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The Korean Journal of Pathology 2003;37(4): 287-290.
Scleroma of the Larynx: A Case Report.
Hun Soo Kim, Seok Won Park, Jin Man Kim
1Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr
2Department of Otolaryngology, Chungnam National University School of Medicine, Daejeon, Korea.
Scleroma of the larynx is a rare specific granulomatous disease and is usually presented as alaryngeal extension of a primary rhinoscleroma. We report an unusual case of laryngeal scleromain a 64-year-old female patient whose presented with progressive upper respiratory obstructivesymptoms lasted for 2 years. Symptoms were acutely exaggerated during the course of one month.On physical examination, the nasal mucosa was atrophic and crusted, and septal perforationwas noted. The fiberoptic laryngoscopy revealed a yellowish granulated epiglottic mass with adirty surface mimicking laryngeal cancer. Histological sectioning showed the characteristic featuresof scleroma including Mikulicz cells with scattered plasma cells and some neutrophils.Warthin-starry stains and electron microscopy examination showed numerous short rods insidethe cytoplasm of the Mikulicz cells. After the diagnosis, the patient underwent an emergency tracheostomyfollowed by long-term antibiotic treatment, and her symptoms have slowly improved.
Key Words: Larynx; Scleroma; Mikulicz Cell; Warthin; Starry Stain