVNKTL.
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Citations
Citations to this article as recorded by
- Mimicry in the vasculature: a review of diagnostic clues in cutaneous intravascular lymphoid proliferations
MA Faraz, S Tu Zahra, F Ocampo-Gonzalez, SC Shalin, Aadil Ahmed
Diagnostic Histopathology.2026;[Epub] CrossRef - Intravascular Lymphoma: A Unique Pattern Underlying a Protean Disease
Mario Della Mura, Joana Sorino, Filippo Emanuele Angiuli, Gerardo Cazzato, Francesco Gaudio, Giuseppe Ingravallo
Cancers.2025; 17(14): 2355. CrossRef - Cutaneous Intravascular Hematolymphoid Entities: A Review
Emily Hatheway Marshall, Bethany Brumbaugh, Allison Holt, Steven T. Chen, Mai P. Hoang
Diagnostics.2024; 14(7): 679. CrossRef - CD30- and CD56-positive atypical intravascular lymphocytes of the uterine cervix, mimicking intravascular lymphoma: A case report and review of the literature
Daisuke Yamashita, Munemichi Otani, Hayato Maruoka, Takuya Aoki, Shigeo Hara
Journal of Clinical and Experimental Hematopathology.2024; 64(4): 328. CrossRef
- Mimicry in the vasculature: a review of diagnostic clues in cutaneous intravascular lymphoid proliferations
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