Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study.

Sung Ran Hong; In Sun Kim; Dong Won Kim; Mi Jin Kim; Ae Ree Kim; Young Ok Kim; Hye Sun Kim; Seo Hee Rha; Gyeong Sin Park; Yong Koo Park; Yong Wook Park; Ho Sung Park; Kwang Sun Suh; Jin Hee Sohn; Mi Kyung Shin; Hoon Kyu Oh; Ki Jung Yun; Hye Kyoung Yoon; Shi Nae Lee; Ah Won Lee; Hyo Jin Lee; Hyun Yee Cho; Chan Choi; Woon Won Jung

doi:10.4132/KoreanJPathol.2009.43.4.342

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Original Article Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Korean Women: A Multicenter Study.: Sung Ran Hong, In Sun Kim, Dong Won Kim, Mi Jin Kim, Ae Ree Kim, Young Ok Kim, Hye Sun Kim, Seo Hee Rha, Gyeong Sin Park, Yong Koo Park, Yong Wook Park, Ho Sung Park, Kwang Sun Suh, Jin Hee Sohn, Mi Kyung Shin, Hoon Kyu Oh, Ki Jung Yun, Hye Kyoung Yoon, Shi Nae Lee, Ah Won Lee, Hyo Jin Lee, Hyun Yee Cho, Chan Choi, Woon Won Jung; Journal of Pathology and Translational Medicine 2009;43(4):342-350
DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.4.342

¹Department of Pathology, Kwandong University Cheil General Hospital & Women's Healthcare Center, Seoul, Korea.
²Department of Pathology, Korea University Anam Hospital, Seoul, Korea. iskim@korea.ac.kr
³Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea.
⁴Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.
⁵Department of Pathology, Korea University Guro Hospital, Seoul, Korea.
⁶Department of Pathology, Kosin University College of Medicine, Busan, Korea.
⁷Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
⁸Department of Pathology, Catholic University, St. Mary's Hospital, Seoul, Korea.
⁹Department of Pathology, Kyung Hee University Medical Center, Seoul, Korea.
¹⁰Department of Pathology, Hanyang University Kuri Hospital, Guri, Korea.
¹¹Department of Pathology, Chonbuk National University College of Medicine, Jeonju, Korea.
¹²Department of Pathology, Chungnam National University College of Medicine, Daejeon, Korea.
¹³Department of Pathology, Sunghyunkwan University Kangbuk Samsung Medical Center, Seoul, Korea.
¹⁴Department of Pathology, Hallym University, Gangnam Sacred Heart Hospital, Seoul, Korea.
¹⁵Department of Pathology, Daegu Catholic University Medical Center, Daegu, Korea.
¹⁶Department of Pathology, Wonkwang University College of Medicine, Iksan, Korea.
¹⁷Department of Pathology, Inje University Busan Paik Hospital, Busan, Korea.
¹⁸Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea.
¹⁹Department of Pathology, Catholic University, Gangnam St. Mary's Hospital, Seoul, Korea.
²⁰Department of Pathology, National Police Hospital, Seoul, Korea.
²¹Department of Pathology, Medical School Gil Medical Center, Incheon, Korea.
²²Department of Pathology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
²³Department of Clinical Pathology, College of Health Science, Korea University, Seoul, Korea.

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Abstract

Background
DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. High-risk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.

Keywords: Uterine cervix;Human papillomavirus;DNA chips;Papanicolaou test;South Korea;

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