Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Sentinel lymph node"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review
Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist’s Point of View
Sophia K. Apple
J Pathol Transl Med. 2016;50(2):83-95.   Published online January 12, 2016
DOI: https://doi.org/10.4132/jptm.2015.11.23
  • 19,541 View
  • 459 Download
  • 32 Web of Science
  • 27 Crossref
AbstractAbstract PDF
Breast cancer staging, in particular N-stage changed most significantly due to the advanced technique of sentinel lymph node biopsy two decades ago. Pathologists have more thoroughly examined and scrutinized sentinel lymph node and found increased number of small volume metastases. While pathologists use the strict criteria from the Tumor Lymph Node Metastasis (TNM) Classification, studies have shown poor reproducibility in the application of American Joint Committee on Cancer and International Union Against Cancer/TNM guidelines for sentinel lymph node classification in breast cancer. In this review article, a brief history of TNM with a focus on N-stage is described, followed by innate problems with the guidelines, and why pathologists may have difficulties in assessing lymph node metastases uniformly. Finally, clinical significance of isolated tumor cells, micrometastasis, and macrometastasis is described by reviewing historical retrospective data and significant prospective clinical trials.

Citations

Citations to this article as recorded by  
  • Association between postoperative pathological results and non-sentinel nodal metastasis in breast cancer patients with sentinel lymph node-positive breast cancer
    Lingguang Dong, Suosu Wei, Zhen Huang, Fei Liu, Yujie Xie, Jing Wei, Chongde Mo, Shengpeng Qin, Quanqing Zou, Jianrong Yang
    World Journal of Surgical Oncology.2024;[Epub]     CrossRef
  • Clonal dominance defines metastatic dissemination in pancreatic cancer
    I-Lin Ho, Chieh-Yuan Li, Fuchenchu Wang, Li Zhao, Jingjing Liu, Er-Yen Yen, Charles A. Dyke, Rutvi Shah, Zhaoliang Liu, Ali Osman Çetin, Yanshuo Chu, Francesca Citron, Sergio Attanasio, Denise Corti, Faezeh Darbaniyan, Edoardo Del Poggetto, Sara Loponte,
    Science Advances.2024;[Epub]     CrossRef
  • Prognosis of isolated tumor cells and use of molecular classification in early stage endometrioid endometrial cancer
    Eric Rios-Doria, Nadeem R Abu-Rustum, Kaled M Alektiar, Vicky Makker, Ying L Liu, Dmitriy Zamarin, Claire F Friedman, Carol Aghajanian, Lora H Ellenson, Sarah Chiang, Britta Weigelt, Jennifer J Mueller, Mario M Leitao
    International Journal of Gynecologic Cancer.2024; 34(9): 1373.     CrossRef
  • Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma
    Takashi Matsuzuka, Kiyoaki Tsukahara, Seiichi Yoshimoto, Kazuaki Chikamatsu, Akihiro Shiotani, Isao Oze, Yoshiko Murakami, Takeshi Shinozaki, Yuichiro Enoki, Shinichi Ohba, Daisuke Kawakita, Nobuhiro Hanai, Yusuke Koide, Michi Sawabe, Yusuke Nakata, Yujir
    Scientific Reports.2023;[Epub]     CrossRef
  • The Role of Nodes and Nodal Assessment in Diagnosis, Treatment and Prediction in ER+, Node-Positive Breast Cancer
    Charlene Kay, Carlos Martinez-Perez, J. Michael Dixon, Arran K. Turnbull
    Journal of Personalized Medicine.2023; 13(10): 1476.     CrossRef
  • Artificial Intelligence in Breast Cancer Diagnosis and Personalized Medicine
    Jong Seok Ahn, Sangwon Shin, Su-A Yang, Eun Kyung Park, Ki Hwan Kim, Soo Ick Cho, Chan-Young Ock, Seokhwi Kim
    Journal of Breast Cancer.2023; 26(5): 405.     CrossRef
