Journal of Pathology and Translational Medicine

Original Article

The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists: Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Park, Soon Won Hong, Mi Kyung Shin; J Pathol Transl Med. 2017;51(4):410-417. Published online June 14, 2017; DOI: https://doi.org/10.4132/jptm.2017.04.05

9,165 View
221 Download
21 Web of Science
20 Crossref

Background
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea.
Methods
Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed.
Results
Sixty out of 74 institutes answering the surveys reported the results of thyroid FNA in accordance with TBSRTC. The average malignancy rates for resected cases in 15 institutes were as follows: nondiagnostic, 45.6%; benign, 16.5%; atypical of undetermined significance, 68.8%; suspicious for follicular neoplasm (SFN), 30.2%; suspicious for malignancy, 97.5%; malignancy, 99.7%.
Conclusions
More than 80% of Korean institutes were using TBSRTC as of 2012. All malignancy rates other than the SFN and malignancy categories were higher than those reported by other countries. Therefore, the guidelines for treating patients with thyroid nodules in Korea should be revisited based on the malignancy rates reported in this study.

Citations

Citations to this article as recorded by

Improved Diagnostic Accuracy of Thyroid Fine-Needle Aspiration Cytology with Artificial Intelligence Technology
Yujin Lee, Mohammad Rizwan Alam, Hongsik Park, Kwangil Yim, Kyung Jin Seo, Gisu Hwang, Dahyeon Kim, Yeonsoo Chung, Gyungyub Gong, Nam Hoon Cho, Chong Woo Yoo, Yosep Chong, Hyun Joo Choi
Thyroid®.2024; 34(6): 723. CrossRef
Welcoming the new, revisiting the old: a brief glance at cytopathology reporting systems for lung, pancreas, and thyroid
Rita Luis, Balamurugan Thirunavukkarasu, Deepali Jain, Sule Canberk
Journal of Pathology and Translational Medicine.2024; 58(4): 165. CrossRef
Predictors of Malignancy in Thyroid Nodules Classified as Bethesda Category III
Xiaoli Liu, Jingjing Wang, Wei Du, Liyuan Dai, Qigen Fang
Frontiers in Endocrinology.2022;[Epub] CrossRef
Risk stratification of indeterminate thyroid nodules by novel multigene testing: a study of Asians with a high risk of malignancy
Chunfang Hu, Weiwei Jing, Qing Chang, Zhihui Zhang, Zhenrong Liu, Jian Cao, Linlin Zhao, Yue Sun, Cong Wang, Huan Zhao, Ting Xiao, Huiqin Guo
Molecular Oncology.2022; 16(8): 1680. CrossRef
CD56 Expression in Papillary Thyroid Carcinoma Is Highly Dependent on the Histologic Subtype: A Potential Diagnostic Pitfall
Uiju Cho, Yourha Kim, Sora Jeon, Chan Kwon Jung
Applied Immunohistochemistry & Molecular Morphology.2022; 30(5): 389. CrossRef
Malignancy rates in thyroid nodules: a long-term cohort study of 17,592 patients
M Grussendorf, I Ruschenburg, G Brabant
European Thyroid Journal.2022;[Epub] CrossRef
Subclassification of the Bethesda Category III (AUS/FLUS): A study of thyroid FNA cytology based on ThinPrep slides from the National Cancer Center in China
