Journal of Pathology and Translational Medicine

Young Jin Suh

3 Articles

Loss of Human Leukocyte Antigen Class I Expression Is Associated with Poor Prognosis in Patients with Advanced Breast Cancer: Hong Sik Park, Uiju Cho, So Young Im, Chang Young Yoo, Ji Han Jung, Young Jin Suh, Hyun Joo Choi; J Pathol Transl Med. 2019;53(2):75-85. Published online November 14, 2018; DOI: https://doi.org/10.4132/jptm.2018.10.11

7,862 View
188 Download
32 Web of Science
34 Crossref

Background
Human leukocyte antigen class I (HLA-I) molecules play important roles in regulating immune responses. Loss or reduction of HLA-I expression has been shown to be associated with prognosis in several cancers. Regulatory T-cells (Tregs) also play critical functions in immune response regulation. Evaluation of HLA-I expression status by the EMR8-5 antibody and its clinical impact in breast cancer have not been well studied, and its relationship with Tregs remains unclear.
Methods
We evaluated HLA-I expression and Treg infiltration by immunohistochemistry in 465 surgically resected breast cancer samples. We examined the correlation between HLA-I expression and Treg infiltration and clinicopathologic characteristics and survival analyses were performed.
Results
Total loss of HLA-I expression was found in 84 breast cancer samples (18.1%). Univariate survival analysis revealed that loss of HLA-I expression was significantly associated with worse disease-specific survival (DSS) (p = .029). HLA-I was not an independent prognostic factor in the entire patient group, but it was an adverse independent prognostic factor for DSS in patients with advanced disease (stage II–IV) (p = .031). Treg numbers were significantly higher in the intratumoral stroma of HLA-I–positive tumors than in HLA-I–negative tumors (median 6.3 cells/high power field vs 2.1 cells/high power field, p < .001). However, Tregs were not an independent prognostic factor in our cohort.
Conclusions
Our findings suggest that the loss of HLA-I expression is associated with poor prognosis in breast cancer patients, highlighting the role of HLA-I alterations in immune evasion mechanisms of breast cancer. HLA-I could be a promising marker that enables the application of more effective and precise immunotherapies for patients with advanced breast cancer.

