Journal of Pathology and Translational Medicine

Chang Suk Kang

8 Articles

Mucosal Schwann Cell Hamartoma in Colorectal Mucosa: A Rare Benign Lesion That Resembles Gastrointestinal Neuroma: Jiheun Han, Yosep Chong, Tae-Jung Kim, Eun Jung Lee, Chang Suk Kang; J Pathol Transl Med. 2017;51(2):187-189. Published online August 25, 2016; DOI: https://doi.org/10.4132/jptm.2016.07.02

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Multiple non-polypoid mucosal Schwann cell hamartomas presenting as edematous and submucosal tumor-like lesions: a case report
Takeshi Okamoto, Takaaki Yoshimoto, Katsuyuki Fukuda
BMC Gastroenterology.2021;[Epub] CrossRef
Mucosal schwann cell hamartoma of the gall bladder
Kanika Sharma, AnjanKumar Dhua, Prabudh Goel, Vishesh Jain, DevendraKumar Yadav, Prashant Ramteke
Journal of Indian Association of Pediatric Surgeons.2021; 26(3): 182. CrossRef
Mucosal Schwann Cell Hamartoma in sigmoid colon – A rare case report and review of literature
Xiuyan Feng, Hongzhi Xu, Nestor Dela Cruz
Human Pathology: Case Reports.2020; 19: 200337. CrossRef
Spindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma
Patrice Grech, John B Schofield
Histopathology.2020; 76(3): 342. CrossRef
Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart
Yuan Li, Pouneh Beizai, John W. Russell, Lindsey Westbrook, Arash Nowain, Hanlin L. Wang
Annals of Diagnostic Pathology.2020; 47: 151531. CrossRef
Mucosal Schwann Cell Hamartoma Presenting as Diffuse Fine Nodularities
Han Beol Jang, Jong Ok Kim, Sang-Bum Kang
The Korean Journal of Gastroenterology.2020; 76(3): 171. CrossRef
A case of Schwann cell hamartoma of the tongue
Saya TAKIKAWA, Shigeo TANAKA, Masamichi KOMIYA, Masaaki SUEMITSU, Tadahiko UTSUNOMIYA, Kayo KUYAMA
Japanese Journal of Oral and Maxillofacial Surgery.2020; 66(12): 601. CrossRef
Hamartoma de células de Schwann mucoso: revisión de una entidad descrita recientemente
Francisco García-Molina, José Antonio Ruíz-Macia, Joaquin Sola
Revista Española de Patología.2018; 51(1): 49. CrossRef
Neural and neurogenic tumours of the gastroenteropancreaticobiliary tract
Aoife J McCarthy, Dipti M Karamchandani, Runjan Chetty
Journal of Clinical Pathology.2018; 71(7): 565. CrossRef
Case of colonic mucosal Schwann cell hamartoma and review of literature on unusual colonic polyps
JayaKrishna Chintanaboina, Kofi Clarke
BMJ Case Reports.2018; : bcr-2018-224931. CrossRef

Necrotizing Sarcoid Granulomatosis: Possibly Veiled Disease in Endemic Area of Mycobacterial Infection: Yosep Chong, Eun Jung Lee, Chang Suk Kang, Tae-Jung Kim, Jung Sup Song, Hyosup Shim; J Pathol Transl Med. 2015;49(4):346-350. Published online June 1, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.17

