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Case Study
Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia
Hyo Jeong Kang, Hui Jeong Jeong, So-Woon Kim, Eunsil Yu, Young-Joo Lee, So Yeon Kim, Jihun Kim
J Pathol Transl Med. 2018;52(4):226-231.   Published online December 27, 2017
DOI: https://doi.org/10.4132/jptm.2017.11.12
  • 6,382 View
  • 149 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.

Citations

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  • Hepatocellular carcinoma arising from hepatic adenoma in a young woman
    Haythem Yacoub, Hela Kchir, Dhouha Cherif, Hajer Hassine, Slim Haouet, Asma Ayari, Habiba Mizouni, Saber Mannai, Mohamed Tahar Khalfallah, Nadia Maamouri
    Clinical Case Reports.2020; 8(9): 1659.     CrossRef
  • Metanephric adenoma with osseous metaplasia and bone marrow elements
    Alessandro Pietro Aldera, Jeff John, Dharshnee Chetty, Dhirendra Govender
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Review
Article image
Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips
So-Woon Kim, Jin Roh, Chan-Sik Park
J Pathol Transl Med. 2016;50(6):411-418.   Published online October 13, 2016
DOI: https://doi.org/10.4132/jptm.2016.08.08
  • 45,812 View
  • 1,809 Download
  • 243 Web of Science
  • 237 Crossref
AbstractAbstract PDF
Immunohistochemistry (IHC) is an important auxiliary method for pathologists in routine diagnostic work as well as in basic and clinical research including exploration of biomarkers, as IHC allows confirmation of target molecule expressions in the context of microenvironment. Although there has been a considerable progress in automation and standardization of IHC, there are still many things to be considered in proper optimization and appropriate interpretation. In this review, we aim to provide possible pitfalls and useful tips for practicing pathologists and residents in pathology training. First, general procedure of IHC is summarized, followed by pitfalls and tips in each step and a summary of troubleshooting. Second, ways to an accurate interpretation of IHC are discussed, with introduction to general quantification and analysis methods. This review is not intended to provide complete information on IHC, but to be used as a basic reference for practice and publication.

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Brief Case Reports
Clear Cell Papulosis: A Case Report
So-Woon Kim, Jin Roh, Chan-Sik Park
J Pathol Transl Med. 2016;50(5):401-403.   Published online May 29, 2016
DOI: https://doi.org/10.4132/jptm.2016.02.16
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Indeterminate Dendritic Cell Tumor: A Case Report of a Rare Langerhans Cell Lineage Disease
Jin Roh, So-Woon Kim, Chan-Sik Park
J Pathol Transl Med. 2016;50(1):78-81.   Published online August 4, 2015
DOI: https://doi.org/10.4132/jptm.2015.07.03
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