Journal of Pathology and Translational Medicine

Volume 52(5); September 2018

Original Articles

C-reactive Protein Overexpression in the Background Liver of Hepatitis B Virus–Associated Hepatocellular Carcinoma Is a Prognostic Biomarker: Jin Ho Shin, Eunsil Yu, Eun Na Kim, Chong Jai Kim; J Pathol Transl Med. 2018;52(5):267-274. Published online July 27, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.14

7,364 View
177 Download
5 Web of Science
6 Crossref

Background
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC). Peripheral blood C-reactive protein (CRP) concentration and CRP overexpression in HCC cells are proven to be prognostic markers for HCC, but the significance of CRP expression in non-neoplastic hepatocytes, which are the primary origin of CRP, has not been studied. This study was conducted to determine the clinicopathologic significance of CRP immunoreactivity in the background liver of HBV-associated HCC.
Methods
CRP immunostaining was done on tissue microarrays of non-neoplastic liver tissues obtained from surgically resected, treatment-naïve HBV-associated HCCs (n = 156). The relationship between CRP immunoreactivity and other clinicopathologic parameters including cancer-specific survival was analyzed. CRP immunoreactivity was determined using a 4-tier grading system: grades 0, 1, 2, and 3.
Results
CRP was positive in 139 of 156 cases (89.1%) of non-neoplastic liver in patients with HCCs: grade 1 in 83 cases (53.2%); grade 2 in 50 cases (32.1%); and grade 3 in six cases (3.8%). The patients with diffuse CRP immunoreactivity (grade 3) had decreased cancer-specific survival (p = .031) and a tendency for shorter interval before early recurrence (p = .050). The degree of CRP immunoreactivity correlated with serum CRP concentration (p < .001).
Conclusions
CRP immunoreactivity in non-neoplastic liver is a novel biomarker for poor cancer-specific survival of HBV-associated HCC and correlates with serum CRP concentration.

Citations

Citations to this article as recorded by

Analysis of Inflammatory and Thyroid Hormone Levels Based on Hepatitis A and B Virus Immunity Status: Age and Sex Stratification
Hyeokjun Yun, Jae-Sik Jeon, Jae Kyung Kim
Viruses.2024; 16(8): 1329. CrossRef
Ferritin and procalcitonin serve as discriminative inflammatory biomarkers and can predict the prognosis of severe fever with thrombocytopenia syndrome in its early stages
Keping Chen, Huidi Sun, Yu Geng, Chuankun Yang, Chun Shan, Yuxin Chen
Frontiers in Microbiology.2023;[Epub] CrossRef
Evaluation of Serum Ferritin, Procalcitonin, and C-Reactive Protein for the Prediction of Severity and Mortality in Hemorrhagic Fever With Renal Syndrome
Lihe Che, Zedong Wang, Na Du, Liang Li, Yinghua Zhao, Kaiyu Zhang, Quan Liu
Frontiers in Microbiology.2022;[Epub] CrossRef
Hepatocellular adenomas: recent updates
Haeryoung Kim, Young Nyun Park
Journal of Pathology and Translational Medicine.2021; 55(3): 171. CrossRef
A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer
Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu, Yajun Chen
BMC Cancer.2020;[Epub] CrossRef
CRP Levels in Viral Hepatitis: A Meta-Analysis Study
Sukhpal Singh, Abhishek Bansal, Pardeep Kumar
International Journal of Infection.2020;[Epub] CrossRef

Differential MicroRNA Expression between EGFR T790M and L858R Mutated Lung Cancer: Ji Yeon Kim, Woo Jeong Lee, Ha Young Park, Ahrong Kim, Dong Hoon Shin, Chang Hun Lee; J Pathol Transl Med. 2018;52(5):275-282. Published online August 16, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.29

6,906 View
126 Download
6 Web of Science
5 Crossref

Abstract PDF Supplementary Material

Background
MicroRNAs (miRNAs) are short, non-coding RNAs that mediate post-transcriptional gene regulation. They are commonly deregulated in human malignancies, including non-small cell lung cancer (NSCLC). The aim of this study is to investigate miRNA expression in T790M-mutated NSCLC resistant to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors.
Methods
Six cases of resected NSCLC harboring the T790M mutation were examined. We performed miRNA time polymerase chain reaction (PCR) array profiling using EGFR T790M-mutated NSCLC and L858R-mutated NSCLC. Once identified, miRNAs that were differentially expressed between the two groups were validated by quantitative real-time polymerase chain reaction (qRT-PCR).
Results
miRNA PCR array profiling revealed three up-regulated miRNAs whose expression levels were altered 4.0-fold or more in the EGFR T790M mutation group than in the L858R group: miR-1 (fold change, 4.384), miR-196a (fold change, 4.138), and miR-124 (fold change, 4.132). The three differentially expressed miRNAs were validated by qRT-PCR, and they were found to be overexpressed in the T790M group relative to L858R group. In particular, expression levels of miR-1 and miR-124 were significantly higher in the T790M group (p-value of miR-1 = .004, miR-124 = .007, miR-196a = .096).
Conclusions
MiR-1, miR-124, and miR-196a are overexpressed in EGFR T790M mutated NSCLC.

Citations

Citations to this article as recorded by

Whole exome sequencing and MicroRNA profiling of lung adenocarcinoma identified risk prediction features for tumors at stage I and its substages
Hao Ho, Sung-Liang Yu, Hsuan-Yu Chen, Shin-Sheng Yuan, Kang-Yi Su, Yi-Chiung Hsu, Chung-Ping Hsu, Cheng-Yen Chuang, Ya-Hsuan Chang, Yu-Cheng Li, Chiou-Ling Cheng, Gee-Chen Chang, Pan-Chyr Yang, Ker-Chau Li
Lung Cancer.2023; 184: 107352. CrossRef
Dynamic Evaluation of Circulating miRNA Profile in EGFR-Mutated NSCLC Patients Treated with EGFR-TKIs
Alessandro Leonetti, Mjriam Capula, Roberta Minari, Giulia Mazzaschi, Alessandro Gregori, Btissame El Hassouni, Filippo Papini, Paola Bordi, Michela Verzè, Amir Avan, Marcello Tiseo, Elisa Giovannetti
Cells.2021; 10(6): 1520. CrossRef
Generation of osimertinib-resistant cells from epidermal growth factor receptor L858R/T790M mutant non-small cell lung carcinoma cell line
Nalini Devi Verusingam, Yi-Chen Chen, Heng-Fu Lin, Chao-Yu Liu, Ming-Cheng Lee, Kai-Hsi Lu, Soon-Keng Cheong, Alan Han-Kiat Ong, Shih-Hwa Chiou, Mong-Lien Wang
Journal of the Chinese Medical Association.2021; 84(3): 248. CrossRef
Cell Behavior of Non-Small Cell Lung Cancer Is at EGFR and MicroRNAs Hands
Sarah Sayed Hassanein, Sherif Abdelaziz Ibrahim, Ahmed Lotfy Abdel-Mawgood
International Journal of Molecular Sciences.2021; 22(22): 12496. CrossRef
The Roles of MicroRNA in Lung Cancer
Kuan-Li Wu, Ying-Ming Tsai, Chi-Tun Lien, Po-Lin Kuo, Jen-Yu Hung
International Journal of Molecular Sciences.2019; 20(7): 1611. CrossRef

p40 Immunohistochemistry Is an Excellent Marker in Primary Lung Squamous Cell Carcinoma: Khairunisa Ahmad Affandi, Nur Maya Sabrina Tizen, Muaatamarulain Mustangin, Reena Rahayu MdReena Rahayu Md Zin; J Pathol Transl Med. 2018;52(5):283-289. Published online August 31, 2018; DOI: https://doi.org/10.4132/jptm.2018.08.14