Citations

Citations to this article as recorded by

Estrogen Signaling in Early-Stage Breast Cancer: Impact on Neoadjuvant Chemotherapy and Immunotherapy
Chiara Corti, Busem Binboğa Kurt, Beyza Koca, Tasnim Rahman, Fabio Conforti, Laura Pala, Giampaolo Bianchini, Carmen Criscitiello, Giuseppe Curigliano, Ana C. Garrido-Castro, Sheheryar K. Kabraji, Adrienne G. Waks, Elizabeth A. Mittendorf, Sara M. Tolaney
Cancer Treatment Reviews.2025; 132: 102852. CrossRef
MHC-I upregulation by macbecin II in the solid tumors potentiates the effect of active immunotherapy
Ravindra Pramod Deshpande, Kerui Wu, Shih-Ying Wu, Abhishek Tyagi, Eleanor C Smith, Jee-Won Kim, Kounosuke Watabe
EMBO Molecular Medicine.2025; 17(4): 797. CrossRef
Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Cancer
Ponkrit Kaewkedsri, Piyapharom Intarawichian, Sirawich Jessadapattarakul, Waritta Kunprom, Supinda Koonmee, Malinee Thanee, Ongart Somintara, Anongporn Wongbuddha, Payia Chadbunchachai, Supajit Nawapun, Chaiwat Aphivatanasiri
Breast Cancer: Targets and Therapy.2025; Volume 17: 123. CrossRef
Comment on “Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta‑Analysis”
Wei Han, Li-zhou Shi, Yu-wei Zhang, Hao-nan Wang
Molecular Diagnosis & Therapy.2024; 28(2): 237. CrossRef
Immunotherapy resistance in solid tumors: mechanisms and potential solutions
Daniel S. Lefler, Steven A. Manobianco, Babar Bashir
Cancer Biology & Therapy.2024;[Epub] CrossRef
Assessment of cancer cell‐expressed HLA class I molecules and their immunopathological implications
Terufumi Kubo, Shiori Asano, Kenta Sasaki, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Yoshihiko Hirohashi, Toshihiko Torigoe
HLA.2024;[Epub] CrossRef
Human Leukocyte Antigen Class I Expression and Natural Killer Cell Infiltration and Its Correlation with Prognostic Features in Luminal Breast Cancers
Maria Vernet-Tomas, Ivonne Vazquez, Francesc Olivares, David Lopez, Jose Yelamos, Laura Comerma
Breast Cancer: Targets and Therapy.2024; Volume 16: 657. CrossRef
Upregulation of MHC I antigen processing machinery gene expression in breast cancer cells by Trichostatin A
A. H. Murtadha, N. A. Sharudin, I. I.M. Azahar, A. T. Che Has, N. F. Mokhtar
Молекулярная биология.2024; 58(1): 121. CrossRef
HLA-I and breast cancer prognosis: A systematic review and meta-analysis
Francisco Cezar Aquino de Moraes, Jorge Henrique Cavalcanti Orestes Cardoso, Francinny Alves Kelly, Michele Kreuz, Lilianne Rodrigues Fernandes, Maria Cristina Figueroa Magalhães, Rommel Mario Rodríguez Burbano
Human Immunology.2024; 85(6): 111148. CrossRef
Cancer Immunology: Immune Escape of Tumors—Expression and Regulation of HLA Class I Molecules and Its Role in Immunotherapies
Yuan Wang, Simon Jasinski-Bergner, Claudia Wickenhauser, Barbara Seliger
Advances in Anatomic Pathology.2023; 30(3): 148. CrossRef
In Silico Pipeline to Identify Tumor-Specific Antigens for Cancer Immunotherapy Using Exome Sequencing Data
Diego Morazán-Fernández, Javier Mora, Jose Arturo Molina-Mora
Phenomics.2023; 3(2): 130. CrossRef
HLA and tumour immunology: immune escape, immunotherapy and immune-related adverse events
Ning Jiang, Yue Yu, Dawei Wu, Shuhang Wang, Yuan Fang, Huilei Miao, Peiwen Ma, Huiyao Huang, Min Zhang, Yu Zhang, Yu Tang, Ning Li
Journal of Cancer Research and Clinical Oncology.2023; 149(2): 737. CrossRef
Relationship between Systemic Inflammatory Markers, GLUT1 Expression, and Maximum 18F-Fluorodeoxyglucose Uptake in Non-Small Cell Lung Carcinoma and Their Prognostic Significance
Sonya Youngju Park, Deog-Gon Cho, Byoung-Yong Shim, Uiju Cho
Diagnostics.2023; 13(6): 1013. CrossRef
Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis
Weiqiang Qiao, Zhiqiang Jia, Wanying Guo, Qipeng Liu, Xiao Guo, Miao Deng
Molecular Diagnosis & Therapy.2023; 27(5): 573. CrossRef
Challenges and solutions for therapeuticTCR‐based agents
Manish Malviya, Zita E. H. Aretz, Zaki Molvi, Jayop Lee, Stephanie Pierre, Patrick Wallisch, Tao Dao, David A. Scheinberg
Immunological Reviews.2023; 320(1): 58. CrossRef
Molecular mechanisms of impaired antigenic presentation as a cause of tumor escape from immune surveillance
A.A. Korotaeva, A.A. Borunova, A.Yu. Kuzevanova, T.N. Zabotina, A.A. Alimov
Russian Journal of Archive of Pathology.2023; 85(6): 76. CrossRef
Immune Escape Mechanism of Cancer
Ayse Caner
Current Molecular Biology Reports.2023; 10(1): 9. CrossRef
