The Expression of Transforming Growth Factor-beta1 and alpha-Smooth Muscle Actin is Increased in the Human Myxomatous Valve.

Jeong Hwan Park; Ho Joong Youn; Jung Sook Yoon; Chul Soo Park; Soo Sung Oh; Woo Baek Chung; Jong Won Chung; Yun Seok Choi; Dong Hyun Lee; Yong Seog Oh; Wook Sung Chung; Soon Jo Hong; Youn Soo Lee; Sung Bo Sim; Sun Hee Lee

doi:10.4132/KoreanJPathol.2009.43.2.152

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Original Article The Expression of Transforming Growth Factor-beta1 and alpha-Smooth Muscle Actin is Increased in the Human Myxomatous Valve.: Jeong Hwan Park, Ho Joong Youn, Jung Sook Yoon, Chul Soo Park, Soo Sung Oh, Woo Baek Chung, Jong Won Chung, Yun Seok Choi, Dong Hyun Lee, Yong Seog Oh, Wook Sung Chung, Soon Jo Hong, Youn Soo Lee, Sung Bo Sim, Sun Hee Lee; Journal of Pathology and Translational Medicine 2009;43(2):152-156
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.2.152

¹Division of Cardiology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea. younhj@catholic.ac.kr
²Department of Hospital Pathology, The Catholic University of Korea, Seoul, Korea.
³Department of Thoracic and Cardiovascular Surgery, The Catholic University of Korea, Seoul, Korea.

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Abstract

BACKGROUND
In vitro experimental studies have reported that transforming growth factor-beta1 (TGF-beta1) stimulates the production of alpha-smooth muscle actin (alpha-SMA) in porcine valves. However, the relation between TGF-beta1 and alpha-SMA in myxomatous valves has not been elucidated.
METHODS
We classified 27 subjects into two groups: 1) myxomatous group (M:F=11:12, mean age=55+/-15 years) and 2) rheumatic group (M:F=3:1, mean age=41+/-17 years) according to preoperative echocardiographic and postoperative histologic findings. Twenty-seven valve specimens from the patients who underwent valve replacement were obtained. Tissue samples were analyzed by immunohistochemistry for TGF-beta1 and alpha-SMA. The positively stained areas were measured using an image analysis program (Image Pro-Plus 4.5), and then the TGF-beta1 volume fraction (TGF-VF) and alpha-SMA volume fraction (alpha-SMA-VF) were calculated.
RESULTS
TGF-VF in myxomatous valves was higher than in rheumatic valves (2,759+/-2,294 vs 864+/-276, p=0.04). alpha-SMA-VF in myxomatous valves was higher than in rheumatic valves (4,122+/-2,275 vs 2,421+/-844, p=0.002). There was a significant correlation between TGF-beta1 and alpha-SMA in myxomatous valves (r=0.38, p=0.04). There was no significant correlation between TGF-beta1 and alpha-SMA in rheumatic valves (r=-0.50, p=0.67).
CONCLUSIONS
TGF-beta1 and alpha-SMA may be related to the pathogenesis of myxomatous valves. The activation of TGF-beta1 might increase the expression of alpha-SMA in human myxomatous valves.

Keywords: Transforming growth factor-beta1;Alpha-Smooth muscle actin;Myxomatous valve

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