The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma.

Tae Jung Jang; Kyung Seob Lee

doi:10.4132/KoreanJPathol.2009.43.3.206

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Original Article The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma.: Tae Jung Jang, Kyung Seob Lee; Journal of Pathology and Translational Medicine 2009;43(3):206-211
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.3.206

¹Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
²Department of Urology, Dongguk University College of Medicine, Gyeongju, Korea. taejung@mail.dongguk.ac.kr

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Abstract

BACKGROUND
The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions.
METHODS
The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry.
RESULTS
The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors.
CONCLUSIONS
This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.

Keywords: Bladder cancer;Cyclooxygenase-2;Survivin

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