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Ji Yun Jeong 5 Articles
Current status of cytopathology practice in Korea: impact of the coronavirus pandemic on cytopathology practice
Soon Auck Hong, Haeyoen Jung, Sung Sun Kim, Min-Sun Jin, Jung-Soo Pyo, Ji Yun Jeong, Younghee Choi, Gyungyub Gong, Yosep Chong
J Pathol Transl Med. 2022;56(6):361-369.   Published online October 27, 2022
  • 1,092 View
  • 57 Download
AbstractAbstract PDFSupplementary Material
The Continuous Quality Improvement program for cytopathology in 2020 was completed during the coronavirus pandemic. In this study, we report the result of the quality improvement program.
Data related to cytopathology practice from each institute were collected and processed at the web-based portal. The proficiency test was conducted using glass slides and whole-slide images (WSIs). Evaluation of the adequacy of gynecology (GYN) slides from each institution and submission of case glass slides and WSIs for the next quality improvement program were performed.
A total of 214 institutions participated in the annual cytopathology survey in 2020. The number of entire cytopathology specimens was 8,220,650, a reduction of 19.0% from the 10,111,755 specimens evaluated in 2019. Notably, the number of respiratory cytopathology specimens, including sputum and bronchial washing/ brushing significantly decreased by 86.9% from 2019, which could be attributed to the global pandemic of coronavirus disease. The ratio of cases with atypical squamous cells to squamous intraepithelial lesions was 4.10. All participating institutions passed the proficiency test and the evaluation of adequacy of GYN slides.
Through the Continuous Quality Improvement program, the effect of coronavirus disease 2019 pandemic, manifesting with a reduction in the number of cytologic examinations, especially in respiratory-related specimen has been identified. The Continuous Quality Improvement Program of the Korean Society for Cytopathology can serve as the gold standard to evaluate the current status of cytopathology practice in Korea.
Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer
Young Min Jo, Tae In Park, Hwa Young Lee, Ji Yun Jeong, Won Kee Lee
J Pathol Transl Med. 2016;50(2):122-128.   Published online February 8, 2016
  • 10,590 View
  • 76 Download
  • 10 Citations
AbstractAbstract PDF
Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p<.047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p=.076 in ADC and p=.631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p=.047), but no significance was found in SQCC (p=.068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p=.210) or SQCC (p=.533). Conclusions: AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC.


Citations to this article as recorded by  
  • Aquaporin-mediated dysregulation of cell migration in disease states
    Ian M. Smith, Shohini Banerjee, Allison K. Moses, Kimberly M. Stroka
    Cellular and Molecular Life Sciences.2023;[Epub]     CrossRef
  • The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article
    Lukasz Jaskiewicz, Anna Romaszko-Wojtowicz, Anna Doboszynska, Agnieszka Skowronska
    Cells.2023; 12(3): 468.     CrossRef
  • Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets
    Mahdieh-Sadat Moosavi, Yalda Elham
    Pathology & Oncology Research.2020; 26(2): 615.     CrossRef
  • Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications
    Ekta Yadav, Niket Yadav, Ariel Hus, Jagjit S. Yadav
    Respiratory Medicine.2020; 174: 106193.     CrossRef
  • Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers
    Pak Hin Chow, Joanne Bowen, Andrea J Yool
    Cancers.2020; 12(7): 1911.     CrossRef
  • Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung
    Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
    Journal of Pathology and Translational Medicine.2019; 53(1): 13.     CrossRef
  • Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer‐associated fibroblasts
    Ahmed E Hegab, Mari Ozaki, Naofumi Kameyama, Jingtao Gao, Shizuko Kagawa, Hiroyuki Yasuda, Kenzo Soejima, Yongjun Yin, Robert D Guzy, Yoshikazu Nakamura, David M Ornitz, Tomoko Betsuyaku
    The Journal of Pathology.2019; 249(2): 193.     CrossRef
  • Anti-cancer effect of Aquaporin 5 silencing in colorectal cancer cells in association with inhibition of Wnt/β-catenin pathway
    Wei Wang, Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Hongzhi Sun, Guang Bai
    Cytotechnology.2018; 70(2): 615.     CrossRef
  • Knockdown of aquaporin-5 sensitizes colorectal cancer cells to 5-fluorouracil via inhibition of the Wnt–β-catenin signaling pathway
    Qing Li, Tao Yang, Dongsheng Li, Feng Ding, Guang Bai, Wei Wang, Hongzhi Sun
    Biochemistry and Cell Biology.2018; 96(5): 572.     CrossRef
  • Implications of KRAS mutations in acquired resistance to treatment in NSCLC
    Marzia Del Re, Eleonora Rofi, Giuliana Restante, Stefania Crucitta, Elena Arrigoni, Stefano Fogli, Massimo Di Maio, Iacopo Petrini, Romano Danesi
    Oncotarget.2018; 9(5): 6630.     CrossRef
Signet-Ring Cell Carcinoma of the Distal Common Bile Duct: Report of a Case
Hyung Jun Kwon, Ghil-Suk Yoon, Yong Chul Kwon, Sang Geol Kim, Ji Yun Jeong
Korean J Pathol. 2014;48(4):315-318.   Published online August 26, 2014
  • 6,238 View
  • 37 Download
  • 4 Citations