Upregulation of MHC I Antigen Processing Machinery Gene Expression in Breast Cancer Cells by Trichostatin A
A. H. Murtadha, N. A. Sharudin, I. I. M. Azahar, A. T. Che Has, N. F. Mokhtar
Molecular Biology.2023; 57(6): 1212. CrossRef
Human Leukocyte Antigen Class I Antigen-Processing Machinery Upregulation by Anticancer Therapies in the Era of Checkpoint Inhibitors
Ananthan Sadagopan, Theodoros Michelakos, Gabriella Boyiadzis, Cristina Ferrone, Soldano Ferrone
JAMA Oncology.2022; 8(3): 462. CrossRef
Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response
Brandie C. Taylor, Justin M. Balko
Frontiers in Immunology.2022;[Epub] CrossRef
Immune Checkpoint Blockade in Hormone Receptor-Positive Breast Cancer: Resistance Mechanisms and Future Perspectives
Ioannis A. Vathiotis, Ioannis Trontzas, Niki Gavrielatou, Georgia Gomatou, Nikolaos K. Syrigos, Elias A. Kotteas
Clinical Breast Cancer.2022; 22(7): 642. CrossRef
Aberrant synaptophysin expression in classic Hodgkin lymphoma
Soyoung Im, Jeong-A. Kim, Gyeongsin Park, Uiju Cho
Diagnostic Pathology.2022;[Epub] CrossRef
Expression of HLA class I is associated with immune cell infiltration and patient outcome in breast cancer
Song-Hee Han, Milim Kim, Yul Ri Chung, Ji Won Woo, Hye Yeon Choi, So Yeon Park
Scientific Reports.2022;[Epub] CrossRef
Immune landscape and therapeutic strategies: new insights into PD-L1 in tumors
Yuan Wei, Xiao Xiao, Xiang-Ming Lao, Limin Zheng, Dong-Ming Kuang
Cellular and Molecular Life Sciences.2021; 78(3): 867. CrossRef
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of breast cancer
Leisha A Emens, Sylvia Adams, Ashley Cimino-Mathews, Mary L Disis, Margaret E Gatti-Mays, Alice Y Ho, Kevin Kalinsky, Heather L McArthur, Elizabeth A Mittendorf, Rita Nanda, David B Page, Hope S Rugo, Krista M Rubin, Hatem Soliman, Patricia A Spears, Sara
Journal for ImmunoTherapy of Cancer.2021; 9(8): e002597. CrossRef
Resistance mechanisms to checkpoint inhibitors
Sarah A Weiss, Mario Sznol
Current Opinion in Immunology.2021; 69: 47. CrossRef
The Immunology of Hormone Receptor Positive Breast Cancer
Jonathan Goldberg, Ricardo G. Pastorello, Tuulia Vallius, Janae Davis, Yvonne Xiaoyong Cui, Judith Agudo, Adrienne G. Waks, Tanya Keenan, Sandra S. McAllister, Sara M. Tolaney, Elizabeth A. Mittendorf, Jennifer L. Guerriero
Frontiers in Immunology.2021;[Epub] CrossRef
B4GALNT2 Gene Promotes Proliferation, and Invasiveness and Migration Abilities of Model Triple Negative Breast Cancer (TNBC) Cells by Interacting With HLA-B Protein
Pu Yu, Lili Zhu, Kang Cui, Yabing Du, Chaojie Zhang, Wang Ma, Jia Guo
Frontiers in Oncology.2021;[Epub] CrossRef
Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies
Nina Radosevic-Robin, Pier Selenica, Yingjie Zhu, Helen H. Won, Michael F. Berger, Lorenzo Ferrando, Emiliano Cocco, Maud Privat, Flora Ponelle-Chachuat, Catherine Abrial, Jean-Marc Nabholtz, Frederique Penault-Llorca, Jorge S. Reis-Filho, Maurizio Scaltr
npj Breast Cancer.2021;[Epub] CrossRef
Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?
Liam Masterson, James Howard, Jazmina Gonzalez‐Cruz, Christopher Jackson, Catherine Barnett, Lewis Overton, Howard Liu, Rahul Ladwa, Fiona Simpson, Margie McGrath, Ben Wallwork, Terry Jones, Christian Ottensmeier, Melvin L.K. Chua, Chris Perry, Rajiv Khan
International Journal of Cancer.2020; 146(8): 2305. CrossRef
Co-expression of HLA-I loci improved prognostication in HER2+ breast cancers
Julia Y. Tsang, Chun-Sing Ho, Yun-Bi Ni, Yan Shao, Ivan K. Poon, Siu-Ki Chan, Sai-Yin Cheung, Ka-Ho Shea, Monalyn Marabi, Gary M. Tse
Cancer Immunology, Immunotherapy.2020; 69(5): 799. CrossRef
Breast cancer patients overall survival depends on a combination of the polymorphisms of tumor necrosis factor gene and HLA-haplotypes
T.F. Malivanova, E.V. Alferova, A.S. Ostashkin, T.A. Astrelina, N.N. Mazurenko
Molecular Genetics Microbiology and Virology (Russian version).2020; 38(1): 40. CrossRef
The Overall Survival of Breast Cancer Patients Depends on a Combination of Polymorphisms of Tumor Necrosis Factor Gene and HLA Haplotypes
T. F. Malivanova, E. V. Alferova, A. S. Ostashkin, T. A. Astrelina, N. N. Mazurenko
Molecular Genetics, Microbiology and Virology.2020; 35(1): 38. CrossRef
The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy
Fernando Souza-Fonseca-Guimaraes, Joseph Cursons, Nicholas D. Huntington
Trends in Immunology.2019; 40(2): 142. CrossRef

