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8 "Hye Sook Min"
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Original Article
The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists
Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Park, Soon Won Hong, Mi Kyung Shin
J Pathol Transl Med. 2017;51(4):410-417.   Published online June 14, 2017
DOI: https://doi.org/10.4132/jptm.2017.04.05
  • 9,164 View
  • 221 Download
  • 21 Web of Science
  • 20 Crossref
AbstractAbstract PDF
Background
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea.
Methods
Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed.
Results
Sixty out of 74 institutes answering the surveys reported the results of thyroid FNA in accordance with TBSRTC. The average malignancy rates for resected cases in 15 institutes were as follows: nondiagnostic, 45.6%; benign, 16.5%; atypical of undetermined significance, 68.8%; suspicious for follicular neoplasm (SFN), 30.2%; suspicious for malignancy, 97.5%; malignancy, 99.7%.
Conclusions
More than 80% of Korean institutes were using TBSRTC as of 2012. All malignancy rates other than the SFN and malignancy categories were higher than those reported by other countries. Therefore, the guidelines for treating patients with thyroid nodules in Korea should be revisited based on the malignancy rates reported in this study.

Citations

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  • Thyroid Fine-Needle Aspiration Cytology Practice in Korea
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Review
Pathology Reporting of Thyroid Core Needle Biopsy: A Proposal of the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group
Chan Kwon Jung, Hye Sook Min, Hyo Jin Park, Dong Eun Song, Jang Hee Kim, So Yeon Park, Hyunju Yoo, Mi Kyung Shin, Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group
J Pathol Transl Med. 2015;49(4):288-299.   Published online June 17, 2015
DOI: https://doi.org/10.4132/jptm.2015.06.04
  • 17,116 View
  • 434 Download
  • 103 Web of Science
  • 98 Crossref
AbstractAbstract PDF
In recent years throughout Korea, the use of ultrasound-guided core needle biopsy (CNB) has become common for the preoperative diagnosis of thyroid nodules. However, there is no consensus on the pathology reporting system for thyroid CNB. The Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group held a conference on thyroid CNB pathology and developed guidelines through contributions from the participants. This article discusses the outcome of the discussions that led to a consensus on the pathology reporting of thyroid CNB.

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    H.C. Kim, Y.J. Kim, H.Y. Han, J.M. Yi, J.H. Baek, S.Y. Park, J.Y. Seo, K.W. Kim
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    Jung Hwan Baek
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    Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
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    Soon-Hyun Ahn, So-Yeon Park, Sang Il Choi
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    Chong Hyun Suh, Young Jun Choi, Jong Jin Lee, Woo Hyun Shim, Jung Hwan Baek, Han Cheol Chung, Young Kee Shong, Dong Eun Song, Tae Yon Sung, Jeong Hyun Lee
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    Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
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    Chan Kwon Jung, Jung Hwan Baek
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    Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
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    Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Jae Kyun Kim, Tae-Yon Sung, Jong Ho Yoon, Young Kee Shong
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    Dong Gyu Na, Ji-hoon Kim, Dea Sik Kim, Soo Jin Kim
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    Dong Gyu Na, Dae Sik Kim, Soo Jin Kim, Jae Wook Ryoo, So Lyung Jung
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    Dong Gyu Na, Jung Hwan Baek, Jin Yong Sung, Ji-Hoon Kim, Jae Kyun Kim, Young Jun Choi, Hyobin Seo
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    Paul A. VanderLaan
    Cancer Cytopathology.2016; 124(12): 862.     CrossRef
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    Chong Hyun Suh, Jung Hwan Baek, Jeong Hyun Lee, Young Jun Choi, Kyung Won Kim, Jayoun Lee, Ki-Wook Chung, Young Kee Shong
    Endocrine.2016; 54(2): 315.     CrossRef
  • The Role of Core-Needle Biopsy for Thyroid Nodules with Initially Nondiagnostic Fine-Needle Aspiration Results: A Systematic Review and Meta-Analysis
    Chong Hyun Suh, Jung Hwan Baek, Kyung Won Kim, Tae Yon Sung, Tae Yong Kim, Dong Eun Song, Young Jun Choi, Jeong Hyun Lee
    Endocrine Practice.2016; 22(6): 679.     CrossRef
  • Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?
    Beril Guler, Tugce Kiran, Dilek Sema Arici, Erhan Aysan, Fatma Cavide Sonmez
    Endocrine Pathology.2016; 27(4): 352.     CrossRef
  • A Multicenter Prospective Validation Study for the Korean Thyroid Imaging Reporting and Data System in Patients with Thyroid Nodules
    Eun Ju Ha, Won-Jin Moon, Dong Gyu Na, Young Hen Lee, Nami Choi, Soo Jin Kim, Jae Kyun Kim
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  • Impact of Reclassification on Thyroid Nodules with Architectural Atypia: From Non-Invasive Encapsulated Follicular Variant Papillary Thyroid Carcinomas to Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features
    Min Ji Jeon, Dong Eun Song, Chan Kwon Jung, Won Gu Kim, Hyemi Kwon, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Rafael Rosell
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Case Study
Follicular Proliferative Lesion Arising in Struma Ovarii
Min Jee Park, Min A Kim, Mi Kyung Shin, Hye Sook Min
J Pathol Transl Med. 2015;49(3):262-266.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.26
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  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Malignant struma ovarii is extremely rare and difficult to diagnose histologically, particularly in cases of follicular carcinoma. This case study is intended to describe three cases of follicular proliferative lesion arising in struma ovarii that we experienced. The first case was clearly malignant given the clinical picture of multiple recurrences, but there was little histological evidence of malignancy. Our second case featured architectural and cellular atypia and necrosis and was diagnosed as malignant despite the absence of vascular and stromal invasion. Our third case exhibit-ed solid microfollicular proliferation without any definite evidence of malignancy (even the molecular data was negative); however, we could not completely exclude malignant potential after conducting a literature review. In cases such as our third case, it has been previously suggested that a diagnostic term recognizing the low-grade malignant potential, such as “proliferative stromal ovarii” or “follicular proliferative lesion arising in the stromal ovarii” would be appropriate.

