Warning: fopen(/home/virtual/jptm/journal/upload/ip_log/ip_log_2022-09.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Journal of Pathology and Translational Medicine
Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Pathol Transl Med > Volume 41(3); 2007 > Article
Original Article Mucin Phenotype and CDX2 Expression as Prognostic Factors in Gastric Carcinomas.
Chan Kwon Jung, Kyo Young Song, Gyeongsin Park, Cho Hyun Park, Myeong Gyu Choi, Young Seon Hong, Kyo Young Lee
Journal of Pathology and Translational Medicine 2007;41(3):139-148
DOI: https://doi.org/
  • 1,409 Views
  • 22 Download
  • 0 Crossref
  • 0 Scopus
1Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. leekyoyo@catholic.ac.kr
2Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background
: Mucin phenotypic markers and CDX2 are widely expressed in gastric carcinomas, however, recent studies have produced conflicting results regarding whether the expression patterns of these markers have clinicopathologic significance.
Methods
: We examined samples from 217 gastric carcinoma patients immunohistochemically to determine if the expression of mucin phenotypic markers and CDX2 was correlated with postoperative survival and other clinicopathologic factors.
Results
: All tumors were phenotypically classified as gastric (type G, 81 cases), gastric and intestinal mixed (type GI, 55 cases), intestinal (type I, 43 cases), or unclassified (type U, 38 cases). The occurrence of type G and GI tumors was positively correlated with tumor progression whereas that of type U tumors was negatively correlated with tumor progression. CDX2 expression was correlated with type I tumors. Tumors that expressed MUC5AC or MUC6 had a better prognosis than those that did not. When the relationship between phenotype and prognosis was considered, type GI had the best prognosis, followed by type G, then type U.
Conclusions
: The mucin phenotypic markers may be useful for predicting tumor progression and survival in patients with gastric carcinomas. Additionally, CDX2 may play an important role in gastric carcinogenesis of type I tumors.

Related articles

JPTM : Journal of Pathology and Translational Medicine