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Incidental Lung Cavity in the Heartland
Biplab K. Saha, Om Dawani, Woon H Chong, Alyssa Bonnier
The American Journal of the Medical Sciences.2022; 363(2): 191. CrossRef
A rare presentation of necrotizing sarcoidosis
Nirali Sheth, Umaima Dhamrah, Branden Ireifej, David Song, Penpa Bhuti, Jagbir Singh, Henry Fan, Sibghatallah Ummar, Vikash Jaiswal, Nishan Babu Pokhrel
Respirology Case Reports.2022;[Epub] CrossRef
Necrotizing Granulomatous Dacryoadenitis With Non-Necrotizing Granulomatous Scar Hypertrophy: Two Histological Variants of Sarcoidosis in the Same Patient
Erin E. Godbout, M. Kristina Subik, Tal J. Rubinstein
Ophthalmic Plastic & Reconstructive Surgery.2021; 37(1): e30. CrossRef
Necrotizing sarcoid granulomatosis simulating pulmonary malignancy
Jun Hyeok Kim, Bo Da Nam, Jung Hwa Hwang, Dong Won Kim, Ki-Up Kim, Young Woo Park
Medicine.2021; 100(49): e28208. CrossRef
Necrotizing Sarcoid Granulomatosis: A Disease Not to be Forgotten
A. I. Parejo-Morón, M. L. Tornero-Divieso, M. R. Férnandez-Díaz, L. Muñoz-Medina, O. Preda, N. Ortego-Centeno
Case Reports in Medicine.2020; 2020: 1. CrossRef
Clinical Reasoning: A woman with monocular vision loss
Husain Danish, Tatiana Bakaeva, Isaac Solomon, Sashank Prasad
Neurology.2020; 95(8): e1105. CrossRef
Cavity forms of thoracic sarcoidosis (literature review, clinical and radiological observations)
A. V. Lenshin, A. V. Il'in, Yu. M. Perelman
PULMONOLOGIYA.2020; 30(6): 831. CrossRef
Thoracic sarcoidosis versus tuberculosis: Need for a multi-disciplinary approach
Agrima Mian, Animesh Ray
Indian Journal of Radiology and Imaging.2018; 28(02): 267. CrossRef
Necrotizing sarcoid granulomatosis with clinical presentations of recurrent acute abdomen. Case report and literature review
V. I. Vasilyev, S. G. Palshina, B. D. Chaltsev, S. G. Radenska-Lopovok, T. N. Safonova
Terapevticheskii arkhiv.2017; 89(11): 60. CrossRef

Cytological Evaluation and REBA HPV-ID HPV Testing of Newly Developed Liquid-Based Cytology, EASYPREP: Comparison with SurePath: Youn Soo Lee, Gyungyub Gong, Jin Hee Sohn, Ki Sung Ryu, Jung Hun Lee, Shin Kwang Khang, Kyung-Ja Cho, Yong-Man Kim, Chang Suk Kang; Korean J Pathol. 2013;47(3):265-274. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.265

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Abstract PDF

Background

The objective of this study was to evaluate a newly-developed EASYPREP liquid-based cytology method in cervicovaginal specimens and compare it with SurePath.

Methods

Cervicovaginal specimens were prospectively collected from 1,000 patients with EASYPREP and SurePath. The specimens were first collected by brushing for SurePath and second for EASYPREP. The specimens of both methods were diagnosed according to the Bethesda System. Additionally, we performed to REBA HPV-ID genotyping and sequencing analysis for human papillomavirus (HPV) on 249 specimens.

Results

EASYPREP and SurePath showed even distribution of cells and were equal in cellularity and staining quality. The diagnostic agreement between the two methods was 96.5%. Based on the standard of SurePath, the sensitivity, specificity, positive predictive value, and negative predictive value of EASYPREP were 90.7%, 99.2%, 94.8%, and 98.5%, respectively. The positivity of REBA HPV-ID was 49.4% and 95.1% in normal and abnormal cytological samples, respectively. The result of REBA HPV-ID had high concordance with sequencing analysis.

Conclusions

EASYPREP provided comparable results to SurePath in the diagnosis and staining quality of cytology examinations and in HPV testing with REBA HPV-ID. EASYPREP could be another LBC method choice for the cervicovaginal specimens. Additionally, REBA HPV-ID may be a useful method for HPV genotyping.

