Journal of Pathology and Translational Medicine

Volume 9(2); October 1975

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Effect of Inhalation Anesthesia with Several Anesthetics on the Ultrastructure of the Rat Lung: Suk Jae Hong; J Pathol Transl Med. 1975;9(2):115-129.

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Abstract: This study was undertaken to investigate the ultrastructural changes of the lung with special references to the alveolar lining cells of rats after inhalation anesthesia with ether, halothane and methoxyflurane respectively. The results were summarized as follow: 1) Light microscopically, the findings of lung tissue were very similar in the all groups. Immediately after anesthsia, mild congestion arid interstitial edema were noted. Four and 12 hours after anesthesia, the alveolar linings cells were increased in number with mild thickening of the alveolar septae. Increase of bronchiolar secretory activities were not prominent. 2) Electron microscopically, no significant change was noted in type I alveolar cell in the all groups. Most prominent changes were occurred in the type II alveolar cells in the all groups. with the ether anesthesia, marked changes of osmiophilic inclusion bodies, such as increased number, pleomorphism, decreased density and vacuolization were noted immediately after anesthesia. These changes were considerably recovered at 4 hours and completely returned to the normal pattern at 12 hours. Halothane and methoxyflurane anesthesis also induced similar changes in the type Ⅱ ceIls, but they were milder than ether anesthesized animals. Osmiophilic inclusion bodies were increased in number, with pleomorphism of the shape, decreased density, vacuolization and extrusion of their contents. After 4 and 12 hours, the number of type Ⅱ cells was also increased. The endothelial cells of alveolar capillaries showed nearly normal pictures in the ether anesthesized groups, but showed mild swelling, increase of pinocytotic vesicles, dilatation of rough ER and vacuolar formation in the both halothane and methoxyflurane anesthesized groups immediately after anesthesias. These changes were markedly recovered at 4 hours an completely returned to normal at 12 hours. The number of alveolar phagocytes were slightly increased in all experimental groups at 4 and 12 hours, with increase of autophagic vacuoles. 3) These findings suggest that ether anesthesia induces marked degenerative and adaptive changes in the alveolar type Ⅱ cells, particularly in their osmiophilic inclusion body, but does not effect alveolar capillary endothelial cells. On the other hand, halothane and methoxyflurane induce relatively milder degenerative and adaptive changes on the alveolar type Ⅱ cells, while mild degenerative changes are induced in the alveolar capillary endothelial cells. All these changes, occurred on the type Ⅱ epithelial cells and alveolar capillary endothelial cells, are reversible changes and times required for their recovery are relatively short.

The Changes of Endothelial Cells in Rat Lung Alveoli Induced by Carbon Monoxide Poisoning: Jong Chul Ahn, In Soo Suh, Tae Joong Sohn; J Pathol Transl Med. 1975;9(2):131-135.

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Abstract: The blood capillaries of alveolar wall were the route of gas exchange, so that some morphologic and functional changes were suspected in these capillaries in case of altered gas exchange states, such as carbon monoxide poisoning. This study was carried out to investigate the morphologic alteration in these capillaries. Rabbits were forced to inhalate 0.2％ CO gas for 2 hours (3 animals) and 4 hours (3 animals) and 0.1％ CO gas for 2 hours daily for 5 days respectively. The lungs were extracted out and observed by the electron microscope. Results were summarized as follow: Pinocytotic vesicles were increased in number with occasional large vacuole formation. Also noted were increase of lysosome, swelling of mitochondria with loss of crests, dilatation of interendothelial gap and irregularity of plasma membrane. No significant change was noted in the nuclei. The results suggested that CO poisoning induced increased permeability with degenerative changes of the endothelial cells, although these cells could easily contact to oxygen of alveolarlumen.

The Changes of Myocardial Mitochondria Induced by Carbon Monoxide Poisoning: In Soo Suh; J Pathol Transl Med. 1975;9(2):137-143.

