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Uncommon granulomatous manifestation in Epstein-Barr virus–positive follicular dendritic cell sarcoma: a case report
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Case Study Uncommon granulomatous manifestation in Epstein-Barr virus–positive follicular dendritic cell sarcoma: a case report
Henry Goh Di Shen1orcid , Yue Zhang1orcid , Wei Qiang Leow1,2,3orcid

DOI: https://doi.org/10.4132/jptm.2024.09.27 [Epub ahead of print]
Published online: October 31, 2024
1Duke-NUS Medical School, Singapore
2Department of Anatomical Pathology, Singapore General Hospital, Singapore
3School of Biological Sciences, Nanyang Technological University, Singapore
Corresponding author:  Henry Goh Di Shen, Tel: +65-88772440, 
Email: henry.g@u.duke.nus.edu
Received: 1 July 2024   • Revised: 10 September 2024   • Accepted: 26 September 2024
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Hepatic Epstein-Barr virus–positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) represents a rare form of liver malignancy. The absence of distinct clinical and radiological characteristics, compounded by its rare occurrence, contributes to a challenging diagnosis. Here, we report a case of a 54-year-old Chinese female with a background of chronic hepatitis B virus treated with entecavir and complicated by advanced fibrosis presenting with a liver mass found on her annual surveillance ultrasound. Hepatectomy was performed under clinical suspicion of hepatocellular carcinoma. Immunomorphologic characteristics of the tumor were consistent with EBV+ IFDCS with distinct non-caseating granulomatous inflammation. Our case illustrates the importance of considering EBV+ IFDCS in the differential diagnosis of hepatic inflammatory lesions. Awareness of this entity and its characteristic features is essential for accurately diagnosing and managing this rare neoplasm.

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