Citations to this article as recorded by  
  • Rare histotypes of epithelial biliary tract tumors: A literature review
    Elena Sapuppo, Oronzo Brunetti, Dalila Tessitore, Giovanni Brandi, Nicola Di Giovanni, Guido Fadda, Claudio Luchini, Maurizio Martini, Davide Quaresmini, Antonio Russo, Mariacarmela Santarpia, Aldo Scarpa, Mario Scartozzi, Giovanni Tuccari, Tindara Franch
    Critical Reviews in Oncology/Hematology.2023; 181: 103892.     CrossRef
  • Primary signet-ring cell carcinoma of the extrahepatic bile duct: A case report
    Chao-Bang Xie, Yang Wu, Feng Li, Kai-Fei Zhao, Rong-Shu Shi, Qiong Huang, Jin Ao, Di Ke
    World Journal of Gastrointestinal Oncology.2022; 14(7): 1356.     CrossRef
  • Duodenal Stenosis Due to Carcinoma of the Lower Bile Duct: A Case Report
    Takumi Maki, Atsushi Irisawa, Kenji Notohara, Goro Shibukawa, Ai Sato, Akane Yamabe, Yoshitsugu Yoshida, Shogo Yamamoto, Nobutoshi Soeta, Takuro Saito
    Clinical Medicine Insights: Case Reports.2020; 13: 117954762091945.     CrossRef
  • Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman
    Jessemae L. Welsh, Omar Jaber, Marina Ivanovic, Frederick C. Johlin, Rami G. El Abiad, Gerald H. Clamon, Mark C. Smith, Carlos H. F. Chan
    Journal of Gastrointestinal Cancer.2018; 49(1): 63.     CrossRef
MAD2 Expression in Ovarian Carcinoma: Different Expression Patterns and Levels among Various Types of Ovarian Carcinoma and Its Prognostic Significance in High-Grade Serous Carcinoma
Po Eun Park, Ji Yun Jeong, Sun Zoo Kim, Ji Young Park
Korean J Pathol. 2013;47(5):418-425.   Published online October 25, 2013
  • 5,571 View
  • 33 Download
  • 5 Citations
AbstractAbstract PDF

Mitotic arrest deficiency protein 2 (MAD2) is a key component of spindle assembly checkpoint function, which mediates cell apoptosis through microtubule kinetics. Aberrant expression of MAD2 is believed to be associated with the development of chromosome instability. MAD2 also has a signihicant role in cellular drug resistance to taxane chemotherapeutic agents.


Expression of MAD2 and p53 was investigated using immunohistochemistry in 85 cases of ovarian carcinomas. Clinicopathological data including progression-free survival were analyzed.


A significant (p=.035) association was observed between the grade of serous carcinoma and the expression level of MAD2. While low-grade serous carcinoma showed a low-level expression of MAD2, high-grade serous carcinoma showed a high-level expression of MAD2. We also determined that low-level expression of MAD2 was associated with reduced progression-free survival (PFS) (p=.016) in high-grade serous carcinoma.


MAD2 expression in ovarian carcinoma is related to the grade of serous carcinoma and PFS of high-grade serous carcinoma. Expression level of MAD2 detected by immunohistochemistry may serve as an indicator in predicting the response of microtubule-interfering chemotherapeutic agents.


Citations to this article as recorded by  
  • The role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer
    Mark Bates, Cathy D. Spillane, Michael F. Gallagher, Amanda McCann, Cara Martin, Gordon Blackshields, Helen Keegan, Luke Gubbins, Robert Brooks, Doug Brooks, Stavros Selemidis, Sharon O’Toole, John J. O’Leary, David Wai Chan
    PLOS ONE.2020; 15(12): e0243715.     CrossRef
  • Aneuploidy: Cancer strength or vulnerability?
    Giorgia Simonetti, Samantha Bruno, Antonella Padella, Elena Tenti, Giovanni Martinelli
    International Journal of Cancer.2019; 144(1): 8.     CrossRef
  • The association between MAD2 and prognosis in cancer: a systematic review and meta-analyses
    Tara Byrne, Helen G. Coleman, Janine A. Cooper, W. Glenn McCluggage, Amanda McCann, Fiona Furlong
    Oncotarget.2017; 8(60): 102223.     CrossRef
  • Identification of transcription factors (TFs) and targets involved in the cholangiocarcinoma (CCA) by integrated analysis
    L Yang, S Feng, Y Yang
    Cancer Gene Therapy.2016; 23(12): 439.     CrossRef
  • Proteins of the mitotic checkpoint and spindle are related to chromosomal instability and unfavourable prognosis in patients with myelodysplastic syndrome
    Kelly Roveran Genga, Francisco Dário Rocha Filho, Francisco Valdeci de Almeida Ferreira, Juliana Cordeiro de Sousa, Fernando Sergio Studart, Silvia Maria Meira Magalhães, Fabíola Fernandes Heredia, Ronald Feitosa Pinheiro
    Journal of Clinical Pathology.2015; 68(5): 381.     CrossRef
Fine-Needle Aspiration Cytology of Low-Grade Cribriform Cystadenocarcinoma with Many Psammoma Bodies of the Salivary Gland
Ji Yun Jeong, Dongbin Ahn, Ji Young Park
Korean J Pathol. 2013;47(5):481-485.   Published online October 25, 2013
  • 5,872 View
  • 36 Download
  • 11 Citations
AbstractAbstract PDF