Huan Zhao, HuiQin Guo, LinLin Zhao, Jian Cao, Yue Sun, Cong Wang, ZhiHui Zhang
Cancer Cytopathology.2021; 129(8): 642. CrossRef
Effect of the Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP) Nomenclature Revision on Indian Thyroid Fine-Needle Aspiration Practice
Chanchal Rana, Pooja Ramakant, Divya Goel, Akanksha Singh, KulRanjan Singh, Suresh Babu, Anand Mishra
American Journal of Clinical Pathology.2021; 156(2): 320. CrossRef
Comprehensive DNA Methylation Profiling Identifies Novel Diagnostic Biomarkers for Thyroid Cancer
Jong-Lyul Park, Sora Jeon, Eun-Hye Seo, Dong Hyuck Bae, Young Mun Jeong, Yourha Kim, Ja Seong Bae, Seon-Kyu Kim, Chan Kwon Jung, Yong Sung Kim
Thyroid.2020; 30(2): 192. CrossRef
Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta‐analysis
Huy Gia Vuong, Hanh Thi Tuyet Ngo, Andrey Bychkov, Chan Kwon Jung, Trang Huyen Vu, Kim Bach Lu, Kennichi Kakudo, Tetsuo Kondo
Cancer Cytopathology.2020; 128(4): 238. CrossRef
Thyroid cancer among patients with thyroid nodules in Yemen: a three-year retrospective study in a tertiary center and a specialty clinic
Butheinah A. Al-Sharafi, Jamila A. AlSanabani, Ibraheem M. Alboany, Amani M. Shamsher
Thyroid Research.2020;[Epub] CrossRef
Is Bethesda classification sufficient to predict thyroid cancer in endemic regions?
Gamze ÇITLAK, Bahar CANBAY TORUN
Journal of Surgery and Medicine.2020; 4(9): 794. CrossRef
Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
PLOS ONE.2020; 15(11): e0241597. CrossRef
Nuclear features of papillary thyroid carcinoma: Comparison of Core needle biopsy and thyroidectomy specimens
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho, Younghye Kim, Seung Yeon Ha
Annals of Diagnostic Pathology.2018; 32: 35. CrossRef
Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors
Chan Kwon Jung, Yourha Kim, Sora Jeon, Kwanhoon Jo, Sohee Lee, Ja Seong Bae
Human Pathology.2018; 81: 9. CrossRef
The History of Korean Thyroid Pathology
Soon Won Hong, Chan Kwon Jung
International Journal of Thyroidology.2018; 11(1): 15. CrossRef
Thyroid FNA cytology in Asian practice—Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid carcinomas
K. Kakudo, M. Higuchi, M. Hirokawa, S. Satoh, C. K. Jung, A. Bychkov
Cytopathology.2017; 28(6): 455. CrossRef
Thyroid Fine-Needle Aspiration Cytology Practice in Korea
Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
Journal of Pathology and Translational Medicine.2017; 51(6): 521. CrossRef
Current Practices of Thyroid Fine-Needle Aspiration in Asia: A Missing Voice
Andrey Bychkov, Kennichi Kakudo, SoonWon Hong
Journal of Pathology and Translational Medicine.2017; 51(6): 517. CrossRef
Current Status of Thyroid Fine-Needle Aspiration Practice in Thailand
Somboon Keelawat, Samreung Rangdaeng, Supinda Koonmee, Tikamporn Jitpasutham, Andrey Bychkov
Journal of Pathology and Translational Medicine.2017; 51(6): 565. CrossRef

