Abstract

Inflammatory fibrous histiocytoma, known as an unusual variant of malignant fibrous histiocytoma, is characterized by diffuse and at times intense neutrophlic infiltration unassociated with tissue necrosis in the background of bidirectional proliferation of neoplastic histiocytes, morphologically. This report presents a case of inflammatory fibrous histiocytoma, arising in the posterior mediastinum of 45-year-old female patient. Preoperative leukocytosis aside from diffuse neutrophilic infiltration within the non-necrotic tumor tissue has been corrected after operation, but develops again with recurrence of metastatic lesion. The possible suggestions about the chemotactic effect of this neoplasm upon blood leukocytes of the host are discussed.