Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct

Myunghee Kang; Na Rae Kim; Dong Hae Chung; Hyun Yee Cho; Yeon Ho Park

doi:10.4132/jptm.2018.09.03

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Case Study Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct: Myunghee Kang¹, Na Rae Kim^,1, Dong Hae Chung¹, Hyun Yee Cho¹, Yeon Ho Park²; Journal of Pathology and Translational Medicine 2019;53(2):112-118.
DOI: https://doi.org/10.4132/jptm.2018.09.03
Published online: October 1, 2018

¹Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea

²Department of Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea

Corresponding Author Na Rae Kim, MD, PD Department of Pathology, Gil Medical Center, Gachon University College of Medicine, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, Korea Tel: +82-32-460-3073 Fax: +82-32-460-2394 E-mail: clara_nrk@gilhospital.com

• Received: July 9, 2018 • Revised: August 22, 2018 • Accepted: September 3, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract
CASE REPORT
DISCUSSION
NOTES
REFERENCES

Abstract

We report a rare case of hilar squamous cell carcinoma. A 62-year-old Korean woman complaining of nausea was referred to our hospital. Her biliary computed tomography revealed a 28 mm-sized protruding solid mass in the proximal common bile duct. The patient underwent left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct. Microscopically, the tumor was a moderately differentiated squamous cell carcinoma of the extrahepatic bile duct, without any component of adenocarcinoma or metaplastic portion in the biliary epithelium. Immunohistochemically, the tumor was positive for cytokeratin (CK) 5/6, CK19, p40, and p63. Squamous cell carcinoma of the extrahepatic bile duct is rare. To date, only 24 cases of biliary squamous cell carcinomas have been reported. Here, we provide a clinicopathologic review of previously reported extrahepatic bile duct squamous cell carcinomas.
Keywords: Carcinoma, squamous cell; Klatskin tumor; Hepatic duct, common; Hilum; Chemotherapy

Cholangiocarcinoma is a malignant tumor arising from the biliary tree at any portion of the bile duct: from the bile ductules of the intrahepatic area to the ampulla of Vater. Most of the tumors are adenocarcinomas, and squamous cell carcinoma (SCC) of the extrahepatic bile duct is rare. Since the first reported case by Cabot and Painter [1], about 24 cases of bile duct SCC have been reported in the literature [2-18].

Here, we review the clinicopathologic characteristics of the reported cases of biliary SCC.

