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Volume 53(3); May 2019
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Reviews
Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group
Dong Hoon Shin, Hyo Sup Shim, Tae Jung Kim, Heae Surng Park, Yun La Choi, Wan Seop Kim, Lucia Kim, Sun Hee Chang, Joon Seon Song, Hyo jin Kim, Jung Ho Han, Chang Hun Lee, Geon Kook Lee, Se Jin Jang
J Pathol Transl Med. 2019;53(3):153-158.   Published online February 28, 2019
DOI: https://doi.org/10.4132/jptm.2019.02.22
  • 5,730 View
  • 234 Download
  • 4 Citations
AbstractAbstract PDF
Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is an effective first line drug for advanced non-small cell lung cancer patients who harbor activating EGFR mutation. During the course of treatment, resistance against TKI arises which can be contributed to EGFR T790M mutation in about 50–60% of patients. Third generation TKI may overcome the resistance. In patients who cannot undergo tissue biopsy due to variable reasons, liquid biopsy is an excellent alternative for the detection of EGFR T790M mutation. However, this relatively novel method requires standardization and vigorous quality insurance. Thus, a standard set of guideline recommendations for liquid biopsy for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of provisional guideline recommendations that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

Citations

Citations to this article as recorded by  
  • Exosomes in Lung Cancer: Actors and Heralds of Tumor Development
    Amaia Sandúa, Estibaliz Alegre, Álvaro González
    Cancers.2021; 13(17): 4330.     CrossRef
  • Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
    Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
    Journal of Pathology and Translational Medicine.2021; 55(3): 181.     CrossRef
  • Current status and future perspectives of liquid biopsy in non-small cell lung cancer
    Sunhee Chang, Jae Young Hur, Yoon-La Choi, Chang Hun Lee, Wan Seop Kim
    Journal of Pathology and Translational Medicine.2020; 54(3): 204.     CrossRef
  • Prevalence of T790M mutation among TKI-therapy resistant Lebanese lung cancer patients based on liquid biopsy analysis: a first report from a major tertiary care center
    Hazem Assi, Arafat Tfayli, Nada Assaf, Sarah Abou Daya, Aram H. Bidikian, Dima Kawsarani, Puzant Fermanian, Ghazi Zaatari, Rami Mahfouz
    Molecular Biology Reports.2019; 46(4): 3671.     CrossRef
Primary Age-Related Tauopathy: An Elderly Brain Pathology Frequently Encountered during Autopsy
Daru Kim, Hyung-Seok Kim, Seong-Min Choi, Byeong C. Kim, Min-Cheol Lee, Kyung-Hwa Lee, Jae-Hyuk Lee
J Pathol Transl Med. 2019;53(3):159-163.   Published online March 19, 2019
DOI: https://doi.org/10.4132/jptm.2019.03.14
  • 5,305 View
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  • 15 Citations
AbstractAbstract PDF
Due to the progressive aging of Korean society and the introduction of brain banks to the Korean medical system, the possibility that pathologists will have access to healthy elderly brains has increased. The histopathological analysis of an elderly brain from a subject with relatively well-preserved cognition is quite different from that of a brain from a demented subject. Additionally, the histology of elderly brains differs from that of young brains. This brief review discusses primary age-related tauopathy; this term was coined to describe elderly brains with Alzheimer’s diseasetype neurofibrillary tangles mainly confined to medial temporal structures, and no β-amyloid pathology.

