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Brief Case Report
Bronchial Washing Cytology of Pulmonary Langerhans Cell Histiocytosis: A Case Report
Taeyeong Kim, Hyeong Ju Kwon, Minseob Eom, Sang Wook Kim, Min Hi Sin, Soon-Hee Jung
J Pathol Transl Med. 2017;51(4):444-447.   Published online July 14, 2017
  • 7,196 View
  • 108 Download
Original Article
No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea
Minseob Eom, Jamshid Abdul-Ghafar, Sun-Mi Park, Joung Ho Han, Soon Won Hong, Kun Young Kwon, Eun Suk Ko, Lucia Kim, Wan Seop Kim, Seung Yeon Ha, Kyo Young Lee, Chang Hun Lee, Hye Kyoung Yoon, Yoo Duk Choi, Myoung Ja Chung, Soon-Hee Jung
Korean J Pathol. 2013;47(2):124-129.   Published online April 24, 2013
  • 7,611 View
  • 50 Download
  • 5 Citations
AbstractAbstract PDF

Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA.


We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA.


Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls.


SV40 is not associated with the development of MM in Korea.


Citations to this article as recorded by  
  • Binding of SV40’s Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study
    Raisa Kociurzynski, Sophie D. Beck, Jean-Baptiste Bouhon, Winfried Römer, Volker Knecht
    Langmuir.2019; 35(9): 3534.     CrossRef
  • Estimated future incidence of malignant mesothelioma in South Korea: Projection from 2014 to 2033
    Kyeong Min Kwak, Domyung Paek, Seung-sik Hwang, Young-Su Ju, Mark Allen Pershouse
    PLOS ONE.2017; 12(8): e0183404.     CrossRef
  • The function, mechanisms, and role of the genes PTEN and TP53 and the effects of asbestos in the development of malignant mesothelioma: a review focused on the genes' molecular mechanisms
    Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
    Tumor Biology.2014; 35(2): 889.     CrossRef
  • The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma
    Leonardo Vinícius Monteiro de Assis, Jamille Locatelli, Mauro César Isoldi
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2014; 1845(2): 232.     CrossRef
  • Pleural Mesothelioma: An Institutional Experience of 66 Cases
    Soomin Ahn, In Ho Choi, Joungho Han, Jhingook Kim, Myung-Ju Ahn
    Korean Journal of Pathology.2014; 48(2): 91.     CrossRef
Review & Perspective
Guideline Recommendations for EGFR Mutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
Hyo Sup Shim, Jin-Haeng Chung, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Geon Kook Lee, Soon-Hee Jung, Se Jin Jang
Korean J Pathol. 2013;47(2):100-106.   Published online April 24, 2013
  • 8,639 View
  • 60 Download
  • 10 Citations
AbstractAbstract PDF

Mutations of the epidermal growth factor receptor (EGFR) are the strongest predictive factor for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. EGFR TKIs are approved in Korea as a first-line treatment for lung cancer patients with mutated EGFR. Rapid and accurate EGFR mutation testing is essential for patient selection and establishing targeted therapies with EGFR TKIs. Thus, a standard set of guideline recommendations for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of guideline recommendations for EGFR mutation testing that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.


