Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2022-10.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Pathol Transl Med > Volume 49(6); 2015 > Article
Brief Case Report Apocrine Carcinoma of the Axilla Associated with Extramammary Paget’s Disease: A Case Report and Review of the Literature
Hye Ra Jung, Sun Young Kwon, Daegu Son1
Journal of Pathology and Translational Medicine 2015;49(6):535-537.
DOI: https://doi.org/10.4132/jptm.2015.06.22
Published online: September 17, 2015
  • 7,693 Views
  • 47 Download
  • 4 Crossref
  • 4 Scopus

Department of Pathology, Keimyung University School of Medicine, Daegu, Korea

1Department of Plastic Surgery, Keimyung University School of Medicine, Daegu, Korea

Corresponding Author: Hye Ra Jung, MD Department of Pathology, Keimyung University School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, Korea Tel: +82-53-580-3826, Fax: +82-53-250-7211, E-mail:junghr0519@dsmc.or.kr
• Received: May 7, 2015   • Revised: June 18, 2015   • Accepted: June 22, 2015

© 2015 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Paget’s disease has traditionally been divided into mammary and extramammary. Extramammary Paget’s disease (EMPD) most commonly affects the anogenital area, though it can rarely affect the axillae, in which apocrine glands are normally encountered [1]. Herein, we report a rare case of apocrine carcinoma associated with EMPD of the axilla with review of the relevant literature.
The publication of the case information and materials was approved by the Institutional Review Board of Keimyung University Dongsan Medical Center.
A 77-year-old man was referred with a 3-month history of an erythematous, hyperkeratotic, and inflamed eczematous patch with focal desquamation and itching sensation in the left axilla. Examination of the left axilla showed a discrete red patch with irregular margins and exudative surface, measuring 5×3 cm. No fungal hyphae were noted on the KOH test. Histological examination of a punch biopsy showed round, pale malignant cells scattered individually and in groups throughout the epidermis, particularly in the basal layer. Also, a focal intradermal invasive lesion was noted. The patient was treated with wide excision with margins up to 2 cm. The cut surface of the resected specimen showed a round, pale, tan to white and solid subcutaneous mass, measuring 0.8 cm in diameter. The mass was attached to the overlying skin. Histologically, the subcutaneous mass consisted of large, round to polygonal cells with abundant eosinophilic cytoplasm, indicative of apocrine carcinoma. Some sweat glands in the dermis were filled with malignant cells, similar to those in the subcutaneous mass. These cells also involved the epidermis and showed a typical pagetoid spread. The infiltrative and intraepithelial tumor cells stained positive with periodic acid Schiff and showed strong positive immunohistochemical staining for cytokeratin 7 (CK7) and HER2, confirming the diagnosis of invasive apocrine carcinoma with EMPD (Fig. 1). The tumor cells showed focal and weak positivity for anti-gross cystic disease fluid protein-15 (GCDFP-15) and were negative for GATA-3, estrogen receptor, and progesterone receptor.
Based on these results, the patient was evaluated for evidence of breast cancer to rule out metastatic apocrine carcinoma from the breast. Chest radiograph and breast ultrasonogram showed no definite lesion. After 6 months of follow-up, the patient is healthy and free of symptoms.
Paget’s disease is an intraepithelial neoplastic lesion involving Paget cells, which are regarded as apocrine origin because of their immunohistochemical characteristics; positive staining for carcinoembryonic antigen, GCDFP-15, and CK7 [2].
In rare cases, Paget’s disease co-exists with underlying invasive apocrine carcinoma. EMPD with underlying invasive apocrine carcinoma in the axilla is rarer. Morgan et al. [3] reported a case of axillary EMPD with underlying apocrine carcinoma. They reported that 45.5% (5/11) of previously reported axillary EMPDs were associated with an underlying carcinoma [3]. Chiu et al. [4] reported seven cases of EMPD in the unilateral axilla, with only one patient having underlying adnexal carcinoma (14.3%).
Wilkinson and Brown [5] classified vulvar EMPD into intraepithelial Paget’s disease, intraepithelial Paget’s disease with invasion (IP), and intraepithelial Paget’s disease with underlying adenocarcinoma (IEPUA). Based on Wilkinson and Brown’s classification, the present case was thought to be IEPUA. In other studies of EMPD in the vulvar region, IEPUA represents between 2% and 37% of all cases [6-9]. Kodama et al. [8] reported a recurrence rate of 79.8% and a survival rate of 27.7% for patients with IEPUA. Parker et al. [9] have similarly reported poor prognosis for patients with IP and IEPUA [7]. However, in the report of Chiu et al. [4], no patient experienced recurrence after surgery (mean time of follow-up, 65.7 months) even in the cases of underlying malignancy (i.e., at least IP or IEPUA). All patients in their study underwent local wide excision with margins up to 2–3 cm. The authors offer that the low recurrence rate of patients in their study might be a result of the clear anatomy of the axillary region compared with that of the anogenital area, the early stages of their cases, and the limited follow-up.
When apocrine carcinoma is present in the axilla, metastasis from breast apocrine carcinoma or primary breast cancer in ectopic mammary tissue must be ruled out. Immunohistochemistry is not helpful in differentiating these options [10]. In apocrine carcinoma of ectopic mammary tissue, remaining ectopic mammary tissue is present in the sample. To exclude the possibility of metastatic mammary apocrine carcinoma, additional breast examination and radiologic work-up are needed. In the present case, there was no evidence of apocrine carcinoma arising in ectopic mammary tissue or of metastatic mammary apocrine carcinoma.
We report a rare case of EMPD with underlying invasive apocrine carcinoma in the axilla in order to increase awareness of EMPD in the axilla and to highlight its association at this site with adjacent underlying apocrine carcinoma.