Citations

Citations to this article as recorded by  
  • Abnormal tau in amyloid PET negative individuals
    Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J. Ward, Susan M. Landau, William J Jagust
    Neurobiology of Aging.2022; 109: 125.     CrossRef
  • Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation
    Juan Jiang, Chen Yang, Jia-Qi Ai, Qi-Lei Zhang, Xiao-Lu Cai, Tian Tu, Lily Wan, Xiao-Sheng Wang, Hui Wang, Aihua Pan, Jim Manavis, Wei-Ping Gai, Chong Che, Ewen Tu, Xiao-Ping Wang, Zhen-Yan Li, Xiao-Xin Yan
    Frontiers in Aging Neuroscience.2022;[Epub]     CrossRef
  • LATE: Nicht jede Demenz ist Alzheimer – Diskussion einer neuen Krankheitsentität am Fallbeispiel
    Doreen Görß, Ingo Kilimann, Martin Dyrba, Sascha Nitsch, Bernd Krause, Stefan Teipel
    Der Nervenarzt.2021; 92(1): 18.     CrossRef
  • Alpha‐lipoic acid ameliorates tauopathy‐induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor
    Elahe Zarini-Gakiye, Nima Sanadgol, Kazem Parivar, Gholamhassan Vaezi
    Metabolic Brain Disease.2021; 36(4): 669.     CrossRef
  • Implications for microglial sex differences in tau-related neurodegenerative diseases
    Yasmine V. Doust, Anna E. King, Jenna M. Ziebell
    Neurobiology of Aging.2021; 105: 340.     CrossRef
  • G protein‐coupled receptor kinases are associated with Alzheimer's disease pathology
    Thais Rafael Guimarães, Eric Swanson, Julia Kofler, Amantha Thathiah
    Neuropathology and Applied Neurobiology.2021; 47(7): 942.     CrossRef
  • Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease
    Elahe Zarini-Gakiye, Gholamhassan Vaezi, Kazem Parivar, Nima Sanadgol
    CNS & Neurological Disorders - Drug Targets .2021; 20(5): 451.     CrossRef
  • Primary age-related tauopathy in a Chinese cohort
    Xin Wang, Lei Zhang, Hui Lu, Juan-li Wu, Hua-zheng Liang, Chong Liu, Qing-qing Tao, Zhi-ying Wu, Ke-qing Zhu
    Journal of Zhejiang University-SCIENCE B.2020; 21(3): 256.     CrossRef
  • Brain Aging, Cardiovascular Diseases, Mixed Dementia, and Frailty in the Oldest Old: From Brain Phenotype to Clinical Expression
    Gianmarco Rosa, Chiara Giannotti, Lucia Martella, Federico Massa, Gianluca Serafini, Matteo Pardini, Flavio Mariano Nobili, Fiammetta Monacelli, Patricia Mecocci
    Journal of Alzheimer's Disease.2020; 75(4): 1083.     CrossRef
  • Extracellular Sortilin Proteopathy Relative to β-Amyloid and Tau in Aged and Alzheimer’s Disease Human Brains
    Tian Tu, Juan Jiang, Qi-Lei Zhang, Lily Wan, Ya-Nan Li, Aihua Pan, Jim Manavis, Xiao-Xin Yan
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
  • A “Stress Test” of the 2018 NIA AA Research Criteria for Alzheimer’s Disease