Clinical summary: A 62-year-old Korean woman complained of continuous nausea and abdominal discomfort for two months. Except for the diagnosis of thyroid papillary carcinoma 13 years prior to presentation, she had no history of other malignancies or cholelithiasis. Abdominal computed tomography (CT) performed at a local clinic revealed a dilated bile duct (Fig. 1A). Magnetic resonance cholangiopancreatography revealed luminal narrowing in the distal bile duct with proximal dilation (Fig. 1B). Perihilar proximal biliary cholangiocarcinoma was suspected. Liver magnetic resonance images (MRI) showed a 1 cm-sized, non-enhancing, T2 high signal intensity lesion in the left lobe, suggesting hepatic cyst or abscess. Metastasis to the common hepatic artery, portocaval lymph node, and hepatic duct ligament was also suspected. Preoperatively, an endoscopic retrograde cholangiopancreatography-assisted biopsy was performed, and a diagnosis of carcinoma with squamous differentiation was rendered. Subsequently, left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct were performed. After surgical resection, abdominal CT revealed an enlarged common hepatic arterial lymph node, resulting in suspicion of metastasis. The patient developed ascites and a pleural effusion. In addition, a thrombus developed in the superior vena cava. Heparin was used for treatment of thrombus; however, heparin-induced thrombocytopenia was followed. The patient received 5-fluorouracil (5-FU) and cisplatin, but chemotherapy had to be stopped after the first cycle due to pancytopenia, aggravating thrombocytopenia, and persistent fever. The patient refused additional chemoradiotherapy. During the postoperative 15 months, liver MRI showed metastasis with increased size in the hepatic duct lymph nodes, portocaval, and paraduodenal areas, and the largest size increased from 1.8 to 3.1 cm in short diameter. The patient was alive over the 15-month follow-up period.
Pathological findings: Left hemihepatectomy with S1 segmentectomy and segmental excision of the common bile duct were performed. Serial sections revealed a firm grayish-white mass measuring 2.8 cm at the proximal common hepatic duct near the hilar region (Fig. 2A). The mass did not involve the cystic duct or the right and left hepatic ducts. Microscopically, the papillary-protruded mass was composed entirely of squamous cells with eosinophilic keratin pearls (Fig. 2B). The surface of the mass was denuded and inflamed due to preoperative stent insertion. No mucin production or duct formation was detected. There were no metaplastic or biliary intraepithelial neoplastic lesions. An abrupt transition to neoplastic squamous epithelium from the cuboidal biliary epithelium was noted (Fig. 2C). Mitosis was frequently found. The tumor extended to the pericholedochal fibroconnective tissue. Lymphovascular and perineural invasion were noted. The tumor cells were positive for cytokeratin (CK) 5/6 (CK5/6; 1:100, D5/16 B4, Dako, Glostrup, Denmark), CK19 (prediluted, B/70, Novocastra, Newcastle upon Tyne, UK), p63 (prediluted, DAK-P63, Dako) (Fig. 2D), p40 (prediluted, BC28, Dako), and Ki-67 (1:100, MIB-1, Dako). However, the tumor cells were negative for CK7 (1:100, OV-TL 12/30, Dako), CK20 (1:100, KS 20.8, Dako), periodic acid Schiff, and polyclonal carcinoembryonic antigen (prediluted, polyclonal, Dako). The tumor cells were focally non-block positive for p16 (1:200, JC8, Santa Cruz Biotechnology, Santa Cruz, CA, USA). Entirely embedded sections of tumor and bile duct revealed no adenocarcinoma component. The tumor was diagnosed as a pure SCC with moderate differentiation. Ultrastructurally, polygonal to elongated tumor cells were filled with dilated rough endoplasmic reticulums, intermediate filaments, and primary and secondary lysosomes with prominent golgi apparatus (Fig. 3). Well-formed desmosomes were found. The gallbladder was separately submitted and showed only inflammation without any stones. A 1 cm-sized abscess with periductal inflammation was noted in the background liver parenchyma. Aspiration cytology of the enlarged common hepatic arterial lymph node showed metastatic SCC (pT2aN1M0, stage IIIc according to American Joint Committee on Cancer). Human papillomavirus was not detected using the HPV 9G DNA kit (BMT, Chuncheon, Korea) in accordance with the manufacturer’s protocol.; Approval was obtained from our Institutional Review Board (No. GCIRB2018-066) for this case report with a waiver of informed consent.

DISCUSSION

Histologically, the biliary mucosa is composed of a singlelayered cuboidal epithelium without squamous epithelial cells. Adenocarcinoma is the most common histologic type of biliary tract malignancies, and biliary SCC is rare. By definition, the diagnosis of adenosquamous carcinoma of the gallbladder and extrahepatic bile ducts can be made when SCC comprises more than 25% of the tumor component, but the current classification system by the World Health Organization requires that no glandular component is present for a diagnosis of biliary SCC.