Brief Case Report

Dedifferentiated Endometrioid Adenocarcinoma of the Uterus: Highly Aggressive and Poor Prognostic Tumor: Shin Young Park, Moon Hyang Park, Hyoung Suk Ko, Eun Jung Cha, Jang Sihn Sohn, Un Suk Jung, Chul Jung Kim, Jin Suk Kim; Korean J Pathol. 2014;48(4):327-330. Published online August 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.327

11,423 View
117 Download
11 Crossref

PDF

Citations

Citations to this article as recorded by

Treatment and outcomes in undifferentiated and dedifferentiated endometrial carcinoma
Sarah Nicole Hamilton, Anna V. Tinker, Janice Kwon, Peter Lim, Iwa Kong, Sona Sihra, Martin Koebel, Cheng Han Lee
Journal of Gynecologic Oncology.2022;[Epub] CrossRef
Cytological aspects of an endometrial dedifferentiated carcinoma that was associated with a highly aggressive clinical course
Takako WAKAHARA, Sumiyo ADACHI, Kyota HANAMI, Takayoshi KOYASU, Yoshimitsu RYO, Kazunori FUGO, Kazuto YAMAZAKI
The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 385. CrossRef
Cytologic features of undifferentiated and dedifferentiated carcinomas of the endometrium
Amir‐Hossein Akbari, Lu Wang, Robert A. Soslow, Rajmohan Murali
Cancer Cytopathology.2021; 129(2): 121. CrossRef
Magnetic resonance imaging findings in 11 cases of dedifferentiated endometrial carcinoma of the uterus
Nao Kikkawa, Kimiteru Ito, Hiroshi Yoshida, Mayumi Kobayashi Kato, Yuko Kubo, Yasuyuki Onishi, Haruto Sugawara, Tomoyasu Kato, Masahiko Kusumoto
Japanese Journal of Radiology.2021; 39(5): 477. CrossRef
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
Rajmohan Murali, Ben Davidson, Oluwole Fadare, Joseph A. Carlson, Christopher P. Crum, C. Blake Gilks, Julie A. Irving, Anais Malpica, Xavier Matias-Guiu, W. Glenn McCluggage, Khush Mittal, Esther Oliva, Vinita Parkash, Joanne K. L. Rutgers, Paul N. Staat
International Journal of Gynecological Pathology.2019; 38(Supplement): S40. CrossRef
Dedifferentiated endometrial adenocarcinoma with neuroendocrine differentiation and ballooning-cell features: Report of a rare entity with an unusual histology
Sara Makhdoum, M. Ruhul Quddus, Michele M. Lomme, Katrine Hansen, W. Dwayne Lawrence
Human Pathology: Case Reports.2019; 15: 92. CrossRef
Unique Molecular Features in High-Risk Histology Endometrial Cancers
Pooja Pandita, Xiyin Wang, Devin E. Jones, Kaitlyn Collins, Shannon M. Hawkins
Cancers.2019; 11(11): 1665. CrossRef
Dedifferentiated endometrioid adenocarcinoma with trophoblastic components and elevated serum alfa-fetoprotein
He Cai, Rong Zhou, Wanying Liang, Jianliu Wang
Medicine.2018; 97(17): e0551. CrossRef
Dedifferentiated endometrioid carcinoma of the uterus : report of four cases and review of literature
Jiheun Han, Eun Young Ki, Sung Eun Rha, SooYoung Hur, Ahwon Lee
World Journal of Surgical Oncology.2017;[Epub] CrossRef
Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma
Shinichi Harada, Keiki Nagaharu, Youichirou Baba, Tetsuya Murata, Toshiro Mizuno, Keiki Kawakami
Case Reports in Oncological Medicine.2017; 2017: 1. CrossRef
Ampullary carcinosarcoma with osteosarcomatous, small cell neuroendocrine carcinoma and conventional adenocarcinoma components; First report
Pallavi Rao, Sadiq S. Sikora, Srikanth Narayanaswamy, Nandita Ghosal, Dinesh Kini
Pathology - Research and Practice.2016; 212(11): 1071. CrossRef

Case Study

Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study: Hyoungsuk Ko, Shin Young Park, Eun Jung Cha, Jang Sihn Sohn; Korean J Pathol. 2013;47(3):289-292. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.289

7,128 View
44 Download
16 Crossref

Abstract PDF

Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.

