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The Korean Journal of Pathology 1979;13(2): 83-92.
건강 성인 및 건강 신생아와 일부 빈혈성 질환 환자에 있어서 혈색소의 전기영동법적 관찰
A Study on Hemoglobin Electrophoresis in Healthy Adult Persons, Newborns at Birth and Patients with Anemic Diseases
ABSTRACT
The author investigated hemoglobin types in the peripheral blood obtained from antecubital vein of 90 cases of the healthy adult persons and 18 cases of the patients with anemia, and in the cord blood of 30 cases of the newborns at birth. The patients with anemia consisted of 6 cases of iron deficiency anemia, 6 cases of aplastic anemia and 6 cases of malignant tumor associated with anemia. The hemoglobin concentration estimated by cyanmethemoglobin method and the hemoglobin types estimated by cellulose acetate electrophoresis. The results obtained were summarized as follows : 1. In the healthy adult persons, the mean hemoglobin concentration was 16.0±1.2g/dl in male and 14.4±1.3g/dl in female. The mean percentages of HbA and HbA2 were 96.83±0.58 and 3.12±0.58%, respectively. 2. In the newborns at birth, the mean hemoglobin concentration was 16.7±1.5g/dl and the mean percentages of HbA and HbF were 27.3±5.5% and 72.7±5.5%, respectively. 3. In the patients with aplastic anemia, the mean percentages of HbA, HbA2 and HbF were 93.7±1.7, 2.6±0.4% and 4.2±1.8%, respectively. The mean percentage of HbF in the patients with aplastic anemia was significantly increased than that in the healthy adult persons, while the mean percentages of HbA and HbA2 were significantly decreased. 4. In the patients with iron deficiency anemia, the mean percentages of HbA and HbA2 were 97.6±0.4 and 2.4±0.4%, respectively. The mean percentage of HbA in the patient with iron deficiency anemia was significantly increased than that in the healthy adult persons, while the mean percentage of HbA2 was significantly decreased. 5. In the anemia patients with malignancy, the mean percentages of HbA and HbA2 were 96.8±0.78% and 3.2±0.78%, respectively. And the mean percentages of HbA and HbA2 were not significantly different between the healthy adult persons and the anemia patients with malignancy. According to these results, it may be somewhat helpful to estimate the hemoglobin types in the diagnosis and treatment of aplastic anemia and iron deficiency anemia.
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