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Mineui Hong 3 Articles
CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated T-Lymphoproliferative Disorder
Mineui Hong, Young Hyeh Ko
J Pathol Transl Med. 2015;49(6):525-530.   Published online September 30, 2015
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  • 84 Download
  • 1 Citations
AbstractAbstract PDF
Eosinophilic ulcer of the oral mucosa (EUOM) is a very rare, benign, self-limiting ulcerative lesion of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of CD30+ T-cell lymphoproliferative disease (LPD) of the oral mucosa. The etiology and pathogenesis of the disease are unknown. We report two cases in children who were initially diagnosed with EUOM and CD30+ T-cell LPD, respectively. However, retrospective analysis revealed that a majority of infiltrated atypical T cells were positive for Epstein-Barr virus (EBV). The present cases suggest that the pathogenesis and etiology of EUOM or CD30+ T-cell LPD occurring in children are different from those in adults. EUOM or CD30+ T-cell LPD in children is a manifestation of EBV-positive T-cell LPD, and should therefore be distinguished from the disease in adults.


Citations to this article as recorded by  
  • Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity
    Ziv Schwartz, Robert B. Bowe, Morton Coleman, Cynthia M. Magro
    Annals of Diagnostic Pathology.2018; 37: 57.     CrossRef
Indolent CD56-Positive Clonal T-Cell Lymphoproliferative Disease of the Stomach Mimicking Lymphomatoid Gastropathy
Mineui Hong, Won Seog Kim, Young Hyeh Ko
Korean J Pathol. 2014;48(6):430-433.   Published online December 31, 2014
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  • 58 Download
  • 2 Citations


Citations to this article as recorded by  
  • Case Report: Primary Indolent Epstein-Barr Virus-Positive T-Cell Lymphoproliferative Disease Involving the Central Nervous System
    Kun Wang, Jinjian Li, Xuehui Zhou, Junhui Lv, Yirong Wang, Xinwei Li
    Frontiers in Surgery.2022;[Epub]     CrossRef
  • Indolent NK cell proliferative lesion mimicking NK/T cell lymphoma in the gallbladder
    Su Hyun Hwang, Joon Seong Park, Seong Hyun Jeong, Hyunee Yim, Jae Ho Han
    Human Pathology: Case Reports.2016; 5: 39.     CrossRef
EBV-Positive T/NK-Cell Lymphoproliferative Disease of Childhood
Mineui Hong, Young Hyeh Ko, Keon Hee Yoo, Hong Hoe Koo, Seok Jin Kim, Won Seog Kim, Heejung Park
Korean J Pathol. 2013;47(2):137-147.   Published online April 24, 2013
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  • 103 Download
  • 24 Citations
AbstractAbstract PDF

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH), EBV-positive systemic T-cell lymphoproliferative disease (STLPD) of childhood, and chronic active EBV (CAEBV) infection may develop after primary EBV infection. This study reviewed the clinicopathological spectrum of EBV-associated T- and natural killer (NK)-cell LPD, including STLPD and CAEBV infection, with an analysis of T-cell clonality.


Clinicopathological features of seven patients with EBV-associated HLH or STLPD and 12 patients with CAEBV infection were reviewed. Immunohistochemical staining and a T-cell receptor (TCR) gene rearrangement study were performed.


STLPD and EBV-positive HLH showed significantly overlapping clinicopathological findings. One patient with STLPD and one patient with EBV-positive HLH demonstrated moderate to severe atypia of the infiltrating lymphocytes, whereas the remaining patients lacked significant atypia. Twelve patients had CAEBV infection, four of whom suffered mosquito-bite hypersensitivity, five showed NK lymphocytosis, and one suffered hydroa vacciniforme. Infiltrating lymphocytes were predominantly small and devoid of atypia. Hemophagocytic histiocytosis was found in seven of 11 patients. Monoclonality was detected in three (50%) of the six patients with successful TCR gene analysis.


EBV-positive HLH and STLPD share similar clinicopathological findings and may constitute a continuous spectrum of acute EBV-associated T- or NK-cell proliferative disorders. The distinction of EBV-positive T-cell LPD from EBV-positive HLH may be difficult during routine diagnoses because of the technical limitations of clonality assessment.


Citations to this article as recorded by  
  • The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
    Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Barreto de Oliveira Araujo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel Boyer, Mariarita Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee-Joo Chng,
    Leukemia.2022; 36(7): 1720.     CrossRef
  • Chronic active Epstein–Barr virus enteritis: A literature review
    Yang Shen, Yu Fang Wang
    Journal of Digestive Diseases.2022; 23(5-6): 248.     CrossRef
  • EBV-Associated Lymphoproliferative Disorders
    Young Hyeh Ko
    Clinical Pediatric Hematology-Oncology.2021; 28(1): 14.     CrossRef
  • Clinicopathologic findings of chronic active Epstein–Barr virus infection in adults: A single-center retrospective study in China
    Jing Lin, Haicong Wu, Lei Gu, Xia Wu, Miaofang Su, Haiyan Lin, Bang Liu, Jiaolong Zheng, Xuan Mei, Dongliang Li
    Clinical and Experimental Medicine.2021; 21(3): 369.     CrossRef
  • Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein–Barr virus infection
    Honghao Ma, Liping Zhang, Ang Wei, Jun Yang, Dong Wang, Qing Zhang, Yunze Zhao, Sitong Chen, Hongyun Lian, Li Zhang, Chunju Zhou, Maoquan Qin, Zhigang Li, Tianyou Wang, Rui Zhang
    Orphanet Journal of Rare Diseases.2021;[Epub]     CrossRef
  • Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting
    Jeffrey I. Cohen, Keiji Iwatsuki, Young-Hyeh Ko, Hiroshi Kimura, Irini Manoli, Koichi Ohshima, Stefania Pittaluga, Leticia Quintanilla-Martinez, Elaine S. Jaffe
    Leukemia & Lymphoma.2020; 61(4): 808.     CrossRef
  • EBV-positive T/NK-associated lymphoproliferative disorders of childhood: A complete autopsy report
    JonathanY Keow, WilliamM Stecho, AaronR Haig, NikhilA Sangle
    Indian Journal of Pathology and Microbiology.2020; 63(1): 78.     CrossRef
  • Chronic active Epstein‐Barr virus infection: A heterogeneous entity requiring a high index of suspicion for diagnosis
    Sarah L. Ondrejka, Eric D. Hsi
    International Journal of Laboratory Hematology.2020; 42(S1): 99.     CrossRef
  • Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
    Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
    Frontiers in Pediatrics.2019;[Epub]     CrossRef
  • A clinicopathologic study of the spectrum of systemic forms of EBV‐associated T‐cell lymphoproliferative disorders of childhood: A single tertiary care pediatric institution experience in North America
    Amy M. Coffey, Annisa Lewis, Andrea N. Marcogliese, M. Tarek Elghetany, Jyotinder N. Punia, Chung‐Che Chang, Carl E. Allen, Kenneth L. McClain, Amos S. Gaikwad, Nader Kim El‐Mallawany, Choladda V. Curry
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Unusual lymphoid malignancy and treatment response in two children with Down syndrome
    Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts
    Stefan Dojcinov, Falko Fend, Leticia Quintanilla-Martinez
    Pathogens.2018; 7(1): 28.     CrossRef
  • Cutaneous Hematolymphoid and Histiocytic Proliferations in Children
    Alejandro A Gru, Louis P Dehner
    Pediatric and Developmental Pathology.2018; 21(2): 208.     CrossRef
  • Clinicopathological categorization of Epstein–Barr virus-positive T/NK-cell lymphoproliferative disease: an analysis of 42 cases with an emphasis on prognostic implications
    Jin Ho Paik, Ji-Young Choe, Hyojin Kim, Jeong-Ok Lee, Hyoung Jin Kang, Hee Young Shin, Dong Soon Lee, Dae Seog Heo, Chul-Woo Kim, Kwang-Hyun Cho, Tae Min Kim, Yoon Kyung Jeon
    Leukemia & Lymphoma.2017; 58(1): 53.     CrossRef
  • Cutaneous EBV-related lymphoproliferative disorders
    Alejandro A. Gru, Elaine S. Jaffe
    Seminars in Diagnostic Pathology.2017; 34(1): 60.     CrossRef
  • T- and NK-Cell Lymphomas and Systemic Lymphoproliferative Disorders and the Immunodeficiency Setting
    Dita Gratzinger, Daphne de Jong, Elaine S. Jaffe, Amy Chadburn, John K. C. Chan, John R. Goodlad, Jonathan Said, Yasodha Natkunam
    American Journal of Clinical Pathology.2017; 147(2): 188.     CrossRef
  • Systemic Epstein-Barr Virus-positive T-Cell Lymphoproliferative Disease of Childhood With Good Response to Steroid Therapy
    Do-Hoon Kim, Myungshin Kim, Yonggoo Kim, Kyungja Han, Eunhee Han, Jae Wook Lee, Nack-Gyun Chung, Bin Cho
    Journal of Pediatric Hematology/Oncology.2017; 39(8): e497.     CrossRef
  • Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease
    Paibel Aguayo-Hiraldo, Reuben Arasaratnam, Rayne H. Rouce
    Boletín Médico del Hospital Infantil de México.2016; 73(1): 31.     CrossRef
  • Severe Epstein-Barr virus infection in primary immunodeficiency and the normal host
    Austen J. J. Worth, Charlotte J. Houldcroft, Claire Booth
    British Journal of Haematology.2016; 175(4): 559.     CrossRef
  • Recent advances in the risk factors, diagnosis and management of Epstein-Barr virus post-transplant lymphoproliferative disease
    Paibel Aguayo-Hiraldo, Reuben Arasaratnam, Rayne H. Rouce
    Boletín Médico Del Hospital Infantil de México (English Edition).2016; 73(1): 31.     CrossRef
  • Epstein-Barr Virus–Associated Lymphomas
    Ewelina Grywalska, Jacek Rolinski
    Seminars in Oncology.2015; 42(2): 291.     CrossRef
  • Epstein–Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype
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    Leukemia & Lymphoma.2015; 56(8): 2408.     CrossRef
  • Hemophagocytic syndromes — An update
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    Blood Reviews.2014; 28(4): 135.     CrossRef
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    The Journal of Dermatology.2014; 41(1): 29.     CrossRef

JPTM : Journal of Pathology and Translational Medicine