20,133 View
316 Download
29 Web of Science
29 Crossref

Abstract PDF

Background
Lung cancer is the third most common cancer worldwide. With major advances in the molecular testing of lung cancers and the introduction of targeted therapies, the distinction between adenocarcinoma and squamous cell carcinoma as well as pathologic subtyping has become important. Recent studies showed that p40 is highly specific for squamous and basal cells and is superior to p63 for diagnosing lung squamous cell carcinoma. The aim of this study was to evaluate the use of p40 immunohistochemical stain in the diagnosis of non-small cell lung carcinoma and its potential to replace current p63 antibody as the best immunohistochemical squamous marker.
Methods
Seventy formalin-fixed paraffin-embedded cases previously diagnosed as primary lung squamous cell carcinoma (n = 35) and lung adenocarcinoma (n = 35) from January 2008 to December 2016 were retrieved. The results of tumour cell immunoreactivity for p40 and p63 antibodies in lung squamous cell carcinoma and lung adenocarcinoma were compared.
Results
p40 was expressed in 27 cases of lung squamous cell carcinoma (77.1%). All cases of lung adenocarcinoma (35/35, 100%) were negative for p40. p63 expression was positive in 30 cases of lung squamous cell carcinoma (85.7%) and 13 cases of lung adenocarcinoma (37.1%). Reactivity for both p40 and p63 in lung squamous cell carcinoma was strong and diffuse, whereas variable reactivity was observed in lung adenocarcinoma.
Conclusions
p40 is an excellent marker for distinguishing lung squamous cell carcinoma from adenocarcinoma, and p40 expression is equivalent to p63 expression in lung squamous cell carcinoma.

Citations

Citations to this article as recorded by

Cancer of Unknown Primary With Squamous Cell Carcinoma Phenotype Presenting as Isolated Axillary Mass
Nicole Liang, Mohamed Alshal, Lynne J Goebel
Cureus.2025;[Epub] CrossRef
Lack of imbalance between the master regulators TTF1/NKX2-1 and ΔNp63/p40 implies adverse prognosis in non-small cell lung cancer
Martina Vescio, Matteo Bulloni, Giuseppe Pelosi, Linda Pattini
Scientific Reports.2024;[Epub] CrossRef
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer
Xinyuan Tong, Ayushi S. Patel, Eejung Kim, Hongjun Li, Yueqing Chen, Shuai Li, Shengwu Liu, Julien Dilly, Kevin S. Kapner, Ningxia Zhang, Yun Xue, Laura Hover, Suman Mukhopadhyay, Fiona Sherman, Khrystyna Myndzar, Priyanka Sahu, Yijun Gao, Fei Li, Fuming
Cancer Cell.2024; 42(3): 413. CrossRef
Common practice issues in pulmonary cytology/small biopsy: Diagnostic pitfalls and appropriate use of immunohistochemical stains
Jessie Xiong, Erik Polsdofer, Jian Jing
Human Pathology Reports.2024; 36: 300735. CrossRef
Integrating AI-Powered Digital Pathology and Imaging Mass Cytometry Identifies Key Classifiers of Tumor Cells, Stroma, and Immune Cells in Non–Small Cell Lung Cancer
Alessandra Rigamonti, Marika Viatore, Rebecca Polidori, Daoud Rahal, Marco Erreni, Maria Rita Fumagalli, Damiano Zanini, Andrea Doni, Anna Rita Putignano, Paola Bossi, Emanuele Voulaz, Marco Alloisio, Sabrina Rossi, Paolo Andrea Zucali, Armando Santoro, V
Cancer Research.2024; 84(7): 1165. CrossRef
Advances in combined neuroendocrine carcinoma of lung cancer
Zesen Han, Fujun Yang, Fang Wang, Huayu Zheng, Xiujian Chen, Hongyu Meng, Fenglei Li
Pathology and Oncology Research.2024;[Epub] CrossRef
Evolving Precision First-Line Systemic Treatment for Patients with Unresectable Non-Small Cell Lung Cancer
Tianhong Li, Weijie Ma, Ebaa Al-Obeidi
Cancers.2024; 16(13): 2350. CrossRef
Antibody-Conjugated Nanodiamond Enzyme for Targeted Non-Small-Cell Lung Cancer by Regulating Oxidative Stress
Xiaoying Guan, Jingwen Yang, Ziying Liu, Guowei Yang, Xiumei Tian
ACS Applied Nano Materials.2024; 7(20): 23670. CrossRef
Multifocal Pulmonary Opacities in an Elderly Smoker
Patton C McClelland, Zachary Jarrett, Christian C Lamb, Mateo Houle
Cureus.2024;[Epub] CrossRef
Clonal dynamics and Stereo-seq resolve origin and phenotypic plasticity of adenosquamous carcinoma
Ruiying Zhao, Yunhua Xu, Yedan Chen, Jiajun Zhang, Fei Teng, Sha Liao, Shengnan Chen, Qian Wu, Chan Xiang, Jiaohui Pang, Zhanxian Shang, Jikai Zhao, Hairong Bao, Hua Bao, Yang Shao, Shun Lu, Yuchen Han
npj Precision Oncology.2023;[Epub] CrossRef
Keratin 5 in Lung Cancer Specimens: Comparison of Four Antibody Clones and KRT5 mRNA-ISH
Christian Thomsen, Laura Blok-Husum, Jeanette Bæhr Georgsen, Torben Steiniche, Mogens Vyberg
Applied Immunohistochemistry & Molecular Morphology.2023; 31(6): 347. CrossRef
Carcinoma of unknown primary (CUP): an update for histopathologists
Katie Beauchamp, Bruce Moran, Timothy O’Brien, Donal Brennan, John Crown, Kieran Sheahan, Maura Bríd Cotter
Cancer and Metastasis Reviews.2023; 42(4): 1189. CrossRef
Advances in Genomic Data and Biomarkers: Revolutionizing NSCLC Diagnosis and Treatment
Juan Carlos Restrepo, Diana Dueñas, Zuray Corredor, Yamil Liscano
Cancers.2023; 15(13): 3474. CrossRef
Kallikrein-related peptidase 13 expression and clinicopathological features in lung squamous cell carcinoma
Ryusuke Sumiya, Kazuhiko Yamada, Teruki Hagiwara, Satoshi Nagasaka, Hideki Miyazaki, Toru Igari, Yuki Kawamura
Molecular and Clinical Oncology.2023;[Epub] CrossRef
Pre-clinical lung squamous cell carcinoma mouse models to identify novel biomarkers and therapeutic interventions
Priyanka Sahu, Chantal Donovan, Keshav Raj Paudel, Sophie Pickles, Vrushali Chimankar, Richard Y. Kim, Jay C. Horvart, Kamal Dua, Antonio Ieni, Francesco Nucera, Helle Bielefeldt-Ohmann, Sarah Mazilli, Gaetano Caramori, J. Guy Lyons, Philip M. Hansbro
Frontiers in Oncology.2023;[Epub] CrossRef
Intraosseous clear cell mucoepidermoid carcinoma: A case report and evaluation
Adesh S. Manchanda, Ramandeep S. Narang, Komaldeep K. Sandhu
Journal of Oral and Maxillofacial Pathology.2023; 27(4): 780. CrossRef
A targeted expression panel for classification, gene fusion detection and PD-L1 measurements – Can molecular profiling replace immunohistochemistry in non-small cell lung cancer?
Anita Tranberg Simonsen, Amalie Utke, Johanne Lade-Keller, Lasse Westphal Thomsen, Torben Steiniche, Magnus Stougaard
Experimental and Molecular Pathology.2022; 125: 104749. CrossRef
Basal cell carcinoma arising in association with maxillary odontogenic keratocyst in a patient with Gorlin-Goltz syndrome
Mutsuki Kawabe, Yoshitane Tsukamoto, Shohei Matuo, Shuji Kanda, Susumu Hashitani
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2022; 34(3): 333. CrossRef
Cutaneous Metastases from Thymic Carcinoma Primary Tumor: A Rare Case
Eva Krishna Sutedja, Trustia Rizqandaru, Kartika Ruchiatan, Endang Sutedja
International Medical Case Reports Journal.2022; Volume 15: 293. CrossRef
Primary nonkeratinizing squamous cell carcinoma of the scapular bone: A case report
Yang Li, Jian-Lin Zuo, Jin-Shuo Tang, Xian-Yue Shen, Sheng-Hao Xu, Jian-Lin Xiao
World Journal of Clinical Cases.2021; 9(4): 976. CrossRef
Survival-associated N6-adenosine methyltransferase signatures in lung squamous cell carcinoma and clinical verification
Jialin Qu, Li Wang, Man Jiang, Zhimin Wei, Guangming Fu, Xiaochun Zhang
BMC Cancer.2021;[Epub] CrossRef
Pulmonary adenomyoma presenting as a right cardiophrenic angle mass
Osigbemhe Iyalomhe, Sam Sadigh, Charuhas Deshpande, Leslie Litzky, Anna Moran, Scott Simpson
Radiology Case Reports.2020; 15(5): 502. CrossRef
Head-to-Head Comparison of p63 and p40 in Non-Neuroendocrine Carcinomas of the Tubal Gut
Ahmed M. Bakhshwin, Ilyssa O. Gordon, Kathryn Bock Brown, Xiuli Liu, Daniela S. Allende
International Journal of Surgical Pathology.2020; 28(8): 835. CrossRef
Greater specificity of p40 compared with p63 in distinguishing squamous cell carcinoma from adenocarcinoma in effusion cellblocks
Nah Ihm Kim, Ji Shin Lee
Cytojournal.2020; 17: 13. CrossRef
Incidental Thyroid Mass in a Patient With Oropharyngeal Squamous Cell Carcinoma
Kinneri Mehta, Misha Movahed-Ezazi, Akshay V. Patel
JAMA Otolaryngology–Head & Neck Surgery.2020; 146(9): 859. CrossRef
Three dimensional texture analysis of noncontrast chest CT in differentiating solitary solid lung squamous cell carcinoma from adenocarcinoma and correlation to immunohistochemical markers
Rui Han, Roshan Arjal, Jin Dong, Hong Jiang, Huan Liu, Dongyou Zhang, Lu Huang
Thoracic Cancer.2020; 11(11): 3099. CrossRef
The role of the immunohistochemical marker p40 in the differential diagnosis of adenocarcinoma and nonkeratinizing squamous cell cancer of the lung
E.M. Olyushina, M.M. Byakhova, L.E. Zavalishina, Yu.Yu. Andreeva, A.B. Semenova, G.A. Frank
Arkhiv patologii.2020; 82(5): 50. CrossRef
Role of Immunocytochemistry in the Cytological Diagnosis of Pulmonary Tumors
Jasna Metovic, Luisella Righi, Luisa Delsedime, Marco Volante, Mauro Papotti
Acta Cytologica.2020; 64(1-2): 16. CrossRef
Subtyping Lung Cancer Using DNA Methylation in Liquid Biopsies
Sandra P. Nunes, Francisca Diniz, Catarina Moreira-Barbosa, Vera Constâncio, Ana Victor Silva, Júlio Oliveira, Marta Soares, Sofia Paulino, Ana Luísa Cunha, Jéssica Rodrigues, Luís Antunes, Rui Henrique, Carmen Jerónimo
Journal of Clinical Medicine.2019; 8(9): 1500. CrossRef

