Journal of Pathology and Translational Medicine

Original Articles

Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma: Kijong Yi, Hyunsung Kim, Yumin Chung, Hyein Ahn, Jongmin Sim, Young Chan Wi, Ju Yeon Pyo, Young-Soo Song, Seung Sam Paik, Young-Ha Oh; J Pathol Transl Med. 2016;50(5):327-336. Published online August 31, 2016; DOI: https://doi.org/10.4132/jptm.2016.06.22

8,672 View
162 Download
4 Web of Science
3 Crossref

Background
Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important role during embryogenesis and also during cancer metastasis. Paired-related homeobox protein 1 (Prrx-1) is an EMT inducer that has recently been introduced, and its prognostic significance in HCC is largely unknown.
Methods
Tissue microarray was constructed using surgically resected primary HCCs from 244 cases. Immunohistochemical staining of E-cadherin and Prrx-1 was performed. The correlation between E-cadherin loss and Prrx-1 expression, as well as other clinicopathologic factors, was evaluated.
Results
E-cadherin expression was decreased in 96 cases (39.4%). Loss of E-cadherin correlated with a higher recurrence rate (p < .001) but was not correlated with patient’s survival. Thirty-two cases (13.3%) showed at least focal nuclear Prrx-1 immunoreactivity while all non-neoplastic livers (n = 22) were negative. Prrx-1 expression was not associated with E-cadherin loss, survival or recurrence rates, pathologic factors, or the Ki-67 labeling index. Twenty tumors that were positive for E-cadherin and Prrx-1 had significantly higher nuclear grades than the rest of the cohort (p = .037). In Cox proportional hazard models, E-cadherin loss and large vessel invasion were independent prognostic factors for shorter disease-free survival. Cirrhosis and high Ki-67 index (> 40%) were independent prognostic factors for shorter overall survival.
Conclusions
Prrx-1 was expressed in small portions of HCCs but not in normal livers. Additional studies with a large number of Prrx-1-positive cases are required to confirm the results of this study.

Citations

Citations to this article as recorded by

The Prognostic Importance of Ki-67 in Gastrointestinal Carcinomas: A Meta-analysis and Multi-omics Approach
Mahdieh Razmi, Fatemeh Tajik, Farideh Hashemi, Ayna Yazdanpanah, Fatemeh Hashemi-Niasari, Adeleh Divsalar
Journal of Gastrointestinal Cancer.2024;[Epub] CrossRef
Homotypic cell-in-cell structures as an adverse prognostic predictor of hepatocellular carcinoma
Ruizhi Wang, Yichao Zhu, Hao Zhong, Xinyue Gao, Qiang Sun, Meifang He
Frontiers in Oncology.2022;[Epub] CrossRef
Dysregulated paired related homeobox 1 impacts on hepatocellular carcinoma phenotypes
Weronika Piorońska, Zeribe Chike Nwosu, Mei Han, Michael Büttner, Matthias Philip Ebert, Steven Dooley, Christoph Meyer
BMC Cancer.2021;[Epub] CrossRef

Significance of Parafibromin Expression in Laryngeal Squamous Cell Carcinomas: Inju Cho, Mija Lee, Sharon Lim, Ran Hong; J Pathol Transl Med. 2016;50(4):264-269. Published online June 23, 2016; DOI: https://doi.org/10.4132/jptm.2016.04.24

8,332 View
58 Download
5 Web of Science
3 Crossref

Abstract PDF

Background
Parafibromin is a product of the tumor suppressor gene that has been studied as a potential indicator of tumor aggressiveness in the parathyroid, breast, colorectum, and stomach. However, the clinical significance and potential function of parafibromin expression in head and neck squamous cell carcinomas remain largely unknown. The aim of this study was to evaluate the expression of parafibromin in laryngeal squamous cell carcinoma (LSCC) and to verify its potential as a biomarker of tumor behavior.
Methods
Parafibromin expression was evaluated in 30 cases of LSCC using immunohistochemistry. The correlations between parafibromin expression and clinicopathologic parameters were investigated.
Results
Parafibromin expression was positive in 15 cases (50%) and negative in 15 cases (50%). Tumor size and T stage showed a statistically significant inverse relationship with parafibromin expression (p=.028 and p<.001, respectively). Parafibromin expression was not associated with age, sex, lymph node metastasis, tumor differentiation, or tumor location. There was no statistically significant relationship between parafibromin expression and progression-free survival in the patients (p>.05).
Conclusions
Our results indicate that the downregulation or loss of parafibromin expression can be employed as a novel marker of tumor progression or aggressiveness in LSCC.

