Abstract

Since the Cuthbertson’s report that traumatic injuries caused a marked increase of non-protein nitrogen in the urine, it has been generally believed that the traumatic injuries enhanced the catabolism of the body, and this increased catabolism was induced by the secretion of corticoids following trauma. However, it has also been known that traumatic injuries stimulate and increase the anabolism as well as catabolism(Whipple). Investigations have been carried out by the members of our department on the mechanism of the inversion of albumin globulin ratio of plasma protein and the elevation of plasma fibrinogen after burn. According to Lee and Kim(1969), the inversion of albumin-globulin ratio of plasma protein after burn is due to the increased synthesis of albumin and its accelerated "turn-over rate, and the coincidental decreased synthesis of fibrinogen and its retarded turn-over rate. On the other hand, it is well known that both albumin and fibrinogen are produced solely in the liver. Lee(1968) in our laboratories reported that the marked decrease of the incorporation rate of DL-lysine-T(G) into the liver protein in the burned rats, and Kim and Kim (1969) reported that in the burned mice the incorporation rate of L-leucine-U-l4C into the liver protein reached its maximum only 5 minutes after the injection and the curve for the changes of the incorporation rate of L-leucine-U-l4C into the liver protein plotted against time showed the same pattern as in the normal mice. The authors performed the autoradiographic observation on the incorporation rate of L-leucine-U-l4C into the liver cells and the renal tubular cells in both of normal and burned mice, to confirm of Kim’s studies morphologically. The following results were obtained: 1. In the burned mice, the labeled rate of L-leucine-U-l4C into the liver cell reached its maximum later than that in the normal mice, on the other hand, in the renal tubular cells the results were in opposite. 2. In the burned mice, the maximum number of grain of L-leucine-U-l4C reached earlier than that in the normal mice, on the other hand, in the renal tubular cells the inverse results were showed.