- Extremely well-differentiated adenocarcinoma of the stomach: diagnostic pitfalls in endoscopic biopsy
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Jongwon Lee, In-Seob Lee, Ji Yong Ahn, Young Soo Park, Jihun Kim
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J Pathol Transl Med. 2022;56(2):63-72. Published online November 16, 2021
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DOI: https://doi.org/10.4132/jptm.2021.10.12
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 Abstract
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- Background
Extremely well-differentiated adenocarcinoma (EWDA) is a deceptively bland-looking adenocarcinoma of the stomach. It often causes diagnostic problems, especially in endoscopic biopsy samples. To better recognize this deceptively bland lesion, we carefully reviewed a series of EWDAs treated at our institution.
Methods
A total of 55 specimens from 19 patients were obtained. Endoscopic, gross and microscopic features defining EWDA were described and documented. For comparison, hyperplastic polyp specimens were randomly selected and analyzed.
Results
Most cases (18 of 19, 94.7%) were advanced gastric cancer (AGC) and primarily located in the body of the stomach (15 of 19, 79.0%). The majority of AGCs were non-ulcerated (11 of 18, 61.1%) with an undermining growth pattern and a relatively small mucosal involvement. Specific histologic features included an irregular glandular shape, an undulating apical cytoplasmic border, disproportionately large glands, a variably distended mucinous cytoplasm. Classical features, such as small infiltrating glands or desmoplastic reactions, were barely observed. Identification of irregularly spaced nuclei and disruption of the foveolar epithelial structure, along with atypical features described above were helpful in making a diagnosis especially in gastric forceps biopsies.
Conclusions
Awareness of the histomorphologic characteristics described in this report would lead to timely diagnosis and prevent repeated endoscopic procedures.
- Breast implant–associated anaplastic large cell lymphoma: the first South Korean case
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Jongwon Lee, Hyungwoo Cho, Dok Hyun Yoon, Eun Key Kim, Gyungyub Gong, Cheolwon Suh, Joo-ryung Huh
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J Pathol Transl Med. 2020;54(5):432-434. Published online August 18, 2020
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DOI: https://doi.org/10.4132/jptm.2020.07.01
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Citations
Citations to this article as recorded by  - Breast Reconstruction after Breast Implant-Associated Anaplastic Large Cell Lymphoma Treatment: A Case Report and Literature Review
Won-Seob Lee, Tae-Gon Kim, Jun-Ho Lee, Il-Kug Kim
Journal of Clinical Medicine.2023; 12(5): 1885. CrossRef - Breast implant-associated anaplastic large cell lymphoma: a case report with a history of spontaneously resolved late seroma
Do Yeon Kim, Joon Hur, Woo Yeon Han, Kyunghyun Min, Jong Won Lee, Jin Sup Eom, Hyun Ho Han, Eun Key Kim
Archives of Aesthetic Plastic Surgery.2021; 27(4): 143. CrossRef - Comment on “Breast implant-associated anaplastic large cell lymphoma: the first South Korean case”
Il-Kug Kim, Tae Gon Kim
Journal of Pathology and Translational Medicine.2021; 55(6): 419. CrossRef
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