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

Fig. 1.
(A) Slide scan of the left axillary lesion shows a round mass in the subcutaneous tissue. (B) Large tumor cells with abundant cytoplasm show a pagetoid spread pattern in the epidermis. (C) Tumor cells with abundant eosinophilic cytoplasm infiltrating the dermis. (D) Tumor cells showing diffuse strong positive staining for cytokeratin 7.
jptm-2015-06-22f1.gif
  • 1. Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF, Xu G. Lever’s histopathology of the skin. Philadelphia: Lippincott Williams & Wilkins, 2009.
  • 2. Merot Y, Mazoujian G, Pinkus G, Momtaz TK, Murphy GF. Extramammary Paget’s disease of the perianal and perineal regions: evidence of apocrine derivation. Arch Dermatol 1985; 121: 750–2. ArticlePubMed
  • 3. Morgan JM, Carmichael AJ, Ritchie C. Extramammary Paget’s disease of the axilla with an underlying apocrine carcinoma. Acta Derm Venereol 1996; 76: 173–4. PubMed
  • 4. Chiu CS, Yang CH, Chen CH. Extramammary Paget’s disease of the unilateral axilla: a review of seven cases in a 20-year experience. Int J Dermatol 2011; 50: 157–60. ArticlePubMed
  • 5. Wilkinson EJ, Brown HM. Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. Hum Pathol 2002; 33: 549–54. ArticlePubMed
  • 6. Shaco-Levy R, Bean SM, Vollmer RT, et al. Paget disease of the vulva: a histologic study of 56 cases correlating pathologic features and disease course. Int J Gynecol Pathol 2010; 29: 69–78. ArticlePubMed
  • 7. Jones IS, Crandon A, Sanday K. Paget’s disease of the vulva: diagnosis and follow-up key to management; a retrospective study of 50 cases from Queensland. Gynecol Oncol 2011; 122: 42–4. ArticlePubMed
  • 8. Kodama S, Kaneko T, Saito M, Yoshiya N, Honma S, Tanaka K. A clinicopathologic study of 30 patients with Paget’s disease of the vulva. Gynecol Oncol 1995; 56: 63–70. ArticlePubMed
  • 9. Parker LP, Parker JR, Bodurka-Bevers D, et al. Paget’s disease of the vulva: pathology, pattern of involvement, and prognosis. Gynecol Oncol 2000; 77: 183–9. ArticlePubMed
  • 10. Toledo-Pastrana T, Llombart-Cussac B, Traves-Zapata V, et al. Case report: differential diagnosis between primary cutaneous apocrine adenocarcinoma versus extramammary or metastatic breast adenocarcinoma. Am J Dermatopathol 2014; 36: e175–8. Article

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Axillary masses as clinical manifestations of male sweat gland carcinoma associated with extramammary Paget’s disease and accessory breast carcinoma: two cases report and literature review
      Jing Wu, Hongdan Chen, Juanhui Dong, Yong Cao, Wei Li, Fan Zhang, Xiaohua Zeng
      World Journal of Surgical Oncology.2022;[Epub]     CrossRef
    • Co-occurrence of apocrine adenocarcinoma and invasive mammary-type ductal carcinoma in extramammary Paget disease of the axilla
      Seung Bin Jang, Sung-Eun Kim, Young Ah Kim, Hye Ryeon Choi
      Archives of Plastic Surgery.2020; 47(01): 83.     CrossRef
    • Mohs micrographic surgery combined local flaps in treatment of EMPD: A retrospective case
      Lili Li, Chen Wang, Minghai Wei, Qitao Huang, Lan Wei, Nannan Pan, Zhi Xie
      Dermatologic Therapy.2018; 31(5): e12663.     CrossRef
    • Cutaneous Apocrine Carcinoma With an In Situ Component and Histiocytoid and Signet-Ring Cells
      Jérémie Berdugo, Vincent Dumont-Mackay, Sophie Brissy-Lachery, Yves E. Leclerc, Josée Doyon, Andrew Mitchell, Tony Petrella, Delphine Désy
      The American Journal of Dermatopathology.2017; 39(6): e76.     CrossRef


    JPTM : Journal of Pathology and Translational Medicine