Journal of Pathology and Translational Medicine

Case Reports

Primary Thymic Mucinous Adenocarcinoma: A Case Report: Jamshid Abdul-Ghafar, Suk-Joong Yong, Woocheol Kwon, Il Hwan Park, Soon-Hee Jung; Korean J Pathol. 2012;46(4):377-381. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.377

7,810 View
75 Download
19 Crossref

Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.

Citations

Citations to this article as recorded by

Primary mucinous adenocarcinoma of the thymus
Kohei Soejima, Hidehito Matsuoka
The Journal of the Japanese Association for Chest Surgery.2024; 38(6): 545. CrossRef
Stage IV thymic mucinous adenocarcinoma under long-term disease control after primary tumor resection: A case report
Chihaya Maeda, Tomoyuki Hishida, Kyohei Masai, Keisuke Asakura, Katsura Emoto, Hisao Asamura
The Journal of the Japanese Association for Chest Surgery.2022; 36(2): 156. CrossRef
Lenvatinib-refractory thymic mucinous carcinoma with PIK3CA mutation
Akihiro Tsukaguchi, Shoichi Ihara, Hironao Yasuoka, Seigo Minami
International Cancer Conference Journal.2022; 12(1): 36. CrossRef
Thymic mucinous adenocarcinoma: A case report
Hideki Tsubouchi, Naoki Ozeki, Yuka Suzuki, Koji Kawaguchi, Takayuki Fukui, Toyofumi F. Chen-Yoshikawa
The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 547. CrossRef
Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
Man Li, Xiao-Yu Pu, Li-Hua Dong, Peng-Yu Chang
World Journal of Clinical Cases.2021; 9(7): 1676. CrossRef
Primary Mucinous Adenocarcinoma of the Thymus: a Rare Type of Thymic Carcinoma—Case Report
Koichi Tomoshige, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Ryusuke Machino, Satoshi Mizoguchi, Takamune Matumoto, Yutaka Maeda, Takeshi Nagayasu
SN Comprehensive Clinical Medicine.2021; 3(5): 1233. CrossRef
Primary mucinous adenocarcinoma of the thymus: A case report
Tomoka Hamahiro, Ryo Maeda, Takanori Ayabe, Yuichiro Sato, Masaki Tomita
Respiratory Medicine Case Reports.2021; 34: 101497. CrossRef
Primary Thymic Mucinous Adenocarcinoma: A Case Report Focusing on Radiological Findings and Review of the Literature
Young Hoon Koo, Jae Wook Lee, Jai Soung Park, Kyung Eun Shin, Heon Lee, Susie Chin
Iranian Journal of Radiology.2020;[Epub] CrossRef
Mucinous adenocarcinoma of the thymus: report of a case
Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara
General Thoracic and Cardiovascular Surgery.2018; 66(2): 111. CrossRef
Thymic enteric type adenocarcinoma: A case report with cytological features
Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta
Diagnostic Cytopathology.2018; 46(1): 92. CrossRef
Primary thymic adenocarcinomas: a clinicopathological and immunohistochemical study of 16 cases with emphasis on the morphological spectrum of differentiation
Neda Kalhor, Cesar A. Moran
Human Pathology.2018; 74: 73. CrossRef
Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Pathology - Research and Practice.2017; 213(2): 106. CrossRef
Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
Journal of Pathology and Translational Medicine.2017; 51(5): 509. CrossRef
Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano
Pathology International.2016; 66(1): 29. CrossRef
Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
Akihiko Sawaki, Mikiya Ishihara, Yuji Kozuka, Hiroyasu Oda, Satoshi Tamaru, Yumiko Sugawara, Yoshiki Yamashita, Toshiro Mizuno, Taizo Shiraishi, Naoyuki Katayama
International Cancer Conference Journal.2016; 5(2): 113. CrossRef
Adenocarcinoma of the Thymus, Enteric Type
Bernhard Moser, Ana Iris Schiefer, Stefan Janik, Alexander Marx, Helmut Prosch, Wolfgang Pohl, Barbara Neudert, Anke Scharrer, Walter Klepetko, Leonhard Müllauer
American Journal of Surgical Pathology.2015; 39(4): 541. CrossRef
A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer
Eun Na Cho, Hye Sung Park, Tae Hoon Kim, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang
Tuberculosis and Respiratory Diseases.2015; 78(2): 112. CrossRef
A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature
Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh
Journal of Pathology and Translational Medicine.2015; 49(4): 331. CrossRef
Primary mucinous adenocarcinoma of the thymus: a case report
Tadashi Sakane, Kotaro Mizuno, Risa Oda, Takuya Matsui, Makoto Ito, Takeshi Yamada
The Journal of the Japanese Association for Chest Surgery.2014; 28(7): 904. CrossRef