Microtubule-Associated Protein Tau, α-Tubulin and βIII-Tubulin Expression in Breast Cancer: Soyoung Im, Changyoung Yoo, Ji-Han Jung, Ye-Won Jeon, Young Jin Suh, Youn Soo Lee, Hyun Joo Choi; Korean J Pathol. 2013;47(6):534-540. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.534

8,047 View
62 Download
10 Crossref

Abstract PDF

Background

The microtubule-associated protein Tau binds to both inner and outer surfaces of microtubules, leading to tubulin assembly and microtubule stabilization. The aim of this study was to evaluate the significance of Tau, α-tubulin, and βIII-tubulin expression in breast carcinoma and to assess their relationships with disease progression in the context of taxane treatment.

Methods

Immunohistochemical expressions of Tau, α-tubulin, and βIII-tubulin were assessed in 183 breast cancer cases. Expression was correlated with clinicopathologic parameters, disease progression and overall survival.

Results

Tau expression was correlated with lymph node metastasis and estrogen receptor (ER) positivity (p=.003 and p<.001, respectively). Loss of α-tubulin was significantly correlated with distant metastasis (p=.034). Loss of βIII-tubulin was correlated with lymph node metastasis and ER positivity (p=.004 and p<.001, respectively). In taxane-treated cases, Tau expression and loss of α-tubulin and βIII-tubulin expression were related to disease progression (p=.001, p=.028, and p=.030, respectively). Tau expression was associated with a worse survival rate in taxane-treated patients (p=.049).

Conclusions

Tau expression and loss of α-tubulin and βIII-tubulin expression were correlated with aggressive behavior in taxane-treated breast cancer. Further evaluation of Tau, α-tubulin and βIII-tubulin may be useful in predicting clinical behavior and seeking therapeutic measures in taxane-based chemotherapy for breast cancer.

Citations

Citations to this article as recorded by

Genes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model
Tania Koning, Gloria M. Calaf
Biology.2024; 13(11): 849. CrossRef
Tubulin Isotypes: Emerging Roles in Defining Cancer Stem Cell Niche
Tessy Thomas Maliekal, Dhrishya Dharmapal, Suparna Sengupta
Frontiers in Immunology.2022;[Epub] CrossRef
RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage
Brittany M. Haynes, Kristen Cunningham, Malathy P. V. Shekhar
BMC Cancer.2022;[Epub] CrossRef
Influence of Paclitaxel and Doxorubicin Therapy of ßIII-Tubulin, Carbonic Anhydrase IX, and Survivin in Chemically Induced Breast Cancer in Female Rat
Alena Pastornická, Silvia Rybárová, Slávka Drahošová, Jozef Mihalik, Andrea Kreheľová, Andriana Pavliuk-Karachevtseva, Ingrid Hodorová
International Journal of Molecular Sciences.2021; 22(12): 6363. CrossRef
Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease
Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-an Wei, Jie Liu
Biomaterials.2020; 237: 119822. CrossRef
HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells
J. R. Ribeiro, C. Schorl, N. Yano, N. Romano, K. K. Kim, R. K. Singh, R. G. Moore
Journal of Ovarian Research.2016;[Epub] CrossRef
A strategy to identify housekeeping genes suitable for analysis in breast cancer diseases
Tatiana M. Tilli, Cláudio da Silva Castro, Jack A. Tuszynski, Nicolas Carels
BMC Genomics.2016;[Epub] CrossRef
Increased expression of αTubulin is associated with poor prognosis in patients with pancreatic cancer after surgical resection
Chao Lin, Guo-chao Zhao, Ya-dong Xu, Dan-song Wang, Da-yong Jin, Yuan Ji, Wen-hui Lou, Wen-chuan Wu
Oncotarget.2016; 7(37): 60657. CrossRef
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins
Xiaoyu Wang, Yuanzhi Lao, Naihan Xu, Zhichao Xi, Man Wu, Hua Wang, Xiyi Li, Hongsheng Tan, Menghong Sun, Hongxi Xu
Scientific Reports.2015;[Epub] CrossRef
Regulation of human MAPT gene expression
Marie-Laure Caillet-Boudin, Luc Buée, Nicolas Sergeant, Bruno Lefebvre
Molecular Neurodegeneration.2015;[Epub] CrossRef