Citations

Citations to this article as recorded by

Intussusception of Heterotopic Gastric Mucosa in the Transverse Colon: A Rare Cause of Perforation and Bleeding
Sho Fujiwara, Ryuichi Nishimura, Nozomi Koyamada
Cureus.2024;[Epub] CrossRef
Gastric heterotopia of colon found cancer workup in liver abscess: A case report
Jun Gi Park, Jeong Ill Suh, Yeo Un Kim
World Journal of Clinical Cases.2022; 10(15): 5012. CrossRef
Gastric heterotopia in the ileum mimicking Meckel's diverticulum
Reza Shojaeian, Negar Nekooei, Paria Dehghanian
Journal of Pediatric Surgery Case Reports.2022; 84: 102361. CrossRef
Sometimes Things Are Not Where They Are Supposed to Be: A Case Report of Gastric Heterotopia in the Rectum
Asher Lippe, Scott Lippe
Physician's Journal of Medicine.2022;[Epub] CrossRef
Gastric heterotopia of the rectum
Eduardo Dantas, Diva Yamaguti, Kendi Yamazaki
Gastroenterología y Hepatología.2021; 44(8): 579. CrossRef
Bleeding Gastric Heterotopia of Cecal Diverticulum in an Adolescent: A Case Report
Hyun-Il Seo, Jae-Young Kwak
Advances in Pediatric Surgery.2021; 27(1): 32. CrossRef
Gastric heterotopia of the rectum
Eduardo Dantas, Diva Yamaguti, Kendi Yamazaki
Gastroenterología y Hepatología (English Edition).2021; 44(8): 579. CrossRef
Polypoid Gastric Heterotopia of Colon
Marcela Adriana Duran Alvarez, Carla Noemi Tafur Sanchez
GE - Portuguese Journal of Gastroenterology.2020; 27(1): 65. CrossRef
Heterotopic Respiratory Mucosa in the Rectum: An Unusual Type and Site of Heterotopia in the Gastrointestinal Tract
Caroline Bsirini, Pratyusha Tirumanisetty, Joseph N. Dytoc, Diana Agostini-Vulaj, Christopher Steevens, Asad Ullah, Aaron R. Huber
International Journal of Surgical Pathology.2019; 27(2): 221. CrossRef
Perforation of Heterotopic Gastric Mucosa in ileal duplication in an adult: A case report
Vaanathi Paulvannan, Seshukumar Bylapudi, Mithun Kumar Ramesh Kumar, Mahesh Nachimuthu, Paulvannan Subramanian
Journal of Surgical Case Reports.2019;[Epub] CrossRef
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst
Louis J. Ligthelm, Belinda K. Bunn, Erich J. Raubenheimer, Willie F. P. van Heerden
Head & Neck.2018;[Epub] CrossRef
The outlet patch: gastric heterotopia of the colorectum and anus
Abul A S R Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam‐Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth A Montgomery
Histopathology.2018; 73(2): 220. CrossRef
Large heterotopic gastric mucosa and a concomitant diverticulum in the rectum: Clinical experience and endoscopic management
Wen-Guo Chen, Hua-Tuo Zhu, Ming Yang, Guo-Qiang Xu, Li-Hua Chen, Hong-Tan Chen
World Journal of Gastroenterology.2018; 24(30): 3462. CrossRef
Gastric heterotopia in the rectum. A rare cause of ectopic gastric tissue
George A. Salem, Javid Fazili, Tauseef Ali
Arab Journal of Gastroenterology.2017; 18(1): 42. CrossRef
Gastric heterotopia in rectum: A literature review and its diagnostic pitfall
Peyman Dinarvand, Ashley A. Vareedayah, Nancy J Phillips, Christine Hachem, Jinping Lai
SAGE Open Medical Case Reports.2017;[Epub] CrossRef
Heterotopic gastric mucosa in the anus and rectum: first case report of endoscopic submucosal dissection and systematic review
Federico Iacopini, Takuji Gotoda, Walter Elisei, Patrizia Rigato, Fabrizio Montagnese, Yutaka Saito, Guido Costamagna, Giampaolo Iacopini
Gastroenterology Report.2016; 4(3): 196. CrossRef

Original Article

Four Cases of Intrapulmonary Hamartoma: An ultrastructural study.: Ho Jong Chun, Keun Hong Kee, Chae Hong Suh, Jang Sihn Sohn, Chung Hee Chi; Korean J Pathol. 1988;22(1):70-81.

1,517 View
13 Download

Abstract PDF: Tumors of the lung and bronchi containing cartilage were known by a variety of names, chondroma, adenochondroma, chondromatous hamartoma and mixed tumor. This variation in nomenclatures explain the difference of illustration on the nature of these tumor. The concept pulmonary harmatomas are benign neoplasm and not developmental malformations, has gained wide acceptance in recent years. We have experienced four cases of intrapulmonary hamartoma which were all discovered during routine chest film check up for certificate of health and evaluation of other disease. One case is added further detailed histologic examination by electron microscopy. The age at time of the detection were 53 (male), 23 (male), 39 (female), and 56 (female) years old. The mean size is 4.3x3.7x3.4 cm. The locations were three left upper lobes and one right upper lobe. Lobectomy and wedge resecions were done. Cut surface showed promiment lobular structures, papillary configuration and multiple cleft like spaces. Predominant cellular components were cartilage but fat tissue in one of the four cases. Microscopic findings showed abundant hyaline cartilages bearing lobular configuration and overlying pseudostratified ciliated columnar and cuboidal epithelium. Fibromyxoid and undifferentiated cells were seen in myxoid and fatty tissue. Electron microscopic findings revealed stellate, undifferentiated mesenchymal cells bearing collagen formation, stellate smooth muscle and transition areas between undifferentiated mesenchymal cells and mature cartilage. Epithelial components were similar to terminal bronchiole and alveolar epithelium. These findings suggest the concept that intrapulmonary hamartoma represent a histologic specturm of benign mesenchymal neoplasms, which originate in peribronchial connective tissue.

First
Prev
Page of 1
Next
Last

Search