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The Korean Journal of Pathology 2011;45(1): 111-114.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.1.111
Sclerosing Angiomatoid Nodular Transformation (SANT) in Spleen: A Case Report.
Hyun Jung Lee, Song Yi Choi, Song Mei Huang, Ji Young Sul, Jin Man Kim
1Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea. jinmank@cnu.ac.kr
2Department of Surgery, Chungnam National University College of Medicine, Daejeon, Korea.
3Cancer Research Institute, Daejeon Regional Cancer Center, and Infection Signaling Network Research Center, Chungnam National University College of Medicine, Daejeon, Korea.
Sclerosing angiomatoid nodular transformation (SANT) of spleen is a rare inflammatory tumor-like vascular lesion composed of angiomatoid nodules in a fibrosclerotic background. We report herein on a case of SANT in the spleen with its pathologic features, and review the related literature. A 50-year-old woman presented with mild left upper quadrant discomfort and tenderness and she showed a 6 cm-sized solitary splenic mass on computed tomography. She underwent laparoscopic splenectomy. Grossly, the spleen showed a well circumscribed round-shaped solid mass with multinodular hemorrhagic surfaces. Microscopically, the mass consisted of multiple angiomatoid nodules surrounded by collagen bundles with fibroblasts and a lymphoplasma cell infiltration. Immunohistochemically, the cells of the angiomatoid nodules were positive for CD31, CD30, CD34, alpha-smooth muscle actin, and VWF-VIII, but they were negative for CD8, anaplastic lymphoma kinase protein, and D2-40. The patient has been under close follow-up without recurrence.
Key Words: Spleen; Hamartoma; Antigens, CD31