The pathogenesis of this rare biliary SCC has not been elucidated to date. It is presumed that the normal columnar epithelium undergoes squamous metaplasia by continuous irritation due to an inflammatory stimulus, which then may result in carcinomatous changes through dysplasia [1]. Predisposing conditions that can lead to squamous metaplasia of the biliary epithelium and biliary SCC include hepatolithiasis, recurrent pyogenic cholangitis, and clonorchiasis [1]. Secondly, pluripotent bile duct stem cells are known to undergo malignant transformation. Other possible theories include heterotopic squamous epithelium or squamous metaplasia of preexisting adenocarcinoma [9,13]. The second and third theories might explain biliary SCC cases that lack preexisting normal squamous epithelium, like the present case. Our patient’s histology revealed pure SCC, and there was no hepatolithiasis or choledochal cysts on imaging studies. There was no underlying squamous epithelium, but there was an abrupt transition to dysplastic squamous epithelium from the biliary mucosa. On the other hand, a previous case reported by Abbas et al. [10] showed biliary SCC associated with high-grade squamous dysplasia, similar to cervical carcinogenesis. Their finding supports the metaplasia-dysplasia-carcinoma sequence theory. However, the direct causality of inflammation-metaplasia-dysplasia should be questioned. Whether gallstones predispose to cholangiocarcinoma remain unclear, and most reported cases have not been accompanied by a metaplasia-dysplasia lesion. Another possible theory may be that SCCs are derived from undifferentiated basal cells. Immunoreactivity for CK7, CK8, CK14, CK18, and/or CK5/6 suggests the origin of the cancer cells to be the basal cells of keratinized squamous epithelium. Moreover, positive staining for biliary CK19 would confirm the bile ductular ontogeny of the neoplastic cells [19].

The incidence of cholangiocarcinoma increases with age, and most reported cases occur in the fifth to seventh decades. Due to its rare incidence and strict diagnostic criteria, biliary SCC is rarely reported, and there are few reports to be retrieved for review. From the literature, we found 34 cases of biliary SCCs in the extrahepatic bile duct. Among the 34 reported cases of SCC of the extrahepatic duct, only 24 provided well-described clinicopathologic data [2-18]. Only one case associated with a choledochal cyst demonstrated predisposing precursors. A review of the cases revealed that age ranged from 24 to 86 years (mean, 62 years). The male-to-female ratio was 16:9. The site of occurrence of biliary SCC was the common hepatic duct region in four cases, hilar region in seven cases, proximal common bile duct region in two cases, mid portion in five cases, and distal common bile duct in seven cases.

A review of the previously reported cases demonstrated that the prognosis of biliary SCCs is extremely grave. Cholangiocarcinoma containing a component of SCC showed the following trends: rapid progression to advanced stage, short survival time, large tumor size, aggressive intrahepatic spreading, and frequent metastasis. Findings related to poor prognosis include elevated preoperative level carbohydrate antigen 19-9, resection margin involvement, advanced T category, and metastatic lymph node [20]. The mortality rate of biliary SCCs was up to 63.6% (14/22 cases of available data) during the follow-up period (mean, 14.8 months). Twenty out of 25 cases with available data (80%) underwent surgical resection with or without chemoradiotherapy. Among them, nine cases were combined with chemoradiotherapy. Two out of 25 cases (8%) received only conservative treatment. Ten cases (40%) received chemotherapy with or without radiation. The mean survival of patients without surgery was less than 12 months. Unlike head and neck SCCs, there is no supportive evidence for radiation therapy for unresectable biliary SCC. However, there are some reports of chemotherapy’s important palliative value for painful localized metastasis or uncontrolled bleeding [20]. These results are summarized in Table 1. Patients undergoing surgery had a better prognosis than those receiving conservative, non-surgical treatments (median survival, 32 months vs 3 months, p = .009). However, age and stage at diagnosis and associated general medical condition were also influential factors. Cases with additional chemotherapy showed a tendency toward poorer prognosis than those with surgery only, although the difference was not statistically significant (median survival, 12 months vs 32 months; p = .085). Other clinical findings, including sex, age, and site of bile duct involvement, had no impact on prognosis.

Due to the extremely rare incidence of biliary SCCs, no standardized therapeutic strategies have been established. The recommended treatment for biliary SCCs is surgical resection with or without chemoradiotherapy, and the recommended chemotherapy is GEMOX (gemcitabine plus oxaliplatin) or GP (gemcitabine plus cisplatin), as in bile duct adenocarcinomas [20]. Similar to the treatment for cancers of the gastrointestinal tract such as esophageal cancers, chemotherapy with docetaxel plus cisplatin plus 5-FU therapy or S-1 plus cisplatin therapy may be helpful. With such a regimen (S-1 plus cisplatin), one patient with biliary SCC was successfully treated [16]. Combined targeted therapy, such as epidermal growth factor receptor-targeted therapy, has shown certain benefits in other cancer types, and its effects are being investigated.