Citations

Citations to this article as recorded by

Advances in the application of label‐free quantitative proteomics techniques in malignancy research
Xiao Meng, Dong Liu, Yan Guan
Biomedical Chromatography.2023;[Epub] CrossRef
The roles of the tumor suppressor parafibromin in cancer
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
The clinicopathological and prognostic significances of CDC73 expression in cancers: a bioinformatics analysis
Hua-Chuan Zheng, Bao-Cheng Gong, Shuang Zhao
Oncotarget.2017; 8(56): 95270. CrossRef

Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma: Hyojin Kim, Seol Bong Yoo, Pingli Sun, Yan Jin, Sanghoon Jheon, Choon Taek Lee, Jin-Haeng Chung; Korean J Pathol. 2013;47(1):44-51. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.44

9,809 View
44 Download
35 Crossref

Abstract PDF

Background

Epithelial-mesenchymal transition (EMT) is an important step in the invasion and progression of cancer and in the development of chemoresistance by cancer cells.

Methods

To address the clinical significance of the EMT pathway in lung adenocarcinoma and the association of the pathway with histological subtype, we examined 193 surgically resected lung adenocarcinoma samples for the expression of representative EMT-related proteins (E-cadherin, β-catenin, and vimentin) by immunohistochemistry. Histological subtypes were classified according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results for EMT-related protein expression were analyzed for correlation with clinicopathological features and with survival.

Results

The loss of E-cadherin expression and aberrant β-catenin expression were significantly associated with larger tumor size, pleural invasion, lymphatic/vascular invasion, and advanced pathological stage (p<0.05). The alteration of the E-cadherin/β-catenin complex was least frequently observed in the lepidic-predominant group, but these associations were not statistically significant. In the multivariate analysis, altered E-cadherin/β-catenin complex expression was found to be an independent poor prognostic factor (p=0.017; hazard ratio, 1.926; 95% confidence interval, 1.119 to 3.314).

Conclusions

The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma.

