A case designated malignant mesothelioma most probably arising from the tunica vaginalis propria testis is described. The pathological diagnosis was based upon the clinical findings, gross and microscopic morphology, histochemical studies and likeness to the reported examples of mesothelioma arising from pleural and peritoneal mesothelial surfaces. About 5 years before admission the patient underwent orchiectomy under the diagnosis of hydrocele at local clinic with chief complaint of scrotal swelling for 5 years. From 1 year thereafter he noted a small slowly growing mass in the operation site of scrotum. At the time of second operation, 5 years later, a slightly tender, firm, man’s fist sized scrotal mass was excised. The malignant character of the neoplasm was demonstrated by the growing pattern, cytologic alterations and metastasis to the inguinal and pelvice lymph nodes and lungs.