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Original Article
Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma
Kyungseek Chang, Sung-Im Do, Kyungeun Kim, Seoung Wan Chae, In-gu Do, Hyun Joo Lee, Dong Hoon Kim, Jin Hee Sohn
J Pathol Transl Med. 2021;55(5):317-323.   Published online August 9, 2021
DOI: https://doi.org/10.4132/jptm.2021.06.28
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  • 102 Download
  • 1 Citations
AbstractAbstract PDFSupplementary Material
Background
Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.
Methods
Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.
Results
Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).
Conclusions
Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.

Citations

Citations to this article as recorded by  
  • Knockdown of FBI-1 Inhibits the Warburg Effect and Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents via miR-3692/HIF-1α
    Juan Liu, Chao Yang, Xiao-Mei Huang, Pan-Pan Lv, Ya-Kun Yang, Jin-Na Zhao, Si-Yuan Zhao, Wan-Jun Sun
    Frontiers in Oncology.2021;[Epub]     CrossRef
Brief Case Report
Traumatic Bowel Perforation and Inguinal Hernia Masking a Mesenteric Calcifying Fibrous Tumor
Dong Hyun Kim, Kyueng-Whan Min, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn, Jung-Soo Pyo, Sung-Im Do, Kyungeun Kim, Hyun Joo Lee
J Pathol Transl Med. 2015;49(3):267-269.   Published online May 15, 2015
DOI: https://doi.org/10.4132/jptm.2015.03.20
  • 6,657 View
  • 45 Download
  • 1 Citations
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Citations

Citations to this article as recorded by  
  • Calcifying Fibrous Tumor
    Angeliki Chorti, Theodossis S. Papavramidis, Antonios Michalopoulos
    Medicine.2016; 95(20): e3690.     CrossRef
Case Report
Extranodal Follicular Dendritic Cell Sarcoma with Rapid Growth in Parapharynx: A Case Report
Jung-Soo Pyo, Guhyun Kang, Sung-Im Do, Seoung Wan Chae, Kyungeun Kim, Sang Hyuk Lee, Yoon-La Choi, Joon Hyuk Choi, Jin Hee Sohn, Dong-Hoon Kim
Korean J Pathol. 2012;46(3):306-310.   Published online June 22, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.306
  • 5,737 View
  • 39 Download
  • 9 Citations
AbstractAbstract PDF

Follicular dendritic cell sarcoma (FDCS) is a rare malignancy arising from the antigen-presenting cells in the lymph node and extranodal tissue. We describe a 31-year-old male patient who presented with a swelling of the left parapharynx. The radiologic findings showed a 4.7×4.5×1.9 cm-sized, ill-defined mass in the left parapharyngeal space. A fine-needle aspiration cytology was performed and it showed scattered, irregular, cohesive clusters of tumor cells with a spindle-to-ovoid shape with irregular contours in a background of lymphocytes. Based on these findings, a diagnosis of spindle cell neoplasm was made. The surgically resected tumor was composed of elongated, ovoid or polygonal cells showing positive immunohistochemistry for CD21, CD23, and CD35. Postoperatively, the residual tumor was observed to undergo a rapidly growth. There is an overlap in the cytologic and histologic findings between FDCS of the parapharynx and other tumors. Pathologists should therefore be aware of its characteristics not only to provide an accurate diagnosis but also to recommend the appropriate clinical management.

Citations

Citations to this article as recorded by  
  • Cytomorphology of follicular dendritic cell sarcoma: a report of 7 cases with an emphasis on the diagnostic challenges
    Cody Weimholt, Jalal B. Jalaly, Cedric Bailey
    Journal of the American Society of Cytopathology.2023;[Epub]     CrossRef
  • Follicular dendritic cells
    Seham A. Abd El‐Aleem, Entesar Ali Saber, Neven M. Aziz, Hani El‐Sherif, Asmaa M. Abdelraof, Laiche Djouhri
    Journal of Cellular Physiology.2022; 237(4): 2019.     CrossRef
  • Extranodal Follicular Dendritic Cell Sarcoma of the Head and Neck Region: A Clinicopathological Study of 7 Cases
    Nasir Ud Din, Zubair Ahmad, Shabina Rahim, Karen Fritchie, Muhammad Usman Tariq, Arsalan Ahmed
    International Journal of Surgical Pathology.2022; : 106689692211333.     CrossRef
  • Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases
    Xing Zhao, Dayong Sun, Gang Zhang
    Oncology Letters.2021;[Epub]     CrossRef
  • Cytological diagnosis of follicular dendritic cell sarcoma: A case report and review of literature
    A. Dutta, P. Arun, P. Roy, I. Arun
    Cytopathology.2018; 29(5): 461.     CrossRef
  • Follicular dendritic cells and related sarcoma
    Fabio Facchetti, Luisa Lorenzi
    Seminars in Diagnostic Pathology.2016; 33(5): 262.     CrossRef
  • Extranodal follicular dendritic cell sarcoma: A clinicopathological report of four cases and a literature review
    RUI-FEN WANG, WEI HAN, LEI QI, LI-HUI SHAN, ZHENG-CAI WANG, LI-FENG WANG
    Oncology Letters.2015; 9(1): 391.     CrossRef
  • Follicular Dendritic Cell Sarcoma of Parapharyngeal Space: A Case Report and Review of the Literature
    Turki Al-Hussain, Muhammad Saleem, Suresh Babu Velagapudi, Mohammad Anas Dababo
    Head and Neck Pathology.2015; 9(1): 135.     CrossRef
  • Clinical and pathological features of head and neck follicular dendritic cell sarcoma
    Ji Li, Min-Li Zhou, Shui-Hong Zhou
    Hematology.2015; 20(10): 571.     CrossRef

JPTM : Journal of Pathology and Translational Medicine