Hedgehog Related Protein Expression in Breast Cancer: Gli-2 Is Associated with Poor Overall Survival: Soyoung Im, Hyun Joo Choi, Changyoung Yoo, Ji-Han Jung, Ye-Won Jeon, Young Jin Suh, Chang Suk Kang; Korean J Pathol. 2013;47(2):116-123. Published online April 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.116

8,526 View
98 Download
31 Crossref

Abstract PDF

Background

The hedgehog (Hh) signaling pathway is known to play a critical role in various malignancies, but its clinicopathologic role in breast cancer is yet to be established.

Methods

Tissue microarray blocks from 334 cases of breast cancer were prepared. The expression of six Hh signaling proteins including sonic hedgehog (Shh), patched (Ptch), smoothened (Smo), and the glioma-associated oncogene (Gli)-1, Gli-2, and Gli-3 were analyzed immunohistochemically.

Results

The expression of Hh signaling proteins was significantly correlated with some prognostic factors including the correlation of lymph node metastasis with the expression of Shh (p=0.001) and Ptch (p=0.064), the correlation of the stages with Shh and Gli-3 expression (p=0.007 and p=0.024, respectively), the correlation of the nuclear grade with the Smo (p=0.004) and Gli-3 (p=0.000), and the correlation of the histologic grade with the Ptch (p=0.016), Smo (p=0.007), and Gli-3 (p=0.000). The Shh, Ptch, Smo, Gli-1, and Gli-2 expression was significantly different between the phenotypes (p=0.000, p=0.001, p=0.004, p=0.039, and p=0.031, respectively). Gli-2 expression was correlated with a worse overall survival outcome (p=0.012).

Conclusions

Hh pathway activation is correlated with a more aggressive clinical behavior in breast carcinomas. The comparison of phenotypes suggested that the Hh pathway may be a useful therapeutic target for breast carcinoma. Patients with Gli-2 expression had a significantly lower overall survival rate and, therefore, it showed promise as a prognostic marker.