Citations to this article as recorded by  
  • Favorable Conditions for the Detection of EGFR T790M Mutation Using Plasma Sample in Patients with Non-Small-Cell Lung Cancer
    Insu Kim, Hee Yun Seol, Soo Han Kim, Mi-Hyun Kim, Min Ki Lee, Jung Seop Eom
    Cancers.2023; 15(5): 1445.     CrossRef
  • Coordination games in cancer
    Péter Bayer, Robert A. Gatenby, Patricia H. McDonald, Derek R. Duckett, Kateřina Staňková, Joel S. Brown, Jun Tanimoto
    PLOS ONE.2022; 17(1): e0261578.     CrossRef
  • Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
    Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
    Journal of Pathology and Translational Medicine.2021; 55(3): 181.     CrossRef
  • Primary HHV-8 (-) Effusion-Based Non-Germinal Center B Cell Diffuse Large B Cell Lymphoma Successfully Treated with Standard Anthracycline-Based Chemoimmunotherapy
    Justin J Kuhlman, Muhamad Alhaj Moustafa, Liuyan Jiang, Han W Tun
    Journal of Blood Medicine.2021; Volume 12: 833.     CrossRef
  • Molecular Testing of Lung Cancers
    Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
    Journal of Pathology and Translational Medicine.2017; 51(3): 242.     CrossRef
  • Strategic management of transthoracic needle aspirates for histological subtyping andEGFRtesting in patients with peripheral lung cancer: An institutional experience
    Choonhee Son, Eun-Ju Kang, Mee Sook Roh
    Diagnostic Cytopathology.2015; 43(7): 532.     CrossRef
  • Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal Growth Factor Receptor (EGFR) Mutation in Advanced Lung Cancer
    Jooae Choe, Mi Young Kim, Jung Hwan Baek, Chang-Min Choi, Hwa Jung Kim
    Medicine.2015; 94(29): e1209.     CrossRef
  • Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non-small-cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage
    Tae-Jung Kim, Chan Kwon Park, Chang Dong Yeo, Kihoon Park, Chin Kook Rhee, Jusang Kim, Seung Joon Kim, Sang Haak Lee, Kyo-Young Lee, Hyoung-Kyu Yoon
    Journal of Surgical Oncology.2014; 110(3): 245.     CrossRef
  • Novel EGFR mutation-specific antibodies for lung adenocarcinoma: Highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R mutation in exon 21 by immunohistochemistry
    An Na Seo, Tae-In Park, Yan Jin, Ping-Li Sun, Hyojin Kim, Hyun Chang, Jin-Haeng Chung
    Lung Cancer.2014; 83(3): 316.     CrossRef
  • Molecular Pathology of Lung Cancer: Current Status and Future Directions
    Mee Sook Roh
    Tuberculosis and Respiratory Diseases.2014; 77(2): 49.     CrossRef
Case Report
Primary Thymic Mucinous Adenocarcinoma: A Case Report
Jamshid Abdul-Ghafar, Suk-Joong Yong, Woocheol Kwon, Il Hwan Park, Soon-Hee Jung
Korean J Pathol. 2012;46(4):377-381.   Published online August 23, 2012
  • 6,990 View
  • 57 Download
  • 18 Citations
AbstractAbstract PDF

Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of thymic carcinoma. With a review of literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment of a mediastinal mass. The patient had no medical history of cancer. The clinicoradiological examination disclosed no tumor elsewhere. After the surgical excision of mediastinal mass, it was grossly a round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed cords, small nests and dilated glands infiltrating the fibrotic parenchyma, while the cystic areas were lined by mucinous epithelium with tumor cells floating in extracellular-mucin pools. Some cystic walls underwent malignant transformation of the benign thymic epithelium. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) 7, CK20, CD5, and CDX-2, and negative for thyroid transcription factor-1. In conclusion, the mucinous thymic adenocarcinoma should be recognized as a separate histopathological entity and considered in the differential diagnosis of mediastinal carcinomas.


