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- Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
- Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
- J Pathol Transl Med. 2019;53(3):192-197. Published online April 11, 2019
- DOI: https://doi.org/10.4132/jptm.2019.03.20
- 5,821 View
- 153 Download
- 5 Web of Science
- 6 Crossref
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Abstract
PDF - A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
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Citations
Citations to this article as recorded by
- Cytologic features of mesenchymal, melanocytic and haematolymphoid tumours of the central nervous system and metastases
Carmen Bárcena, José A. Jiménez‐Heffernan
Cytopathology.2024; 35(5): 590. CrossRef - A Hemangiopericytoma in the External Auditory Canal: A Rare Clinical Presentation and Management
Vaibhavi Patil, Prasad Deshmukh, Sagar S Gaurkar , Ayushi Ghosh Moulic, Jasleen Kaur
Cureus.2024;[Epub] CrossRef - Scoring system for intraoperative diagnosis of intracranial schwannoma by squash cytology
Hirotaka Fujita, Takuma Tajiri, Tomohisa Machida, Nozomi Nomura, Suguru Toguchi, Hitoshi Itoh, Shinichiro Hiraiwa, Tomoko Sugiyama, Chie Inomoto, Masaaki Imai, Shinri Oda, Masami Shimoda, Naoya Nakamura
Cytopathology.2022; 33(2): 196. CrossRef - Occurrence of a solitary fibrous tumor adjacent to the resection bed of a high-grade meningioma: A case report
Coby Cunningham, Rocco Dabecco, Justin Davanzo
Interdisciplinary Neurosurgery.2021; 25: 101277. CrossRef - A case of solitary fibrous tumor arising in the meninge
Saori NAKANISHI, Naoto KURODA, Toshiko TAKAI, Mari KOJIMA, Misato OONOGI
The Journal of the Japanese Society of Clinical Cytology.2021; 60(4): 224. CrossRef - Intraoperative frozen cytology of intraosseous cystic meningioma in the sphenoid bone
Na Rae Kim, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2020; 54(6): 508. CrossRef
- Cytologic features of mesenchymal, melanocytic and haematolymphoid tumours of the central nervous system and metastases
- Malignant Solitary Fibrous Tumor with Heterologous Rhabdomyosarcomatous Differentiation: A Case Report
- Jeong-Hwa Kwon, Joon Seon Song, Hye Won Jung, Jong-Seok Lee, Kyung-Ja Cho
- J Pathol Transl Med. 2017;51(2):171-175. Published online February 3, 2017
- DOI: https://doi.org/10.4132/jptm.2016.08.29
- 7,597 View
- 114 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
- Malignant solitary fibrous tumor (MSFT) is a well-described entity, from which heterologous differentiation is extremely rare. We encountered a case of MSFT with rhabdomyosarcomatous differentiation in a 56-year-old man. This patient presented with a large mass in his posterior thigh. He had been treated with chemoradiation for sarcoma involving the cervical spine, right femoral head, and both lungs 6 months earlier. A wide excision was performed. The mass measured 10.6 cm and showed a fish-flesh cut surface with necrotic foci. Microscopically, the tumor showed heterogeneous cellularity with a hemangiopericytic vascular pattern. A hypercellular area showed spindle cells or epithelioid cells with high mitotic activity (63/10 high-power fields) and immunoreactivity for CD34 and CD99. A hypocellular area and a cystic area showed pleomorphic rhabdoid cells with immunoreactivity for desmin and myogenin. This is a report of a rare case of MSFT with rhabdomyosarcomatous differentiation and presents new histologic features of MSFT.
