Fig. 1Immunohistochemical staining of mucin (MUC) 1 and MUC4 in gallbladder adenocarcinoma. (A) MUC1, intensity score 1. Weak positive expression along the apical membrane of tumor cells in well-formed tubules is noted. (B) MUC1, intensity score 2. Strong positive cytoplasmic expression of tumor cells in moderately differentiated tubules is noted. (C) MUC4, intensity score 1. Weak positive cytoplasmic expression of tumor cells in well-formed tubules is noted. (D) MUC4, intensity score 2. Strong positive expression in the cytoplasm of poorly differentiated individual tumor cells is noted.
Fig. 2Kaplan-Meier survival analyses for gallbladder adenocarcinoma stratified according to mucin (MUC) 1 (A) and MUC4 (B) expression. Neither MUC1 nor MUC4 expression correlated with overall survival. MUC1 (p=0.747), MUC4 (p=0.162).
Table 1Correlation between mucin (MUC) 1 or MUC4 expression and clinicopathological parameters
Table 2The extent and intensity scores of mucin (MUC) 1 and MUC4 expression in gallbladder adenocarcinoma (n=54)
Table 3Cox regression analyses assessing prognostic significance in gallbladder adenocarcinoma