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High-Risk Human Papillomavirus Detection via Cobas® 4800 and REBA HPV-ID® Assays
Sasiprapa Liewchalermwong, Shina Oranratanaphan, Wichai Termrungruanglert, Surang Triratanachat, Patou Tantbirojn, Nakarin Kitkumthorn, Parvapan Bhattarakosol, Arkom Chaiwongkot
Viruses.2022; 14(12): 2713. CrossRef
Evaluation of nuclear chromatin using grayscale intensity and thresholded percentage area in liquid-based cervical cytology
Hyekyung Lee, Myungein Han, Taejo Yoo, Chanho Jung, Hyun-Jin Son, Migyung Cho
Diagnostic Cytopathology.2018; 46(5): 384. CrossRef
Comparison of EASYPREP®and SurePath®in thyroid fine-needle aspiration
Yosep Chong, Ki Hyun Baek, Jee Young Kim, Tae-Jung Kim, Eun Jung Lee, Chang Suk Kang
Diagnostic Cytopathology.2016; 44(4): 283. CrossRef

Hedgehog Related Protein Expression in Breast Cancer: Gli-2 Is Associated with Poor Overall Survival: Soyoung Im, Hyun Joo Choi, Changyoung Yoo, Ji-Han Jung, Ye-Won Jeon, Young Jin Suh, Chang Suk Kang; Korean J Pathol. 2013;47(2):116-123. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.116

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Abstract PDF

Background

The hedgehog (Hh) signaling pathway is known to play a critical role in various malignancies, but its clinicopathologic role in breast cancer is yet to be established.

Methods

Tissue microarray blocks from 334 cases of breast cancer were prepared. The expression of six Hh signaling proteins including sonic hedgehog (Shh), patched (Ptch), smoothened (Smo), and the glioma-associated oncogene (Gli)-1, Gli-2, and Gli-3 were analyzed immunohistochemically.

Results

The expression of Hh signaling proteins was significantly correlated with some prognostic factors including the correlation of lymph node metastasis with the expression of Shh (p=0.001) and Ptch (p=0.064), the correlation of the stages with Shh and Gli-3 expression (p=0.007 and p=0.024, respectively), the correlation of the nuclear grade with the Smo (p=0.004) and Gli-3 (p=0.000), and the correlation of the histologic grade with the Ptch (p=0.016), Smo (p=0.007), and Gli-3 (p=0.000). The Shh, Ptch, Smo, Gli-1, and Gli-2 expression was significantly different between the phenotypes (p=0.000, p=0.001, p=0.004, p=0.039, and p=0.031, respectively). Gli-2 expression was correlated with a worse overall survival outcome (p=0.012).

Conclusions

Hh pathway activation is correlated with a more aggressive clinical behavior in breast carcinomas. The comparison of phenotypes suggested that the Hh pathway may be a useful therapeutic target for breast carcinoma. Patients with Gli-2 expression had a significantly lower overall survival rate and, therefore, it showed promise as a prognostic marker.