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Citations
Citations to this article as recorded by- A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp
Kwang-Ryeol Kim, Ki Hong Kim
Keimyung Medical Journal.2023; 42(2): 107. CrossRef - Malignant solitary fibrous tumor of maxilla presenting as proptosis: A case report
Pravin Kumar, Arpita Jindal, Bhushan Bhalgat, Phanindra Kumar Swain, Raj Govind Sharma
Journal of Cancer Research and Therapeutics.2023; 19(Suppl 2): S991. CrossRef - Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review
Ahmed Rabie, Abdulkarim Hasan, Yasein Mohammed, Ayman Abdelmaksoud, Ali A. Rabaan
Journal of Pathology and Translational Medicine.2022; 56(2): 103. CrossRef - Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2019; 53(3): 192. CrossRef
- A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp
Original Article
- Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis
- Nayoung Han, Hannah Kim, Soo Kee Min, Sun-Ha Paek, Chul-Kee Park, Seung-Hong Choi, U-Ri Chae, Sung-Hye Park
- J Pathol Transl Med. 2016;50(2):113-121. Published online December 14, 2015
- DOI: https://doi.org/10.4132/jptm.2015.10.30
- 10,355 View
- 114 Download
- 21 Web of Science
- 18 Crossref
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Abstract
PDF
- Background
The term solitary fibrous tumor (SFT) is preferred over meningeal hemangiopericytoma (HPC), because NAB2-STAT6 gene fusion has been observed in both intracranial and extracranial HPCs. HPCs are now considered cellular variants of SFTs. Methods: This study analyzes 19 patients with STAT6-confirmed SFTs, who were followed for over 11 years in a single institution. Ten patients (10/19, 56.2%) had extracranial metastases (metastatic group), while the remainder (9/19) did not (non-metastatic group). These two groups were compared clinicopathologically. Results: In the metastatic group, the primary metastatic sites were the lungs (n = 6), bone (n = 4), and liver (n = 3). There was a mean lag time of 14.2 years between the diagnosis of the initial meningeal tumor to that of systemic metastasis. The median age at initial tumor onset was 37.1 years in the metastatic group and 52.5 in the non-metastatic group. The 10-year survival rates of the metastatic- and non-metastatic groups were 100% and 33%, respectively. The significant prognostic factors for poor outcomes on univariate analysis included advanced age (≥45 years) and large initial tumor size (≥5 cm). In contrast, the patients with higher tumor grade, high mitotic rate (≥5/10 high-power fields), high Ki-67 index (≥5%), and the presence of necrosis or CD34 positivity showed tendency of poor prognosis but these parameters were not statistically significant poor prognostic markers. Conclusions: Among patients with SFTs, younger patients (<45 years) experienced longer survival times and paradoxically had more frequent extracranial metastases after long latent periods than did older patients. Therefore, young patients with SFTs require careful surveillance and follow-up for early detection of systemic metastases. -
Citations
Citations to this article as recorded by- Meningeal Solitary Fibrous Tumor: A Single-Center Retrospective Cohort Study
Siyer Roohani, Yasemin Alberti, Maximilian Mirwald, Felix Ehret, Carmen Stromberger, Soleiman Fabris Roohani, Katja Bender, Anne Flörcken, Sven Märdian, Daniel Zips, David Kaul, Manish Charan
Sarcoma.2024; 2024: 1. CrossRef - De-differentiation associated with drop metastasis of a recurrent intracranial solitary fibrous tumor: a case report and literature review
Chenhui Zhao, Xiran Fan, Wanwan Gao, Fan Zhang, Haijun Lv, Xiaochun Jiang, Guangfu Di
International Journal of Neuroscience.2022; 132(8): 843. CrossRef - Long-term extracranial metastatic relapse of an intraventricular solitary fibrous tumor: a case report
Tarek Assi, Elie Samaha, Hussein Nassereddine
Anti-Cancer Drugs.2022; 33(1): e764. CrossRef - Multidisciplinary Treatment of Liver Metastases from Intracranial SFTs/HPCs: A Report of Three Consecutive Cases
Felix J. Krendl, Franka Messner, Gregor Laimer, Angela Djanani, Andreas Seeber, Georg Oberhuber, Dietmar Öfner, Dominik Wolf, Stefan Schneeberger, Reto Bale, Christian Margreiter
Current Oncology.2022; 29(11): 8720. CrossRef - A review of solitary fibrous tumor/hemangiopericytoma tumor and a comparison of risk factors for recurrence, metastases, and death among patients with spinal and intracranial tumors.