Citations

Citations to this article as recorded by

Dysregulation of deubiquitination in breast cancer
Lili Kong, Xiaofeng Jin
Gene.2024; 902: 148175. CrossRef
siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression
Prakash Chaudhary, Kiran Yadav, Ho Jin Lee, Keon Wook Kang, Jongseo Mo, Jung-Ae Kim
Breast Cancer Research.2024;[Epub] CrossRef
Implicating clinical utility of altered expression of PTCH1 & SMO in oral squamous cell carcinoma
Hitarth V. Patel, Jigna S. Joshi, Franky D. Shah
Journal of Molecular Histology.2024; 55(4): 379. CrossRef
A clinicopathological exploration of Hedgehog signaling: implications in oral carcinogenesis
Hitarth V. Patel, Jigna S. Joshi, Franky D. Shah
Journal of Cancer Research and Clinical Oncology.2023; 149(18): 16525. CrossRef
GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells
Min Lin, Haiyan Zhu, Qi Shen, Lu-Zhe Sun, Xueqiong Zhu
Cellular Signalling.2022; 92: 110278. CrossRef
Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched
Álvaro Javier Feliz Morel, Anida Hasanovic, Aurélie Morin, Chloé Prunier, Virginie Magnone, Kevin Lebrigand, Amaury Aouad, Sarah Cogoluegnes, Judith Favier, Claude Pasquier, Isabelle Mus-Veteau
Pharmaceutics.2022; 14(5): 988. CrossRef
Case Report: Submucosal gastroblastoma with a novel PTCH1::GLI2 gene fusion in a 58-year-old man
Cuimin Chen, Junliang Lu, Huanwen Wu
Frontiers in Oncology.2022;[Epub] CrossRef
Higher Expressions of SHH and AR Are Associated with a Positive Receptor Status and Have Impact on Survival in a Cohort of Croatian Breast Cancer Patients
Ivan Budimir, Čedna Tomasović-Lončarić, Kristina Kralik, Josipa Čonkaš, Domagoj Eljuga, Rado Žic, Božo Gorjanc, Hrvoje Tucaković, Doroteja Caktaš, Josip Jaman, Valentino Lisek, Zlatko Vlajčić, Krešimir Martić, Petar Ozretić
Life.2022; 12(10): 1559. CrossRef
New insight into the role of PTCH1 protein in serous ovarian carcinomas
Valentina Karin‑Kujundzic, Adriana Covarrubias‑Pinto, Anita Skrtic, Semir Vranic, Ljiljana Serman
International Journal of Oncology.2022;[Epub] CrossRef
Hedgehog gene expression patterns among intrinsic subtypes of breast cancer: Prognostic relevance
Araceli García-Martínez, Ariadna Pérez-Balaguer, Fernando Ortiz-Martínez, Eloy Pomares-Navarro, Elena Sanmartín, Marta García-Escolano, Yoel G. Montoyo-Pujol, Elena Castellón-Molla, Gloria Peiró
Pathology - Research and Practice.2021; 223: 153478. CrossRef
Coexpression of Epha10 and Gli3 Promotes Breast Cancer Cell Proliferation, Invasion and Migration
Jing Peng, Danhua Zhang
Journal of Investigative Medicine.2021; 69(6): 1215. CrossRef
The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong, Chung Yeng Looi
Biomedicines.2021; 9(9): 1188. CrossRef
HER2-mediated GLI2 stabilization promotes anoikis resistance and metastasis of breast cancer cells
Parul Gupta, Nehal Gupta, Neel M. Fofaria, Alok Ranjan, Sanjay K. Srivastava
Cancer Letters.2019; 442: 68. CrossRef
Role of Hedgehog Signaling in Breast Cancer: Pathogenesis and Therapeutics
Natalia Riobo-Del Galdo, Ángela Lara Montero, Eva Wertheimer
Cells.2019; 8(4): 375. CrossRef
Carbonic anhydrase XII expression is linked to suppression of Sonic hedgehog ligand expression in triple negative breast cancer cells
G. Guerrini, J. Durivault, I. Filippi, M. Criscuoli, S. Monaci, J. Pouyssegur, A. Naldini, F. Carraro, S.K. Parks
Biochemical and Biophysical Research Communications.2019; 516(2): 408. CrossRef
Sonic hedgehog and Wnt/β-catenin pathways mediate curcumin inhibition of breast cancer stem cells
Xiaoting Li, Xiaoqian Wang, Chunfeng Xie, Jianyun Zhu, Yu Meng, Yue Chen, Yuan Li, Ye Jiang, Xue Yang, Shijia Wang, Jiaqi Chen, Qi Zhang, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Yu Zhao
