Fig. 1Representative histologic (A, C, E) and cytologic (B, D, F) features of pleomorphic carcinoma. (A) Large cell carcinoma. The pleomorphic epithelioid cells form a solid sheet without glandular or squamous differentiation. (B) Large cell carcinoma. The cluster is composed of pleomorphic large cells with abundant thick cytoplasm. (C) Spindle cell component. The neoplastic spindle cells are arranged in interlacing fascicles. (D) Spindle cell component. The pleomorphic spindle cells are arranged in fascicles with hyperchromatic nuclei (inset). (E) Giant cell component. The tumor cells are pleomorphic and discohesive. (F) Giant cell component. Mono-, bi-, and multi-nucleated giant cells reveal bizarre and hyperchromatic nuclei and prominent nucleoli.
Fig. 2Numerous neutrophils are visible in the background.
Fig. 3Immunocytochemical stain results. (A) The epithelial cells show immunoreactivity to cytokeratin. (B) The vimentin is expressed mainly in the spindle cells and in some of the epithelioid cells.
Table 1Clinical features of the 7 patients enrolled in the study
Table 2Component of tumor cells observed in the pathological and cytological specimen
Table 3Cytologic features of the 7 cases