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The Korean Journal of Pathology 2004;38(4): 244-248.
Rarity of EGFR and c-ErbB-2 Overexpressions in Hepatocellular Carcinoma: An Immunohistochemical Study.
Woo Sung Moon, Hyun Jin Son, Ho Sung Park, Min Young Park
Department of Pathology, Chonbuk National University, Medical School and Institute for Medical Sciences, Jeonju, Korea. mws@chonbuk.ac.kr
BACKGROUND: The overexpression of epidermal growth factor receptor (EGFR) and c-erbB-2 oncogenes has been implicated in the development of many types of cancer. However, the role of EGFR and c-erbB-2 overexpression in hepatocellular carcinoma (HCC) has not been fully elucidated. METHODS: The aim of this study was to evaluate the immunohistochemical expression of EGFR and c-erbB-2 oncoprotein in a series of 52 HCCs. RESULTS: All but one of the HCC tumor tissues were negative for EGFR monoclonal antibody, clone H11. All of the HCC tumor tissue samples were negative for EGFR monoclonal antibody, clone 29.1.1. However, strong EGFR immunoreactivity was detected in sinusoidal endothelial cells of HCC in 25 tumors (48%) using EGFR 29.1.1 antibody. The expression of c-erbB-2 was observed in 6% (3/52) of the HCCs. No significant correlation was found between p53 mutation and the expression of c-erbB-2. CONCLUSION: Our results suggest that both EGFR and c-erbB-2 oncoprotein overexpressions in tumor cells are rare and do not seem to predominantly contribute to the malignant phenotype in HCC.
Key Words: Carcinoma; Hepatocellular-Receptor; Epidermal Growth Factor-erbB-2-Immunohistochemistry