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GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells
Min Lin, Haiyan Zhu, Qi Shen, Lu-Zhe Sun, Xueqiong Zhu
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Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched
Álvaro Javier Feliz Morel, Anida Hasanovic, Aurélie Morin, Chloé Prunier, Virginie Magnone, Kevin Lebrigand, Amaury Aouad, Sarah Cogoluegnes, Judith Favier, Claude Pasquier, Isabelle Mus-Veteau
Pharmaceutics.2022; 14(5): 988. CrossRef
Case Report: Submucosal gastroblastoma with a novel PTCH1::GLI2 gene fusion in a 58-year-old man
Cuimin Chen, Junliang Lu, Huanwen Wu
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Higher Expressions of SHH and AR Are Associated with a Positive Receptor Status and Have Impact on Survival in a Cohort of Croatian Breast Cancer Patients
Ivan Budimir, Čedna Tomasović-Lončarić, Kristina Kralik, Josipa Čonkaš, Domagoj Eljuga, Rado Žic, Božo Gorjanc, Hrvoje Tucaković, Doroteja Caktaš, Josip Jaman, Valentino Lisek, Zlatko Vlajčić, Krešimir Martić, Petar Ozretić
Life.2022; 12(10): 1559. CrossRef
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Valentina Karin‑Kujundzic, Adriana Covarrubias‑Pinto, Anita Skrtic, Semir Vranic, Ljiljana Serman
International Journal of Oncology.2022;[Epub] CrossRef
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Araceli García-Martínez, Ariadna Pérez-Balaguer, Fernando Ortiz-Martínez, Eloy Pomares-Navarro, Elena Sanmartín, Marta García-Escolano, Yoel G. Montoyo-Pujol, Elena Castellón-Molla, Gloria Peiró
Pathology - Research and Practice.2021; 223: 153478. CrossRef
Coexpression of Epha10 and Gli3 Promotes Breast Cancer Cell Proliferation, Invasion and Migration
Jing Peng, Danhua Zhang
Journal of Investigative Medicine.2021; 69(6): 1215. CrossRef
The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong, Chung Yeng Looi
Biomedicines.2021; 9(9): 1188. CrossRef
HER2-mediated GLI2 stabilization promotes anoikis resistance and metastasis of breast cancer cells
Parul Gupta, Nehal Gupta, Neel M. Fofaria, Alok Ranjan, Sanjay K. Srivastava
Cancer Letters.2019; 442: 68. CrossRef
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Natalia Riobo-Del Galdo, Ángela Lara Montero, Eva Wertheimer
Cells.2019; 8(4): 375. CrossRef
Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells
G. Guerrini, J. Durivault, I. Filippi, M. Criscuoli, S. Monaci, J. Pouyssegur, A. Naldini, F. Carraro, S.K. Parks
Biochemical and Biophysical Research Communications.2019; 516(2): 408. CrossRef
Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells
Xiaoting Li, Xiaoqian Wang, Chunfeng Xie, Jianyun Zhu, Yu Meng, Yue Chen, Yuan Li, Ye Jiang, Xue Yang, Shijia Wang, Jiaqi Chen, Qi Zhang, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Yu Zhao
Anti-Cancer Drugs.2018; 29(3): 208. CrossRef
Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer
Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chang
International Journal of Molecular Sciences.2018; 19(5): 1375. CrossRef
Cancer Stem Cell Metabolism and Potential Therapeutic Targets
Vusala Snyder, Tamika C. Reed-Newman, Levi Arnold, Sufi Mary Thomas, Shrikant Anant
Frontiers in Oncology.2018;[Epub] CrossRef
Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency
Anida Hasanovic, Isabelle Mus-Veteau
Cells.2018; 7(8): 107. CrossRef
Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia
Emily-Marie Latuske, Hauke Stamm, Marianne Klokow, Gabi Vohwinkel, Jana Muschhammer, Carsten Bokemeyer, Manfred Jücker, Maxim Kebenko, Walter Fiedler, Jasmin Wellbrock
Oncotarget.2017; 8(17): 29187. CrossRef
Prognostic role of Gli1 expression in breast cancer: a meta-analysis
Bilan Wang, Ting Yu, Yuzhu Hu, Mengmeng Xiang, Haoning Peng, Yunzhu Lin, Lu Han, Lingli Zhang
Oncotarget.2017; 8(46): 81088. CrossRef
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Nadia B. Hassounah, Martha Nunez, Colleen Fordyce, Denise Roe, Ray Nagle, Thomas Bunch, Kimberly M. McDermott
Molecular Cancer Research.2017; 15(10): 1421. CrossRef
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration
Manuela Torres Andion Vidal, Sílvia Vanessa Lourenço, Fernando Augusto Soares, Clarissa Araújo Gurgel, Eduardo J. B. Studart, Ludmila de Faro Valverde, Iguaracyra Barreto de Oliveira Araújo, Eduardo Antônio Gonçalves Ramos, Flávia Caló de Aquino Xavier, J
Tumor Biology.2016; 37(7): 9587. CrossRef
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Deep Shah, Clodia Osipo
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Milena Rondón-Lagos, Victoria Villegas, Nelson Rangel, Magda Sánchez, Peter Zaphiropoulos
International Journal of Molecular Sciences.2016; 17(8): 1357. CrossRef
The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24− phenotype
Haishan Zhao, Hongtao Tang, Qinghuan Xiao, Miao He, Lin Zhao, Yingzi Fu, Huizhe Wu, Zhaojin Yu, Qian Jiang, Yuanyuan Yan, Feng Jin, Minjie Wei
Molecular Medicine Reports.2016; 14(6): 5261. CrossRef
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Hyung Wook Chun, Ran Hong
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Jennifer Sims-Mourtada, Lynn M. Opdenaker, Joshua Davis, Kimberly M. Arnold, Daniel Flynn
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Journal of Breast Cancer.2015; 18(4): 339. CrossRef
Prognostic impact of the expression of Hedgehog proteins in cervical carcinoma FIGO stages I–IV treated with radiotherapy or chemoradiotherapy
Louise Bohr Mordhorst, Cecilia Ahlin, Bengt Sorbe
Gynecologic Oncology.2014; 135(2): 305. CrossRef
Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression
Hai-Xia Fan, Shan Wang, Hong Zhao, Nian Liu, Dong Chen, Miao Sun, Jin-Hua Zheng
Medical Oncology.2014;[Epub] CrossRef