Chronic Placental Inflammation as a Risk Factor of Severe Retinopathy of Prematurity: Chae Young Kim, Euiseok Jung, Eun Na Kim, Chong Jai Kim, Joo Yong Lee, Ji Hye Hwang, Woo Sun Song, Byong Sop Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim; J Pathol Transl Med. 2018;52(5):290-297. Published online July 16, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.09

11,209 View
126 Download
16 Web of Science
16 Crossref

Abstract PDF

Background
Chronic placental inflammation (CPI) has been implicated in the pathogenesis of diseases in premature infants, whereas retinopathy of prematurity (ROP) is a major complication primarily affecting preterm and very low-birth-weight (VLBW) infants. This study aims to investigate the association between CPI and ROP in VLBW infants.
Methods
We performed a retrospective review of clinical records of VLBW infants born between 2013 and 2016. Placental pathology findings including CPI cases were analyzed using logistic regression to study infants’ morbidities and other clinical characteristics.
Results
A total of 402 infants with a mean (standard deviation) gestational age of 28.5 (2.8) weeks and birth weight of 1,027.2 (304.4) g were included. The incidence of ROP was 24.1%. CPI was found in 90 infants (22.4%), among which 28.9% (26 of 90) developed ROP, and 21.1% (19 of 90) underwent laser photocoagulation. Lower gestational age, lower birth weight, longer duration of oxygen supply, and presence of CPI were associated with the development of ROP. After adjustment for gestational age, birth weight, sex, duration of oxygen supply, and other overlapping placental pathology, CPI was associated with the odds for type 1 ROP that required laser photocoagulation (adjusted odds ratio, 2.739; 95% confidence interval, 1.112 to 6.749; p = .029).
Conclusions
CPI was associated with severe ROP requiring treatment with laser photocoagulation in VLBW infants.

Citations

Citations to this article as recorded by

Comprehensive assessment of placental inflammation: Novel approach in predicting retinopathy of prematurity
Salma El Emrani, Esther J.S. Jansen, Jelle J. Goeman, Jacqueline U.M. Termote, Enrico Lopriore, Nicoline E. Schalij-Delfos, Lotte E. van der Meeren
Early Human Development.2025; 204: 106239. CrossRef
Histological Chorioamnionitis and Funisitis as New Risk Factors for Retinopathy of Prematurity: A Meta-analysis
Salma El Emrani, Esther J.S. Jansen, Jelle J. Goeman, Enrico Lopriore, Jacqueline U.M. Termote, Nicoline E. Schalij-Delfos, Lotte E. van der Meeren
American Journal of Perinatology.2024; 41(S 01): e3264. CrossRef
Retinopathy of prematurity and placental histopathology findings: A retrospective cohort study
Sam Ebenezer Athikarisamy, Geoffrey C. Lam, Matthew N. Cooper, Tobias Strunk
Frontiers in Pediatrics.2023;[Epub] CrossRef
Identification of clinical factors associated with timing and duration of spontaneous regression of retinopathy of prematurity not requiring treatment
Jamee Schoephoerster, Sydney Roston, Scott Lunos, Sara E. Ramel, Jill Anderson, Michael K. Georgieff, Ellen C. Ingolfsland
Journal of Perinatology.2023; 43(6): 702. CrossRef
Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation
Xudong Wang, Tianxi Wang, Enton Lam, David Alvarez, Ye Sun
International Journal of Molecular Sciences.2023; 24(15): 12090. CrossRef
The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms
Kristin Krueger, Elke Boehme, Alexa Karina Klettner, Marietta Zille
Critical Reviews in Food Science and Nutrition.2022; 62(27): 7518. CrossRef
Retinopathy prematurity: a systematic review and meta-analysis study based on neonatal and maternal risk factors
Tahereh Bahmani, Arezoo Karimi, Nazanin Rezaei, Salman Daliri
The Journal of Maternal-Fetal & Neonatal Medicine.2022; 35(25): 8032. CrossRef
Diallyl Trisulfide Promotes Placental Angiogenesis by Regulating Lipid Metabolism and Alleviating Inflammatory Responses in Obese Pregnant Mice
Miaomiao Wang, Zhaoyu Wang, Yueyue Miao, Hongkui Wei, Jian Peng, Yuanfei Zhou
Nutrients.2022; 14(11): 2230. CrossRef
Risk factors for the development of retinopathy in premature infants
O.Yu. Obolonska, L.I. Vakulenko, L.P. Badogina, O.I. Obolonskyi, I.A. Likhachova, O.V. Kovryga
CHILD`S HEALTH.2022; 17(3): 138. CrossRef
Development of the genomic inflammatory index (GII) to assess key maternal antecedents associated with placental inflammation
Kirsi S. Oldenburg, Lauren A. Eaves, Lisa Smeester, Hudson P. Santos, T. Michael O'Shea, Rebecca C. Fry
Placenta.2021; 111: 82. CrossRef
Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants
Claudia Ioana Borțea, Florina Stoica, Marioara Boia, Emil Radu Iacob, Mihai Dinu, Roxana Iacob, Daniela Iacob
Medicina.2021; 57(5): 420. CrossRef
Efficacy of Aflibercept Treatment and Its Effect on the Retinal Perfusion in the Oxygen-Induced Retinopathy Mouse Model of Retinopathy of Prematurity
Sarina M. Amin, Andres Gonzalez, Jade Guevara, Charlotte Bolch, Lorick Andersen, W. Clay Smith, Swati Agarwal-Sinha
Ophthalmic Research.2021; 64(1): 91. CrossRef
A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity
Alison L. Kent, Mohamed E. Abdel-Latif, Timothy Cochrane, Margaret Broom, Jane E. Dahlstrom, Rohan W. Essex, Bruce Shadbolt, Riccardo Natoli
Pediatric Research.2020; 87(1): 131. CrossRef
Human placental suppressors of cytokine signalling (SOCS) and inflammatory cytokines are dysregulated in assisted reproduction, advanced maternal age and pre-term birth
S. J. Knight, A. D. Smith, H. Kim, A. C. Collier
Clinical and Experimental Obstetrics & Gynecology.2020;[Epub] CrossRef
Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth
Jun Seok Son, Xiangdong Liu, Qiyu Tian, Liang Zhao, Yanting Chen, Yun Hu, Song Ah Chae, Jeanene M. de Avila, Mei‐Jun Zhu, Min Du
The Journal of Physiology.2019; 597(13): 3333. CrossRef
Cumulative evidence for association of sepsis and retinopathy of prematurity
Jichong Huang, Ying Tang, Tingting Zhu, Yafei Li, Hua Chun, Yi Qu, Dezhi Mu
Medicine.2019; 98(42): e17512. CrossRef

Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression: Bo Gun Jang, Hye Sung Kim, Weon Young Chang, Jeong Mo Bae, Gyeong Hoon Kang; J Pathol Transl Med. 2018;52(5):298-306. Published online July 18, 2018; DOI: https://doi.org/10.4132/jptm.2018.06.29

7,245 View
151 Download
16 Web of Science
12 Crossref

Abstract PDF

Background
A receptor tyrosine kinase for ephrin ligands, EPHB2, is expressed in normal colorectal tissues and colorectal cancers (CRCs). The aim of this study was to investigate EPHB2 expression over CRC progression and determine its prognostic significance in CRC.
Methods
To measure EPHB2 mRNA and protein expression, real-time polymerase chain reaction and immunohistochemistry were performed in 32 fresh-frozen and 567 formalin-fixed paraffin-embedded CRC samples, respectively. We further investigated clinicopathological features and overall and recurrence-free survival according to EPHB2 protein expression.
Results
The EPHB2 level was upregulated in CRC samples compared to non-cancerous tissue in most samples and showed a strong positive correlation with AXIN2. Notably, CD44 had a positive association with both mRNA and protein levels of EPHB2. Immunohistochemical analysis revealed no difference in EPHB2 expression between adenoma and carcinoma areas. Although EPHB2 expression was slightly lower in invasive fronts compared to surface area (p < .05), there was no difference between superficial and metastatic areas. EPHB2 positivity was associated with lymphatic (p < .001) and venous (p = .001) invasion, TNM stage (p < .001), and microsatellite instability (p = .036). Kaplan–Meier analysis demonstrated that CRC patients with EPHB2 positivity showed better clinical outcomes in both overall (p = .049) and recurrence-free survival (p = .015). However, multivariate analysis failed to show that EPHB2 is an independent prognostic marker in CRCs (hazard ratio, 0.692; p = .692).
Conclusions
Our results suggest that EPHB2 is overexpressed in a subset of CRCs and is a significant prognostic marker.

Citations

Citations to this article as recorded by

Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets
João Figueira Scarini, Moisés Willian Aparecido Gonçalves, Reydson Alcides de Lima-Souza, Luccas Lavareze, Talita de Carvalho Kimura, Ching-Chu Yang, Albina Altemani, Fernanda Viviane Mariano, Heloisa Prado Soares, Gary Chris Fillmore, Erika Said Abu Egal
Frontiers in Oncology.2024;[Epub] CrossRef
Comprehensive pan-cancer analysis reveals EPHB2 is a novel predictive biomarker for prognosis and immunotherapy response
Shengshan Xu, Youbin Zheng, Min Ye, Tao Shen, Dongxi Zhang, Zumei Li, Zhuming Lu
BMC Cancer.2024;[Epub] CrossRef
Therapeutic effects of ephrin B receptor 2 inhibitors screened by molecular docking on cutaneous squamous cell carcinoma
Yan Li, Xuanfen Zhang
Journal of Dermatological Treatment.2022; 33(1): 373. CrossRef
The EPH/Ephrin System in Colorectal Cancer
Stavros P. Papadakos, Leonidas Petrogiannopoulos, Alexandros Pergaris, Stamatios Theocharis
International Journal of Molecular Sciences.2022; 23(5): 2761. CrossRef
Prognostic Significance of Autophagy-Relevant Gene Markers in Colorectal Cancer
Qinglian He, Ziqi Li, Jinbao Yin, Yuling Li, Yuting Yin, Xue Lei, Wei Zhu
Frontiers in Oncology.2021;[Epub] CrossRef
Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy
Bahar Dasgeb, Leila Youssefian, Amir Hossein Saeidian, Jun Kang, Wenyin Shi, Elizabeth Shoenberg, Adam Ertel, Paolo Fortina, Hassan Vahidnezhad, Jouni Uitto
International Journal of Dermatology and Venereology.2021; 4(2): 70. CrossRef
Delineation of colorectal cancer ligand-receptor interactions and their roles in the tumor microenvironment and prognosis
Hexin Lin, Lu Xia, Jiabian Lian, Yinan Chen, Yiyi Zhang, Zhicheng Zhuang, HuaJun Cai, Jun You, Guoxian Guan
Journal of Translational Medicine.2021;[Epub] CrossRef
Downregulation of hsa-microRNA-204-5p and identification of its potential regulatory network in non-small cell lung cancer: RT-qPCR, bioinformatic- and meta-analyses
Chang-Yu Liang, Zu-Yun Li, Ting-Qing Gan, Ye-Ying Fang, Bin-Liang Gan, Wen-Jie Chen, Yi-Wu Dang, Ke Shi, Zhen-Bo Feng, Gang Chen
Respiratory Research.2020;[Epub] CrossRef
The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment
Oscar J Buckens, Btissame El Hassouni, Elisa Giovannetti, Godefridus J Peters
Expert Opinion on Investigational Drugs.2020; 29(6): 567. CrossRef
Expression Profile and Prognostic Significance of EPHB3 in Colorectal Cancer
Bo Jang, Hye Kim, Jeong Bae, Woo Kim, Chang Hyun, Gyeong Kang
Biomolecules.2020; 10(4): 602. CrossRef
Gene Expression Signature to Predict Prognosis and Adjuvant Chemosensitivity of Colorectal Cancer Patients

Jianxia Li, Jianwei Zhang, Huabin Hu, Yue Cai, Jiayu Ling, Zehua Wu, Yanhong Deng
Cancer Management and Research.2020; Volume 12: 3301. CrossRef
SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers
Bo Gun Jang, Hye Sung Kim, Jeong Mo Bae, Woo Ho Kim, Heung Up Kim, Gyeong Hoon Kang
Scientific Reports.2020;[Epub] CrossRef