Enrico Giordan, Elisabetta Marton, Alexandra M. Wennberg, Angela Guerriero, Giuseppe Canova
Neurosurgical Review.2021; 44(3): 1299. CrossRef - Intracranial Solitary Fibrous Tumor of the Skull Base: 2 Cases and Systematic Review of the Literature
Sricharan Gopakumar, Visish M. Srinivasan, Caroline C. Hadley, Adrish Anand, Marc Daou, Patrick J. Karas, Jacob Mandel, Shankar P. Gopinath, Akash J. Patel
World Neurosurgery.2021; 149: e345. CrossRef - Hemangiopericytoma/Solitary Fibrous Tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center
Pedro Miguel González-Vargas, José Luis Thenier-Villa, Pablo Sanromán Álvarez, Alexandre Serantes Combo, Lourdes Calero Félix, Raúl Alejandro Galárraga Campoverde, Eva Azevedo González, Álvaro Martín-Gallego, Rosa Martínez-Rolan, Adolfo de la Lama Zaragoz
Neurocirugía.2020; 31(1): 14. CrossRef - Hemangiopericytoma/Solitary Fibrous Tumor in the central nervous system. Experience with surgery and radiotherapy as a complementary treatment: A 10-year analysis of a heterogeneous series in a single tertiary center
Pedro Miguel González-Vargas, José Luis Thenier-Villa, Pablo Sanromán Álvarez, Alexandre Serantes Combo, Lourdes Calero Félix, Raúl Alejandro Galárraga Campoverde, Eva Azevedo González, Álvaro Martín-Gallego, Rosa Martínez-Rolan, Adolfo de la Lama Zaragoz
Neurocirugía (English Edition).2020; 31(1): 14. CrossRef - Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification
Kyoung Su Sung, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Se Hoon Kim, Chang-Ok Suh, Sun Ho Kim, Kyu-Sung Lee, Won Seok Chang, Jong Hee Chang
Journal of Neurosurgery.2019; 130(2): 418. CrossRef - Grading of meningeal solitary fibrous tumors/hemangiopericytomas: analysis of the prognostic value of the Marseille Grading System in a cohort of 132 patients
Nicolas Macagno, Rob Vogels, Romain Appay, Carole Colin, Karima Mokhtari, Benno Küsters, Pieter Wesseling, Dominique Figarella‐Branger, Uta Flucke, Corinne Bouvier
Brain Pathology.2019; 29(1): 18. CrossRef - Solitary fibrous tumor of the pineal region with delayed ectopic intracranial metastasis: A case report and review of the literature
Yongjie Wang, Jingying Zhang, Qichang Liu, Fuyi Liu, Xiangdong Zhu, Jianmin Zhang
Medicine.2019; 98(21): e15737. CrossRef - Case report: neonatal giant forehead hemangiopericytoma with a 5-year follow-up
AiJun Peng, LiBing Zhang, Hai Zhao, LiangXue Zhou
Medicine.2019; 98(47): e17888. CrossRef - Liquid Biopsy in Rare Cancers: Lessons from Hemangiopericytoma
Chiara Nicolazzo, Luciano Colangelo, Alessandro Corsi, Guido Carpino, Angela Gradilone, Chiara Sonato, Cristina Raimondi, Eugenio Gaudio, Paola Gazzaniga, Walter Gianni
Analytical Cellular Pathology.2018; 2018: 1. CrossRef - Surveillance for metastatic hemangiopericytoma-solitary fibrous tumors-systematic literature review on incidence, predictors and diagnosis of extra-cranial disease
Tarini Ratneswaren, Florence Rosie Avila Hogg, Mathew Joseph Gallagher, Keyoumars Ashkan
Journal of Neuro-Oncology.2018; 138(3): 447. CrossRef - Intracranial Solitary Fibrous Tumor
Eveline Claus, Patrick Seynaeve, Jeroen Ceuppens, Alain Vanneste, Koenraad Verstraete
Journal of the Belgian Society of Radiology.2017;[Epub] CrossRef - Comparison and evaluation of risk factors for meningeal, pleural, and extrapleural solitary fibrous tumors: A clinicopathological study of 92 cases confirmed by STAT6 immunohistochemical staining
Ji Min Kim, Yoon-La Choi, Yu Jin Kim, Hyung Kyu Park
Pathology - Research and Practice.2017; 213(6): 619. CrossRef - Molecular Testing of Brain Tumor
Sung-Hye Park, Jaekyung Won, Seong-Ik Kim, Yujin Lee, Chul-Kee Park, Seung-Ki Kim, Seung-Hong Choi
Journal of Pathology and Translational Medicine.2017; 51(3): 205. CrossRef - Solitary fibrous tumour presenting with a single bone metastasis: report of six cases and literature review
Vittoria Colia, Salvatore Provenzano, Carlo Morosi, Paola Collini, Salvatore Lorenzo Renne, Paolo G. Dagrada, Claudia Sangalli, Angelo Paolo Dei Tos, Andrea Marrari, Paolo G. Casali, Silvia Stacchiotti
Clinical Sarcoma Research.2016;[Epub] CrossRef
- Meningeal Solitary Fibrous Tumor: A Single-Center Retrospective Cohort Study
Case Study
- A Solitary Fibrous Tumor with Giant Cells in the Lacrimal Gland: A Case Study
- Da Hye Son, Su Hyun Yoo, Ho-Seok Sa, Kyung-Ja Cho
- Korean J Pathol. 2013;47(2):158-162. Published online April 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.158
- 7,108 View
- 55 Download
- 7 Crossref
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Abstract
PDF
Orbital solitary fibrous tumor (SFT) has recently been proposed as the encompassing terminology for hemangiopericytoma, giant cell angiofibroma (GCAF), and fibrous histiocytoma of the orbit. The lacrimal gland is a very rare location for both SFT and GCAF. A 39-year-old man presented with a painless left upper eyelid mass. An orbital computed tomography scan identified a 1.1 cm-sized well-defined nodule located in the left lacrimal gland. He underwent a mass excision. Histopathologic examination showed a proliferation of relatively uniform spindle cells with a patternless or focally storiform pattern. Dilated vessels were prominent, but angiectoid spaces lined with giant cells were absent. Floret-type giant cells were mostly scattered in the periphery. The tumor was immunoreactive for CD34 and CD99, but negative for smooth muscle actin and S-100 protein. This is the first Korean case of SFT of the lacrimal gland with overlapping features of GCAF, suggesting a close relationship between the two entities.
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Citations
Citations to this article as recorded by- A review of solitary fibrous tumours of the orbit and ocular adnexa
Cornelius René, Paolo Scollo, Dominic O’Donovan
Eye.2023; 37(5): 858. CrossRef - A giant orbital solitary fibrous tumor treated by surgical excision: a case report and literature review
Qi Zhou, Yuting Liu, Fang Wang, Yang Cao, Hongbin Lv, Xibo Zhang
Diagnostic Pathology.2023;[Epub] CrossRef - Giant cell-rich solitary fibrous tumour of the lacrimal gland with prominent angiomatoid cystic changes and an underlying NAB2ex3-STAT6ex18 fusion
Khaled A Alsaadi, Manar Alwohaib, Karen Pinto, Rola H Ali
BMJ Case Reports.2022; 15(2): e247141. CrossRef - Cystic appearance - a new feature of solid fibrous tumours in the lacrimal gland: a case report with literature review
Ancuta-Augustina Gheorghisan-Galateanu, Dana Cristina Terzea, Iulia Burcea, Roxana Dusceac, Cristina Capatina, Catalina Poiana
Diagnostic Pathology.2019;[Epub] CrossRef - Solitary Fibrous Tumor in the Lacrimal Gland Fossa: A Case Report
Jacqueline Mupas-Uy, Yoshiyuki Kitaguchi, Yasuhiro Takahashi, Emiko Takahashi, Hirohiko Kakizaki
Case Reports in Ophthalmology.2016; 7(2): 398. CrossRef - Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review
Aleksandra Petrovic, Aurélie Obéric, Alexandre Moulin, Mehrad Hamedani
Graefe's Archive for Clinical and Experimental Ophthalmology.2015; 253(9): 1609. CrossRef - Angiofibroma de células gigantes en mucosa yugal: una entidad rara en una localización infrecuente
Alejandro Rubio Fernández, María López Macías, Weimar Toro Zambrano, Mario Díaz Delgado, Alicia Hernández Amate
Revista Española de Patología.2014; 47(4): 223. CrossRef
- A review of solitary fibrous tumours of the orbit and ocular adnexa
Case Reports
- Solitary Fibrous Tumor of the Conjunctiva with Heretofore Undescribed Pathologic Findings.