Here, we reported a case of SCC of the hilar bile duct and reviewed previous reports regarding biliary SCCs. The poor prognosis observed in SCC patients may be attributed to its rarity, initial advanced stage, and lack of accumulated clinical data.

Author Contributions

Investigation: YHP

Supervision: DHC, HYC.

Writing—original draft: MK, NRK.

Writing—review & editing: MK, NRK.

Conflicts of Interest

The authors declare that they have no potential conflicts of interest.

Fig. 1.

(A) Computed tomography reveals perihilar cholangiocarcinoma with metastatic lymph nodes. (B) Magnetic resonance cholangiopancreatography shows strictures of the left intrahepatic duct to common hepatic duct.

Fig. 2.

(A) The gross specimen revealed a protruded mass (arrows) accounting for all layers of the hepatic duct wall. (B) Histologically, thickened papillary squamous epithelium shows moderately differentiated dyskeratotic squamous cells with keratin pearls with stromal invasion. (C) Surface epithelium shows a transition from unilayered cuboidal to squamous epithelium (arrow). (D) Immunohistochemically, the tumor cells are positive for p63 (left) and p40 (right).

Fig. 3.

Ultrastructurally, ovoid-shaped tumor cells have cytoplasmic tonofilaments (white arrows) and are connected with wellformed desmosomes (black arrows, ×2,500).

Table 1.

Clinicopathologic summary of reported cases of squamous cell carcinoma of the extrahepatic bile duct

