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The Korean Journal of Pathology 2003;37(3): 214-217.
Sinonasal Undifferentiated Carcinoma: A Case Report.
Hwal Woong Kim, Gyung Hyuck Ko, Chul Woo Kim
1Department of Pathology, Gyeongsang National University College of Medicine, Jinju, Korea. hawk7023@chollian.net
2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a case of SNUC in an old woman. The tumor was located at the nasal cavity and ethmoid sinus, extending to the cranial cavity. The nasopharynx was free from the tumor. Microscopically, the tumor formed nests or sheets containing medium-sized cells with small amounts of eosinophilic cytoplasm. High mitotic rates and tumor necrosis were characteristic. There was no evidence of glandular or squamous differentiation. The tumor was focally weak positive for cytokeratin, but negative for vimentin, leukocyte common antigen, S-100 protein, chromogranin, synaptophysin and neuron specific enolase. Epstein Barr Virus EBER-1 was not detected by in situ hybridization. SNUC is a highly aggressive tumor and must be distinguished from less aggressive sinonasal neoplasms.