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Abstract: It was well known that carbon monoxide induced significant derangements of various parameters of cardiac functions. Recently, Adams et al. reported considerably decreased myocardial oxygen consumption which suggested deranged function of myocardial mitochondria. In order to observe the morphologic changes of the myocardial myocardria, ten rabbits were exposured to the carbon monoxide: Three animals were exposured to 0.2％ CO gas for 2 hours: Three were exposured to 0.2％ for 4 hours: Four were exposures to 0.1％ for 2 hours daily for 5 days. Results obtained were summarized as follow: Mitochondria of myocardial fiber showed marked degenerative changes. Cristae were fragmented and decreased in number with partial disruption. Numerous electron dense granules were occurred in the site of cristae disruption. Mitochondria were fused together to form large irregular shaped body, chondriosphere of de Robertis. No significant changes were noted in the nuclei, myofilament and intercalated disc in all of the experimental groups. Sarcoplasmic reticulum is markedly dilated and glycogen particles and lipid droplets were slightly decreased.

Pathological Findings of 2,235 Cases of Endometrial Biopsies and 518 Cases of Cervical Biopsies: Ok kyung Kim; J Pathol Transl Med. 1975;9(2):145-154.

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Abstract: Total 2753 cases of endometrial and cervical biopsies during 12 years period from Jan. 1964 to June, 1975 were examined at the Dept. of Pathology, Ewha Womans University Hospital. The total 2235 endometrial biopsies revealed 1187 cases (53％) of necrotic decidual or placental tissue, 115 cases (5％) of endometritis, 101 cases (4.5％) of endometrial hyperplasia, 24 cases(1.2％) of polyp, and 16 cases(0.8％) of malignancies. Among the 115 cases of endometritis, 92％ of non-specific chronic endometritis and 8% of tuberculous endometritis were found. 101 cases of endometrial hyperplasia revealed 62 cases (62%) of cystic hyperplasia and 39 cases (38％) of adenomatous and atypical hyperplasia. 16 cases of malignancies showed 50% of choricarcinoma, 21% of adenocarcinoma, 21％ of squamous cell carcinoma, and 8% of adenoacanthoma. The 518 cervical biopsies show 216 cases(41%) of chronic cervicitis, 100 cases(19%) of cervical polyp, 9 cases(1.7％) of cervical dysplasia, and 189(36％) of malignancies. The 189 cases of malignancies revealed 4.8％ of Carcinoma in situ, and 31.7% of invasive cancer in which 94％ of the squamous cell carcinoma, and 2％l of adenoacanthoma, were identified. Materials and Methods; The present study based on the pathological findings of the 2235 cases of endometrial biopsies and 518 cases of cervical biopsies which were performed at the OB-Cyn clinic with variable symptoms in different age groups. Most of the cases were specimens derived from the dilatation and curettage (D&C)with anesthesia. Few of them were the performances of the menstrual regulation (M-R) which was followed by the suction curettage. The average 5 gms of tissue obtained from the performances were immediately placed in 10% buffered formalin, and submitted to our histology. Biopsies were sectioned at least 3 levels and stained with H&E. Results and Summary: Histopathologic studies were made on the 2235 endometrial biopsies. Following results are obtained. 1. Most frequent age group of patients with endometrial biopsies was in between 20-40 years old with average age of 30 years. The cervical biopsies were in between 30-50 years old with average age of 40 years. 2. Most common clinical symptoms of endometrial biopsies were bleeding, amenorrhea, and sterility in order. The cervical biopsies were bleeding, leukorrhea, and backache in order. 3. The endometritis was 5％ of all endometrial biopsies which were slightly higher than the report made in the United State. Tuberculous endometritis was 8% of all endometritis and was 2% of all sterility patients. 4. 4,5％ of all endometrial biopsies showed endometrial hyperplasia in which cystic hype rplasia was 60%, and adenomatous and atypical hyperplasia was 38％. The average age was 39 years old which was 15 years earlier than the average of the endometrial adenocarcinoma. 5. The hydatidiform mole was 2.6% of all endometrial biopsies which was higher incidence than the report made in the United State. The average age was 26 years old which was relatively younger than other University Hospital reports. 6. 0.8% malignancies of all endometrial biopsies were diagnosed. Of these malignancies, the choriocarcinoma was one-half with average age of 54 years old, and the squamous cell carcinoma was one-fourth with average age of 54 years old. 7. Majority of 41％ cervicitis among all cervical biopsies were non specific chronic cervicitis. The cervical dysplasia with average ages of 39 years old and the carcinoma in situ with average of 43 years old were 6% of all cervical biopsies. 8. The invasive carcinoma was 31.7% of all cervical biopsies. It is significant to note the large difference of incidence in between the carcinoma in situ and invasive cancer of this study in comparison with the reports made in the United State and Western Europe where the precancerous lessions were much higher than invasive cancer. The average age of invasive cancer was 4 years higher than Carcinoma in situ while the difference of years was 10 years in the western countries. 9. Among the cervical carcinoma, the squamous cell carcinoma was 94% and adenocarcinoma was 3.7%. The conclusion of the study is that all pathogists are familiar with histologic interpretation of endometrial specimens. On the contrary, meaningful interpretation of cytologic material from the endometrium requires considerable experience. therefore the confirmatory diagnosis should be made on the basis of a endometrial biopsy. Among the Korean female, the analysis of endometrial biopsies revealed greater incidence of hydatidiform mole and choriocarcinoma in comparison with greater incidence of adenocarcinoma in the United State and Europe. Tuberculous endometritis is one of the frequent causes of sterility in Korea. The lower incidence of precancerous lesion in perhaps due to the lack of understanding for routine screening of cancer among ordinary female. Therefore, understanding on routine screening of cancer should be emphasized.

