E-submission
Articles
- Page Path
- HOME > J Pathol Transl Med > Forthcoming articles > Article
- Original Article Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
-
Agnes Stephanie Harahap1,2
, Mutiah Mutmainnah3
, Maria Francisca Ham1,2
, Dina Khoirunnisa4
, Abdillah Hasbi Assadyk5
, Husni Cangara6
, Aswiyanti Asri7
, Diah Prabawati Retnani8
, Fairuz Quzwain9
, Hasrayati Agustina10
, Hermawan Istiadi11
, Indri Windarti12
, Krisna Murti13
, Muhammad Takbir14
, Ni Made Mahastuti15
, Nila Kurniasari16
, Nungki Anggorowati17
, Pamela Abineno18
, Yulita Pundewi Setyorini19
, Kennichi Kakudo20
-
DOI: https://doi.org/10.4132/jptm.2024.07.25 [Epub ahead of print]
Published online: September 12, 2024
2Human Cancer Research Center-Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
3Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia
4Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung, Indonesia
5Department of Otorhinolaryngology, Head and Neck Surgery, Harapan Kita National Women and Children Health Center, Jakarta, Indonesia
6Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
7Department of Anatomical Pathology, Faculty of Medicine, Andalas University, Padang, Indonesia
8Department of Anatomical Pathology, Faculty of Medicine, Universitas Brawijaya/RSUD dr. Saiful Anwar, Malang, Indonesia
9Department of Anatomical Pathology, Faculty of Medicine and Health Science, Universitas Jambi, Jambi, Indonesia
10Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung, Indonesia
11Department of Anatomical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
12Department of Anatomical Pathology, Faculty of Medicine, University of Lampung, Lampung, Indonesia
13Department of Anatomical Pathology, Faculty of Medicine, University of Sriwijaya, Palembang, Indonesia
14Department of Anatomical Pathology, Labuha Hospital, South Halmahera, Indonesia
15Department of Anatomical Pathology, Faculty of Medicine, Universitas Udayana, Prof. Dr. I.G.N.G. Ngoerah Hospital, Denpasar, Indonesia
16Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga/Dr Soetomo Academic Hospital, Surabaya, Indonesia
17Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/UGM Academic Hospital, Yogyakarta, Indonesia
18Department of Anatomical Pathology, Dr. Ben Mboi Hospital, Kupang, Indonesia
19Kanujoso Djatiwibowo Hospital, Balikpapan, Indonesia
20Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi, Japan
-
Corresponding author:
Agnes Stephanie Harahap, Tel: +62-8-18765563, Fax: +62-21-3912477,
Email: agnes.stephanie01@ui.ac.id
- 304 Views
- 31 Download
- 0 Crossref
- 0 Scopus
Abstract
Background
The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms.
Methods
This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RAS mutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test.
Results
Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k = 0.14 to 0.28) and poor to fair based on an eight-point system (k = –0.02 to 0.24). Agreements on vascular (κ = 0.35) and capsular invasion (κ = 0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ = 0.74). Following the training, agreement using the eight-point system significantly improved (p = 0.001).
Conclusions
The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.
Cited- Related articles
-