  • Clinicopathological predictors of finding additional inguinal lymph node metastases in penile cancer patients after positive dynamic sentinel node biopsy: a European multicentre evaluation
    Hielke M. de Vries, Hack Jae Lee, Wayne Lam, Rosa S. Djajadiningrat, Sarah R. Ottenhof, Eduard Roussel, Bin Klaas Kroon, Igle Jan de Jong, Pedro Oliveira, Hussain M. Alnajjar, Maarten Albersen, Asif Muneer, Vijay Sangar, Arie Parnham, Benjamin Ayres, Nick
    BJU International.2022; 130(1): 126.     CrossRef
  • Fast Segmentation of Metastatic Foci in H&E Whole-Slide Images for Breast Cancer Diagnosis
    Muhammad-Adil Khalil, Yu-Ching Lee, Huang-Chun Lien, Yung-Ming Jeng, Ching-Wei Wang
    Diagnostics.2022; 12(4): 990.     CrossRef
  • Comparative Analysis of Postoperative Complications of Sentinel Node Identification Using the SentiMag® Method and the Use of a Radiotracer in Patients with Breast Cancer
    Andrzej Lorek, Katarzyna Steinhof-Radwańska, Wojciech Zarębski, Joanna Lorek, Zoran Stojčev, Jacek Zych, Aleksandra Syrkiewicz, Paweł Niemiec, Karol Szyluk
    Current Oncology.2022; 29(5): 2887.     CrossRef
  • Improving Cancer Metastasis Detection via Effective Contrastive Learning
    Haixia Zheng, Yu Zhou, Xin Huang
    Mathematics.2022; 10(14): 2404.     CrossRef
  • Spatiality Sensitive Learning for Cancer Metastasis Detection in Whole-Slide Images
    Haixia Zheng, Yu Zhou, Xin Huang
    Mathematics.2022; 10(15): 2657.     CrossRef
  • Independent assessment of a deep learning system for lymph node metastasis detection on the Augmented Reality Microscope
    David Jin, Joseph H. Rosenthal, Elaine E. Thompson, Jared Dunnmon, Arash Mohtashamian, Daniel Ward, Ryan Austin, Hassan Tetteh, Niels H. Olson
    Journal of Pathology Informatics.2022; 13: 100142.     CrossRef
  • Generalization of Deep Learning in Digital Pathology: Experience in Breast Cancer Metastasis Detection
    Sofia Jarkman, Micael Karlberg, Milda Pocevičiūtė, Anna Bodén, Péter Bándi, Geert Litjens, Claes Lundström, Darren Treanor, Jeroen van der Laak
    Cancers.2022; 14(21): 5424.     CrossRef
  • Assessment of cellular and humoral immunity in sentinel lymph node in breast cancer
    A. D. Neryakhin, A. U. Gallyamov, D. N. Kamilianov, E. H. Sunagatullina, R. U. Kamalov, L. A. Sharafutdinova
    Ural Medical Journal.2022; 21(6): 13.     CrossRef
  • Lessons Learned from Designing an AI-Enabled Diagnosis Tool for Pathologists
    Hongyan Gu, Jingbin Huang, Lauren Hung, Xiang 'Anthony' Chen
    Proceedings of the ACM on Human-Computer Interaction.2021; 5(CSCW1): 1.     CrossRef
  • Deep Regional Metastases Segmentation for Patient-Level Lymph Node Status Classification
    Lu Wang, Tian Song, Takafumi Katayama, Xiantao Jiang, Takashi Shimamoto, Jenq-Shiou Leu
    IEEE Access.2021; 9: 129293.     CrossRef
  • Isolated tumor cells in the regional lymph nodes in patients with squamous cell carcinoma of the esophagus are rarely observed but often represent part of a true metastasis
    Dea Natalie Munch Jepsen, Anne-Marie Kanstrup Fiehn, Bonnie Svendsen, Michael Patrick Achiam, Birgitte Federspiel
    Annals of Diagnostic Pathology.2020; 45: 151478.     CrossRef
  • Independent risk factors for axillary lymph node metastasis in breast cancer patients with one or two positive sentinel lymph nodes
    Wei Zhang, Jing Xu, Ke Wang, Xiao-Jiang Tang, Hua Liang, Jian-Jun He
    BMC Women's Health.2020;[Epub]     CrossRef
  • The spectrum of pathological diagnoses in non-sentinel axillary lymph node biopsy: A single institution's experience
    Wei Huang, Xiaoyu Tang, Jozef Malysz, Bing Han, Zhaohai Yang
    Annals of Diagnostic Pathology.2020; 49: 151646.     CrossRef
