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- Bronchial Washing Cytology of Pulmonary Langerhans Cell Histiocytosis: A Case Report
- Taeyeong Kim, Hyeong Ju Kwon, Minseob Eom, Sang Wook Kim, Min Hi Sin, Soon-Hee Jung
- J Pathol Transl Med. 2017;51(4):444-447. Published online July 14, 2017
- DOI: https://doi.org/10.4132/jptm.2017.02.15
- 8,144 View
- 119 Download
- 2 Web of Science
- No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
- Minseob Eom, Jamshid Abdul-Ghafar, Sun-Mi Park, Joung Ho Han, Soon Won Hong, Kun Young Kwon, Eun Suk Ko, Lucia Kim, Wan Seop Kim, Seung Yeon Ha, Kyo Young Lee, Chang Hun Lee, Hye Kyoung Yoon, Yoo Duk Choi, Myoung Ja Chung, Soon-Hee Jung
- Korean J Pathol. 2013;47(2):124-129. Published online April 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.124
- 8,542 View
- 53 Download
- 6 Crossref
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Abstract
PDF Background Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA.
Methods We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA.
Results Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls.
Conclusions SV40 is not associated with the development of MM in Korea.
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Citations
Citations to this article as recorded by
- Association Study of Pleural Mesothelioma and Oncogenic Simian Virus 40 in the Crocidolite-Contaminated Area of Dayao County, Yunnan Province, Southwest China
Ru-ai Liu, Bo-yong Wang, Xin Chen, Yuan-qian Pu, Jia-ji Zi, Wen Mei, Ye-pin Zhang, Lu Qiu, Wei Xiong
Genetic Testing and Molecular Biomarkers.2024; 28(5): 189. CrossRef - Binding of SV40’s Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study
Raisa Kociurzynski, Sophie D. Beck, Jean-Baptiste Bouhon, Winfried Römer, Volker Knecht
Langmuir.2019; 35(9): 3534. CrossRef - Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033
Kyeong Min Kwak, Domyung Paek, Seung-sik Hwang, Young-Su Ju, Mark Allen Pershouse
PLOS ONE.2017; 12(8): e0183404. CrossRef - The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
Tumor Biology.2014; 35(2): 889. CrossRef - The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma
Leonardo Vinícius Monteiro de Assis, Jamille Locatelli, Mauro César Isoldi
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2014; 1845(2): 232. CrossRef - Pleural Mesothelioma: An Institutional Experience of 66 Cases
Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn
Korean Journal of Pathology.2014; 48(2): 91. CrossRef
- Association Study of Pleural Mesothelioma and Oncogenic Simian Virus 40 in the Crocidolite-Contaminated Area of Dayao County, Yunnan Province, Southwest China
- Guideline Recommendations for
EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group - Hyo Sup Shim, Jin-Haeng Chung, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Geon Kook Lee, Soon-Hee Jung, Se Jin Jang
- Korean J Pathol. 2013;47(2):100-106. Published online April 24, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.2.100
- 9,781 View
- 85 Download
- 12 Crossref
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Abstract
PDF
Mutations of the epidermal growth factor receptor (
EGFR ) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutatedEGFR . Rapid and accurateEGFR mutation testing is essential for patient selection and establishing targeted therapies with EGFR TKIs. Thus, a standard set of guideline recommendations forEGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of guideline recommendations forEGFR mutation testing that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.-
Citations
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Insu Kim, Hee Yun Seol, Soo Han Kim, Mi-Hyun Kim, Min Ki Lee, Jung Seop Eom
Cancers.2023; 15(5): 1445. CrossRef - Novel Targets, Novel Treatments: The Changing Landscape of Non-Small Cell Lung Cancer
Dorine de Jong, Jeeban P. Das, Hong Ma, Jacienta Pailey Valiplackal, Conor Prendergast, Tina Roa, Brian Braumuller, Aileen Deng, Laurent Dercle, Randy Yeh, Mary M. Salvatore, Kathleen M. Capaccione
Cancers.2023; 15(10): 2855. CrossRef - Coordination games in cancer
Péter Bayer, Robert A. Gatenby, Patricia H. McDonald, Derek R. Duckett, Kateřina Staňková, Joel S. Brown, Jun Tanimoto
PLOS ONE.2022; 17(1): e0261578. CrossRef - Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
Journal of Pathology and Translational Medicine.2021; 55(3): 181. CrossRef - Primary HHV-8 (-) Effusion-Based Non-Germinal Center B Cell Diffuse Large B Cell Lymphoma Successfully Treated with Standard Anthracycline-Based Chemoimmunotherapy
Justin J Kuhlman, Muhamad Alhaj Moustafa, Liuyan Jiang, Han W Tun
Journal of Blood Medicine.2021; Volume 12: 833. CrossRef - Molecular Testing of Lung Cancers
Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
Journal of Pathology and Translational Medicine.2017; 51(3): 242. CrossRef - Strategic management of transthoracic needle aspirates for histological subtyping and EGFR testing in patients with peripheral lung cancer: An institutional experience
Choonhee Son, Eun‐Ju Kang, Mee Sook Roh
Diagnostic Cytopathology.2015; 43(7): 532. CrossRef - Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal Growth Factor Receptor (EGFR) Mutation in Advanced Lung Cancer
Jooae Choe, Mi Young Kim, Jung Hwan Baek, Chang-Min Choi, Hwa Jung Kim
Medicine.2015; 94(29): e1209. CrossRef - Reliable EGFR mutation testing in ultrasound-guided supraclavicular lymph node fine-needle aspirates: a cohort study with diagnostic performance analysis
Amir Awwad, Sandeep Tiwari, Vishakha Sovani, David R Baldwin, Maruti Kumaran
BMJ Open Respiratory Research.2015; 2(1): e000075. CrossRef - Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non‐small‐cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage
Tae‐Jung Kim, Chan Kwon Park, Chang Dong Yeo, Kihoon Park, Chin Kook Rhee, Jusang Kim, Seung Joon Kim, Sang Haak Lee, Kyo‐Young Lee, Hyoung‐Kyu Yoon
Journal of Surgical Oncology.2014; 110(3): 245. CrossRef - Novel EGFR mutation-specific antibodies for lung adenocarcinoma: Highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R mutation in exon 21 by immunohistochemistry
An Na Seo, Tae-In Park, Yan Jin, Ping-Li Sun, Hyojin Kim, Hyun Chang, Jin-Haeng Chung
Lung Cancer.2014; 83(3): 316. CrossRef - Molecular Pathology of Lung Cancer: Current Status and Future Directions
Mee Sook Roh
Tuberculosis and Respiratory Diseases.2014; 77(2): 49. CrossRef
- Favorable Conditions for the Detection of EGFR T790M Mutation Using Plasma Sample in Patients with Non-Small-Cell Lung Cancer
- Primary Thymic Mucinous Adenocarcinoma: A Case Report
- Jamshid Abdul-Ghafar, Suk-Joong Yong, Woocheol Kwon, Il Hwan Park, Soon-Hee Jung
- Korean J Pathol. 2012;46(4):377-381. Published online August 23, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.377
- 7,818 View
- 75 Download
- 19 Crossref
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Abstract
PDF
Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.
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Citations
Citations to this article as recorded by- Primary mucinous adenocarcinoma of the thymus
Kohei Soejima, Hidehito Matsuoka
The Journal of the Japanese Association for Chest Surgery.2024; 38(6): 545. CrossRef - Stage IV thymic mucinous adenocarcinoma under long-term disease control after primary tumor resection: A case report
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