Studies of PAS-Positive Material in Circulating Lymphocytes in Patients with Various Diseases: Moon Sook Cho; J Pathol Transl Med. 1975;9(2):157-162.

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Abstract: In an attempt to elucidate the relationship of PAS-positive material of circulating Iymphocytes to the numbers of circulating lymphocytes in various diseases, the author investigated changes in periodic acid-Schiff reaction and absolute count of the circulating lymphocytes in 79 cases of the patients with various diseases and 18 healthy persons. The results thus obtained were summarized as follows: In the patients with Pulmonary tuberculosis, typhoid fever, nephritis, pleurisy, meningitis, CVA, essential hypertension, liver cirrhosis, hepatoina, drug intoxication, diabetes mellitus, and peptic ulcer, the PAS-positive material in the circulating lymphocytes significantly increased. This increase in the PAS-positive material in the circulating lymphocytes was not related to the number of the circulating lymphocytes. It was suggested that the PAS positive material of circulating lymphocytes may be influenced by some substance, which would be related to any immunological reaction and produce in various diseases.

A Histopathologic Study on Primary Tumors of Oral Cavity: Byung Gill Kim, Eui Keun Ham, Sang Kook Lee, Chae Koo Lee; J Pathol Transl Med. 1975;9(2):163-169.

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Abstract: A histopathologic study was made on 393 primary tumors of oral cavity that were examined at the Department of Pathology, College of Medicine, Seoul National University, during a period of twelve years from 1963 to 1974. Following results were obtained. 1. Of three hundred ninety three primary tumors of oral cavity, there were 164(41.7%) benign and 229 (58.3%) malignant tumors. 2. Among all tumors of oral cavity, the tumor type in the highest incidence was squamous cell carcinoma(38.9%), and next the common type were mixed tumor (18.8%) and hemangioma (9.2%). 3. The benign oral tumors occurred frequently in the fifth decade (28. 3%) with mean age of 43.9 years, and the malignant oral tumors occurred frequently in the third facade(24.6%) with mean average of 39.0 years. In all them examined, two months of age was the youngest, who had hemangioma and 83 years of age with squamous cell carcinoma the oldest. 4. Out of 393 all tumors of oral cavity examined, 220 cases(56%)were in male and 173 cases (44%) in female. Among them, the malignant oral tumors showed male predominance over female in ratio of 1.7:1, while there was no significant sex difference in the benign oral tumors. 5. The site incidence in all oral tumors were the highest in tongue (26.0%) and next common in palate (17.3%) and parotid gland (12.5%) in orders.

Hematological Study on Aplastic Anemia Emphasizing Bone Marrow Findings: In Ki Baik, Sang In Kim; J Pathol Transl Med. 1975;9(2):171-178.

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Abstract: A hematological study on the 161 cases of aplastic anemia was done emphasizing the correlation between the bone marrow finding and the etiological background and hematological values. The cases involved in this study were selected from the accumulated cases during a period of 13 years from 1960 to 1973, in the Department of Clinical Pathology, College of Medicine, Seoul National University. The results are summerized as follows. 1. Age distribution of aplastic anemia was highest in 10 to 19 years of age group and male to female ratio was l.6 : 1. 2. Idiopathic type of unknown etiology was 75.2 percent of the total 161 cases and the most common etiological agents suggested in secondary type were benzene (5%), chloramphenicol (5%), herb medicines (5%), and the antibiotics other than chloramphenicol (3.7%) 3. Anemia was the most commonly encountered initial symptom with the hematocrit value of 0∼19 volume percent in 53% and hemoglobin value of 0∼5.9gm/dl in 50% of the total aplastic anemia patient respectively. The initial value of corrected reticulocyte count was less than 0.55 percent in 77 percent of total cases. 4. Initial WBC count was ]ess than 2,000/mm3 in 24% of total cases, however the lowest WBC count during hospital course was less than 2,000/mm3 in 45 percent of total cases. 5. Initial platelet count was less than 30,000/mm3 in 29 percent and only 19 percent of total cases showed more than 100,000/mm3. The lowest platelet count during hospital course was less than 30,000/mm3 in 45 percent and more than 100,000/mm3 in 10 percent of the total cases respectively. 6. The cellularity of bone marrow was normocellular to hypercellular in 14 percent and the remaining cases were hypocellular to acellular. Total nucleated cells and immature granulocytes are decreased in reverse proportion to the increase of lymphocytes. There was no definite relationship between the number of normoblast and the cellularity of bone marrow, but the number of lymphocytes and plasma cells were significantly increased in hypocellular marrow. 7. Tissue basophils and reticulum cells were more frequently encountered in hypersensitivity type and especially in hypocellular type of marrow. 8. Some cases of aplastic anemia due to herb medicine showed an increased number of tissue basophils and reticulum cells in bone marrow. In summary, the bone marrow findings of the aplastic anemia, especially those of hypersensitivity type showed an increased number of lymphocytes, plasma cells, tissue basophils and reticulum cells strongly suggesting the immunologic reactions in the initiation of aplastic anemia.

The Influence of Technical Factors on NBT test: Young Hee Choi, Sang In Kim; J Pathol Transl Med. 1975;9(2):181-189.

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Abstract: The results of NBT test were found very depending on how the testis performed. NBT tests performed simultaneously on various concentration of heparin, various length of incubation time, different mixing instruments, venous blood and capillary blood, and scoring of three good trained technicians, from 90 healthy individuals. Heparin increased proportions of NBT positive neutrophils and lowest possible concentration should be used. NBT tests showed a considerably higher proportion of NBT positive neutrophils in capillary blood than in venous blood. 15 minutes incubation time at 37℃ affected unstable and obscure formazan deposits on NBT positive neutrophils than 25 minutes. Scoring of different good trained technicians are the same results on NBT positive neutrophils.