Citations

Citations to this article as recorded by

Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma
Eunhyang Park, Soo Young Park, Ping-Li Sun, Yan Jin, Ji Eun Kim, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Hyojin Kim, Jin-Haeng Chung
Oncotarget.2106; 7(27): 42502. CrossRef
Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma
Wenhan Cai, Miao Jing, Jiaxin Wen, Hua Guo, Zhiqiang Xue
Frontiers in Genetics.2022;[Epub] CrossRef
Clinicopathological significance and prognostic value of E-cadherin expression in non-small cell lung cancer
Dong Chao, Gawei Hu, Qingxin Li
Medicine.2021; 100(7): e24748. CrossRef
Aberrant Expression of β-Catenin Correlates with Infiltrating Immune Cells and Prognosis in NSCLC
Hongmei Zheng, Yue Ning, Yang Yang, Yuting Zhan, Haihua Wang, Qiuyuan Wen, Jinwu Peng, Songqing Fan
Pathology and Oncology Research.2021;[Epub] CrossRef
Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer
Anna Wrona, Aleksandra Sejda, Rafał Dziadziuszko, Jacek Jassem
Journal of Histochemistry & Cytochemistry.2021; 69(11): 711. CrossRef
Analysis of genes associated with prognosis of lung adenocarcinoma based on GEO and TCGA databases
Ye Yu, Xuemei Tian
Medicine.2020; 99(19): e20183. CrossRef
The roles of TG-interacting factor in cadmium exposure-promoted invasion and migration of lung cancer cells
Yadong Wang, Li Shi, Jiangmin Li, Haiyu Wang, Haiyan Yang
Toxicology in Vitro.2019; 61: 104630. CrossRef
Pizotifen inhibits the proliferation and invasion of gastric cancer cells
Ying Jiang, Wei Wang, Xi Wu, Jihua Shi
Experimental and Therapeutic Medicine.2019;[Epub] CrossRef
SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients
Camille Emprou, Pauline Le Van Quyen, Jérémie Jégu, Nathalie Prim, Noëlle Weingertner, Eric Guérin, Erwan Pencreach, Michèle Legrain, Anne‐Claire Voegeli, Charlotte Leduc, Bertrand Mennecier, Pierre‐Emmanuel Falcoz, Anne Olland, Nicolas Santelmo, Elisabet
Cancer Medicine.2018; 7(7): 3278. CrossRef
E-Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma
Kerstin W. Sinkevicius, Kelly J. Bellaria, Juliana Barrios, Patrizia Pessina, Manav Gupta, Christine Fillmore Brainson, Roderick T. Bronson, Carla F. Kim
American Journal of Respiratory Cell and Molecular Biology.2018; 59(2): 237. CrossRef
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells
Linjun Niu, Ang Liu, Wei Xu, Liang Yang, Wugang Zhu, Yuming Gu
Oncology Letters.2018;[Epub] CrossRef
Implications of NOVA1 suppression within the microenvironment of gastric cancer: association with immune cell dysregulation
Eun Kyung Kim, Sun Och Yoon, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi, Woo Ick Yang
Gastric Cancer.2017; 20(3): 438. CrossRef
High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma
Kotaro Higashi, Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe
Annals of Nuclear Medicine.2017; 31(8): 590. CrossRef
MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status
Hyojin Kim, Jeong Mi Yang, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung, Jin Ho Paik
Oncotarget.2017; 8(5): 8484. CrossRef
A meta-analysis of abnormal β-catenin immunohistochemical expression as a prognostic factor in lung cancer: location is more important
Y. Yang, J. Shen, Jiaxi He, Jianxing He, G. Jiang
Clinical and Translational Oncology.2016; 18(7): 685. CrossRef
Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma
Sumi Yun, Ping-Li Sun, Yan Jin, Hyojin Kim, Eunhyang Park, Soo Young Park, Kyuho Lee, Kyoungyul Lee, Jin-Haeng Chung
Journal of Pathology and Translational Medicine.2016; 50(4): 251. CrossRef
Prognostic Values of Vimentin Expression and Its Clinicopathological Significance in Non-Small Cell Lung Cancer: A Meta-Analysis of Observational Studies with 4118 Cases
Zhihua Ye, Xin Zhang, Yihuan Luo, Shikang Li, Lanshan Huang, Zuyun Li, Ping Li, Gang Chen, Aamir Ahmad
PLOS ONE.2016; 11(9): e0163162. CrossRef
Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression
DAE HYUN SONG, GYUNG HYUCK KO, JEONG HEE LEE, JONG SIL LEE, GYEONG-WON LEE, HYEON CHEOL KIM, JUNG WOOK YANG, ROK WON HEO, GU SEOB ROH, SUN-YOUNG HAN, DONG CHUL KIM
Oncology Letters.2016; 11(2): 998. CrossRef
Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells
CONG CHEN, YUYANG XUE, DEJUN ZHANG, WEI XU, HAO XU, HONG YAO, DONGSHENG PEI, YUMING GU
Oncology Letters.2016; 11(3): 2039. CrossRef
NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal
Sun Och Yoon, Eun Kyung Kim, Mira Lee, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi, Woo Ick Yang
Oncotarget.2016; 7(3): 2475. CrossRef
Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer
XIANHUA XU, JI EUN KIM, PING-LI SUN, SEOL BONG YOO, HYOJIN KIM, YAN JIN, JIN-HAENG CHUNG
Experimental and Therapeutic Medicine.2015; 9(2): 311. CrossRef
FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/β-catenin Complex Formation
Qiong Shi, Xu Song, Jun Wang, Jia Gu, Weijian Zhang, Jinxia Hu, Xiuping Zhou, Rutong Yu
Journal of Molecular Neuroscience.2015; 55(1): 32. CrossRef
Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells
Lanhai Lü, Xiqiang Liu, Cheng Wang, Fengchun Hu, Jianning Wang, Hongzhang Huang
Toxicology in Vitro.2015; 29(8): 1965. CrossRef
Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells
JINGLI SHI, FEI LIU, WENZHANG ZHANG, XIN LIU, BIHUA LIN, XUDONG TANG
Oncology Reports.2015; 33(6): 2972. CrossRef
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas
A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
British Journal of Cancer.2014; 110(11): 2688. CrossRef
The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
Korean Journal of Pathology.2014; 48(4): 263. CrossRef
Adenoid dysplasia of the oral mucosa
Belinda Bunn, Keith Hunter, Syed Ali Khurram, W.F.P. van Heerden
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2014; 118(5): 586. CrossRef
FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer
An Na Seo, Yan Jin, Hee Jin Lee, Ping-Li Sun, Hyojin Kim, Sanghoon Jheon, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
Virchows Archiv.2014; 465(5): 547. CrossRef
FNC, a Novel Nucleoside Analogue, Blocks Invasion of Aggressive Non-Hodgkin Lymphoma Cell Lines Via Inhibition of the Wnt/β-Catenin Signaling Pathway
Yan Zhang, Chen-Ping Wang, Xi-Xi Ding, Ning Wang, Fang Ma, Jin-Hua Jiang, Qing-Duan Wang, Jun-Biao Chang
Asian Pacific Journal of Cancer Prevention.2014; 15(16): 6829. CrossRef
β-Catenin overexpression is associated with gefitinib resistance in non-small cell lung cancer cells
Xia Fang, Pan Gu, Caicun Zhou, Aibin Liang, Shenxiang Ren, Fang Liu, Yu Zeng, Yunjin Wu, Yinmin Zhao, Binbin Huang, Zongmei Zhang, Xianghua Yi
Pulmonary Pharmacology & Therapeutics.2014; 28(1): 41. CrossRef
Tumor‐size‐based morphological features of metastatic lymph node tumors from primary lung adenocarcinoma
Eiji Yamada, Genichiro Ishii, Nao Aramaki, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Motohiro Kojima, Kanji Nagai, Atsushi Ochiai
Pathology International.2014; 64(12): 591. CrossRef
Prognostic and Clinicopathological Significance of Downregulated E-Cadherin Expression in Patients with Non-Small Cell Lung Cancer (NSCLC): A Meta-Analysis
Yan-Long Yang, Ming-Wu Chen, Lei Xian, Alfons Navarro
PLoS ONE.2014; 9(6): e99763. CrossRef
Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
Guofeng Yu, Yingying Jing, Xingrui Kou, Fei Ye, Lu Gao, Qingmin Fan, Yang Yang, Qiudong Zhao, Rong Li, Mengchao Wu, Lixin Wei, Xin-Yuan Guan
PLoS ONE.2013; 8(9): e73312. CrossRef
A Comprehensive Comparative Analysis of the Histomorphological Features of ALK-Rearranged Lung Adenocarcinoma Based on Driver Oncogene Mutations: Frequent Expression of Epithelial-Mesenchymal Transition Markers than Other Genotype
Hyojin Kim, Se Jin Jang, Doo Hyun Chung, Seol Bong Yoo, Pingli Sun, Yan Jin, Kyung Han Nam, Jin-Ho Paik, Jin-Haeng Chung, Alfredo Fusco
PLoS ONE.2013; 8(10): e76999. CrossRef
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly, Vera Levina
Molecular Cancer.2013;[Epub] CrossRef

Loss of E-cadherin and Acquisition of Vimentin in Epithelial-Mesenchymal Transition are Noble Indicators of Uterine Cervix Cancer Progression: Na-Hye Myong; Korean J Pathol. 2012;46(4):341-348. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.341

8,821 View
78 Download
57 Crossref

Abstract PDF

Background

Epithelial-mesenchymal transition (EMT) has been known to play a key role in the stromal invasion of carcinoma in situ (CIS) lesion. Loss of E-cadherin and acquisition of vimentin are two critical steps in EMT, that are induced by Snail-1 upregulation associated with overexpression of epidermal growth factor receptor (EGFR). However, roles of EMT-related proteins in human cervical tissues have not been fully elucidated. In this study, we investigated the immunoexpressions of EMT-related proteins in CIS, microinvasive squamous cell carcinoma (SCC), and invasive SCC to demonstrate their key roles in tumor progression.

Methods

Eighty one CIS, 17 microinvasive, and 21 invasive SCC cases were immunostained with primary antibodies for Snail-1, EGFR, E-cadherin, and vimentin on paraffin-embedded tissue microarray blocks.

Results

EGFR and Snail-1 proteins were highly expressed but the levels were not significantly different between the three groups. However, loss of E-cadherin and acquisition of vimentin were proven to occur significantly higher in microinvasive and invasive SCC cases than in CIS.

Conclusions

E-cadherin and vimentin were found to be two useful indicators of EMT in evaluating stromal invasion of CIS. However, it was not demonstrated for Snail-1 and EGFR proteins to play any key role in the progression of cervix cancer.