No.	Age (yr)/Sex	Site	Clinical summary including tumor markers	Remarkable pathologic findings	Distant metastasis	TNM/AJCC at the diagnosis	Treatment	Outcome (follow-up)
1	58/M	Proximal CBD (upper 1/4)	Jaundice, knife-like abdominal pain	No	Liver, retroperitoneal lymph node	Stage IVB^a	No surgery	Died (23 days)
2	24/F	Junction of proximal CBD and cystic duct	Jaundice, RUQ pain, elevated CEA	SCC, MD without lymphovascular, perineural invasion	Liver	T2aN0M1 Stage IVB^a	Pancreaticoduodenectomy, CTx (cyclophosphamide, MTX, doxorubicin, procarbazine)	Died (8 mo)
3	68/M	Mid CBD	Secondary biliary cirrhosis, portal hypertension, hepatic failure	SCC, WD	No	TxNOMO in autopsy Stage I	Cholecystectomy with T tube and wedge biopsy of liver	Died (6 mo)
4	56/M	Hilar	Jaundice	SCC, PD	Liver	Stage IVB^a	Cholecystectomy with T tube, RT	Died (3 mo)
5	68/M	Mid CBD	Jaundice, elevated CA19-9, elastase I	SCC, WD with direct invasion of pancreas head	No	TxNOMO Stage III	Pancreaticoduodenectomy, CTx (cisplatin, 5-FU), immunotherapy (OK-432)	Alive (3 mo)
6	68/M	Distal CBD	Jaundice, elevated CA19-9	1.8 cm, direct invasion of pancreas	No	T3N0M0 Stage IIIA^a	Pancreaticoduodenectomy	Alive (27 mo)
7	50/M	Hilar	Elevated CA19-9, AFR CEA, PIVKA II	4 cm	Liver (S2,1 cm)	TxNxMl Stage IVB^a	Extended left hepatic lobectomy, T tube	Died (10 mo)
8	75/M	Distal CBD	Jaundice, elevated CA19-9	1.5 cm	No	TxN1M0 Stage III^a	Pancreaticoduodenectomy	Alive (6 mo)
8	75/M	Distal CBD	Jaundice, elevated CA19-9	CEA+CA19-9+	No	TxN1M0 Stage III^a	Pancreaticoduodenectomy	Alive (6 mo)
9	57/F	Distal CBD and ampulla of Vater	Jaundice	Invasion to pancreas and duodenum, CEA- PAS-	No	T3bN0M0 Stage IIIA^a	Pylorus-preserving pancreatoduodenectomy	Not described
10	63/M	Distal CBD	Jaundice, elevated CA19-9	1.5 cm invasion to pancreas and duodenum	No	T2N1M0 Stage II	Pancreaticoduodenectomy	Alive (6 mo)
11	86/F	Junction of CBD and cystic duct	Jaundice, RUQ pain	PanCK	Not described	Not described	CTx, external beam radiation, and high-dose radiation endoluminal brachytherapy (1,800 cGy)	Died (18 mo)
12	61/F	Mid CBD	Jaundice, WNL of CA19-9, CA125, AFP	3 cm，CK(MNF116)+ CK10/13+	Peritoneal carcinomatosis	T3N0M1 Stage IIIA^a	Simple resection and hepatojejunal anastomosis	Died (16 mo)
12	61/F	Mid CBD	History of cholecystectomy	3 cm，CK(MNF116)+ CK10/13+	Peritoneal carcinomatosis	T3N0M1 Stage IIIA^a	Simple resection and hepatojejunal anastomosis	Died (16 mo)
13	60/M	Distal CBD	Recurrent episodes of cholangitis and obstructive jaundice	SCC, WD, 2 cm with metaplasia, dysplasia	No	T2N0M0 Stage ll^a	Pancreaticoduodenectomy	Not described
14	28/F	Hilar	Jaundice, RUQ pain	SCC, MD with high-grade squamous dysplasia	Not described	Not described	Extended left hepatic lobectomy, RT	Alive (18 mo)
15	41/F	Hilar	Jaundice, elevated CA19-9, choledochal cyst	Direct invasion to portal vein and duodenum	Not described	T4NxMx, Stage IV^a	Endoscopic biliary stent, palliative CTx, RT	Not described
16	64/M	Distal CBD	Abdominal discomfort, jaundice	3 cm, CK19+	No	T3N2M0, Stage IIIB^a	Pancreaticoduodenectomy, CTx (CPT-11, PPD)	Hepatic metastasis (30 days) and died (5 mo)
17	66/M	Hilar	Jaundice, elevated CA19-9, SPan-1, DUPAN-2	SCC, WD, 3 cm, invasion of portal vein and liver, CK+ CAM5.2-	T4 (Stage IV)	T4N1M0 Stage IVA^a	Extended right hepatic lobectomy, CTx (cisplatin+5-FU, gemcitabine+S-1)	Hepatic metastasis (6 mo) and died (12 mo)
18	67/M	CHD	Icteric sclera, elevated CA19-9	Synchronous double SCC, WD, 1.5 cm and adenocarcinoma	No	T1N1M0 Stage IIIB^a	Pylorus-preserving pancreatoduodenectomy	Multiple hepatic metastasis (3 mo) and died (8 mo)
18	67/M	CHD	Icteric sclera, elevated CA19-9	Metastatic adenocarcinoma in one regional lymph node	No	T1N1M0 Stage IIIB^a	Pylorus-preserving pancreatoduodenectomy	Multiple hepatic metastasis (3 mo) and died (8 mo)
19	77/F	Mid CBD	Jaundice, WNLofCA19-9, CEA, DUPAN-2	SCC, PD, 1.7 cm, invasion to right hepatic artery	No	T4N0M0, Stage IVA^a	Pylorus-preserving pancreaticoduodenectomy, CTx (gemcitabine)	Local recurrence (20 mo) and died (32 mo)
19	77/F	Mid CBD	Jaundice, WNLofCA19-9, CEA, DUPAN-2	CK5/6+ p53+ PAS-	No	T4N0M0, Stage IVA^a		Local recurrence (20 mo) and died (32 mo)
20	78/M	Distal CBD	Jaundice, brown urine, WNL of CEA, CA19-9, DUPAN-2	SCC, MD, 3 cm	No	T1N1M0 Stage IIIB^a	Subtotal stomach-preserving pancreaticoduodenectomy, CTx (S-1, cisplatin)	Paraaortic lymph node metastasis (6 mo), alive (10 mo),
21	62/M	CHD	Jaundice, RUQ pain, elevated CA19-9	1.5 cm, perineural invasion	Not described	T1N0M0 Stage l^a	Curative resection and choledochojejunostomy, CTx (oral fluoropyrimidine S-1)	Died (5 mo)
21	62/M	CHD	Jaundice, RUQ pain, elevated CA19-9	PanCK+ CAM5.2+ CK5/6+ p63+ p40+ PAS-	Not described	T1N0M0 Stage l^a		Died (5 mo)
22	77/M	CHD	Elevated CA19-9, choledochal cyst	Not described	Not described	Not described	Curative resection and choledochojejunostomy	Died (32 mo)
23	67/F	CHD	티 evated CA19-9	Not described	Not described	Not described	Pancreatiocoduodenectomy	Died (47 mo)
24	73/M	Mid CBD	WNL of CA19-9 and CEA	4 cm, CK5/6+ p63+	No	Not described	Left hepatic lobe and caudate lobe resection, subtotal preserving pancreatoduodenectomy	Alive (45 mo)
25 (present case)	62/F	Hilar	Nausea, abdominal discomfort, elevated CA19-9	2.8 cm, CEA- p40+ p63+ CK5/6+ CK7-	No	T2N1M0, Stage IIIC	Cholecystectomy, left hemihepatectomy, S1 segmentectomy, CTx (5-FU, cisplatin)	Alive (9 mo)

