Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
1Department of Pathology, Gachon University Gil Medical Center, Incheon, Korea.
2Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
© 2014 The Korean Society of Pathologists/The Korean Society for Cytopathology
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Histologic subtype | Loss of PTEN expression (%) | p-value | Normalized Ct value of miR-21 (mean ± standard deviation) | p-value |
---|---|---|---|---|
TC (n = 23) | 4 (17.4) | .025 | –4.13 ± 1.67 | < .001 |
AC (n = 9) | 4 (44.4) | –4.66 ± 1.39 | ||
LCNEC (n = 22) | 16 (72.7) | –6.35 ± 1.30 | ||
SCLC (n = 21) | 9 (42.9) | –6.12 ± 1.27 |
Histologic subtype | Normalized Ct value of miR-21 (mean ± standard deviation) |
p-value | |
---|---|---|---|
Loss of PTEN expression | Positive PTEN expression | ||
Total (n = 75) | –6.11 ± 1.52 | –4.81 ± 1.62 | < .001 |
TC (n = 23) | –4.53 ± 0.14 | –3.36 ± 1.73 | .014 |
AC (n = 9) | –5.32 ± 0.13 | –4.47 ± 1.55 | .487 |
LCNEC (n = 22) | –7.16 ± 0.89 | –5.48 ± 1.22 | .005 |
SCLC (n = 21) | –6.97 ± 1.14 | –5.86 ± 1.22 | .086 |
PTEN, phosphatase and tensin homolog on chromosome ten; miR-21, microRNA-21; TC, typical carcinoid; AC, atypical carcinoid; LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma.
PTEN, phosphatase and tensin homolog on chromosome ten; miR-21, microRNA-21; TC, typical carcinoid; AC, atypical carcinoid; LCNEC, large cell neuroendocrine carcinoma; SCLC, small cell lung carcinoma.