Citations

Citations to this article as recorded by

The effects of low-dose sorafenib on epithelial-mesenchymal transition and multidrug resistance markers in HepG2 cell line
Yaprak DÖNMEZ ÇAKIL, Zeynep AKBULUT, Gamze DEMİREL, Ranan GÜLHAN, Zeynep OZUNAL
The European Research Journal.2023; 9(2): 367. CrossRef
Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets
Xiaofeng Qin, Yujie Ning, Liming Zhou, Youming Zhu
International Journal of Molecular Sciences.2023; 24(5): 4992. CrossRef
Comparative Assessment of E-cadherin’s Expression between the Metastatic and Non-metastatic Oral Squamous Cell Carcinoma: An Immunohistochemical Study
Sufia Khan, Veda Hegde, Deepti Shrivastava, Mohammed Azamulla, Mohammad Khursheed Alam, Kumar Chandan Srivastava
Pesquisa Brasileira em Odontopediatria e Clínica Integrada.2023;[Epub] CrossRef
Role of Vimentin and E-cadherin Expression in Premalignant and Malignant Lesions of Oral Cavity
Sandesh Kumar Gupta, Sunita Agarwal, Shashank Nath Singh, Ritu Sehra, Prem Singh Jat, Pawan Singhal
Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(3): 350. CrossRef
Increased Sphingosine Kinase 1 Expression Is Associated with Poor Prognosis in Human Solid Tumors: A Meta-Analysis
Chuanmeng Zhang, Chenglin Zhou, Jie Xu, Shanshan Xue, Alexander G Mathioudakis
Disease Markers.2022; 2022: 1. CrossRef
Current Progress of EMT: A New Direction of Targeted Therapy for Colorectal Cancer with Invasion and Metastasis
Zhuomin Tan, Wenyan Sun, Ya Li, Xingmeng Jiao, Mingliang Zhu, Junfei Zhang, Chen Qing, Yinnong Jia
Biomolecules.2022; 12(12): 1723. CrossRef
Study of expression of epithelial cadherin in benign and malignant epithelial lesions of uterine cervix
Pooja Gupta, Pooja Agarwal, Lalit Kumar, Shikha Prakash, Poonam Yadav
Journal of Datta Meghe Institute of Medical Sciences University.2022; 17(3): 662. CrossRef
Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods, Zahra Madjd
Cancer Cell International.2021;[Epub] CrossRef
MACC1 Is Associated With Epithelial–Mesenchymal Transition and Can Predict Poor Prognosis in Nasopharyngeal Carcinoma
Hao Cheng, Linxiang Zhou, Yalan Long, Juanjuan Xiang, Longhua Chen
Frontiers in Oncology.2021;[Epub] CrossRef
Cellular and biomolecular detection based on suspended microchannel resonators
Juhee Ko, Jaewoo Jeong, Sukbom Son, Jungchul Lee
Biomedical Engineering Letters.2021; 11(4): 367. CrossRef
Anticancer Properties of Eugenol: A Review
Ali T. Zari, Talal A. Zari, Khalid Rehman Hakeem
Molecules.2021; 26(23): 7407. CrossRef
Up-regulated microRNA-33b inhibits epithelial–mesenchymal transition in gallbladder cancer through down-regulating CROCC
Guohui Xu, Xiaoyong Wei, Qiang Tu, Cuncai Zhou
Bioscience Reports.2020;[Epub] CrossRef
Independent Validation of Tumor Budding Activity and Cell Nest Size as Determinants of Patient Outcome in Squamous Cell Carcinoma of the Uterine Cervix
Somaye Y. Zare, Omonigho Aisagbonhi, Farnaz Hasteh, Oluwole Fadare
American Journal of Surgical Pathology.2020; 44(9): 1151. CrossRef
Study of long non-coding RNA highly upregulated in liver cancer (HULC) in breast cancer: A clinical & in vitro investigation
ReyhanehRavanbakhsh Gavgani, Esmaeil Babaei, MohammadAli Hosseinpourfeizi, Ashraf Fakhrjou, Vahid Montazeri
Indian Journal of Medical Research.2020; 152(3): 244. CrossRef
Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation
Xiaodong Sun, Qianqian Xu, Lian Zeng, Lixia Xie, Qiang Zhao, Hongxia Xu, Xuanbin Wang, Nan Jiang, Pan Fu, Ming Sang
Cancer Medicine.2020; 9(22): 8685. CrossRef
microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity
Xue Bai, Changjun He, Bicheng Fu, Xianglong Kong, Jianlong Bu, Kaibin Zhu, Wei Zheng, Fucheng Zhou, Boxiong Ni
Cell Cycle.2020; 19(23): 3260. CrossRef
TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines
Alfredo I. Sagredo, Eduardo A. Sagredo, Victor Pola, César Echeverría, Rodrigo Andaur, Luis Michea, Andrés Stutzin, Felipe Simon, Katherine Marcelain, Ricardo Armisén
Journal of Cellular Physiology.2019; 234(3): 2037. CrossRef
Overexpression of microRNA‐190 inhibits migration, invasion, epithelial‐mesenchymal transition, and angiogenesis through suppression of protein kinase B‐extracellular signal‐regulated kinase signaling pathway via binding to stanniocalicin 2 in breast canc
Guiming Sun, Meirong Liu, Hui Han
Journal of Cellular Physiology.2019; 234(10): 17824. CrossRef
Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review
Barbora Peltanova, Martina Raudenska, Michal Masarik
Molecular Cancer.2019;[Epub] CrossRef
YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis
Tingting Yang, Fanglin Shu, Hao Yang, Cai Heng, Yi Zhou, Yibing Chen, Xuan Qian, Lei Du, Xia Zhu, Qian Lu, Xiaoxing Yin
Metabolism.2019; 96: 33. CrossRef
Malignant ascites-derived exosomes promote peritoneal tumor cell dissemination and reveal a distinct miRNA signature in advanced gastric cancer
Yanting Hu, Changsong Qi, Xiang Liu, Cheng Zhang, Jing Gao, Yi Wu, Jing Yang, Qian Zhao, Jian Li, Xiaojuan Wang, Lin Shen
Cancer Letters.2019; 457: 142. CrossRef
Silencing of lysyl oxidase‑like 2 inhibits the migration, invasion and epithelial‑to‑mesenchymal transition of renal cell carcinoma cells through the Src/FAK signaling pathway
Xi Hong, Jian‑Jun Yu
International Journal of Oncology.2019;[Epub] CrossRef
YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma
Jingxia Han, Jing Meng, Shuang Chen, Xiaorui Wang, Shan Yin, Qiang Zhang, Huijuan Liu, Rong Qin, Zhongwei Li, Weilong Zhong, Chao Zhang, Heng Zhang, Yuanhao Tang, Tingting Lin, Wanfeng Gao, Xiaoyun Zhang, Lan Yang, Yanrong Liu, Hong-gang Zhou, Tao Sun, Ch
Cancer Research.2019; 79(7): 1451. CrossRef
E-cadherin: Its dysregulation in carcinogenesis and clinical implications
Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, Siew Ching Ngai
Critical Reviews in Oncology/Hematology.2018; 121: 11. CrossRef
NDRG2 suppresses proliferation, migration, invasion and epithelial-mesenchymal transition of esophageal cancer cells through regulating the AKT/XIAP signaling pathway
Cheng-Liang Yang, Xiao-Li Zheng, Ke Ye, Hong Ge, Ya-Nan Sun, Yu-Fei Lu, Qing-Xia Fan
The International Journal of Biochemistry & Cell Biology.2018; 99: 43. CrossRef
NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer
Guoda Han, Zhijiang Wei, Haibin Cui, Wei Zhang, Xiaonan Wei, Zhiliang Lu, Xiyong Bai
Experimental Cell Research.2018; 367(2): 216. CrossRef
Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes
Matthew L. Scott, David T. Coleman, Kinsey C. Kelly, Jennifer L. Carroll, Brittany Woodby, William K. Songock, James A. Cardelli, Jason M. Bodily
Virology.2018; 519: 1. CrossRef
Lamin A/C might be involved in the EMT signalling pathway
Lingkun Zuo, Huanying Zhao, Ronghui Yang, Liyong Wang, Hui Ma, Xiaoxue Xu, Ping Zhou, Lu Kong
Gene.2018; 663: 51. CrossRef
Potential role of periodontal pathogens in compromising epithelial barrier function by inducing epithelial‐mesenchymal transition
A. A. Abdulkareem, R. M. Shelton, G. Landini, P. R. Cooper, M. R. Milward
Journal of Periodontal Research.2018; 53(4): 565. CrossRef
Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery
Varisa Pongrakhananon, Onsurang Wattanathamsan, Masatoshi Takeichi, Paninee Chetprayoon, Pithi Chanvorachote
Journal of Cell Science.2018;[Epub] CrossRef
A Role for βA3/A1-Crystallin in Type 2 EMT of RPE Cells Occurring in Dry Age-Related Macular Degeneration
Sayan Ghosh, Peng Shang, Hiroto Terasaki, Nadezda Stepicheva, Stacey Hose, Meysam Yazdankhah, Joseph Weiss, Taiji Sakamoto, Imran A. Bhutto, Shuli Xia, J. Samuel Zigler, Ram Kannan, Jiang Qian, James T. Handa, Debasish Sinha
Investigative Opthalmology & Visual Science.2018; 59(4): AMD104. CrossRef
Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
Luca Maroni, Laura Agostinelli, Stefania Saccomanno, Claudio Pinto, Debora M. Giordano, Chiara Rychlicki, Samuele De Minicis, Luciano Trozzi, Jesus M. Banales, Espen Melum, Tom H. Karlsen, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni
The American Journal of Pathology.2017; 187(2): 366. CrossRef
Corepressor metastasis-associated protein 3 modulates epithelial-to-mesenchymal transition and metastasis
Liang Du, Zhifeng Ning, Fuxing Liu, Hao Zhang
Chinese Journal of Cancer.2017;[Epub] CrossRef
JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype
Gayoung Lee, Hyun-Man Kim
Biochemical and Biophysical Research Communications.2017; 487(4): 862. CrossRef
Invasive Front Grading and Epithelial-Mesenchymal Transition in Canine Oral and Cutaneous Squamous Cell Carcinomas
E. Nagamine, K. Hirayama, K. Matsuda, M. Okamoto, T. Ohmachi, K. Uchida, T. Kadosawa, H. Taniyama
Veterinary Pathology.2017; 54(5): 783. CrossRef
Protein kinase B
Bhumika Wadhwa, Ubaid Makhdoomi, Ram Vishwakarma, Fayaz Malik
Anti-Cancer Drugs.2017; 28(6): 569. CrossRef
Correlation analysis between the parameters of contrast-enhanced ultrasonography in evaluating cervical cancer metastasis and expression of E-cadherin
Xiaolan Lv, Min Hou, Xiaojing Duan
Oncology Letters.2017; 14(4): 4641. CrossRef
Distribution of telocytes in the corpus and cervix of human uterus: an immunohistochemical study
Martin Klein, Ladislav Urban, Ivan Deckov, Lubos Danisovic, Stefan Polak, Ludovit Danihel, Ivan Varga