    Helmut Hildebrandt, Andreas Kastrup, Paul Eling
    Zeitschrift für Neuropsychologie.2020; 31(1): 26.     CrossRef
  • Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir
    Ida Sonni, Orit H. Lesman Segev, Suzanne L. Baker, Leonardo Iaccarino, Deniz Korman, Gil D. Rabinovici, William J. Jagust, Susan M. Landau, Renaud La Joie
    Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.2020;[Epub]     CrossRef
  • Contemporary approaches to clinical diagnosis and treatment of tau-protein accumulation related multisystem degenerations
    E.E. Vasenina, O.S. Levin
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova.2020; 120(10): 22.     CrossRef
  • Sporadic Creutzfeldt-Jakob Disease and Other Proteinopathies in Comorbidity
    Eva Parobkova, Julie van der Zee, Lubina Dillen, Christine Van Broeckhoven, Robert Rusina, Radoslav Matej
    Frontiers in Neurology.2020;[Epub]     CrossRef
  • Early Dendritic Dystrophy in Human Brains With Primary Age-Related Tauopathy
    Yan-Bin Shi, Tian Tu, Juan Jiang, Qi-Lei Zhang, Jia-Qi Ai, Aihua Pan, Jim Manavis, Ewen Tu, Xiao-Xin Yan
    Frontiers in Aging Neuroscience.2020;[Epub]     CrossRef
Original Articles
Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma
Amany Salama, Mohammad Arafa, Eman ElZahaf, Abdelhadi Mohamed Shebl, Azmy Abd El-Hameed Awad, Sylvia A. Ashamallah, Reda Hemida, Anas Gamal, Abd AlRahman Foda, Khaled Zalata, El-Said M. Abdel-Hady
J Pathol Transl Med. 2019;53(3):164-172.   Published online February 28, 2019
DOI: https://doi.org/10.4132/jptm.2019.02.12
  • 6,493 View
  • 295 Download
  • 5 Citations
AbstractAbstract PDF
Background
In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the relationships among the expression of estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), Ki-67, and the different histopathological prognostic parameters in EC and to assess the value of these in the management of EC.
Methods
We examined 109 cases of EC. Immunohistochemistry for ER, PR, HER2, and Ki-67 were evaluated in relation to age, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage and grade, depth of infiltration, cervical and ovarian involvement, lymphovascular space invasion (LVSI), and lymph node (LN) metastasis.
Results
The mean age of patients in this study was 59.8 ± 8.2 years. Low ER and PR expression scores and high Ki-67 expression showed highly significant associations with non-endometrioid histology (p = .007, p < .001, and p < .001, respectively) and poor differentiation (p = .007, p < .001, and p <. 001, respectively). Low PR score showed a significant association with advanced stage (p = .009). Low ER score was highly associated with LVSI (p = .006), and low PR scores were associated significantly with LN metastasis (p = .026). HER2 expression was significantly related to advanced stages (p = .04), increased depth of infiltration (p = .02), LVSI (p = .017), ovarian involvement (p = .038), and LN metastasis (p = .038). There was a close relationship between HER2 expression and uterine cervical involvement (p = .009). Higher Ki-67 values were associated with LN involvement (p = .012).
Conclusions
The over-expression of HER2 and Ki-67 and low expression of ER and PR indicate a more malignant EC behavior. An immunohistochemical panel for the identification of high risk tumors can contribute significantly to prognostic assessments.