  • Ultrasonographic Algorithm for the Assessment of Sentinel Lymph Nodes That Drain the Mammary Carcinomas in Female Dogs
    Florin Stan, Alexandru Gudea, Aurel Damian, Adrian Florin Gal, Ionel Papuc, Alexandru Raul Pop, Cristian Martonos
    Animals.2020; 10(12): 2366.     CrossRef
  • Prognostic Value of EndoPredict in Women with Hormone Receptor–Positive, HER2-Negative Invasive Lobular Breast Cancer
    Ivana Sestak, Martin Filipits, Richard Buus, Margaretha Rudas, Marija Balic, Michael Knauer, Ralf Kronenwett, Florian Fitzal, Jack Cuzick, Michael Gnant, Richard Greil, Mitch Dowsett, Peter Dubsky
    Clinical Cancer Research.2020; 26(17): 4682.     CrossRef
  • Performance of Molecular Lymphosonography for Detection and Quantification of Metastatic Involvement in Sentinel Lymph Nodes
    Kibo Nam, Robert Stapp, Ji‐Bin Liu, Maria Stanczak, Flemming Forsberg, Patrick L. O'Kane, Zhou Lin, Ziyin Zhu, Jingzhi Li, Charalambos C. Solomides, John R. Eisenbrey, Andrej Lyshchik
    Journal of Ultrasound in Medicine.2019; 38(8): 2103.     CrossRef
  • Application of Circulation Tumor Cells Detection in Diagnosis and Treatment of Breast Tumors
    Fengfeng Cai, Chunmei Cen, Lu Cai, Manuel Antonio Falar Luis, Ewelina Biskup
    Rejuvenation Research.2019; 22(6): 498.     CrossRef
  • Artificial Intelligence–Based Breast Cancer Nodal Metastasis Detection: Insights Into the Black Box for Pathologists
    Yun Liu, Timo Kohlberger, Mohammad Norouzi, George E. Dahl, Jenny L. Smith, Arash Mohtashamian, Niels Olson, Lily H. Peng, Jason D. Hipp, Martin C. Stumpe
    Archives of Pathology & Laboratory Medicine.2019; 143(7): 859.     CrossRef
  • Isolated tumor cells in regional lymph nodes in patients with adenocarcinoma of the esophagogastric junction might represent part of true metastases
    Anne-Marie Kanstrup Fiehn, Dea Natalie Munch Jepsen, Michael Patrick Achiam, Heidi Ugleholdt, Birgitte Federspiel
    Human Pathology.2019; 93: 90.     CrossRef
  • Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer
    David F. Steiner, Robert MacDonald, Yun Liu, Peter Truszkowski, Jason D. Hipp, Christopher Gammage, Florence Thng, Lily Peng, Martin C. Stumpe
    American Journal of Surgical Pathology.2018; 42(12): 1636.     CrossRef
  • One-step nucleic acid amplification (OSNA): where do we go with it?
    Yasuhiro Tamaki
    International Journal of Clinical Oncology.2017; 22(1): 3.     CrossRef
Case Report
Pseudometastasis in Sentinel Lymph Nodes with Cytokeratin Debris-containing Histiocytes in Breast Cancer Patient: A Case Report.
Keum Ha Choi, Eun Jung Cha, Ha Na Choi, Woo Sung Moon
Korean J Pathol. 2007;41(6):427-429.
  • 2,004 View
  • 38 Download
AbstractAbstract PDF
Immunohistochemical staining for cytokeratins can detect false negative nodes in patients with breast carcinoma. We report on a patient with breast carcinoma and pseudometastasis detected by immunohistochemical staining within a negative sentinel lymph node. A 66-year-old woman underwent a simple mastectomy and sentinel lymph node biopsy. Immunohistochemical staining of the sentinel nodes for cytokeratin in permanent sections showed cells with intense cytoplasmic staining in the subcapsular sinus. The cells were negative for epithelial membrane antigen staining, but positive for CD68. In combination with morphologic findings and immunohistochemistry, cytokeratin-positive cells were confirmed as histiocytes with phagocytized cytokeratin debris. Careful correlation with histology and additional IHC could help avoid a misinterpretation of this type of pseudometastasis.

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP