Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea
© 2015 The Korean Society of Pathologists/The Korean Society for Cytopathology
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Risk subgroup | NIH criteria | AFIP criteria |
---|---|---|
Very low | 4 (5.2) | 36 (46.9) |
Low | 48 (62.3) | 22 (28.6) |
Intermediate/moderate | 9 (11.7) | 12 (15.6) |
High | 16 (20.8) | 7 (9.1) |
Variable | n (%) |
---|---|
Median age (range, yr) | 57 (28-86) |
Gender | |
Female | 28 (36.4) |
Male | 49 (63.6) |
Tumor size (cm) | |
≤2 | 8 (10.4) |
>2 and ≤5 | 52 (67.5) |
>5 and ≤10 | 12 (15.6) |
>10 | 5 (6.5) |
Tumor location | |
Stomach | 54 (70.1) |
Duodenum | 12 (15.6) |
Jejunum/ileum | 10 (13.0) |
Rectum | 1 (1.3) |
Mitosis | |
≤5/50HPFs | 62 (80.5) |
6–10/50HPFs | 4 (5.2) |
>10/50HPFs | 11 (14.3) |
Ki-67 LI (%) | |
≤5 | 59 (76.6) |
6–10 | 10 (13.0) |
>10 | 8 (10.4) |
PHH3 MI | |
≤5/50HPFs | 51 (66.2) |
6–10/50HPFs | 11 (14.3) |
>10/50HPFs | 15 (19.5) |
Risk subgroup | NIH criteria | AFIP criteria |
---|---|---|
Very low | 4 (5.2) | 36 (46.9) |
Low | 48 (62.3) | 22 (28.6) |
Intermediate/moderate | 9 (11.7) | 12 (15.6) |
High | 16 (20.8) | 7 (9.1) |
Patient No. | Sex/Age (yr) | Location | Size | Mitosis | Ki-67 LI | PHH3 MI | Risk of tumor progression (%) |
|
---|---|---|---|---|---|---|---|---|
AFIP criteria | PHH3 MI applied | |||||||
1 | M/51 | Duodenum | 4.5 | 2 | 10 | 14 | Low (8.3) | High (50) |
2 | M/48 | Jejunum | 3.0 | 2 | 4 | 6 | Low (4.3) | High (73) |
3 | M/47 | Ileum | 3.9 | 2 | 8 | 10 | Low (4.3) | High (73) |
4 | M/56 | Rectum | 2.1 | 4 | 3 | 7 | Low (8.5) | High (52) |
5 | M/67 | Stomach | 3.0 | 1 | 4 | 8 | Very low (1.9) | Moderate (16) |
6 | M/57 | Stomach | 2.5 | 2 | 3 | 7 | Very low (1.9) | Moderate (16) |
7 | M/57 | Stomach | 4.5 | 3 | 6 | 6 | Very low (1.9) | Moderate (16) |
8 | F/67 | Stomach | 2.9 | 4 | 5 | 10 | Very low (1.9) | Moderate (16) |
9 | M/64 | Stomach | 2.7 | 5 | 5 | 14 | Very low (1.9) | Moderate (16) |
10 | M/64 | Stomach | 2.2 | 5 | 3 | 6 | Very low (1.9) | Moderate (16) |
GIST, gastrointestinal stromal tumor; HPFs, high power fields; Ki-67 LI, Ki-67 labeling index; PHH3 MI, phosphohistone H3 mitotic index.
Values are presented as number (%). GISTs, gastrointestinal stromal tumors; NIH, National Institutes of Health; AFIP, Armed Forces Institute of Pathology.
PHH3 MI, phosphohistone H3 mitotic index; AFIP, Armed Forces Institute of Pathology; Ki-67 LI, Ki-67 labeling index.