Citations

Citations to this article as recorded by  
  • Estrogen/Progesterone Receptor Loss, CTNNB1 and KRAS Mutations Are Associated With Local Recurrence or Distant Metastasis in Low-Grade Endometrial Endometrioid Carcinoma
    Rajni Chibbar, Sabrina Foerstner, Janarathnee Suresh, Richa Chibbar, Alexandre Piche, Deeksha Kundapur, Rani Kanthan, Vijayanand Kundapur, Cheng Han Lee, Anita Agrawal, Raymond Lai
    Applied Immunohistochemistry & Molecular Morphology.2023;[Epub]     CrossRef
  • Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma
    Mohammad Arafa, Abdelhadi Mohamed Shebl, Amany Salama, Eman ElZahaf, Sylvia A. Ashamallah, Abd AlRahman Foda, AzmyAbd El-Hameed Awad, Asem Shalaby
    European Journal of Obstetrics & Gynecology and Reproductive Biology: X.2022; 16: 100172.     CrossRef
  • Immunohistochemical Expression of Oestrogen and Epidermal Growth Factor Receptors in Endometrial Cancerous in Sudanese Patients
    Salwa Abdalraheem Abubaker, Mohamed Elfatih Abdelwadoud, Mutaz Mohamed Ali, Hadia Alhaj Ahmad, Abuobieda Mohamed Khlafalla, Osman Mohammed Elmahi, Hisham Ali Waggiallah
    Journal Of Biochemical Technology.2021; 12(1): 58.     CrossRef
  • Expression of ER/PR Receptor, Her-2/neu, Ki67 and p53 in Endometrial Carcinoma: Clinicopathological Implication and Prognostic Value
    V. B. Shivkumar, Manisha A. Atram, Nitin M. Gangane
    Indian Journal of Gynecologic Oncology.2020;[Epub]     CrossRef
  • Immunohistochemical study of ER, PR, p53 and Ki67 expression in patients with endometrial adenocarcinoma and atypical endometrial hyperplasia
    Rachana Lakhe, Ravi M Swami, Preeti Doshi, Manjiri N Karandikar, Ravindra Nimbargi
    IP Archives of Cytology and Histopathology Research.2020; 5(4): 274.     CrossRef
Prognostic Role of Claudin-1 Immunohistochemistry in Malignant Solid Tumors: A Meta-Analysis
Jung-Soo Pyo, Nae Yu Kim, Won Jin Cho
J Pathol Transl Med. 2019;53(3):173-179.   Published online March 5, 2019
DOI: https://doi.org/10.4132/jptm.2019.02.03
  • 5,238 View
  • 149 Download
  • 4 Citations
AbstractAbstract PDF
Background
Although the correlation between low claudin-1 expression and worse prognosis has been reported, details on the prognostic implications of claudin-1 expression in various malignant tumors remain unclear. The present study aimed to elucidate the prognostic roles of claudin- 1 immunohistochemistry (IHC) in various malignant tumors through a meta-analysis.
Methods
The study included 2,792 patients from 22 eligible studies for assessment of the correlation between claudin-1 expression and survival rate in various malignant tumors. A subgroup analysis based on the specific tumor and evaluation criteria of claudin-1 IHC was conducted.
Results
Low claudin-1 expression was significantly correlated with worse overall survival (OS) (hazard ratio [HR], 1.851; 95% confidence interval [CI], 1.506 to 2.274) and disease-free survival (DFS) (HR, 2.028; 95% CI, 1.313 to 3.134) compared to high claudin-1 expression. Breast, colorectal, esophageal, gallbladder, head and neck, and lung cancers, but not cervical, liver or stomach cancers, were significantly correlated with worse OS. Breast, colorectal, esophageal, and thyroid cancers with low claudin-1 expression were associated with poorer DFS. In the lower cut-off subgroup (< 25.0%) with respect to claudin-1 IHC, low claudin-1 expression was significantly correlated with worse OS and DFS.
Conclusions
Taken together, low claudin-1 IHC expression is significantly correlated with worse survival in various malignant tumors. More detailed criteria for claudin-1 IHC expression in various malignant tumors are needed for application in daily practice.

Citations

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  • The Significance of Relative Claudin Expression in Odontogenic Tumors
    Ekarat Phattarataratip, Kraisorn Sappayatosok
    Head and Neck Pathology.2020; 14(2): 480.     CrossRef
  • Claudin-1 upregulation is associated with favorable tumor features and a reduced risk for biochemical recurrence in ERG-positive prostate cancer
    Simon Kind, Franziska Büscheck, Doris Höflmayer, Claudia Hube-Magg, Martina Kluth, Maria Christina Tsourlakis, Stefan Steurer, Till S. Clauditz, Andreas M. Luebke, Eike Burandt, Waldemar Wilczak, Andrea Hinsch, David Dum, Sören Weidemann, Christoph Fraune
    World Journal of Urology.2020; 38(9): 2185.     CrossRef
  • Characterisation of endogenous Claudin‐1 expression, motility and susceptibility to hepatitis C virus in CRISPR knock‐in cells
    Camille M.H. Clément, Maika S. Deffieu, Cristina M. Dorobantu, Thomas F. Baumert, Nilda Vanesa Ayala‐Nunez, Yves Mély, Philippe Ronde, Raphael Gaudin
    Biology of the Cell.2020; 112(5): 140.     CrossRef
  • Comment on “Prognostic Role of Claudin-1 Immunohistochemistry in Malignant Solid Tumors: A Meta-Analysis”
    Bolin Wang, Yan Huang
    Journal of Pathology and Translational Medicine.2019; 53(6): 411.     CrossRef
Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Miseon Lee, In Ah Park, Sun-Hee Heo, Young-Ae Kim, Gyungyub Gong, Hee Jin Lee
J Pathol Transl Med. 2019;53(3):180-187.   Published online March 11, 2019
DOI: https://doi.org/10.4132/jptm.2019.02.08
  • 5,548 View
  • 181 Download
  • 12 Citations
AbstractAbstract PDF
Background
Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to the production of mutant p53 protein and usually show high levels of p53 protein expression. Tumor-infiltrating lymphocytes (TILs) accumulate as part of the anti-tumor immune response and have a strong prognostic and predictive significance in TNBC. We aimed to elucidate the association between p53 expression and the amount of TILs in TNBC.
Methods
In 678 TNBC patients, we evaluated TIL levels and expression of endoplasmic stress molecules. Immunohistochemical examination of p53 protein expression was categorized into three groups: no, low, and high expression.
Results
No, low, and high p53 expression was identified in 44.1% (n = 299), 20.1% (n = 136), and 35.8% (n = 243) of patients, respectively. Patients with high p53 expression showed high histologic grade (p < .001), high TIL levels (p = .009), and high expression of endoplasmic reticulum stress-associated molecules (p-eIF2a, p = .013; XBP1, p = .007), compared to patients with low p53 expression. There was no significant difference in disease-free (p = .406) or overall survival rates (p = .444) among the three p53 expression groups.
Conclusions
High p53 expression is associated with increased expression of endoplasmic reticulum stress molecules and TIL influx.

