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High-grade Transformation of Primary Nodal Marginal Zone B-Cell Lymphoma: A Case Report.
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HOME > J Pathol Transl Med > Volume 37(4); 2003 > Article
Case Report High-grade Transformation of Primary Nodal Marginal Zone B-Cell Lymphoma: A Case Report.
Joo Heon Kim, Dong Wook Kang, Mee Ja Park, Jin Man Kim
Journal of Pathology and Translational Medicine 2003;37(4):282-286
DOI: https://doi.org/
1Department of Pathology, Eulji University School of Medicine, Korea.
2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr
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Primary nodal marginal zone B-cell lymphoma (MZBCL) is recognized as a rare and distinct entity. The rate of histologic transformation into diffuse large B-cell lymphoma (DLBCL) seems lower than the rate of transformation in follicular lymphoma. We herein report a rare case ofnodal MZBCL showing transformation into DLBCL. The patient was a 73-year-old female withcervical lymphadenopathy. On the initial biopsy, the lymph node architecture was diffuselyeffaced with an extensive interfollicular and parafollicular infiltrate of monocytoid B-cells. Therewere scattered large blastic B-cells without formations of compact sheets. The diagnosis ofnodal MZBCL was made. The patient did not receive chemotherapy and was treated with aconservatively supportive regimen. Forty two months later, the patient developed a new cervicallymphadenopathy and a biopsy was performed. Histologically, the lymph node revealeddiffuse sheets of transformed large B-cells showing prominent nucleoli. The diagnosis ofDLBCL transformed from nodal MZBCL was made. The patient was treated with 3 cycles ofcombined CHOP chemotherapy and she showed clinical improvement. These observationssuggest that an untreated primary nodal MZBCL may undergo high-grade transformation.

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