Anti-Cancer Drugs.2018; 29(3): 208. CrossRef
Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer
Kuo-Shyang Jeng, Chi-Juei Jeng, I-Shyan Sheen, Szu-Hua Wu, Ssu-Jung Lu, Chih-Hsuan Wang, Chiung-Fang Chang
International Journal of Molecular Sciences.2018; 19(5): 1375. CrossRef
Cancer Stem Cell Metabolism and Potential Therapeutic Targets
Vusala Snyder, Tamika C. Reed-Newman, Levi Arnold, Sufi Mary Thomas, Shrikant Anant
Frontiers in Oncology.2018;[Epub] CrossRef
Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency
Anida Hasanovic, Isabelle Mus-Veteau
Cells.2018; 7(8): 107. CrossRef
Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia
Emily-Marie Latuske, Hauke Stamm, Marianne Klokow, Gabi Vohwinkel, Jana Muschhammer, Carsten Bokemeyer, Manfred Jücker, Maxim Kebenko, Walter Fiedler, Jasmin Wellbrock
Oncotarget.2017; 8(17): 29187. CrossRef
Prognostic role of Gli1 expression in breast cancer: a meta-analysis
Bilan Wang, Ting Yu, Yuzhu Hu, Mengmeng Xiang, Haoning Peng, Yunzhu Lin, Lu Han, Lingli Zhang
Oncotarget.2017; 8(46): 81088. CrossRef
Inhibition of Ciliogenesis Promotes Hedgehog Signaling, Tumorigenesis, and Metastasis in Breast Cancer
Nadia B. Hassounah, Martha Nunez, Colleen Fordyce, Denise Roe, Ray Nagle, Thomas Bunch, Kimberly M. McDermott
Molecular Cancer Research.2017; 15(10): 1421. CrossRef
The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration
Manuela Torres Andion Vidal, Sílvia Vanessa Lourenço, Fernando Augusto Soares, Clarissa Araújo Gurgel, Eduardo J. B. Studart, Ludmila de Faro Valverde, Iguaracyra Barreto de Oliveira Araújo, Eduardo Antônio Gonçalves Ramos, Flávia Caló de Aquino Xavier, J
Tumor Biology.2016; 37(7): 9587. CrossRef
Cancer stem cells and HER2 positive breast cancer: The story so far
Deep Shah, Clodia Osipo
Genes & Diseases.2016; 3(2): 114. CrossRef
Tamoxifen Resistance: Emerging Molecular Targets
Milena Rondón-Lagos, Victoria Villegas, Nelson Rangel, Magda Sánchez, Peter Zaphiropoulos
International Journal of Molecular Sciences.2016; 17(8): 1357. CrossRef
The Hedgehog signaling pathway is associated with poor prognosis in breast cancer patients with the CD44+/CD24− phenotype
Haishan Zhao, Hongtao Tang, Qinghuan Xiao, Miao He, Lin Zhao, Yingzi Fu, Huizhe Wu, Zhaojin Yu, Qian Jiang, Yuanyuan Yan, Feng Jin, Minjie Wei
Molecular Medicine Reports.2016; 14(6): 5261. CrossRef
Significance of the hedgehog pathway-associated proteins Gli-1 and Gli-2 and the epithelial-mesenchymal transition-associated proteins Twist and E-cadherin in hepatocellular carcinoma
Hyung Wook Chun, Ran Hong
Oncology Letters.2016; 12(3): 1753. CrossRef
Taxane‐induced hedgehog signaling is linked to expansion of breast cancer stem‐like populations after chemotherapy
Jennifer Sims‐Mourtada, Lynn M. Opdenaker, Joshua Davis, Kimberly M. Arnold, Daniel Flynn
Molecular Carcinogenesis.2015; 54(11): 1480. CrossRef
Loss of Tumor Suppressor ARID1A Protein Expression Correlates with Poor Prognosis in Patients with Primary Breast Cancer
Hyun Deuk Cho, Jong Eun Lee, Hae Yoen Jung, Mee-Hye Oh, Ji-Hye Lee, Si-Hyong Jang, Kyung-Ju Kim, Sun Wook Han, Sung Yong Kim, Han Jo Kim, Sang Byung Bae, Hyun Ju Lee
Journal of Breast Cancer.2015; 18(4): 339. CrossRef
Prognostic impact of the expression of Hedgehog proteins in cervical carcinoma FIGO stages I–IV treated with radiotherapy or chemoradiotherapy
Louise Bohr Mordhorst, Cecilia Ahlin, Bengt Sorbe
Gynecologic Oncology.2014; 135(2): 305. CrossRef
Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression
Hai-Xia Fan, Shan Wang, Hong Zhao, Nian Liu, Dong Chen, Miao Sun, Jin-Hua Zheng
Medical Oncology.2014;[Epub] CrossRef

Author index