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JPTM : Journal of Pathology and Translational Medicine



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2 "Moonsik Kim"
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Original Article
Evaluation of the characteristics of multiple human papillomavirus (HPV) infections identified using the BD Onclarity HPV assay and comparison with those of single HPV infection
Jinhee Kim, Moonsik Kim, Ji Young Park
J Pathol Transl Med. 2022;56(5):289-293.   Published online September 13, 2022
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  • 36 Download
AbstractAbstract PDFSupplementary Material
Human papillomavirus (HPV) infection is a major cause of cervical cancer and associated precursor lesions. Multiple HPV genotype infections have been reported. However, their clinicopathological characteristics still remain elusive.
For this study, 814 consecutive patients who had undergone colposcopy and HPV genotyping test using BD Onclarity HPV assay were retrospectively selected. Clinicopathological parameters of multiple HPV infections were compared with those of single HPV infection.
Multiple HPV infections were found in 110 out of 814 cases (13.5%). Multiple HPV infections were associated with a significantly higher incidence of high-grade intraepithelial lesions (HSILs) compared with single HPV infection. Other high-risk HPV genotypes, in addition to HPV 16, were found more frequently in the multiple HPV infections group; these included HPV 51, 52, 33/58, 56/59/66, and 35/39/68. No specific coinfection pattern was not identified. Additionally, the number of HPV genotypes in multiple HPV infections was not associated with the progression to HSIL or squamous cell carcinoma.
Multiple HPV infections have distinct clinicopathological characteristics (compared with single HPV infection). As their biological behavior is uncertain, close and frequent follow-up is warranted.
Case Study
Renal intravascular large B cell lymphoma: the first case report in Korea and a review of the literature
Moonsik Kim, Haerim Chung, Woo Ick Yang, Hyeon Joo Jeong
J Pathol Transl Med. 2020;54(5):426-431.   Published online August 13, 2020
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  • 101 Download
  • 3 Citations
AbstractAbstract PDFSupplementary Material
Herein, we describe the first case of renal intravascular large B cell lymphoma in Korea occurring in a 66-year-old female. She presented with mild fever and dyspnea. On physical and laboratory evaluations, hemophagocytic lymphohistiocytosis was suspected, but the bone marrow biopsy results were unremarkable. During the work-up, massive proteinuria developed, which led to a renal biopsy. The renal architecture was relatively well-preserved, but the glomeruli were hypercellular with the infiltration of atypical, large lymphoid cells with increased nucleus-cytoplasm ratio and clumped chromatin. Similar cells were also present in the peritubular capillaries. The tumor cells exhibited membranous staining for CD20 and CD79a. After the diagnosis of intravascular large B cell lymphoma, the patient received rituximab-based chemotherapy under close follow-up.


Citations to this article as recorded by  
  • Intravascular large B‐cell lymphoma in renal cell carcinoma incidentally detected by robot‐assisted partial nephrectomy
    Michio Noda, Yutaka Enomoto, Yukari Shirasugi, Sumiyo Ando, Yukimasa Matsuzawa, Haruki Kume
    IJU Case Reports.2022; 5(3): 191.     CrossRef
  • Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature
    Yingying Han, Qingjiao Li, Dan Wang, Lushan Peng, Tao Huang, Chunlin Ou, Keda Yang, Junpu Wang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations
    Faten Aqeel, Serena M. Bagnasco, Duvuru Geetha, Yoshihide Fujigaki
    Case Reports in Nephrology.2022; 2022: 1.     CrossRef

JPTM : Journal of Pathology and Translational Medicine