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The Korean Journal of Cytopathology 2003;14(1): 17-21.
Fine Needle Aspiration Cytology of Insular Carcinoma of the Thyroid.
Kyung Un Choi, Jee Yeon Kim, Jin Sook Lee, Chang Hun Lee
Department of Pathology, Pusan University College of Medicine, Busan, Korea. dlsgo90@hanmail.net
ABSTRACT
Insular carcinoma of the thyroid(ICT) is an uncommon thyroglobulin-producing neoplasm, intermediate between well differentiated and anaplastic carcinoma. Only a few publications have addressed the fine needle aspiration cytologic(FNAC) findings from ICT. We experienced a case histologically diagnosed as ICT and with preoperative FNAC in a 52-year-old woman. The FNAC displayed scanty colloid and abundant monomorphic follicular cells presented singly, in small loose aggregates, and in cohesive trabecular or acinar clusters. Intact insulae of tumor cells were also identified. Necrosis and mitosis were rare. Tumor cells showed round and monomorphic nuclei, finely granular chromatin, and inconspicuous nucleoli. When insular structure is identified in thyroid FNAC specimen, ICT should be included in the differential diagnosis. Herein we discuss and review the cytologic criteria for separation of ICT from other thyroid neoplasms.
Key Words: Insular carcinoma; Thyroid gland; Fine needle aspiration cytology