Fine Needle Aspiration Cytology of Thyroid Follicular Neoplasm: Cytohistologic Correlation and Accuracy: Changyoung Yoo, Hyun Joo Choi, Soyoung Im, Ji Han Jung, Kiouk Min, Chang Suk Kang, Young-Jin Suh; Korean J Pathol. 2013;47(1):61-66. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.61

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Abstract PDF

Background

This study evaluated the accuracy of fine needle aspiration cytology (FNAC) in cases of follicular neoplasm (FN) on the basis of histologic diagnosis, and reviewed the cytologic findings of FN according to the FNAC.

Methods

Among the 66 cases diagnosed with thyroid FN by FNAC during the 7-year period from 2003 to 2009, 36 cases that had undergone thyroid surgery were available for review. Cytologic diagnosis was compared with the histologic diagnosis of each case.

Results

Among the 36 cases with a cytologic diagnosis of thyroid FN, histologic diagnosis was as follows: 20 follicular adenomas (55.6%), 3 Hurthle cell adenomas (8.3%), 2 follicular carcinomas (5.6%), 8 nodular goiters (22.2%), 2 papillary carcinomas (5.6%), and 1 Hashimoto's thyroiditis (2.8%), resulting in a diagnostic accuracy of FNAC for thyroid FN of 69.5%.

Conclusions

This study shows that FNAC for thyroid FN is a useful primary screening method because when FN is diagnosed by FNAC, the rate of FN histologic diagnosis is relatively high, however, adequate sampling and experience is a prerequisite for this procedure.