Citations to this article as recorded by  
  • Stage IV thymic mucinous adenocarcinoma under long-term disease control after primary tumor resection: A case report
    Chihaya Maeda, Tomoyuki Hishida, Kyohei Masai, Keisuke Asakura, Katsura Emoto, Hisao Asamura
    The Journal of the Japanese Association for Chest Surgery.2022; 36(2): 156.     CrossRef
  • Lenvatinib-refractory thymic mucinous carcinoma with PIK3CA mutation
    Akihiro Tsukaguchi, Shoichi Ihara, Hironao Yasuoka, Seigo Minami
    International Cancer Conference Journal.2022; 12(1): 36.     CrossRef
  • Thymic mucinous adenocarcinoma: A case report
    Hideki Tsubouchi, Naoki Ozeki, Yuka Suzuki, Koji Kawaguchi, Takayuki Fukui, Toyofumi F. Chen-Yoshikawa
    The Journal of the Japanese Association for Chest Surgery.2021; 35(5): 547.     CrossRef
  • Metastatic thymic-enteric adenocarcinoma responding to chemoradiation plus anti-angiogenic therapy: A case report
    Man Li, Xiao-Yu Pu, Li-Hua Dong, Peng-Yu Chang
    World Journal of Clinical Cases.2021; 9(7): 1676.     CrossRef
  • Primary Mucinous Adenocarcinoma of the Thymus: a Rare Type of Thymic Carcinoma—Case Report
    Koichi Tomoshige, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Ryusuke Machino, Satoshi Mizoguchi, Takamune Matumoto, Yutaka Maeda, Takeshi Nagayasu
    SN Comprehensive Clinical Medicine.2021; 3(5): 1233.     CrossRef
  • Primary mucinous adenocarcinoma of the thymus: A case report
    Tomoka Hamahiro, Ryo Maeda, Takanori Ayabe, Yuichiro Sato, Masaki Tomita
    Respiratory Medicine Case Reports.2021; 34: 101497.     CrossRef
  • Primary Thymic Mucinous Adenocarcinoma: A Case Report Focusing on Radiological Findings and Review of the Literature
    Young Hoon Koo, Jae Wook Lee, Jai Soung Park, Kyung Eun Shin, Heon Lee, Susie Chin
    Iranian Journal of Radiology.2020;[Epub]     CrossRef
  • Mucinous adenocarcinoma of the thymus: report of a case
    Fumihiko Kinoshita, Fumihiro Shoji, Kazuki Takada, Gouji Toyokawa, Tatsuro Okamoto, Tokujiro Yano, Yoshinao Oda, Yoshihiko Maehara
    General Thoracic and Cardiovascular Surgery.2018; 66(2): 111.     CrossRef
  • Thymic enteric type adenocarcinoma: A case report with cytological features
    Marie Tamai, Mitsuaki Ishida, Yusuke Ebisu, Hisashi Okamoto, Chika Miyasaka, Chisato Ohe, Yoshiko Uemura, Tomohito Saito, Tomohiro Murakawa, Koji Tsuta
    Diagnostic Cytopathology.2018; 46(1): 92.     CrossRef
  • Primary thymic adenocarcinomas: a clinicopathological and immunohistochemical study of 16 cases with emphasis on the morphological spectrum of differentiation
    Neda Kalhor, Cesar A. Moran
    Human Pathology.2018; 74: 73.     CrossRef
  • Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature
    Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
    Pathology - Research and Practice.2017; 213(2): 106.     CrossRef
  • Cytologic Characteristics of Thymic Adenocarcinoma with Enteric Differentiation: A Study of Four Fine-Needle Aspiration Specimens
    Ah-Young Kwon, Joungho Han, Hae-yon Cho, Seokhwi Kim, Heejin Bang, Jiyeon Hyeon
    Journal of Pathology and Translational Medicine.2017; 51(5): 509.     CrossRef
  • Mucinous cystic tumor with CK20 and CDX2 expression of the thymus: Is this a benign counterpart of adenocarcinoma of the thymus, enteric type?
    Jun Akiba, Hiroshi Harada, Shintaro Yokoyama, Toshihiro Hashiguchi, Akihiko Kawahara, Masahiro Mitsuoka, Shinzo Takamori, Hirohisa Yano
    Pathology International.2016; 66(1): 29.     CrossRef
  • Colon cancer chemotherapy for a patient with CDX2-expressing metastatic thymic adenocarcinoma: a case report and literature review
    Akihiko Sawaki, Mikiya Ishihara, Yuji Kozuka, Hiroyasu Oda, Satoshi Tamaru, Yumiko Sugawara, Yoshiki Yamashita, Toshiro Mizuno, Taizo Shiraishi, Naoyuki Katayama
    International Cancer Conference Journal.2016; 5(2): 113.     CrossRef
  • Adenocarcinoma of the Thymus, Enteric Type
    Bernhard Moser, Ana Iris Schiefer, Stefan Janik, Alexander Marx, Helmut Prosch, Wolfgang Pohl, Barbara Neudert, Anke Scharrer, Walter Klepetko, Leonhard Müllauer
    American Journal of Surgical Pathology.2015; 39(4): 541.     CrossRef
  • A Rare Case of Primary Thymic Adenocarcinoma Mimicking Small Cell Lung Cancer
    Eun Na Cho, Hye Sung Park, Tae Hoon Kim, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang
    Tuberculosis and Respiratory Diseases.2015; 78(2): 112.     CrossRef
  • A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature
    Hae Yoen Jung, Hyundeuk Cho, Jin-Haeng Chung, Sang Byoung Bae, Ji-Hye Lee, Hyun Ju Lee, Si-Hyong Jang, Mee-Hye Oh
    Journal of Pathology and Translational Medicine.2015; 49(4): 331.     CrossRef
  • Primary mucinous adenocarcinoma of the thymus: a case report
    Tadashi Sakane, Kotaro Mizuno, Risa Oda, Takuya Matsui, Makoto Ito, Takeshi Yamada
    The Journal of the Japanese Association for Chest Surgery.2014; 28(7): 904.     CrossRef

JPTM : Journal of Pathology and Translational Medicine