1Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
2Division of Medical Oncology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
3Cancer Research Institute, The Catholic University of Korea, Seoul, Korea
4Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
5Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
© 2020 The Korean Society of Pathologists/The Korean Society for Cytopathology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Authors’ contribution
Conceptualization: AL.
Data curation: YSJ, TKY.
Formal analysis: YSJ, SHK, AL.
Methodology: YSJ, SHK, JK, AL.
Project administration: YSJ.
Resources: AL.
Supervision: AL.
Validation: YSJ, JL, AL.
Visualization: YSJ.
Writing—original draft: YSJ.
Writing—review & editing: YSJ, SHK, JK, AL.
Conflicts of Interest: The authors declare that they have no potential conflicts of interest.
Funding
No funding to declare.
Surgical specimen |
CNB |
Total (%) | Concordance rate | Kappaa | p-value | ||
---|---|---|---|---|---|---|---|
Neg | Pos | Equi | |||||
Hormone receptor | |||||||
Neg | 90 | 24 | 114 (18.1) | ||||
Pos | 7 | 508 | 515 (81.9) | 95.1 | 0.824 | < .001 | |
Total | 97 (15.4) | 532 (84.6) | 629 | ||||
ER | |||||||
Neg | 104 | 16 | 120 (19.1) | ||||
Pos | 6 | 503 | 509 (80.9) | 96.5 | 0.883 | < .001 | |
Total | 110 (17.5) | 519 (82.5) | 629 | ||||
PR | |||||||
Neg | 150 | 28 | 178 (28.3) | ||||
Pos | 16 | 435 | 451 (71.7) | 93.0 | 0.824 | < .001 | |
Total | 166 (26.4) | 463 (73.6) | 629 | ||||
HER2 (IHC) | |||||||
Neg | 396 | 1 | 69 | 466 (74.1) | |||
Pos | 0 | 73 | 6 | 79 (12.6) | |||
Equi | 31 | 10 | 43 | 84 (13.4) | 81.4 | 0.591 | < .001 |
Total | 427 (67.9) | 84 (13.4) | 118 (18.8) | 629 | |||
HER2 (IHC + SISH) | |||||||
Neg | 532 | 1 | 533 (84.7) | ||||
Pos | 1 | 95 | 96 (15.3) | 99.7 | 0.988 | < .001 | |
Total | 533 (84.7) | 96 (15.3) | 629 | ||||
Ki67 | ≤20% | > 20% | |||||
≤20% | 225 | 33 | 258 (41.0) | ||||
> 20% | 101 | 270 | 371 (59.0) | 78.7 | 0.577 | < .001 | |
Total | 326 (51.8) | 303 (48.2) | 629 |
Values are presented as number (%) unless otherwise indicated.
CNB, core needle biopsy; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; Neg, negative; Pos, positive; Equi, Equivocal; IHC, immunohistochemistry; SISH, siver in situ hybridization.
a Kappa: < 0.20, poor agreement; 0.21–0.40, fair agreement; 0.41–0.60, moderate agreement; 0.61–0.80, good agreement; 0.81–1.00, very good agreement.
Ki67 |
Digital image analysis |
Manual counting method |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CNB |
Concordance rate (%) | Kappaa | p-value |
CNB |
Concordance rate (%) | Kappaa | p-value | |||||
≤20% | > 20% | Total | ≤20% | > 20% | Total | |||||||
≤20% | 88 | 28 | 116 | 82.3 | 0.639 | <.001 | 137 | 73 | 210 | 76.2 | 0.534 | < .001 |
> 20% | 18 | 126 | 144 | 15 | 144 | 159 | ||||||
Total | 106 | 154 | 260 | 152 | 217 | 369 |