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Autoradiographic Studies of Early Incorporation of L-Leucine-U-l4C into Acinar Cells of the Salivary Glands and the Pancreas of Burned Mice
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Original Article Autoradiographic Studies of Early Incorporation of L-Leucine-U-l4C into Acinar Cells of the Salivary Glands and the Pancreas of Burned Mice
Kong Woo Shin, Young Che Kim
Journal of Pathology and Translational Medicine 1970;4(2):107-114
DOI: https://doi.org/
Department of Pathology. Catholic Medical College, Seoul, Korea
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Since the Cuthbertson’s report that traumatic injuries cause a marked increase of non-protein nitrogen in urine, it has been generally believed that the traumatic injuries enhance the catabolism of the body, and the increased catabolism is induced by the hypersecretion of corticoids following the trauma. However, it has also been reported by some in vestigators that injuries stimulate and increase the anabolism as well as catabolism in the protein metabism. Investigations have been carried out by the members of our department on the mechanism of elevation of plasma fibrinogen after confirmation of its occurrence following the traumatic injuries. They made clear that the inversion of the plasma albumin-globulin ratio of plasma protein after injury was the integral consequence of the decreased albumin amount due to the increased turn-over rate overshadowing the increased anabolism and of the increased fibrinogen amount due to decreased catabolism. Hong(1966) gave traumatic injuries to the pancreas and Im(1966) to the salivary gland, organs which contain large amount of nucleic acid among the body organs, and studied the influence of trauma on enzyme activity and the amount of RNA of those organs and made clear that the traumatic injuries gave rise to a marked increase of amylase activity and amount of ribonucleic acid in the pancreatic cells and a decrease in the amount of ribonucleic acid of the salivary gland. Therefore the authors performed the autoradiographic observation to evaluate the early incorporation rate of L-leucine-U-l4C into the acinar cells of the carotid gland, the sublingual gland and the pancreas of the burned mice. The results were as follows: In the burned mice, the incorporation rate of L-leucine-U-l4C into tile acinar cells of the salivary glands and the Pancreas reached its maximum earlier than that in the normal mice.

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