A Study on the Disorders of Plasma Cell Hyperplasia Including 17 Cases of Multiple Myeloma: Dong Heon Yoon, Han Ik Cho, Sang In Kim; J Pathol Transl Med. 1975;9(2):191-200.

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Abstract: This is an analysis and review for 17 cases of multiple myeloma, 1 case of plasma cell leukemia and 1 case of adult Fanconi syndrome, which have been encountered in. this laboratory during the last 10 years from 1964 to 1975, July. The following results are obtained in analysis of 17 cases of multiple myeloma. 1. The sex ratio was predominant in male, being 4.7 : 1 and the mean of age distribution was 15 years, ranging from 34 to 73 years. 2. The most frequent complaints at the time of admissions were the bony pains (77%), symptoms due to anemia (53%), and symptoms due to hypercalcemia (35%). 3. The means of hemoglobin and ESR were 7.5gm% and 62mm/hr, respectively and the peripheral plasma cells are found in 47% of the cases, ranging 4.5-95% in number of differential counts. 4. The mean of myeloma cell distributions in bone marrow was 46.3%, ranging from 4.5-95% in number of differential counts. 5. Serum M-components were detected in 10 cases among 13(77%) and 7 cases of them were known to be IgA (4) and IgG (3) by immuno-electrophoresis or radial immunodiffusion method. 6. Bence-Jones proteinuria was present in 8 cases (50%) among 16. 7. Multiple punched-out osteolytic lesions were found in 12 cases (85.7%) among 14 by radio-logical bone series. The one case of plasma cell leukemia disclosed 76,400/mm3 in W.B.C. count with 51% of plasma cells in peripheral blood, and the one case of adult Fanconi syndrome revealed atypical plasmacytosis (10%) in bone marrow, but no M-component is identified.

In Vitro the Effectiveness of Antibiophagine to Various Organisms: Jae Soong Kim, Rac Kyun Ro, Jae Sik Kim, Jyung Myung Kim; J Pathol Transl Med. 1975;9(2):203-207.

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Abstract: The authors isolated 27 organisms (11 species) from the patients, observed the effective-ness of antibiophagine to the organisms in vitro, and compared the results with the sensitivities to various antibiotics. The results were summarized as follows: 1. In vitro antibiophagine inhibited to a remarkable extent the growth of Salmonella group D, E. coli, Shigella, Proteus and Enterobacter and inhibited moderately the growth of Staphy-lococci and Salmonella group A. 2. When grossly negative growth on 24-hour culture subcultured, some strains of Salmonella group D, E. coli, Shigella, Klebsiella and Proteus were not cultivated. 3. Some of Staphylococcus albus, Salmonella group A and Enterococcus which proved resistant to the action of various antibiotics were sensitive to antibiophangine. A strain of Staphylococcus aureus, not effective to antibiophagine, was sensitive to some antibiotics. 4. Antibiophagine inhibited the growth of Pneumococcus and Enterobacter of which bacteriophage are not contained in it.

Cellulolytic Action of Streptomyces albus Isolated from Soil: Rac Kyun Ro, Jae Soong Kim, Jae Sik Kim, Jyung Myung Kim; J Pathol Transl Med. 1975;9(2):209-211.

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Abstract: The authors isolated a cellulolytic Streptomyces albus from soil and estimated of the reducing sugars produced from the breakdown of filter paper treated with culture filtrate. After 24 hours, produced reducing sugar was 5μg/ml in concentration and its production seemed to be stimulated by yeast extract enrichement in Dubos medium and inhibited by the increment of alkalinity.

A Comparative Study on Methods for the Determination of SGOT-Activities: In-Seong Choe, Moon-Ki Chang, Young-Hoe Moon*, Sung-Yong Paik*; J Pathol Transl Med. 1975;9(2):213-220.