AJCC, American Joint Committee on Cancer; M, male; F, female; CBD, common bile duct; RUQ, right upper quadrant; CEA, carcinoembryogenic antigen; SCC, squamous cell carcinoma; MD, moderately differentiated; CTx, chemotherapy; MTX, methotrexate; WD, well differentiated; PD, poorly differentiated; RT, radiation therapy; CA 19-9, carbohydrate antigen 19-9; WNL, within normal limit; AFP, α-fetoprotein; CEA, carcinoembryonic antigen; +, positive; –, negative; CK, cytokeratin; 5-FU, 5-fluorouracil; S-1, tegafur/gimeracil/oteracil; CHD, common hepatic duct.

^aThe stage was modified as the AJCC 8th edition.

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Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct

J Pathol Transl Med. 2019;53(2):112-118. Published online October 1, 2018

DOI: https://doi.org/10.4132/jptm.2018.09.03

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Figure

Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct

Fig. 1. (A) Computed tomography reveals perihilar cholangiocarcinoma with metastatic lymph nodes. (B) Magnetic resonance cholangiopancreatography shows strictures of the left intrahepatic duct to common hepatic duct.

Fig. 2. (A) The gross specimen revealed a protruded mass (arrows) accounting for all layers of the hepatic duct wall. (B) Histologically, thickened papillary squamous epithelium shows moderately differentiated dyskeratotic squamous cells with keratin pearls with stromal invasion. (C) Surface epithelium shows a transition from unilayered cuboidal to squamous epithelium (arrow). (D) Immunohistochemically, the tumor cells are positive for p63 (left) and p40 (right).

Fig. 3. Ultrastructurally, ovoid-shaped tumor cells have cytoplasmic tonofilaments (white arrows) and are connected with wellformed desmosomes (black arrows, ×2,500).

Fig. 1.

Fig. 2.

Fig. 3.

