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The Korean Journal of Pathology 2011;45(3): 315-318.
doi: https://doi.org/10.4132/KoreanJPathol.2011.45.3.315
Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings.
Na Rae Kim, Jae Y Ro, Kyung Hwan Shin, Hae Jung Paik, Jung Suk An, Seung Yeon Ha
1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea. syha@gilhosptial.com
2Department of Pathology, The Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA.
3Department of Ophthalmology, Gachon University Gil Hospital, Incheon, Korea.
A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
Key Words: Solitary fibrous tumors; Conjunctiva; Antigens, CD34; CD99; Bcl-2