- Na Rae Kim, Jae Y Ro, Kyung Hwan Shin, Hae Jung Paik, Jung Suk An, Seung Yeon Ha
- Korean J Pathol. 2011;45(3):315-318.
- DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.315
- 3,498 View
- 23 Download
- 1 Crossref
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Abstract
PDF
- A 37-year-old female presented with a conjunctival mass discovered 3 years prior. An excisional biopsy revealed a patternless proliferation of round and spindle-shaped cells with an eosinophilic fibrillary cytoplasm and vesicular nuclei with occasional inclusions. Psammoma bodies were arranged around the dilated irregularly-shaped vessels. Differential diagnoses included conjunctival solitary fibrous tumor (SFT), nevus, glomangioma, ectopic meningioma, and mesectodermal leiomyoma. The tumor cells were immunoreactive for CD34, CD99, bcl-2 and vimentin, and were negative for smooth muscle actin, desmin, glial fibrillary acidic protein, S-100 protein, epithelial membrane antigen, and human melanoma black-45. Ultrastructurally, the tumor cells had rough endoplasmic reticulum, free ribosomes, and scattered mitochondria without basal lamina or cellular junctions, which are features of fibroblasts. A diagnosis of SFT was rendered based on the light microscopic, immunohistochemical, and electron microscopic findings. We report here on the second case of a SFT arising in the conjunctiva, which clinically and histologically mimics conjunctival nevus, glomangioma, ectopic meningioma, and a hybrid neurogenic-myogenic tumor such as mesectodermal leiomyoma.
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Citations
Citations to this article as recorded by- Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis
Nayoung Han, Hannah Kim, Soo Kee Min, Sun-Ha Paek, Chul-Kee Park, Seung-Hong Choi, U-Ri Chae, Sung-Hye Park
Journal of Pathology and Translational Medicine.2016; 50(2): 113. CrossRef
- Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis
- Solitary Fibrous Tumor of the Liver: A Case Report.
- Hee Chul Yu, Baik Hwan Cho, Young Kon Kim, Sang Jae Noh, Woo Sung Moon
- Korean J Pathol. 2010;44(5):536-539.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.5.536
- 3,361 View
- 22 Download
- 1 Crossref
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Abstract
PDF
- Solitary fibrous tumor is an uncommon neoplasm of mesenchymal origin that primarily affects the pleura. This tumor has been rarely found in liver parenchyma. We present an additional case of a solitary fibrous tumor in the liver of a 46-year-old woman. A contrast-enhanced magnetic resonance image revealed a well-defined round hepatic mass with strong homogeneous enhancement on arterial phase imaging. The tumor was composed of cytologically bland spindle cells with alternating hypercellular and hypocellular sclerotic areas. Immunohistochemistry indicated that the tumor cells were positive for vimentin, CD34, CD99 and smooth muscle actin, but negative for cytokeratin, human melanoma black 45, CD117, bcl-2, and S-100 protein.
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Citations
Citations to this article as recorded by- Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis
Nayoung Han, Hannah Kim, Soo Kee Min, Sun-Ha Paek, Chul-Kee Park, Seung-Hong Choi, U-Ri Chae, Sung-Hye Park
Journal of Pathology and Translational Medicine.2016; 50(2): 113. CrossRef
- Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis
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