Squamous Cell Carcinoma of the Extrahepatic Common Hepatic Duct

No.	Age (yr)/Sex	Site	Clinical summary including tumor markers	Remarkable pathologic findings	Distant metastasis	TNM/AJCC at the diagnosis	Treatment	Outcome (follow-up)
1	58/M	Proximal CBD (upper 1/4)	Jaundice, knife-like abdominal pain	No	Liver, retroperitoneal lymph node	Stage IVB^a	No surgery	Died (23 days)
2	24/F	Junction of proximal CBD and cystic duct	Jaundice, RUQ pain, elevated CEA	SCC, MD without lymphovascular, perineural invasion	Liver	T2aN0M1 Stage IVB^a	Pancreaticoduodenectomy, CTx (cyclophosphamide, MTX, doxorubicin, procarbazine)	Died (8 mo)
3	68/M	Mid CBD	Secondary biliary cirrhosis, portal hypertension, hepatic failure	SCC, WD	No	TxNOMO in autopsy Stage I	Cholecystectomy with T tube and wedge biopsy of liver	Died (6 mo)
4	56/M	Hilar	Jaundice	SCC, PD	Liver	Stage IVB^a	Cholecystectomy with T tube, RT	Died (3 mo)
5	68/M	Mid CBD	Jaundice, elevated CA19-9, elastase I	SCC, WD with direct invasion of pancreas head	No	TxNOMO Stage III	Pancreaticoduodenectomy, CTx (cisplatin, 5-FU), immunotherapy (OK-432)	Alive (3 mo)
6	68/M	Distal CBD	Jaundice, elevated CA19-9	1.8 cm, direct invasion of pancreas	No	T3N0M0 Stage IIIA^a	Pancreaticoduodenectomy	Alive (27 mo)
7	50/M	Hilar	Elevated CA19-9, AFR CEA, PIVKA II	4 cm	Liver (S2,1 cm)	TxNxMl Stage IVB^a	Extended left hepatic lobectomy, T tube	Died (10 mo)
8	75/M	Distal CBD	Jaundice, elevated CA19-9	1.5 cm	No	TxN1M0 Stage III^a	Pancreaticoduodenectomy	Alive (6 mo)
8	75/M	Distal CBD	Jaundice, elevated CA19-9	CEA+CA19-9+	No	TxN1M0 Stage III^a	Pancreaticoduodenectomy	Alive (6 mo)
9	57/F	Distal CBD and ampulla of Vater	Jaundice	Invasion to pancreas and duodenum, CEA- PAS-	No	T3bN0M0 Stage IIIA^a	Pylorus-preserving pancreatoduodenectomy	Not described
10	63/M	Distal CBD	Jaundice, elevated CA19-9	1.5 cm invasion to pancreas and duodenum	No	T2N1M0 Stage II	Pancreaticoduodenectomy	Alive (6 mo)
11	86/F	Junction of CBD and cystic duct	Jaundice, RUQ pain	PanCK	Not described	Not described	CTx, external beam radiation, and high-dose radiation endoluminal brachytherapy (1,800 cGy)	Died (18 mo)
12	61/F	Mid CBD	Jaundice, WNL of CA19-9, CA125, AFP	3 cm，CK(MNF116)+ CK10/13+	Peritoneal carcinomatosis	T3N0M1 Stage IIIA^a	Simple resection and hepatojejunal anastomosis	Died (16 mo)
12	61/F	Mid CBD	History of cholecystectomy	3 cm，CK(MNF116)+ CK10/13+	Peritoneal carcinomatosis	T3N0M1 Stage IIIA^a	Simple resection and hepatojejunal anastomosis	Died (16 mo)
13	60/M	Distal CBD	Recurrent episodes of cholangitis and obstructive jaundice	SCC, WD, 2 cm with metaplasia, dysplasia	No	T2N0M0 Stage ll^a	Pancreaticoduodenectomy	Not described
14	28/F	Hilar	Jaundice, RUQ pain	SCC, MD with high-grade squamous dysplasia	Not described	Not described	Extended left hepatic lobectomy, RT	Alive (18 mo)