Citations

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  • Role of gene sequencing in classifying struma ovarii: BRAF p.G469A mutation and TERT promoter alterations favour malignant struma ovarii
    Sophie Neyrand, Alexis Trecourt, Jonathan Lopez, Pierre Alexandre Just, Françoise Descotes, Françoise Borson‐Chazot, Isabelle Ray‐Coquard, Myriam Decaussin‐Petrucci, Mojgan Devouassoux‐Shisheboran
    Histopathology.2024; 84(2): 291.     CrossRef
  • Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations
    Roberta Poli, Maria Scatolini, Enrico Grosso, Francesca Maletta, Marco Gallo, Daniele Liscia, Anna Nelva, Flora Cesario, Giuseppe Forte, Jasna Metovic, Marco Volante, Emanuela Arvat, Mauro Papotti
    Endocrine.2021; 71(1): 216.     CrossRef
  • Proliferative struma ovarii: A rare case report
    Shankhanila Mazumdar, GaganKumar Rangari, Neeraj Dhameja, NishaRani Agrawal
    International Journal of Clinicopathological Correlation.2021; 5(2): 85.     CrossRef
  • Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis
    Takafumi Tsukada, Hiroshi Yoshida, Mitsuya Ishikawa, Yuka Asami, Kouya Shiraishi, Tomoyasu Kato
    Gynecologic Oncology Reports.2019; 30: 100498.     CrossRef
  • A Rare Case: Struma Ovarii in a 14-Year-Old Girl
    Elif Iltar, Isin Ureyen, Tayfun Toptas, Melike Savas, Sema Çekiç, Aysel Uysal
    Journal of Adolescent and Young Adult Oncology.2018; 7(1): 134.     CrossRef
  • Proliferative Highly Differentiated Follicular Carcinoma Of Ovarian Origin (Hdfco) Presenting Long After Bilateral Oophorectomy
    Natalie M. Liu, Neda Moatamed, Racquel S. Bueno, Wendy L. Sacks
    AACE Clinical Case Reports.2017; 3(3): e264.     CrossRef
Original Article
The Diagnostic Usefulness of HMGA2, Survivin, CEACAM6, and SFN/14-3-3 δ in Follicular Thyroid Carcinoma
Min Hye Jang, Kyeong Cheon Jung, Hye Sook Min
J Pathol Transl Med. 2015;49(2):112-117.   Published online March 12, 2015
DOI: https://doi.org/10.4132/jptm.2015.01.31
  • 8,156 View
  • 74 Download
  • 11 Web of Science
  • 12 Crossref
AbstractAbstract PDF
Background
Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy and its differential diagnosis includes follicular adenoma (FA) and adenomatous goiter (AG). Several ancillary markers have been suggested to aid in the diagnosis of FTC, but the successful use of these methods still needs to be validated. Methods: In the present study, we verified the immunoexpression of HMGA2, CEACAM6, survivin, and SFN/14-3-3 δ in lesions including 41 AGs, 72 FAs, and 79 FTCs. We evaluated their diagnostic usefulness, combined with galectin 3, Hector Battifora mesothelial 1 (HBME1), cytokeratin 19, and cyclin D1, in diagnosing FTC. Results: The expressions of HBME1 (65.8%) and HMGA2 (55.7%) were significantly higher in FTCs than in FAs and AGs (p<.001 and p=.005, respectively). HBME1 was the only marker that was more frequently expressed in FTCs than in FAs (p=.021) and it was more frequently expressed in follicular neoplasms than in AGs (p<.001). Among the novel markers, the combination of HMGA2 and HBME1 showed the highest sensitivity (72.2%) and specificity (76.1%) for diagnosing FTC. CEACAM6, survivin, and SFN/14-3-3 δ were barely expressed in most cases. Conclusions: Our present results show that only HMGA2 can be beneficial in differentiating FTC using the novel markers.