Citations

Citations to this article as recorded by  
  • Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy
    Sotiris Loizides, Anastasia Constantinidou
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner
    Xinyu Zhou, Abel Soto-Gamez, Fleur Nijdam, Rita Setroikromo, Wim J. Quax
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • New Challenges in the Differential Diagnosis of High-Grade Triple-Negative Breast Cancer and Serous Carcinoma
    Andrii Puzyrenko, Chandler S Cortina, Julie M Jorns
    International Journal of Surgical Pathology.2022; 30(7): 728.     CrossRef
  • Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer
    Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
    Frontiers in Immunology.2022;[Epub]     CrossRef
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    Ai-Yan Xing, Long Liu, Ke Liang, Bin Wang
    Cancer Investigation.2022; 40(10): 879.     CrossRef
  • Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer
    Arpita Poddar, Sushma R. Rao, Prashanth Prithviraj, George Kannourakis, Aparna Jayachandran
    Current Oncology.2022; 29(10): 6847.     CrossRef
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    Katarzyna Dominika Sluzalska, Jakub Slawski, Martyna Sochacka, Agata Lampart, Jacek Otlewski, Malgorzata Zakrzewska
    Cytokine & Growth Factor Reviews.2021; 57: 93.     CrossRef
  • Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: In Vitro and In Vivo Study
    Hiu Yee Kwan, Qinghua Xu, Ruihong Gong, Zhaoxiang Bian, Chih-Chang Chu
    Frontiers in Oncology.2021;[Epub]     CrossRef
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    Marie Colombe Agahozo, Marcel Smid, Ronald van Marion, Dora Hammerl, Thierry P. P. van den Bosch, Mieke A. M. Timmermans, Chayenne J. Heijerman, Pieter J. Westenend, Reno Debets, John W. M. Martens, Carolien H. M. van Deurzen
    Biology.2021; 10(8): 768.     CrossRef
  • With Our Powers Combined
    Lawrence Kasherman, Katherine Karakasis, Amit M. Oza
    The Cancer Journal.2021; 27(6): 511.     CrossRef
  • The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer


    Li Chen, Xiangyi Kong, Chengrui Yan, Yi Fang, Jing Wang
    OncoTargets and Therapy.2020; Volume 13: 1397.     CrossRef
  • Biomolecular Factors Represented by Bcl-2, p53, and Tumor-Infiltrating Lymphocytes Predict Response for Adjuvant Anthracycline Chemotherapy in Patients with Early Triple-Negative Breast Cancer