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Abstract: In order to compare the accuracy of two methods, conventional Reitman-Frankel method and single vial enzyme test kit method, for the determination of serum glutamic-oxalacetic tran-saminase (SGOT) activities, total 111 serum samples were examined with reference tests of revised Henry method. In the case of SGOT activity being less than 50 A.U., the two test methods and the reference method were in good agreement, respectively. However, in the range of SGOT activity over 50 A.U., which is very significant in diaguostic evaluation, the enzyme kit method excellently agreed with the reference method, whereas the value of SGOT activity determined by Reitman-Frankel method was significantly lower than by the references test. It is suggested that the method of enzyme test kit should be used for the determination of SGOT in clinical diagnosis.

A Study to Evaluate the Normal Values of Carboxyhemoglobin in Hospital: Moon Ja Kang, Kyu Jin Lee, Joo Whan Kim, Young Hoe Moon; J Pathol Transl Med. 1975;9(2):221-224.

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Abstract: Normal values of carboxyhemoglobin will be acquired by more studies. The authors now report the normal values of carboxyhemoglobin in Woosok Hospital of 108 random cases sampled from physical examine at Woosok Hospital by the Heilmyer-modified method. The results obtained are as follows ; 1. Of 108 random cases, 79% is under the value of 2.9% Co=Hb and 45.37% belonged to the level of 0-0.9%. 2. Mean value of carboxyhemoglobin was 1.52%-1.77 and this shows no significant relationship with hemoglobin level. 3. Considering sex, the level of carboxyhemo globin was slightly higher in male than in female.

Cat-Scratch Disease Associated With peripheral Pancytopenia: Soon Yong Lee, Jung Dal Lee; J Pathol Transl Med. 1975;9(2):225-230.

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Abstract: A case of cat-starth disease in a four year old Korean girl is reported, with a brief review of the literature. Clinical manifestations and pathologic findings of the lymphnodes are presented in detail. The patient presented peripheral pancytopenia and enlargement of the cervical and right epitrochlear lymphnodes which suggested a malignancy of the lymphoreticular system. A Possible pathogenesis of the pancytopenia associated with the disease is discussed. This diagnosis of cat-scratch disease in this case is achieved by the criteria proposed previously.

A case of Endocardial Fibroelastosis of the Left Ventricle: Byung Kee Kim, Young Che Kim; J Pathol Transl Med. 1975;9(2):233-238.

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Abstract: The endocardial fibroelastosis is a disease of obscure origin that occures predominently in infants and children but also observed in adults. It is usually diffuse, occasionally patchy thickening of the mural endocardium due to overgrowth of collagenous and elastic tissues. We have experienced a case of 64 years old male, who has the clinical findings of congestive heart failure. The autopsy revealed an enlarged heart of 425gms, with hypertrophy of the left ventricle. Microscopically, the left ventricle showed fibroelastic thickening of the endocardium, the fibroelastic tissue penetrating into the myocardium. The left atrium was free from remarkable findings, and no significant fibrous thickening was noted. The valvular morphology and other chambers of the heart were also free from remarkable findings.

A Case of Cholesterol Pneumonitis Caused by the Rupture of Anterior Mediastinal Dermoid Cyst to the Right Lung: Moon Sook Cho; J Pathol Transl Med. 1975;9(2):241-247.