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars: Mi Young Lee, Eun Shin, Hyunchul Kim, In Suk Kwak, Younghee Choi; J Pathol Transl Med. 2018;52(5):307-313. Published online August 16, 2018; DOI: https://doi.org/10.4132/jptm.2018.08.03

6,994 View
196 Download
9 Web of Science
9 Crossref

Abstract PDF

Background
Although several studies have shown the role of interleukin-31 (IL-31) and its receptors in inducing pruritus in certain skin disorders, knowledge of its role in post-burn hypertrophic scars is insufficient. Therefore, the histopathological expression levels of IL-31, IL-31 receptor alpha (IL-31RA), and oncostatin M receptor (OSMR) in post-burn hypertrophic scar tissues were investigated and compared with normal tissue expression levels.
Methods
Samples of hypertrophic scar tissue were obtained from 20 burn patients through punch biopsy. Normal samples were obtained from areas adjacent to the burn injury site of the same patients. Samples were placed in 10% neutral buffered formalin, embedded in paraplast, and processed into serial 5-μm sections. Immunohistochemistry results were semi-quantitatively evaluated for IL-31, IL-31RA, and OSMR. By hematoxylin and eosin staining, epidermal and dermal thickness were assessed with a microscope and digital camera. Intensities were rated on a scale of 1 to 4.
Results
Percentages for IL-31, IL-31RA, and OSMR in the epidermal basal layer cell cytoplasm were significantly greater in the burn scar tissue compared to normal skin, as well as the dermal and epidermal thickness (p < .05). There was a significant difference in IL-31 epidermal basal layer intensity in burn scar tissue compared to normal skin (p < .05). Besides the OSMR basal layer intensity, IL-31 and IL-31RA intensities between the burn scar and normal tissues were not significant. However, correlations were significant, indicating that the greater the infiltration percentage, the higher the intensity (p < .05).
Conclusions
IL-31, IL-31RA, and OSMR expression levels are increased in hypertrophic scars compared with normal tissue.

Citations

Citations to this article as recorded by

Pharmacotherapy for Keloids and Hypertrophic Scars
Teruo Murakami, Sadayuki Shigeki
International Journal of Molecular Sciences.2024; 25(9): 4674. CrossRef
Understanding Neural Factors in Burn-related Pruritus and Neuropathic Pain
Dulan A Gunawardena, Edward Stanley, Andrea C Issler-Fisher
Journal of Burn Care & Research.2023; 44(5): 1182. CrossRef
Canine interleukin-31 binds directly to OSMRβ with higher binding affinity than to IL-31RA
Yuxin Zheng, Jing Zhang, Tianling Guo, Jin Cao, Lixian Wang, Jie Zhang, Xuefei Pang, Feng Gao, Hua Sun, Haixia Xiao
3 Biotech.2023;[Epub] CrossRef
Multimodal roles of transient receptor potential channel activation in inducing pathological tissue scarification
Yuping Zheng, Qingrui Huang, Yanfeng Zhang, Lanxin Geng, Wuqing Wang, Huimin Zhang, Xiang He, Qiannan Li
Frontiers in Immunology.2023;[Epub] CrossRef
Role of burn severity and posttraumatic stress symptoms in the co-occurrence of itch and neuropathic pain after burns: A longitudinal study
N. E. E. Van Loey, A. E. E. de Jong, H. W. C. Hofland, A. I. M. van Laarhoven
Frontiers in Medicine.2022;[Epub] CrossRef
Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis
Sonja Ständer, Gil Yosipovitch, Franz J. Legat, Jean-Philippe Lacour, Carle Paul, Joanna Narbutt, Thomas Bieber, Laurent Misery, Andreas Wollenberg, Adam Reich, Faiz Ahmad, Christophe Piketty
New England Journal of Medicine.2020; 382(8): 706. CrossRef
Post-Burn Pruritus
Bo Young Chung, Han Bi Kim, Min Je Jung, Seok Young Kang, In-Suk Kwak, Chun Wook Park, Hye One Kim
International Journal of Molecular Sciences.2020; 21(11): 3880. CrossRef
Novel Analgesics with Peripheral Targets
Cosmin I. Ciotu, Michael J.M. Fischer
Neurotherapeutics.2020; 17(3): 784. CrossRef
Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment
Emilie Fowler, Gil Yosipovitch
Current Trauma Reports.2019; 5(2): 90. CrossRef

An Immunohistochemical and Polarizing Microscopic Study of the Tumor Microenvironment in Varying Grades of Oral Squamous Cell Carcinoma: Aeman Khalid, Safia Siddiqui, Bharadwaj Bordoloi, Nafis Faizi, Fahad Samadi, Noora Saeed; J Pathol Transl Med. 2018;52(5):314-322. Published online July 27, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.17

7,501 View
157 Download
1 Web of Science
1 Crossref

Abstract PDF

Background
Invasion of epithelial cells into the connective tissue brings about massive morphological and architectural changes in the underlying stroma. Myofibroblasts reorganize the stroma to facilitate the movement of tumor cells leading to metastasis. The aim of this study was to determine the number and pattern of distribution of myofibroblasts and the qualitative and quantitative change that they cause in the collagen present in the stroma in various grades of oral squamous cell carcinoma (OSCC).
Methods
The study was divided into two groups with group I (test group, 65 cases) consisting of 29 cases of well-differentiated squamous cell carcinoma, 25 moderately differentiated SCC, and 11 poorly differentiated SCC, and group II (control group) consisting of 11 cases of normal mucosa. Sections from each sample were stained with anti–α-smooth muscle actin (α-SMA) antibodies, hematoxylin and eosin, and Picrosirius red. Several additional sections from each grade of OSCC were stained with Masson’s trichrome to observe the changes in collagen. For the statistical analysis, Fisher’s exact test, Tukey’s post hoc honest significant difference test, ANOVA, and the chi-square test were used, and p < .05 was considered statistically significant.
Results
As the tumor stage progressed, an increase in the intensity α-SMA expression was seen, and the network pattern dominated in more dedifferentiated carcinomas. The collagen fibers became thin, loosely packed, and haphazardly aligned with progressing cancer. Additionally, the mean area fraction decreased, and the fibers attained a greenish yellow hue and a weak birefringence when observed using polarizing light microscopy.
Conclusions
Myofibroblasts bring about numerous changes in collagen. As cancer progresses, there isincrease in pathological collagen,which enhances the movement of cells within the stroma.

Citations

Citations to this article as recorded by

Multifractal Alterations in Oral Sub-Epithelial Connective Tissue During Progression of Pre-Cancer and Cancer
Debaleena Nawn, Sawon Pratiher, Subhankar Chattoraj, Debjani Chakraborty, Mousumi Pal, Ranjan Rashmi Paul, Srimonti Dutta, Jyotirmoy Chatterjee
IEEE Journal of Biomedical and Health Informatics.2021; 25(1): 152. CrossRef

Significance of Intratumoral Fibrosis in Clear Cell Renal Cell Carcinoma: Jae Won Joung, Hoon Kyu Oh, Sun Jae Lee, Young Ah Kim, Hyun Jin Jung; J Pathol Transl Med. 2018;52(5):323-330. Published online August 19, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.21

7,326 View
162 Download
17 Web of Science
16 Crossref

Abstract PDF

Background
Intratumoral fibrosis (ITF) is a frequent histologic finding in solid organ tumors. Renal cell carcinoma (RCC) is a highly vascularized tumor with different shapes and degrees of ITF and inflammation. ITF is a poor prognostic factor, especially in breast cancer, and is related to intratumoral necrosis (ITN) and intratumoral inflammation (ITI). However, the significance of ITF in RCC has not been fully studied. In this study, we evaluate the relationships between ITF and other clinicopathologic parameters associated with RCC prognosis.
Methods
ITF was evaluated in 204 clear cell renal cell carcinoma (CCRCC) specimens according to presence and grade of fibrosis, degree of ITI, and presence of ITN. Lysyl oxidase (LOX) expression in tumor cells was also evaluated with clinicopathologic parameters.
Results
Among 204 CCRCC cases, 167 (81.7%) showed ITF, 71 (34.8%) showed ITI, 35 (17.2%) showed ITN, and 111 (54.4%) showed LOX expression. ITF correlated with Fuhrman nuclear grade (p = .046), lymphovascular invasion (LVI) (p = .027), and ITN (p = .036). Patients with ITF had a poor five-year overall survival rate (p = .104).
Conclusions
ITF is related to other poor prognostic factors in CCRCC, such as Fuhrman nuclear grade, ITN, and LVI, but ITF itself had no significant correlation with prognosis of CCRCC.

