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The Korean Journal of Pathology 2011;45(1): 30-35.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.1.30
Use of Calretinin, CD56, and CD34 for Differential Diagnosis of Schwannoma and Neurofibroma.
Ji Young Park, Hoon Park, Nam Jo Park, June Sik Park, Hyun Jung Sung, Sang Sook Lee
1Department of Pathology, Keimyung University School of Medicine, Daegu, Korea. sangsook@dsmc.or.kr
2Department of Otolaryngology, Korea Cancer Center Hospital, Seoul, Korea.
3Department of Otolaryngology, Kyungpook National University School of Medicine, Daegu, Korea.
4Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea.
BACKGROUND: It is important to differentiate between schwannomas and neurofibromas for the cases in which the histopathologic features overlap. Depending on the tumor type, surgeons can decide on a treatment method and whether to preserve or sacrifice the nerve; the possibility of malignant transformation in the case of neurofibromas also needs to be considered. METHODS: We studied 101 cases of schwannoma and 103 cases of neurofibroma. All the hematoxylin and eosin slides for these cases were reviewed, and tissue microarrays were prepared from the representative areas. Immunohistochemical analysis was performed using antibodies for S-100 protein, calretinin, CD56 and CD34. RESULTS: All the tumors except 3 neurofibromas were positive for the S-100 protein. Calretinin was found in 26.7% of the schwannomas (27/101), but it was not found in any of the neurofibromas. CD56 was positive in 77.2% of the schwannomas (78/101) and in 9.8% of the neurofibromas (10/102). CD34 was positive in 42.5% of the schwannomas (43/101) and in 80.2% of the neurofibromas (81/101). Statistically, calretinin was significantly specific for schwannomas (p<0.001) and CD56 was also sensitive for these tumors (p<0.001). On the other hand, a CD34 expression seemed highly sensitive (p<0.001) for neurofibromas. CONCLUSIONS: We concluded that combined immunohistochemical analysis for calretinin, CD56, and CD34 may be very useful for differentiating schwannomas from neurofibromas.
Key Words: Schwannoma; Neurofibroma; Immunohistochemistry; Diagnosis, differential