    Xenia Elena Bacinschi, Anca Zgura, Inga Safta, Rodica Anghel
    Cancer Management and Research.2020; Volume 12: 11965.     CrossRef
Case Studies
A Rare Case of Adenosquamous Carcinoma Arising in the Background of IgG4-Related Lung Disease
Sangjoon Choi, Sujin Park, Man Pyo Chung, Tae Sung Kim, Jong Ho Cho, Joungho Han
J Pathol Transl Med. 2019;53(3):188-191.   Published online March 11, 2019
DOI: https://doi.org/10.4132/jptm.2019.02.21
  • 4,512 View
  • 147 Download
  • 9 Citations
AbstractAbstract PDF
IgG4-related disease is a systemic inflammatory disease and is known as IgG4-related lung disease (IgG4-RLD) when it involves the respiratory system. Primary lung cancer arising from a background of IgG4-RLD is very rare. Herein, we report a case of adenosquamous carcinoma arising from the background of IgG4-RLD and presenting as an interstitial lung disease pattern. A 66-year-old man underwent lobectomy under the impression of primary lung cancer. Grossly, the mass was ill-defined and gray-tan colored, and the background lung was fibrotic. Microscopically, tumor cells showed both squamous and glandular differentiation. Dense lymphoplasmacytic infiltration with fibrosis and obliterative phlebitis were seen in the background lung. IgG4 immunohistochemical stain showed diffuse positivity in infiltrating plasma cells. Primary lung adenosquamous carcinoma has not been reported in a background of IgG4-RLD. Due to the rarity of IgG4-RLD, physicians must follow patients with IgG4-RLD over long periods of time to accurately predict the risk of lung cancer.

Citations

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  • Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses
    Jihee Sohn, Yurimi Lee, Hyun-Soo Kim
    Diagnostics.2022; 12(10): 2339.     CrossRef
  • A Case of IgG4-related Disease Composed of a Paravertebral Tumor Alone with Multiple Lung Cancers
    Mutsumi Ozasa, Toyomitsu Sawai, Yosuke Harada, Sumako Yoshioka, Nobuko Matsuo, Hiroshi Mukae
    Haigan.2021; 61(3): 213.     CrossRef
  • Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation
    Sangjoon Choi, Yoon Yang Jung, Hyun-Soo Kim
    Diagnostics.2021; 11(4): 717.     CrossRef
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    Daiki Sakamoto, Masao Yagi, Hiroshi Iwai
    Practica Oto-Rhino-Laryngologica.2021; 114(7): 547.     CrossRef
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    Sujin Park, Go Eun Bae, Jiyoung Kim, Hyun-Soo Kim
    Diagnostics.2021; 11(8): 1450.     CrossRef
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    Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim
    Diagnostics.2021; 11(11): 2042.     CrossRef
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    Josué Pinto, Carla Damas, António Morais
    Archivos de Bronconeumología.2020; 56(1): 53.     CrossRef
  • Not Cancer After All: Two Rare Cases of IgG4-Related Lung Disease
    Josuèc) Pinto, Carla Damas, António Morais
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    Yutaro Ito, Masanori Harada, Namio Kagoo, Tsutomu Kubota, Koshiro Ichijyo, Eisuke Mochizuki, Masahiro Uehara, Shun Matsuura, Masaru Tsukui, Naoki Koshimizu
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Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
J Pathol Transl Med. 2019;53(3):192-197.   Published online April 11, 2019
DOI: https://doi.org/10.4132/jptm.2019.03.20
  • 4,620 View
  • 132 Download
  • 4 Citations
AbstractAbstract PDF
A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.

Citations

Citations to this article as recorded by  
  • Scoring system for intraoperative diagnosis of intracranial schwannoma by squash cytology
    Hirotaka Fujita, Takuma Tajiri, Tomohisa Machida, Nozomi Nomura, Suguru Toguchi, Hitoshi Itoh, Shinichiro Hiraiwa, Tomoko Sugiyama, Chie Inomoto, Masaaki Imai, Shinri Oda, Masami Shimoda, Naoya Nakamura
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    Coby Cunningham, Rocco Dabecco, Justin Davanzo
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    Saori NAKANISHI, Naoto KURODA, Toshiko TAKAI, Mari KOJIMA, Misato OONOGI
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    Na Rae Kim, Gie-Taek Yie
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JPTM : Journal of Pathology and Translational Medicine