Low-grade cribriform cystadenocarcinoma (LGCCC) is a rare salivary gland tumor that was recently defined as a variant of cystadenocarcinoma by the 2005 World Health Orgazniation (WHO) classification system. We report cytologic findings of an unusual case of LGCCC with many psammoma bodies. A 90-year-old man presented a palpable mass on his left parotid gland. Fine-needle aspiration (FNA) cytology showed tumor cells that were arranged in clusters and dispersed individually. The tumor cells showed mild atypia and had clear or dense cytoplasm with some vacuoles. Numerous psammoma bodies were noted. After surgical resection, the histologic examination revealed a mixed solid and cystic mass showing intraductal growth with focal stromal invasion. The S-100 protein expressed in the tumor cells, but smooth muscle actin and p63 were positive only in myoepithelial cells. Although LGCCCs resemble other salivary gland tumors, differentiating LGCCC during preoperative FNA is important to avoid unnecessary overtreatment.


Citations to this article as recorded by  
  • Salivary Gland Intraductal Carcinoma: How Do 183 Reported Cases Fit Into a Developing Classification
    Lester D.R. Thompson, Justin A. Bishop
    Advances in Anatomic Pathology.2023; 30(2): 112.     CrossRef
  • Intraductal carcinoma of the parotid gland
    Yukiya HIRATA, Kayoko HIGUCHI, Toshitaka NAGAO, Yoko ZUKERAN, Takao KINJO, Naoki WADA
    The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 431.     CrossRef
  • Intraductal carcinoma of the retromolar trigone found with elevated serum CEA and CA19-9 levels: a case report
    Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(5): 292.     CrossRef
  • Endoscopic trans‐pterygoid resection of a low‐grade cribriform cystadenocarcinoma of the infratemporal fossa
    Vikram G. Ramjee, Landon J. Massoth, John P. Richards, Kibwei A. McKinney
    World Journal of Otorhinolaryngology - Head and Neck Surgery.2020; 6(2): 115.     CrossRef
  • Psammoma Bodies in a Large Myoepithelioma
    Marcela Pessoa de Melo, Diego Filipe Bezerra Silva, Rodrigo Alves Ribeiro, Tony Santos Peixoto, Daliana Queiroga de Castro Gomes, Pollianna Muniz Alves, Cassiano Francisco Weege Nonaka, Bárbara Vanessa de Brito Monteiro
    Journal of Craniofacial Surgery.2020; 31(4): e326.     CrossRef
  • Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity
    Francesco Giovacchini, Caterina Bensi, Stefano Belli, Maria Elena Laurenti, Martina Mandarano, Daniele Paradiso, Michele Giansanti, Antonio Tullio
    Journal of Oral Biology and Craniofacial Research.2019; 9(1): 96.     CrossRef
  • What is your diagnosis? Submandibular mass in a dog
    Julie Allen, Ashley M. Talley, Carol B. Grindem, Jennifer A. Neel
    Veterinary Clinical Pathology.2018; 47(4): 676.     CrossRef
  • Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature
    Xiu-Peng Zhang, Gui-Yang Jiang, Qing-Fu Zhang, Hong-Tao Xu, Qing-Chang Li, En-Hua Wang
    Pathology - Research and Practice.2017; 213(4): 405.     CrossRef
  • Cytology of low-grade cribriform cystadenocarcinoma in salivary glands: Cytological and immunohistochemical distinctions from other salivary gland neoplasms
    Yoshiki Ohta, Yuko Hirota, Yohko Kohno, Koji Kishimoto, Tomoko Norose, Nobuyuki Ohike, Masafumi Takimoto, Akira Shiokawa, Hidekazu Ota
    Diagnostic Cytopathology.2016; 44(3): 241.     CrossRef
  • Low-grade cribriform cystadenocarcinoma arising from a minor salivary gland: a case report
    Masashi Kimura, Shinji Mii, Shinichi Sugimoto, Kosuke Saida, Shojiroh Morinaga, Masahiro Umemura
    Journal of Oral Science.2016; 58(1): 145.     CrossRef
  • A Case of Cystadenocarcinoma Arising from Parotid Gland
    Jong Chul Hong, Tae Kyoung Koh, Min Gyoung Pak, Heon Soo Park
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2016; 59(4): 300.     CrossRef

JPTM : Journal of Pathology and Translational Medicine