A Case of Ovarian Microinvasive Mucinous Carcinoma and Co-existent Angiosarcoma.: Jin Hyung Heo, Yoon Hee Lee, Gwang Il Kim, Tae Heon Kim, Haeyoun Kang, Hee Jung An, Bo Sung Yoon, Seok Ju Seong, Hyun Park, Ji Young Kim; Korean J Pathol. 2011;45(1):96-100.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.96

3,057 View
22 Download
5 Crossref

Abstract PDF

Primary ovarian angiosarcoma is very rare with only 27 cases reported so far in the medical literature. We report here on a rare case of ovarian microinvasive mucinous carcinoma that was coexistent with angiosarcoma in a 54-year-old woman. The tumor was a 26x19x10 cm-sized multilocular cystic mass with a 4x3 cm-sized solid hematoma-like nodule in the center. Microscopically, it was composed mostly of mucinous tumor of various grades from borderline to microinvasive carcinoma. The hematoma-like area turned out to be an angiosarcoma, composed of pleomorphic cells that formed slit-like spaces, spindle cells that formed short fascicles and anastomosing vascular channels with atypical endothelial cells. All these cells were positive for CD31, CD34 and factor VIII-related antigen. The patient developed peritoneal and pleural metastases, which were angiosarcoma and mucinous carcinoma, respectively. We believe this case is only the fourth example of an ovarian collision tumor of angiosarcoma and surface epithelial tumor.

Citations

Citations to this article as recorded by

Ovarian angiosarcoma: A systematic review of literature and survival analysis
Shafi Rehman, Arya Harikrishna, Amisha Silwal, B.R. Sumie, Safdar Mohamed, Nisha Kolhe, Meghana Maddi, Linh Huynh, Jesus Gutierrez, Yoshita Rao Annepu, Ameer Mustafa Farrukh
Annals of Diagnostic Pathology.2024; 73: 152331. CrossRef
Tumor to Tumor Metastasis: A Case Report of Metastatic Angiosarcoma to an Ovarian Brenner Tumor and Review of the Literature
Bilge Dundar, Audai Alrwashdeh, Laila Dahmoush
International Journal of Gynecological Pathology.2023; 42(2): 176. CrossRef
Collision Tumors in Ovary: Case Series and Literature Review
Borges A, Loddo A, Martins A, Peiretti M, Fanni D, Djokovic D
Journal of Surgical Oncology.2019; : 1. CrossRef
Angiosarcoma Arising in Ovarian Mucinous Tumor: A Challenge in Intraoperative Frozen Section Diagnosis
Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Tip Pongsuvareeyakul, Sumalee Siriaunkgul
Case Reports in Pathology.2016; 2016: 1. CrossRef
Impact of body burden of pesticide residues on the reproductive tract of buffalo
KARANPREET KAUR, SARVPREET SINGH GHUMAN, OPINDER SINGH, JASBIR SINGH BEDI, JATINDER PAUL SINGH GILL
The Indian Journal of Animal Sciences.2016;[Epub] CrossRef

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma Co-existing with Mucinous Carcinoma: A Case Report.: Sunhee Chang, Sang Hwa Shim, Mee Joo, Hanseong Kim, Yong Kyu Kim; Korean J Pathol. 2010;44(1):97-100.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.1.97

4,121 View
44 Download
9 Crossref

Abstract PDF

An endocrine mucin-producing sweat gland carcinoma (EMPSGC) is a rare skin tumor that most commonly occurs on the eyelids of elderly women. This tumor is morphologically analogous to endocrine ductal carcinoma in situ and solid papillary carcinoma of the breast. We describe one case of a 51-year-old male with an EMPSGC co-existing with mucinous carcinoma of the eyelid. The tumor was composed of dilated ducts with a smooth border and was partially filled with a papillary proliferation. Tumor cells were uniform, small-to-medium in size, and oval-to-polygonal with light eosinophilic cytoplasm. Nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Tumor cells expressed chromogranin, synaptophysin, estrogen and progesterone receptors, cytokeratin 7, and epithelial membrane antigen.