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  • HMGA2 promotes nasopharyngeal carcinoma progression and is associated with tumor resistance and poor prognosis
    Xinting Ouyang, Kangxin Li, Jiaqi Wang, Weijian Zhu, Qiang Yi, Jinghua Zhong
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • miR‐98‐5p promotes apoptosis and inhibits migration and cell growth in papillary thyroid carcinoma through Bax/Caspase‐3 by HMGA2
    Kai Qiu, QingJi Xie, Shan Jiang, Ting Lin
    Journal of Clinical Laboratory Analysis.2020;[Epub]     CrossRef
  • High mobility group A protein-2 as a tumor cancer diagnostic and prognostic marker: a systematic review and meta-analysis
    Yen Thi-Hai Pham, Ovie Utuama, Claire E. Thomas, Jong A. Park, Carlo La Vecchia, Harvey A. Risch, Chi Thi-Du Tran, Thanh V. Le, Paolo Boffetta, Leon Raskin, Hung N. Luu
    European Journal of Cancer Prevention.2020; 29(6): 565.     CrossRef
  • Diagnostic performance of HMGA2 gene expression for differentiation of malignant thyroid nodules: A systematic review and meta‐analysis
    Bo Hyun Kim, Seong Jang Kim, Mijin Kim, Sang‐Woo Lee, Shin Young Jeong, Kyoungjune Pak, Keunyoung Kim, In Joo Kim
    Clinical Endocrinology.2018; 89(6): 856.     CrossRef
  • Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution
    Geneviève Dom, Sandra Frank, Sebastien Floor, Pashalina Kehagias, Frederick Libert, Catherine Hoang, Guy Andry, Alex Spinette, Ligia Craciun, Nicolas de Saint Aubin, Christophe Tresallet, Frederique Tissier, Frederique Savagner, Samira Majjaj, Ilse Gutier
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    Yourha Kim, Min-Hee Kim, Sora Jeon, Jeeyoon Kim, Chankyung Kim, Ja Seong Bae, Chan Kwon Jung, Yves St-Pierre
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    Joanna Waligórska-Stachura, Nadia Sawicka-Gutaj, Maciej Zabel, Mirosław Andrusiewicz, Paweł Gut, Agata Czarnywojtek, Marek Ruchała
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    Adelaide Greco, Sandra Albanese, Luigi Auletta, Peppino Mirabelli, Antonella Zannetti, Crescenzo D'Alterio, Gennaro Di Maro, Francesca Maria Orlandella, Giuliana Salvatore, Andrea Soricelli, Marco Salvatore
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    Irina S. Berjozkina, Tat'jana V. Saprina, Anastasija P. Zima, Anna V. Isaeva, Venera N. Latipova, Marat R. Muhamedov, Leonid R. Bazilevich, Oleg S. Popov, Dar'ja A. Skuratovskaja, Kristina A. Jurova, Larisa C. Litvinova
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Brief Case Report
A Case of Epithelioid Blue Nevus
Chung Hun Lee, Hye Sook Min, Eon Sub Park, Kye Yong Song
Korean J Pathol. 2014;48(6):434-437.   Published online December 31, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.6.434
  • 9,528 View
  • 69 Download
  • 3 Crossref
PDF