Citations

Citations to this article as recorded by

Postoperative prognostic assessment using ECV fraction derived from equilibrium contrast-enhanced CT in thymomas
Koji Takumi, Hiroto Hakamada, Hiroaki Nagano, Ryota Nakanosono, Fumiko Kanzaki, Masanori Nakajo, Kiyohisa Kamimura, Masatoyo Nakajo, Daigo Nagano, Kazuhiro Ueda, Takashi Yoshiura
European Journal of Radiology.2025; 184: 111978. CrossRef
New insights into fibrotic signaling in renal cell carcinoma
Jiao-Yi Chen, Wai-Han Yiu, Patrick Ming-Kuen Tang, Sydney Chi-Wai Tang
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
Tumor-associated fibrosis impairs the response to immunotherapy
Angha Naik, Andrew Leask
Matrix Biology.2023; 119: 125. CrossRef
Decreased renal expression of PAQR5 is associated with the absence of a nephroprotective effect of progesterone in a rat UUO model
P. A. Abramicheva, D. S. Semenovich, L. D. Zorova, I. B. Pevzner, I. A. Sokolov, V. A. Popkov, E. P. Kazakov, D. B. Zorov, E. Y. Plotnikov
Scientific Reports.2023;[Epub] CrossRef
Intratumoral fibrosis and patterns of immune infiltration in clear cell renal cell carcinoma
Songchen Han, Wenbo Yang, Caipeng Qin, Yiqing Du, Mengting Ding, Huaqi Yin, Tao Xu
BMC Cancer.2022;[Epub] CrossRef
Siglec-F–expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis
Seungwon Ryu, Jae Woo Shin, Soie Kwon, Jiwon Lee, Yong Chul Kim, Yoe-Sik Bae, Yong-Soo Bae, Dong Ki Kim, Yon Su Kim, Seung Hee Yang, Hye Young Kim
Journal of Clinical Investigation.2022;[Epub] CrossRef
The atypical sphingosine 1‐phosphate variant, d16:1 S1P, mediates CTGF induction via S1P2 activation in renal cell carcinoma
Melanie Glueck, Alexander Koch, Robert Brunkhorst, Nerea Ferreiros Bouzas, Sandra Trautmann, Liliana Schaefer, Waltraud Pfeilschifter, Josef Pfeilschifter, Rajkumar Vutukuri
The FEBS Journal.2022; 289(18): 5670. CrossRef
The Synergistic Cooperation between TGF-β and Hypoxia in Cancer and Fibrosis
Pramod Mallikarjuna, Yang Zhou, Maréne Landström
Biomolecules.2022; 12(5): 635. CrossRef
In Vitro Characterization of Renal Drug Transporter Activity in Kidney Cancer
Pedro Caetano-Pinto, Nathanil Justian, Maria Dib, Jana Fischer, Maryna Somova, Martin Burchardt, Ingmar Wolff
International Journal of Molecular Sciences.2022; 23(17): 10177. CrossRef
PD-1 immunobiology in glomerulonephritis and renal cell carcinoma
Colleen S. Curran, Jeffrey B. Kopp
BMC Nephrology.2021;[Epub] CrossRef
Intratumoral Fibrosis in Facilitating Renal Cancer Aggressiveness: Underlying Mechanisms and Promising Targets
Chao Hu, Yufeng Zhao, Xuanchuan Wang, Tongyu Zhu
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
What Mediates Fibrosis in the Tumor Microenvironment of Clear Renal Cell Carcinoma
Wenbo Yang, Caipeng Qin, Jingli Han, Songchen Han, Wenjun Bai, Yiqing Du, Tao Xu
Frontiers in Genetics.2021;[Epub] CrossRef
Kidney Cancer and Chronic Kidney Disease: Too Close for Comfort
Pedro Caetano Pinto, Cindy Rönnau, Martin Burchardt, Ingmar Wolff
Biomedicines.2021; 9(12): 1761. CrossRef
The Significance of Fibrosis Quantification as a Marker in Assessing Pseudo-Capsule Status and Clear Cell Renal Cell Carcinoma Prognosis
Caipeng Qin, Huaqi Yin, Huixin Liu, Feng Liu, Yiqing Du, Tao Xu
Diagnostics.2020; 10(11): 895. CrossRef
The challenges of adoptive cell transfer in the treatment of human renal cell carcinoma
Zuzana Strizova, Jirina Bartunkova, Daniel Smrz
Cancer Immunology, Immunotherapy.2019; 68(11): 1831. CrossRef
Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma
Wen-Hao Xu, Yue Xu, Jun Wang, Xi Tian, Junlong Wu, Fang-Ning Wan, Hong-Kai Wang, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye
Aging.2019; 11(16): 6503. CrossRef

Prognostic Role of Metastatic Lymph Node Ratio in Papillary Thyroid Carcinoma: Jung-Soo Pyo, Jin Hee Sohn, Kyungseek Chang; J Pathol Transl Med. 2018;52(5):331-338. Published online August 30, 2018; DOI: https://doi.org/10.4132/jptm.2018.08.07

7,433 View
128 Download
15 Web of Science
13 Crossref

Abstract PDF

Background
The aim of this study is to elucidate the clinicopathological significances, including the prognostic role, of metastatic lymph node ratio (mLNR) and tumor deposit diameter in papillary thyroid carcinoma (PTC) through a retrospective review and meta-analysis.
Methods
We categorized the cases into high (≥ 0.44) and low mLNR (< 0.44) and investigated the correlations with clinicopathological parameters in 64 PTCs with neck level VI lymph node (LN) metastasis. In addition, meta-analysis of seven eligible studies was used to investigate the correlation between mLNR and survival.
Results
Among 64 PTCs with neck level VI LN metastasis, high mLNR was found in 34 PTCs (53.1%). High mLNR was significantly correlated with macrometastasis (tumor deposit diameter ≥ 0.2 cm), extracapsular spread, and number of metastatic LNs. Based on linear regression test, mLNR was significantly increased by the largest LN size but not the largest metastatic LN (mLN) size. High mLNR was not correlated with nuclear factor κB or cyclin D1 immunohistochemical expression, Ki-67 labeling index, or other pathological parameters of primary tumor. Based on meta-analysis, high mLNR significantly correlated with worse disease-free survival at the 5-year and 10-year follow-up (hazard ratio [HR], 4.866; 95% confidence interval [CI], 3.527 to 6.714 and HR, 5.769; 95% CI, 2.951 to 11.275, respectively).
Conclusions
Our data showed that high mLNR significantly correlated with worse survival, macrometastasis, and extracapsular spread of mLNs. Further cumulative studies for more detailed criteria of mLNR are needed before application in daily practice.