Citations

Citations to this article as recorded by

A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma of the Eyelid
Ji Eon Kang, Sung Eun Kim, Suk-Woo Yang
Journal of the Korean Ophthalmological Society.2023; 64(2): 149. CrossRef
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis
Michael H. Froehlich, Keith R. Conti, Ivy I. Norris, Jordan J. Allensworth, Nicole A. Ufkes, Shaun A. Nguyen, Evelyn T. Bruner, Joel Cook, Terry A. Day
Journal of Dermatological Treatment.2022; 33(4): 2182. CrossRef
Next-generation sequencing analysis suggests varied multistep mutational pathogenesis for endocrine mucin-producing sweat gland carcinoma with comments on INSM1 and MUC2 suggesting a conjunctival origin
Joseph G. Mathew, Anita S. Bowman, Jad Saab, Klaus J. Busam, Kishwer Nehal, Melissa Pulitzer
Journal of the American Academy of Dermatology.2022; 86(5): 1072. CrossRef
Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature
Rebecca Tian Mei Au, Manish M. Bundele
Journal of Cutaneous Pathology.2021; 48(9): 1156. CrossRef
An Update on Endocrine Mucin-producing Sweat Gland Carcinoma
Meghana Agni, Meisha L. Raven, Randy C. Bowen, Nora V. Laver, Patricia Chevez-Barrios, Tatyana Milman, Charles G. Eberhart, Steven Couch, Daniel D. Bennett, Daniel M. Albert, R. Nick Hogan, Paul O. Phelps, Hillary Stiefel, Norberto Mancera, Martin Hyrcza,
American Journal of Surgical Pathology.2020; 44(8): 1005. CrossRef
A Case of Endocrine Mucin-Producing Sweat Gland Carcinoma: Is it Still an Under-Recognized Entity?
Khaled A. Murshed, Mohamed Ben-Gashir
Case Reports in Dermatology.2020; 12(3): 255. CrossRef
Endocrine Mucin-Producing Sweat Gland Carcinoma, a Histological Challenge
Mary Anne Brett, Samih Salama, Gabriella Gohla, Salem Alowami
Case Reports in Pathology.2017; 2017: 1. CrossRef
Endocrine mucin‐producing sweat gland carcinoma occurring on extra‐facial site: a case report
Jia‐Huei Tsai, Tzu‐Lin Hsiao, Yi‐Ying Chen, Cheng‐Hsiang Hsiao, Jau‐Yu Liau
Journal of Cutaneous Pathology.2014; 41(6): 544. CrossRef
Endocrine Mucin-Producing Sweat Gland Carcinoma
Catharine A. Dhaliwal, Antonia Torgersen, Jonathan J. Ross, James W. Ironside, Asok Biswas
The American Journal of Dermatopathology.2013; 35(1): 117. CrossRef

Minimal Deviation Adenocarcinoma, Mucinous Type, of the Uterine Cervix: Report of a Case with Extensive Metastasis to the Uterine Corpus and Bilateral Adnexae.: Eundeok Chang, Eunjung Lee, Kyoungmee Kim, Okran Shin, Youngmi Ku, Heejung An, Changsuk Kang; Korean J Pathol. 2004;38(2):121-125.

1,621 View
16 Download

Abstract PDF: Minimal deviation adenocarcinoma is an extremely well differentiated variant of cervical adenocarcinoma, and is frequently misdiagnosed due to its benign-looking histopathological features. A 38-year-old woman was diagnosed as having had a minimal deviation adenocarcinoma in the cervix, metastasizing to the uterine body and bilateral adnexae. She had a history of right salpingo-oophorectomy 3 years ago, and was diagnosed as having a mucinous cystadenoma. Histologically, the tumor cells were so well-differentiated that they appeared to be almost the same as those of the non-neoplastic cervical glands. Similar glands were found in both ovaries and in the left fallopian tube. PAS staining showed a negative or apical positive pattern in the endocervical-like glands. Immunohistochemical studies for CEA, ER/PR, cytokeratin 20, and p53 were negative, but positive for cytokeratin 7. The HPV DNA microarray test was negative. Clinically, this proved to be an advanced, biologically aggressive disease.

Endometrial Mucinous Adenocarcinoma with Extensive Squamous Differentiation: A Case Report.: Ho chang Lee, Pil Gyu Hwang, Soo Youn Cho, Young S Park, In Ae Park; Korean J Pathol. 2003;37(6):438-441.

1,905 View
37 Download

Abstract PDF: Endometrial mucinous adenocarcinoma occurs in 1-9% of endometrial adenocarcinomas and adenocarcinoma with squamous differentiation in approximately 25%. We report a rare case of mucinous adenocarcinoma with squamous differentiation in a 53-year-old woman. Curetting biopsies of the endometrial lesion were taken twice after hormone replacement therapy, which lasted for four months. Because the squamous differentiation was so extensive, the initial diagnosis based on each curetting specimen was squamous papilloma. A total hysterectomy was performed and the tumor was revealed to be a mucinous adenocarcinoma with squamous differentiation. We subsequently discussed the pathogenesis and prognosis of this type of tumor.

First
Prev
Page of 1
Next
Last

Search