15	41/F	Hilar	Jaundice, elevated CA19-9, choledochal cyst	Direct invasion to portal vein and duodenum	Not described	T4NxMx, Stage IV^a	Endoscopic biliary stent, palliative CTx, RT	Not described
16	64/M	Distal CBD	Abdominal discomfort, jaundice	3 cm, CK19+	No	T3N2M0, Stage IIIB^a	Pancreaticoduodenectomy, CTx (CPT-11, PPD)	Hepatic metastasis (30 days) and died (5 mo)
17	66/M	Hilar	Jaundice, elevated CA19-9, SPan-1, DUPAN-2	SCC, WD, 3 cm, invasion of portal vein and liver, CK+ CAM5.2-	T4 (Stage IV)	T4N1M0 Stage IVA^a	Extended right hepatic lobectomy, CTx (cisplatin+5-FU, gemcitabine+S-1)	Hepatic metastasis (6 mo) and died (12 mo)
18	67/M	CHD	Icteric sclera, elevated CA19-9	Synchronous double SCC, WD, 1.5 cm and adenocarcinoma	No	T1N1M0 Stage IIIB^a	Pylorus-preserving pancreatoduodenectomy	Multiple hepatic metastasis (3 mo) and died (8 mo)
18	67/M	CHD	Icteric sclera, elevated CA19-9	Metastatic adenocarcinoma in one regional lymph node	No	T1N1M0 Stage IIIB^a	Pylorus-preserving pancreatoduodenectomy	Multiple hepatic metastasis (3 mo) and died (8 mo)
19	77/F	Mid CBD	Jaundice, WNLofCA19-9, CEA, DUPAN-2	SCC, PD, 1.7 cm, invasion to right hepatic artery	No	T4N0M0, Stage IVA^a	Pylorus-preserving pancreaticoduodenectomy, CTx (gemcitabine)	Local recurrence (20 mo) and died (32 mo)
19	77/F	Mid CBD	Jaundice, WNLofCA19-9, CEA, DUPAN-2	CK5/6+ p53+ PAS-	No	T4N0M0, Stage IVA^a		Local recurrence (20 mo) and died (32 mo)
20	78/M	Distal CBD	Jaundice, brown urine, WNL of CEA, CA19-9, DUPAN-2	SCC, MD, 3 cm	No	T1N1M0 Stage IIIB^a	Subtotal stomach-preserving pancreaticoduodenectomy, CTx (S-1, cisplatin)	Paraaortic lymph node metastasis (6 mo), alive (10 mo),
21	62/M	CHD	Jaundice, RUQ pain, elevated CA19-9	1.5 cm, perineural invasion	Not described	T1N0M0 Stage l^a	Curative resection and choledochojejunostomy, CTx (oral fluoropyrimidine S-1)	Died (5 mo)
21	62/M	CHD	Jaundice, RUQ pain, elevated CA19-9	PanCK+ CAM5.2+ CK5/6+ p63+ p40+ PAS-	Not described	T1N0M0 Stage l^a		Died (5 mo)
22	77/M	CHD	Elevated CA19-9, choledochal cyst	Not described	Not described	Not described	Curative resection and choledochojejunostomy	Died (32 mo)
23	67/F	CHD	티 evated CA19-9	Not described	Not described	Not described	Pancreatiocoduodenectomy	Died (47 mo)
24	73/M	Mid CBD	WNL of CA19-9 and CEA	4 cm, CK5/6+ p63+	No	Not described	Left hepatic lobe and caudate lobe resection, subtotal preserving pancreatoduodenectomy	Alive (45 mo)
25 (present case)	62/F	Hilar	Nausea, abdominal discomfort, elevated CA19-9	2.8 cm, CEA- p40+ p63+ CK5/6+ CK7-	No	T2N1M0, Stage IIIC	Cholecystectomy, left hemihepatectomy, S1 segmentectomy, CTx (5-FU, cisplatin)	Alive (9 mo)

Table 1. Clinicopathologic summary of reported cases of squamous cell carcinoma of the extrahepatic bile duct

The stage was modified as the AJCC 8th edition.

Articles

Abstract

CASE REPORT

DISCUSSION

REFERENCES

Figure & Data

References

Citations

Fig. 1.

Fig. 2.

Fig. 3.

Table 1.