Citations

Citations to this article as recorded by

The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma
Chang Liu, Shangjie Yang, Tian Xue, Qian Zhang, Yanjing Zhang, Yufang Zhao, Guolin Yin, Xiaohui Yan, Ping Liang, Liping Liu
Frontiers in Oncology.2025;[Epub] CrossRef
The Predictive Value of a Nomogram Based on Ultrasound Radiomics, Clinical Factors, and Enhanced Ultrasound Features for Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma
Lei Gao, Xiuli Wen, Guanghui Yue, Hui Wang, Ziqing Lu, Beibei Wu, Zhihong Liu, Yuming Wu, Dongmei Lin, Shijian Yi, Wei Jiang, Yi Hao
Ultrasonic Imaging.2025; 47(2): 93. CrossRef
Lymph Node Metastasis Ratio: Prognostic Significance in Papillary Thyroid Cancer
Ana Rita Ferreira, Diogo Ramalho, Daniela Martins, Andreia Amado, Susana Graça, Carlos Soares, Bela Pereira, Maria João Oliveira, Manuel Oliveira, Antónia Póvoa
Indian Journal of Surgery.2025;[Epub] CrossRef
Application and subgroup analysis of competing risks model based on different lymph node staging systems in differentiated thyroid cancer
Zhe Xu Cao, Jiang Sheng Huang, Ming Ming Wang
Updates in Surgery.2024; 76(5): 1927. CrossRef
Thyroglobulin expression, Ki-67 index, and lymph node ratio in the prognostic assessment of papillary thyroid cancer
Helene Lindfors, Marie Karlsen, Ellinor Karlton, Jan Zedenius, Catharina Larsson, Catharina Ihre Lundgren, C. Christofer Juhlin, Ivan Shabo
Scientific Reports.2023;[Epub] CrossRef
Incidental Node Metastasis as an Independent Factor of Worse Disease-Free Survival in Patients with Papillary Thyroid Carcinoma
Renan Aguera Pinheiro, Ana Kober Leite, Beatriz Godoi Cavalheiro, Evandro Sobroza de Mello, Luiz Paulo Kowalski, Leandro Luongo Matos
Cancers.2023; 15(3): 943. CrossRef
A High-Quality Nomogram for Predicting Lung Metastasis in Newly Diagnosed Stage IV Thyroid Cancer: A Population-Based Study
WenYi Wang, JiaJing Liu, XiaoFan Xu, LiQun Huo, XuLin Wang, Jun Gu
Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
Lymph Node Ratio Predicts Recurrence in Patients with Papillary Thyroid Carcinoma with Low Lymph Node Yield
Il Ku Kang, Joonseon Park, Ja Seong Bae, Jeong Soo Kim, Kwangsoon Kim
Cancers.2023; 15(11): 2947. CrossRef
Superiority of metastatic lymph node ratio over number of node metastases and TNM/AJCC N classification in predicting cancer‐specific survival in medullary thyroid cancer
Andreas Machens, Kerstin Lorenz, Frank Weber, Henning Dralle
Head & Neck.2022; 44(12): 2717. CrossRef
Value of Combining Clinical Factors, Conventional Ultrasound, and Contrast-Enhanced Ultrasound Features in Preoperative Prediction of Central Lymph Node Metastases of Different Sized Papillary Thyroid Carcinomas
Yanfang Wang, Fang Nie, Guojuan Wang, Ting Liu, Tiantian Dong, Yamin Sun
Cancer Management and Research.2021; Volume 13: 3403. CrossRef
Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma
Ji Eun Choi, Ja Seong Bae, Dong-Jun Lim, So Lyung Jung, Chan Kwon Jung
Cancers.2019; 11(6): 816. CrossRef
Patients Aged ≥55 Years With Stage T1-2N1M1 Differentiated Thyroid Cancer Should Be Downstaged in the Eighth Edition AJCC/TNM Cancer Staging System
Zeming Liu, Sichao Chen, Yihui Huang, Di Hu, Min Wang, Wei Wei, Chao Zhang, Wen Zeng, Liang Guo
Frontiers in Oncology.2019;[Epub] CrossRef
Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location
Jung-Soo Pyo, Young-Min Shin, Dong-Wook Kang
Journal of Clinical Medicine.2019; 8(11): 1812. CrossRef

Case Studies

Bile Granuloma Mimicking Peritoneal Seeding: A Case Report: Hasong Jeong, Hye Won Lee, Hye Ra Jung, Ilseon Hwang, Sun Young Kwon, Yu Na Kang, Sang Pyo Kim, Misun Choe; J Pathol Transl Med. 2018;52(5):339-343. Published online July 16, 2018; DOI: https://doi.org/10.4132/jptm.2018.06.02

6,553 View
117 Download
6 Web of Science
8 Crossref

Abstract PDF

Laparoscopic cholecystectomy is a widely used treatment method for most cholelithiasis and is a relatively safe procedure. Foreign body granulomatous reaction to bile or gallstone spillage during laparoscopic cholecystectomy has rarely been reported. We report a case of bile granuloma after laparoscopic cholecystectomy, which mimicked peritoneal seeding. A 59-year-old Korean man presented with right upper quadrant pain. He underwent laparoscopic cholecystectomy for acute cholecystitis with cholelithiasis. Pathologic examination revealed an incidental adenocarcinoma invading the lamina propria with acute cholecystitis and cholelithiasis. After 3 months, follow-up abdominal computed tomography revealed a subhepatic nodule, which showed hypermetabolism on positron emission tomography–computed tomography. Suspecting localized peritoneal seeding, wedge resection of the liver, wedge resection of the transverse colon, and omentectomy were performed. Pathologic examination of the resected specimens revealed multiple bile granulomas. Awareness of bile granuloma mimicking malignancy is noteworthy for patient management to reduce unnecessary procedure during postoperative surveillance.

Citations

Citations to this article as recorded by

A mimic of peritoneal metastatic disease, multifocal intraabdominal foreign body granulomas secondary to feculent peritonitis
Damien Gibson, Christo Joseph, Diarmid P. Foulis, Christophe R. Berney
ANZ Journal of Surgery.2024; 94(4): 763. CrossRef
Practices and Attitudes of Surgeons With Regard to Spilled Gallstones During Laparoscopic Cholecystectomy: A Cross-Sectional Study From Saudi Arabia
Mohammed Alfehaid, Moath Aljohani, Sajad A Salati , Shoug Alaodah, Wejdan Alresheedi, Raghad Almarshud
Cureus.2024;[Epub] CrossRef
Spilled gallstone mimicking intra-abdominal seeding of gallbladder adenocarcinoma: A case report
Cheng-Ken Huang, Ruey-Hwa Lu, Chien-Cheng Chen, Po-Chun Chen, Wen-Chang Hsu, Meng-Jui Tsai, Chin-Tsung Ting
World Journal of Gastrointestinal Surgery.2024; 16(2): 622. CrossRef
Peritoneal bile granuloma formation at the site of caesarean surgical scar
Lila Marshall, Sharlin Varghese, Mary Ciranni-Callon
Journal of Case Reports and Images in Obstetrics and Gynecology.2024; 10(2): 6. CrossRef
Biliary Granulomatous Peritoneal Reaction as Consequence of Cholecystectomy: Case Report and Literature Review
Giuseppe Tarantino, Denise Menghini, Maria Eva Argenziano, Miriam Palmieri, Alessandra Mandolesi, Enrico Dalla Bona, Antonio Benedetti, Mario Guerrieri, Maria Giovanna Danieli
SN Comprehensive Clinical Medicine.2023;[Epub] CrossRef
Foreign body reaction mimicking local recurrence from polyactide adhesion barrier film after laparoscopic colorectal cancer surgery
Tien-Chan Hsieh, Chao-Wen Hsu
Medicine.2022; 101(5): e28692. CrossRef
Spilled gallstones after laparoscopic cholecystectomy: a systematic review
Sajad Ahmad Salati, Mohammed Alfehaid, Saleh Alsuwaydani, Lamees AlSulaim
Polish Journal of Surgery.2022; 94(4): 1. CrossRef
Foreign body granulomas mimic peritoneal dissemination caused by incarcerated femoral hernia perforation: A case report
Shinpei Ogino, Tatsuya Matsumoto, Yosuke Kamada, Noriaki Koizumi, Hiroshi Fujiki, Kenji Nakamura, Takeshi Yamano, Chouhei Sakakura
World Journal of Clinical Oncology.2021; 12(11): 1083. CrossRef

Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review: Nu Ri Jang, Dae Hyung Lee, Eun Jung Jang, Young Kyung Bae, Jina Baek, Min Hye Jang; J Pathol Transl Med. 2018;52(5):344-348. Published online July 17, 2018; DOI: https://doi.org/10.4132/jptm.2018.06.28

6,964 View
139 Download
2 Web of Science
4 Crossref

Abstract PDF

Gynandroblastoma is an extremely rare sex cord-stromal tumor with both female (granulosa cell tumor) and male (Sertoli-Leydig cell tumor) elements. Juvenile granulosa cell tumors are also very rare and are so named because they usually occur in children and adolescents. A 71-year-old woman with right upper quadrant abdominal pain visited our hospital. Pelvic computed tomography showed a large multilocular cystic mass, suspected to be of ovarian origin. We performed a total abdominal hysterectomy (total abdominal hysterectomy was performed) with bilateral salpingooophorectomy. A 13-cm multilocular cystic mass with serous fluid was observed in her right ovary. Upon microscopic examination, the solid component of the mass showed both Sertoli-Leydig cell and juvenile granulosa cell differentiation, which we diagnosed as gynandroblastoma. Gynandroblastoma with a juvenile granulosa cell tumor component is extremely rare and, until now, only six cases have been reported in the English literature. We report the first gynandroblastoma with a juvenile granulosa cell tumor component diagnosed in an elderly patient, along with a literature review.

Citations

Citations to this article as recorded by

Case of Gynandroblastoma of the Ovary with Raised AFP and Associated DICER 1 Mutation
Dipak Limbachiya, Rajnish Tiwari, Rashmi Kumari, Priti Trivedi
The Journal of Obstetrics and Gynecology of India.2024;[Epub] CrossRef
Ovarian cancer in children and adolescents: A unique clinical challenge
Marina Jakimovska Stefanovska, Aleksandar Celebic, Jean Calleja-Agius, Kristina Drusany Staric
European Journal of Surgical Oncology.2024; : 108785. CrossRef
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman
Soohyun Hwang, Byoung-Gie Kim, Sang Yong Song, Hyun-Soo Kim
Diagnostics.2020; 10(8): 537. CrossRef
Clinical and histological criteria for sex cord ovarian stromal tumors
A. М. Beishembaev, K. I. Zhordania
Obstetrics, Gynecology and Reproduction.2020; 14(3): 261. CrossRef

Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma: Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation: Taebum Lee, Sangjoon Choi, Joungho Han, Yoon-La Choi, Kyungjong Lee; J Pathol Transl Med. 2018;52(5):349-353. Published online July 27, 2018; DOI: https://doi.org/10.4132/jptm.2018.07.16

8,667 View
144 Download
14 Web of Science
14 Crossref

Abstract PDF

Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and here we report two rare cases of thoracic NMC with cytohistologic correlation. In aspiration cytology, the tumor presented with mixed cohesive clusters and dispersed single cells, diffuse background necrosis and many neutrophils. Most of the tumor cells had scanty cytoplasm and medium-sized irregular nuclei, which had fine to granular nuclear chromatin. Interestingly, a few dyskeratotic cells or squamoid cell clusters were present in each case. Biopsy specimen histology revealed more frequent squamous differentiation, and additional immunohistochemistry tests showed nuclear expression of NUT. Because this tumor has a notorious progression and has been previously underestimated in terms of its prevalence, awareness of characteristic findings and proper ancillary tests should be considered in all suspicious cases.

Citations

Citations to this article as recorded by

Diagnostic significance and cytological features of NUT carcinoma by EBUS‐FNA, a case report and literature review
Yaping Ju, Miriam Velazquez, Andy Sherrod, Tiannan Wang
Cytopathology.2024; 35(4): 497. CrossRef
Exploring cytologic features and potential diagnostic challenges of metastatic NUT carcinoma to the parotid gland: A case report and a comprehensive literature review
Crystal Y. Li, Salih Salihoglu, Francisco J. Civantos, Jaylou M. Velez Torres
Diagnostic Cytopathology.2024;[Epub] CrossRef
Nuclear Protein in Testis (NUT) Carcinoma: A Comprehensive Immunohistochemical Analysis of 57 Cases With Consideration of Interpretation and Pitfall Recognition
Ayesha Farooq, Allison L. Kerper, Jennifer M. Boland, Ying-Chun Lo
Archives of Pathology & Laboratory Medicine.2024; 148(8): 898. CrossRef
BRD3‐NUTM1‐expressing NUT carcinoma of lung on endobronchial ultrasound‐guided transbronchial needle aspiration cytology, a diagnostic pitfall
Sameer Chhetri Aryal, Shereen Zia, Shannon Rodgers, Yulei Shen, Kyle Perry, Lisi Yuan
Diagnostic Cytopathology.2022;[Epub] CrossRef
Nuclear protein of the testis midline carcinoma of the thorax
Ayae Saiki, Keita Sakamoto, Yuan Bee, Takehiro Izumo
Japanese Journal of Clinical Oncology.2022; 52(6): 531. CrossRef
Approach to Mediastinal Fine Needle Aspiration Cytology
Zaibo Li, Huihong Xu, Fang Fan
Advances in Anatomic Pathology.2022; 29(6): 337. CrossRef
Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review
Jiaqian Yuan, Zhili Xu, Yong Guo
Current Oncology.2022; 29(10): 6807. CrossRef
Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma
Linus D. Kloker, Branko Calukovic, Katrin Benzler, Alexander Golf, Sebastian Böhm, Sven Günther, Marius Horger, Simone Haas, Susanne Berchtold, Julia Beil, Mary E. Carter, Tina Ganzenmueller, Stephan Singer, Abbas Agaimy, Robert Stöhr, Arndt Hartmann, Tho
Frontiers in Oncology.2022;[Epub] CrossRef
Cytomorphology of primary pulmonary NUT carcinoma in different cytology preparations
Rimlee Dutta, Aruna Nambirajan, Saurabh Mittal, Sinchita Roy‐Chowdhuri, Deepali Jain
Cancer Cytopathology.2021; 129(1): 53. CrossRef
Update on genetically defined lung neoplasms: NUT carcinoma and thoracic SMARCA4-deficient undifferentiated tumors
Kyriakos Chatzopoulos, Jennifer M. Boland
Virchows Archiv.2021; 478(1): 21. CrossRef
Immunotherapy and Targeting the Tumor Microenvironment: Current Place and New Insights in Primary Pulmonary NUT Carcinoma
Xiang Li, Hui Shi, Wei Zhang, Chong Bai, Miaoxia He, Na Ta, Haidong Huang, Yunye Ning, Chen Fang, Hao Qin, Yuchao Dong
Frontiers in Oncology.2021;[Epub] CrossRef
Prevalence of NUT carcinoma in head and neck: Analysis of 362 cases with literature review
Taebum Lee, Junhun Cho, Chung‐Hwan Baek, Young‐Ik Son, Han‐Sin Jeong, Man Ki Chung, Sang Duk Hong, Yong Chan Ahn, Dong Ryul Oh, Jae Myoung Noh, Keunchil Park, Myung‐Ju Ahn, Hyung‐Jin Kim, Yi Kyung Kim, Young Hyeh Ko
Head & Neck.2020; 42(5): 924. CrossRef
Lung nuclear protein in testis carcinoma in an elderly Korean woman: A case report with cytohistological analysis
Hwa Jin Cho, Hyun‐Kyung Lee
Thoracic Cancer.2020; 11(6): 1724. CrossRef
Clinicopathological characteristics of primary lung nuclear protein in testis carcinoma: A single‐institute experience of 10 cases
Yoon Ah Cho, Yoon‐La Choi, Inwoo Hwang, Kyungjong Lee, Jong Ho Cho, Joungho Han
Thoracic Cancer.2020; 11(11): 3205. CrossRef

First
Prev
Page of 1
Next
Last

Previous issues