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Abstract: A case of cholesterol pneumonitis caused by the rupture of anterior mediastinal dermoid cyst to the right lung was to be reported and a review of the literature related to this case was presented in history and histopathology. This would be the second case found in Korea. A 43 year-old Korean housewife was admitted to the department of chest surgery in Busan National University Hospital in August 10, 1974, because of severe coughing and blood tinged sputum. About 4 months before admission, she had treated at local clinics for 3 months under diagnosis of the pulmonary abscess with no effects. On physical examination at admission, the patient appeared poor in nutrition. The temperature was 37.2℃, the pulse 80, and the respiration 20 per minute. The blood pressure Ivas 110/70. There was mildly anemic in both conjunctivae. The face was mildly edematous and pale. There was no lymphadenopathy. In the right lower lung field, there was decreased in breathing sound. The hematocrit was 29 percent and the white blood cell count was 4,800 per cubic mm (neutrophil 53%, lymphocyte 34%, and eosinophil 13%). The bleeding time and coagulation time were normal. The cytological examination was negative. The x-ray examination of the chest revealed increased density in the right lower lung field. The radiologist suggested pulmonary abscess. The bronchogram showed the complete obstruction of the right main bronchus with irregular and shouldering filling defect in the proximal portion of the right main bronchus and hazziness in the mid and lower lung fields. So, the radiologist suggested malignancy of the lung. The right lobectomy was performed. Grossly, there was seen a gray white, firm, spherical mass attached at the middle and lower portion of the right lung. The mass measured about 6 cm. in the great diameter and had gray white, relative smooth surface. On sectioning, the half of the mass invaded into the one third to two thirds of the middle and lower lobes of the right lung. And, there was noted the tumor separated by the thin capsule-like fibrous tissue. The inner surface of the cystic mass was smooth and resembled that of the skin. There was noted a few of mamma-like projecting, adult thumb to small finger-tip sized masses from the inner surface of the cyst. There was presented a few of hairs occurring from the any mamma-like masses. In the cystic cavity, there was in part noted thick, yellow white sebaceous material. The lung tissue about the neoplasm was subcrepitant and revealed scattered small yellow-brown to yellow consolidation without cavity. No obstruction of the main bronchus was seen and some of the wall of the small bronchi became thickened out, while others were mildly dilated and contained sebaceous. material. The pulmonary artery was markedly dilated. Histologically, the sections from the lung tissue about the cystic tumor showed scattered and isolated granulomata in the lung tissue. The granulomata were composed of foamy macrophages, small round cells and fibroblasts with many foreign body giant cells. Some of the giant cells contained lipoid materials. The alveoli were filled with foamy cells and multinucleated foamy giant cells and sebaceous materials. The alveolar septum became thickened out by the infiltrate of inflammatory cells, chiefly macrophages and the proliferating fibroblasts and fibrocytes. The foamy macrophages had central or somewhat eccentrical small nuclei and relatively uniform vacuoles of lipid in the cytoplasm. The vacuolated material was stained as red or red-brown color on oil red O stain and dark brown on Ogamoto’s cholesterol stain. The sections from the cystic tumor showed typical dermoid cyst.

Multiple Myeloma and Immunoglobulin: Sung Ho Lee; J Pathol Transl Med. 1975;9(2):249-254.

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Abstract: Multiple myeloma is not rare disease as pathologically. However, according to deveiopment of immunology, monoclonal gammopathy should be analyzed by immunoelectrophoresis. Important informations for patient prognosis and treatment could be obtained by this immunochemical classification. This report concerns a patient with multiple myeloma associated with hyperproteinemia (15.0gm%) with increase IgG.

Biological Characteristic of the Neisseria mucosa Isolated from Blood of a Patient with Acute Lymphoblastic Leukemia: Rac Kyun Ro, Jae Soong Kim, Jae Sik Kim, Jyung Myung Kim; J Pathol Transl Med. 1975;9(2):255-258.

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Abstract: The authors isolated a strain of Neisseria mucosa from a patient with acute lymphoblastic leukemia and observed some biological characteristics. The organism is Gram negative diplococcus with thin capsule and positive for the oxidase, catalase and nitrate reduction test, and grows well on the plain agar at the 2 2℃ and 45℃. No acid production from the various carbohydrates except dextrose observed, and negative H₂S from TSI, urease, phenylalanine deaminase, ornithine and lysine decarboxylase, and nonhemolysis on the blood agar was noted. Intraperitoneal inoculation of the organism revealed pathogenic for the mice.

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