Fig. 1Computed tomography scan image shows a solid and cystic mass in the right hemithorax.
Fig. 2(A) Grossly, the cut surface shows a white to pink fibrous tumor with a fascicular pattern and cartilage component. (B) Low-power microscopic view showing the cartilage, spindle cell and round cell (arrow) components of the tumor. Adipose tissue is also included.
Fig. 3(A) Spindle cell area showing intersecting fascicles of monotonous cells. (B) Round cell area with hemangiopericytoma-like vascular pattern.
Fig. 4(A) Strong smooth muscle actin positivity in the spindle cells contrasting with the background lung parenchyma. (B) Round cells show faint to zero reactivity to smooth muscle actin.
Fig. 5Electron micrographs of (A) the spindle cell area (×10,000) and (B) cells showing cytoplasmic microfilaments with a dense body (arrow) (×20,000).
Table 1.Clinicopathologic features of CPMT
Reference |
Sex/Agea
|
Outcome |
Complication |
Original diagnosis |
Adjunct study |
Cartilage |
Necrosis |
Round cell |
Mitosis |
Jones [9] |
F/28 wk |
Died at 1 hr |
RD |
Hamartoma |
- |
+ |
NS |
NS |
NS |
Robb [3] |
M/NS |
Well at 10 mo |
None |
Fibrosarcoma |
- |
NS |
NS |
+ |
Not numerous |
Guccion and Rosen [5] |
M/NS |
Died shortly after birth |
NS |
Leiomyosarcoma |
- |
NS |
NS |
NS |
15/10 hpf |
Haller et al. [8] |
F/40 wk |
Died at 8 hr |
H, RD |
Mesenchymal tumor |
- |
NS |
NS |
+ |
None |
Warren et al. [7] |
F/30-33 wk |
Intraoperative death |
PHA, RD |
Mesenchymal malformation |
EM |
Entrappedb
|
NS |
NS |
1-5/hpf |
Jimenez et al. [4] |
M/36 wk |
Well at 34 mo |
H, PHA, RD |
Leiomyosarcoma |
EM |
NS |
NS |
NS |
Occasional |
Pettinato et al. [2] |
M/NS |
Well at 6 yr |
PE, RD |
Fibrosarcoma |
IHC, EM |
Entrapped |
+ |
+ |
8-12/10 hpf |
M/NS |
Well at 3 mo |
PE, RD |
Khong and Keeling [6] |
M/27 wk |
Termination |
H, PHA |
Mesenchymal |
- |
+ |
NS |
NS |
Frequent |
McGinnis et al. [1] |
M/33 wk |
Intraoperative death |
H, PHA, RD |
CPMT |
IHC, EM, flow cytometry |
+ |
- |
NS |
1/10 hpf |
Alobeid et al. [17] |
F/35 wk |
Well at 12 mo |
RD |
CPMT |
IHC, EM, karyotyping |
Entrapped |
+ |
NS |
0-3/10 hpf |
Kuhnen et al. [10] |
NS/NS |
Well at 8 mo |
None |
Fibrosarcoma |
IHC |
+ |
- |
NS |
1/10 hpf |
Reiss et al. [13] |
M/24 wk |
Termination |
NS |
CPMT |
IHC |
- |
+ |
NS |
0-4/10 hpf |
Horikoshi et al. [12] |
M/30 wk |
Intrauterine death |
H, PE |
CPMT |
IHC |
- |
+ |
NS |
NS |
Dishop [14] |
M/28 wk |
Died 24 hr |
H, RD |
CPMT |
IHC |
+ |
- |
NS |
Occasional |
de Noronha et al. [15] |
M/24 wk |
Intrauterine death |
H, PHA |
CPMT |
IHC, EM |
+ |
NS |
NS |
Frequent |
Huppmann et al. [16] |
M/23 wk, 6 wk postnatal |
Well at 6.5 yr |
H, RD |
CPMT |
IHC, karyotyping |
+ |
- |
NS |
Brisk/occasional |
Current case |
F/1 mo |
Well at 2 yr |
None |
CPMT |
IHC, EM |
+ |
+ |
+ |
8/10 hpf |