Citations

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Prevalence and Predictors of Malignancy in Contralateral Thyroid Lobe in Patients Undergoing Completion Thyroidectomy
Pradipta Kumar Parida, Siddhartha Pradhan, Chapity Preetam, Pradeep Pradhan, Dillip Kumar Samal, Saurav Sarkar
Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2053. CrossRef
Ultrasonographic and cytologic assessments of follicular neoplasms of the thyroid: Predictive features differentiating follicular carcinoma from follicular adenoma
Hye Shin Ahn, Hee Sung Kim, Min Ji Hong, Paula Soares
PLOS ONE.2022; 17(7): e0271437. CrossRef
2019 Practice guidelines for thyroid core needle biopsy: a report of the Clinical Practice Guidelines Development Committee of the Korean Thyroid Association
Chan Kwon Jung, Jung Hwan Baek, Dong Gyu Na, Young Lyun Oh, Ka Hee Yi, Ho-Cheol Kang
Journal of Pathology and Translational Medicine.2020; 54(1): 64. CrossRef
Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
PLOS ONE.2020; 15(11): e0241597. CrossRef
Core needle biopsy of thyroid nodules: outcomes and safety from a large single-center single-operator study
Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
Acta Radiologica.2018; 59(8): 924. CrossRef
Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions
Kanghee Han, Hwa-Jeong Ha, Joon Seog Kong, Jung-Soon Kim, Jae Kyung Myung, Jae Soo Koh, Sunhoo Park, Myung-Soon Shin, Woo-Tack Song, Hye Sil Seol, Seung-Sook Lee
Journal of Pathology and Translational Medicine.2018; 52(2): 110. CrossRef
Comparison of the Diagnostic Efficacy of Ultrasound-Guided Core Needle Biopsy With 18- Versus 20-Gauge Needles for Thyroid Nodules
Hye Shin Ahn, Mirinae Seo, Su Min Ha, Hee Sung Kim
Journal of Ultrasound in Medicine.2018; 37(11): 2565. CrossRef
Subclassification of Bethesda Atypical and Follicular Neoplasm Categories According to Nuclear and Architectural Atypia Improves Discrimination of Thyroid Malignancy Risk
Joel Xue Yi Lim, Min En Nga, Dedrick Kok Hong Chan, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
Thyroid.2018; 28(4): 511. CrossRef
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Galina Chernaya, Nina Mikhno, Tatiana Khabalova, Svetlana Svyatchenko, Lyudmila Mostovich, Sergey Shevchenko, Lyudmila Gulyaeva
Surgical Oncology.2018; 27(4): 702. CrossRef
The Usefulness of Immunocytochemistry of CD56 in Determining Malignancy from Indeterminate Thyroid Fine-Needle Aspiration Cytology
Hyunseo Cha, Ju Yeon Pyo, Soon Won Hong
Journal of Pathology and Translational Medicine.2018; 52(6): 404. CrossRef
Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology
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Korean Journal of Radiology.2017; 18(1): 217. CrossRef
Radiofrequency ablation of small follicular neoplasms: initial clinical outcomes
Su Min Ha, Jin Yong Sung, Jung Hwan Baek, Dong Gyu Na, Ji-hoon Kim, Hyunju Yoo, Ducky Lee, Dong Whan Choi
International Journal of Hyperthermia.2017; : 1. CrossRef
A meta-analytic review of the Bethesda System for Reporting Thyroid Cytopathology: Has the rate of malignancy in indeterminate lesions been underestimated?
Patrizia Straccia, Esther Diana Rossi, Tommaso Bizzarro, Chiara Brunelli, Federica Cianfrini, Domenico Damiani, Guido Fadda
Cancer Cytopathology.2015; 123(12): 713. CrossRef
Impact of NRAS Mutations on the Diagnosis of Follicular Neoplasm of the Thyroid
Ja-Seong Bae, Seung Kyu Choi, Sora Jeon, Yourha Kim, Sohee Lee, Youn Soo Lee, Chan Kwon Jung
International Journal of Endocrinology.2014; 2014: 1. CrossRef
Diagnosis of Thyroid Follicular Neoplasm: Fine-Needle Aspiration Versus Core-Needle Biopsy
Ra Gyoung Yoon, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Min Ji Hong, Dong Eun Song, Jae Kyun Kim, Jong Ho Yoon, Won Bae Kim
Thyroid.2014; 24(11): 1612. CrossRef

A Proposal for Creating a Guideline for Cancer Registration of the Fibromatosis, PEComa Group, Malignant Lymphoma In Situ and Dendritic Cell Tumors (III): Changyoung Yoo, Chang Suk Kang, Yoon La Choi, Hye Yoon Kang, Jin Man Kim, Young Hye Koh, Joo Hee Lee, Seung Sook Lee, In Sun Kim, Dong Hoon Kim, Yong Ku Park, Jin Hee Sohn; Korean J Pathol. 2012;46(5):436-442. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.436

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Abstract PDF: Background
Understanding the biologic behavior of a tumor is a prerequisite for tumor registration code assignment. The aim of this report was to propose appropriate behavior codes of the International Classification of Disease Oncology 3 (ICD-O3) to rare, yet pathologically interesting hematopoietic and soft tissue tumors.
Methods
The Study Group for Hematopathology, the Bone and Soft Tissue Pathology Study Group, and the Cancer Registration Committee prepared the questionnaire containing provisional behavior codes of selected diseases.
Results
In situ lesions of mantle cell and follicular lymphomas, dendritic cell tumors, and neoplasms with perivascular epithelioid cell differentiation (PEComa), not otherwise specified were classified as malignant (-/3). The fibromatosis group, with the exception of lipofibromatosis, was proposed as benign (-/0). Lipofibromatosis and several diseases that belong to the PEComa group were proposed as uncertain malignant potential (-/1). For the hematologic and soft tissue tumors, 274 and 288 members of the Korean Society of Pathologists, respectively, provided opinions through questionnaire, and most responders showed agreement with the provisional behavior code proposed.
Conclusions
The determination of behavior codes for the rare diseases described in this study, especially those of the PEComa group or malignant lymphoma, could be viewed as impractical and premature, but this study provides the basis for future research on this topic.