Biologia.2017; 72(10): 1217. CrossRef
Epithelial–mesenchymal transition, proliferation, and angiogenesis in locally advanced cervical cancer treated with chemoradiotherapy
Leonardo Rojas‐Puentes, Andrés F. Cardona, Hernán Carranza, Carlos Vargas, Luis F. Jaramillo, Delma Zea, Lucely Cetina, Beatriz Wills, Erika Ruiz‐Garcia, Oscar Arrieta
Cancer Medicine.2016; 5(8): 1989. CrossRef
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway
Zhiqin Liu, Leixi Xue, Zhichun Liu, Jun Huang, Jian Wen, Ji Hu, Lin Bo, Ru Yang
Mediators of Inflammation.2016; 2016: 1. CrossRef
Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions
Maximilian Linxweiler, Florian Bochen, Bernhard Schick, Silke Wemmert, Basel Al Kadah, Markus Greiner, Andrea Hasenfus, Rainer-Maria Bohle, Ingolf Juhasz-Böss, Erich-Franz Solomayer, Zoltan Ferenc Takacs
BMC Cancer.2016;[Epub] CrossRef
The indicative function of Twist2 and E-cadherin in HPV oncogene-induced epithelial-mesenchymal transition of cervical cancer cells
YUAN LIU, WENYAN QIAN, JIAWEN ZHANG, YU DONG, CAN SHI, ZHIQIANG LIU, SUFANG WU
Oncology Reports.2015; 33(2): 639. CrossRef
Prognostic significance of YY1 protein expression and mRNA levels by bioinformatics analysis in human cancers: A therapeutic target
Benjamin Bonavida, Samantha Kaufhold
Pharmacology & Therapeutics.2015; 150: 149. CrossRef
Expression of podoplanin and vimentin is correlated with prognosis in esophageal squamous cell carcinoma
MAKIKO TANAKA, HIROSHI KIJIMA, HIDEO SHIMADA, HIROYASU MAKUUCHI, SOJI OZAWA, SADAKI INOKUCHI
Molecular Medicine Reports.2015; 12(3): 4029. CrossRef
Podoplanin expression is correlated with the prognosis of lung squamous cell carcinoma
Yoichiro IKOMA, Hiroshi KIJIMA, Ryota MASUDA, Makiko TANAKA, Sadaki INOKUCHI, Masayuki IWAZAKI
Biomedical Research.2015; 36(6): 393. CrossRef
Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC
Xiaolu Zhai, Huijun Zhu, Wei Wang, Shu Zhang, Yixin Zhang, Guoxin Mao
Medical Oncology.2014;[Epub] CrossRef
The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
Korean Journal of Pathology.2014; 48(4): 263. CrossRef
Thrombomodulin mediates the migration of cervical cancer cells through the regulation of epithelial–mesenchymal transition biomarkers
Cheng-Jeng Tai, Chao-Wen Cheng, Hou-Yu Su, Wei-Yu Chen, Chun-Te Wu, Feng-Yen Lin, Chien-Kai Wang, Chen-Jei Tai, Po-Li Wei
Tumor Biology.2014; 35(1): 47. CrossRef
Role of epithelial to mesenchymal transition proteins in gynecological cancers: pathological and therapeutic perspectives
Xiao-mei Zhou, Hai Zhang, Xia Han
Tumor Biology.2014; 35(10): 9523. CrossRef
Normal Fibroblasts Induce E-Cadherin Loss and Increase Lymph Node Metastasis in Gastric Cancer
Wen Xu, Xinlei Hu, Zhongting Chen, Xiaoping Zheng, Chenjing Zhang, Gang Wang, Yu Chen, Xinglu Zhou, Xiaoxiao Tang, Laisheng Luo, Xiang Xu, Wensheng Pan, Elad Katz
PLoS ONE.2014; 9(5): e97306. CrossRef
The Culture of Cancer Cell Lines as Tumorspheres Does Not Systematically Result in Cancer Stem Cell Enrichment
Christophe Y. Calvet, Franck M. André, Lluis M. Mir, Anita B. Hjelmeland
PLoS ONE.2014; 9(2): e89644. CrossRef
Role of YY1 in the pathogenesis of prostate cancer and correlation with bioinformatic data sets of gene expression
Vaishali Kashyap, Benjamin Bonavida
Genes & Cancer.2014; 5(3-4): 71. CrossRef
Expression and Significance of Twist and E-cadherin in Ovarian Cancer Tissues
Wen-Shuang Wang, Shou-Li Yu, Xing-Sheng Yang, Shu-De Chang, Jian-Qing Hou
Asian Pacific Journal of Cancer Prevention.2013; 14(2): 669. CrossRef
The glioma-associated oncogene homolog 1 promotes epithelial–mesenchymal transition in human esophageal squamous cell cancer by inhibiting E-cadherin via Snail
S Min, X Xiaoyan, P Fanghui, W Yamei, Y Xiaoli, W Feng
Cancer Gene Therapy.2013; 20(7): 379. CrossRef
TACC3 Is Essential for EGF-Mediated EMT in Cervical Cancer
Geun-Hyoung Ha, Jung-Lye Kim, Eun-Kyoung Yim Breuer, Antimo Migliaccio
PLoS ONE.2013; 8(8): e70353. CrossRef
Overexpression of E2F1 Promotes Tumor Malignancy And Correlates with TNM Stages in Clear Cell Renal Cell Carcinoma
Xin Ma, Yu Gao, Yang Fan, Dong Ni, Yu Zhang, Weihao Chen, Peng Zhang, Erlin Song, Qingbo Huang, Qing Ai, Hongzhao Li, Baojun Wang, Tao Zheng, Taoping Shi, Xu Zhang, Hiromu Suzuki
PLoS ONE.2013; 8(9): e73436. CrossRef
Transforming growth factor-β1 induces bronchial epithelial cells to mesenchymal transition by activating the Snail pathway and promotes airway remodeling in asthma
ZHAO-CHUAN YANG, MING-JI YI, NI RAN, CHONG WANG, PENG FU, XUE-YING FENG, LEI XU, ZHENG-HAI QU
Molecular Medicine Reports.2013; 8(6): 1663. CrossRef

First
Prev
Page of 1
Next
Last

Search