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  • A Curious Case of a Pigmented Lesion
    Dilshad Sachedina, Marisa Taylor
    Indian Journal of Dermatology.2024; 69(1): 104.     CrossRef
  • Recurrence of a Cellular Blue Nevus with Satellitosis—A Diagnostic Pitfall with Clinical Consequences
    Hermann Kneitz, Christian Rose, Valerie Glutsch, Matthias Goebeler
    Dermatopathology.2022; 9(4): 361.     CrossRef
  • Epithelioid Blue Nevus
    Kai-Lv Sun, Jian-Min Chang
    International Journal of Dermatology and Venereology.2020; 3(3): 186.     CrossRef
Original Article
Immunohistochemical and Molecular Characteristics of Follicular Patterned Thyroid Nodules with Incomplete Nuclear Features of Papillary Thyroid Carcinoma.
Hye Sook Min, Gheeyoung Choe, Nam Yun Cho, Gyeong Hoon Kang, Seong Hoe Park, So Yeon Park
Korean J Pathol. 2009;43(6):495-502.
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.495
  • 3,796 View
  • 27 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. METHODS: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). RESULTS: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. CONCLUSIONS: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.

Citations

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  • A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant withBRAFK601E Mutation and Three Conventional Types withBRAFV600E Mutation
    Wook Youn Kim, Young Sin Ko, Tae Sook Hwang, Hye Seung Han, So Dug Lim, Wan Seop Kim, Seo Young Oh
    Korean Journal of Pathology.2013; 47(3): 293.     CrossRef
  • The Frequency ofBRAFMutation in Very Small Papillary Thyroid Carcinomas
    Taeeun Kim, Ji-Hyun Roh, Hee-Jung Park, Jee Eun Kwon, So-Young Kang, Yoon-La Choi, Young Lyun Oh
    The Korean Journal of Pathology.2010; 44(3): 308.     CrossRef
Case Report
Histiocytic Sarcoma of the Spleen: A Case Report and Review of the Literature.
Jin Ho Paik, Yoon Kyung Jeon, Sung Shin Park, Hye Sook Min, Young A Kim, Ji Eun Kim, Chul Woo Kim
Korean J Pathol. 2005;39(5):356-359.
  • 1,840 View
  • 36 Download
AbstractAbstract PDF
True histiocytic sarcoma is an extremely rare tumor. Its clinicopathological features are not clearly understood. Here, we report the first Korean case of primary splenic histiocytic sarcoma. A 64-year-old female having refractory thrombocytopenia, anemia and splenic mass was admitted to the hospital, and received splenectomy. Grossly, spleen was enlarged up to 18 x 13 x 8 cm and occupied with multinodular masses. Microscopically, the masses were composed of atyical large cells with abudant cytoplasm and vesicular nuclei with prominent hemophagocytosis. The tumor cells were CD68 (+), S-100 protein (-), CD21 (-), CD1a (-). After splenectomy, thrombocytopenia and anemia were corrected. However two months later the symptoms recurred, and the patient died 15 months after splenectomy. This case shared the common clinicopathologic features with the several previously reported cases in other countries, represented by splenic mass formation and prominent hemophagocytosis associated with thrombocytopenia and anemia, often leading to poor outcome.
Original Article
Immunohistochemical Analysis of Insular Carcinoma of the Thyroid Gland.
Hye Sook Min, Jin Ho Paik, Kyoung Bun Lee, Seong Hoe Park, Doo Hyun Chung
Korean J Pathol. 2005;39(5):326-331.
  • 2,370 View
  • 40 Download
AbstractAbstract PDF
BACKGROUND
Insular thyroid carcinoma (ITC) is a relatively infrequent thyroid carcinoma that has distinctive histologic features. ITC shows an aggressive clinical course and the predominant presence of an insular component, which has been reported to be an independent factor of a poor prognosis. We retrospectively examined clinical details of the nine ITC patients, which represented 9 years of experience with ITC, and investigated the expressions of variable neuroendocrine and other immunohistochemical markers associated with well-differentiated thyroid carcinomas.
METHODS
We adopted an immunohistochemical approach and studied the expressions of synaptophysin, chromogranin A, CD56, NSE, S-100, RET, PPARgamma, calcitonin, galectin-3, and thyroglobulin in formalin-fixed, paraffin embedded tissue array slides of the 9 ITC patients, and investigated clinical features. Seven cases of follicular carcinoma and 4 cases of medullary carcinoma were also included as controls.
RESULTS
ITCs were positive for synaptophysin (44%, 4/9), CD56 (11%, 1/9), NSE (89%, 8/9), S100 (67%, 6/9), calcitonin (22%, 2/9), galectin-3 (78%, 7/9), and thyroglobulin (100%, 9/9), but completely negative for chromogranin A, RET, and PPARgamma.
CONCLUSION
ITCs express neuroendocrine markers in variable proportions and appear not to be associated with the oncoproteins of conventional thyroid carcinomas. Notably, its differential diagnosis from medullary carcinoma is required in cases showing focal calcitonin positivity.

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