Proposal for Creating a Guideline for Cancer Registration of Microinvasive Tumors of the Breast and Ovary (II): Jin Hee Sohn, Gyungyub Gong, Kyu Rae Kim, Chang Suk Kang, Youn Soo Lee, Jin Man Kim, Woo Hee Jung, Kwang Sun Suh; Korean J Pathol. 2012;46(3):226-232. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.226

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Abstract PDF

Background

Cancer registration in Korea has a longer than 30-years of history, during which time cancer registration has improved and become well-organized. Cancer registries are fundamental for cancer control and multi-center collaborative research. However, there have been discrepancies in assigning behavior codes. Thus, we intend to propose appropriate behavior codes for the International Classification of Disease Oncology, 3rd edition (ICD-O-3) for microinvasive tumors of the ovary and breast not only to improve the quality of the cancer registry but also to prevent conflicts.

Methods

As in series I, two pathology study groups and the Cancer Registration Committee of the Korean Society of Pathologists (KSP) participated. To prepare a questionnaire on provisional behavior code, the relevant subjects were discussed in the workshop, and consensus was obtained by convergence of opinion from members of KSP.

Results

Microinvasive tumor of the breast should be designated as a microinvasive carcinoma which was proposed as malignant tumor (/3). Serous borderline tumor with microinvasion of the ovary was proposed as borderline tumor (/1), and mucinous borderline tumor with microinvasion of the ovary as either borderline (/1) or carcinoma (/3) according to the tumor cell nature.

Conclusions

Some issues should be elucidated with the accumulation of more experience and knowledge. Here, however, we present our second proposal.

Citations

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Update on the Proposal for Creating a Guideline for Cancer Registration of the Gastrointestinal Tumors (I-2)
Eun Sun Jung, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Won Ae Lee, Hee Eun Lee, Sunhoo Park, Jin Hee Sohn, So-Young Jin
Korean Journal of Pathology.2012; 46(5): 443. CrossRef
A Proposal for Creating a Guideline for Cancer Registration of the Fibromatosis, PEComa Group, Malignant LymphomaIn Situand Dendritic Cell Tumors (III)
Changyoung Yoo, Chang Suk Kang, Yoon La Choi, Hye Yoon Kang, Jin Man Kim, Young Hye Koh, Joo Hee Lee, Seung Sook Lee, In Sun Kim, Dong Hoon Kim, Yong Ku Park, Jin Hee Sohn
Korean Journal of Pathology.2012; 46(5): 436. CrossRef

Expression of Human Papillomavirus-Related Proteins and Its Clinical Implication in Tonsillar Squamous Cell Carcinoma: Joon Seon Song, Min-Sik Kim, Joon Wook Park, Youn Soo Lee, Chang Suk Kang; Korean J Pathol. 2012;46(2):177-186. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.177

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Abstract PDF

Background

Human papillomavirus (HPV) is known to cause of oropharyngeal squamous cell carcinoma (SqCC). HPV positive SqCCs overexpress p16 and are associated with better survival. Several markers of cell cycles and apoptosis have been reported as a prognostic value. We examined the prognostic value of HPV status, p16, cyclin D1, and Bcl-2 in patients with tonsillar SqCC.

Methods

Tissue microarrays were constructed in 56 cases of tonsillar SqCC for which we performed an immunohistochemistry and an in situ hybridization (ISH) of the HPV.

Results

Of the 56 cases, 31 (55.3%) were positive for p16 and 20 (35.7%) were positive for HPV ISH. The expressions of p16, cyclin D1, and Bcl-2 were not correlated with the clinicopathologic variables including smoking status, differentiation and pT- and pN-stages. The HPV ISH positive group showed a better overall survival than the HPV negative group (p=0.04), and the p16 positive group showed a better disease free survival (DFS) than the negative group (p=0.016). Cox regression analysis showed that only p16 positivity was an independent prognostic factor for DFS (p=0.03; hazard ratio, 10.1).

Conclusions

Our results indicate that both p16 expression and HPV status are useful indicators for risk stratification in patients with tonsillar SqCC.

Citations

Citations to this article as recorded by

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