Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
1Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
2Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
© 2014 The Korean Society of Pathologists/The Korean Society for Cytopathology
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Case No. | Age (yr) | Sex | Histologic type | Size (cm) | Lobe | Segment | T | N | M | Stage | Smoking | SI (py) | PFT FEV1/FVC (%) | Procedure | CFP (mo) | SP (mo) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 60 | M | SQ | 3.5 | LLL | Superior | 2a | 1 | 0 | IIA | S | N/A | 89/81 | P | 0 | 0 |
2 | 70 | M | SQ | 5.5 | LLL | Bronchus | 2b | 1 | 0 | IIB | E | 35 | 108/101 | S | 58 | 0 |
3 | 66 | M | LCNE | 2.5 | RLL | Posterior basal | 1b | 2 | 0 | IIIA | N | 0 | 93/84 | L | 8 | 0 |
4 | 69 | M | SQ | 7.5 | LLL | Basal | 3 | 1 | 0 | IIIA | S | N/A | 65/84 | L | 0 | 1 |
5 | 71 | M | SQ | 5 | LUL | Apicoposterior | 2a | 0 | 0 | IB | N | 0 | 94/87 | L | 44 | 1 |
6 | 73 | M | SQ | 6.8 | LUL | Anterior | 2b | 2 | 0 | IIIA | E | 40 | 90/68 | L | 0 | 1 |
7 | 58 | M | Ad, SQ | 2.8, 1.1 | RUL | Anterior | 1b | 0 | 0 | IA | E | 25 | 77/85 | L | 60 | 1a |
8 | 68 | M | Ad | 4.5 | LLL | Posterior basal | 2a | 0 | 0 | IB | E | 40 | 123/104 | L | 18 | 1 |
9 | 57 | M | Ad | 2.2 | LLL | Anterior basal | 2a | 2 | 0 | IIIA | S | 40 | 79/67 | L | 11 | 2 |
10 | 63 | M | SQ | 4 | RLL | Lateral basal | 2a | 0 | 0 | IB | E | 40 | 87/90 | L | 0 | 4a |
11 | 59 | M | SQ | 4.8 | RLL | Superior | 2a | 0 | 0 | IB | E | 40 | 71/73 | L | 2 | 4a |
12 | 72 | M | Ad | 2 | LLL | Anterior basal | 1a | 0 | 0 | IA | N | 0 | 110/89 | L | 2 | 4 |
13 | 67 | M | LCC | 6 | LLL | Superior | 2b | 1 | 0 | IIB | S | 60 | 93/90 | P | 0 | 6 |
14 | 75 | M | Ad | 3.5 | RLL | Basal | 2a | 2 | 0 | IIIA | N | 0 | 103/88 | L | 0 | 8 |
15 | 72 | M | LCNE | 2.6 | RLL | Superior | 2a | 0 | 0 | IB | N | 0 | 94/96 | L | 13 | 9 |
16 | 69 | M | LCNE+SQ | 4 | RML | Bronchus | 2a | 2 | 0 | IIIA | E | 30 | 107/110 | L | 48 | 10a |
17 | 50 | M | Ad | 3.5 | LLL | Posterior basal | 2a | 2 | 0 | IIIA | E | N/A | 75/70 | L | 48 | 10a |
18 | 71 | M | SQ | 1.8 | RUL | Anterior | 1a | 0 | 0 | IA | E | 25 | 76/61 | W | 13 | 12a |
19 | 73 | M | SQ | 4.5 | RLL | Lateral basal | 2a | 2 | 0 | IIIA | E | N/A | 90/87 | L | 24 | 13a |
20 | 66 | M | Ad | 2.5 | LLL | Superior | 2a | 1 | 0 | IIA | E | 44 | 108/94 | L | 20 | 13 |
21 | 74 | M | Ad | 0.4 | LLL | Superior | 1a | 1 | 0 | IIA | S | 60 | 118/105 | L | 1 | 15 |
22 | 71 | M | Ad | 3 | LLL | Medial basal | 3 | 2 | 0 | IIIA | S | 49 | 80/89 | L | 20 | 15 |
23 | 76 | M | SQ | 2.3 | RUL | Anterior | 1b | 0 | 0 | IA | E | 50 | 83/77 | L | 0 | 16a |
24 | 63 | M | SCC+NSCC | 2.2 | RUL | Anterior | N/A | N/A | N/A | N/A | S | 20 | 88/77 | W | 1 | 17 |
25 | 70 | M | ASQ | 4.5 | RLL | Lateral basal | 1b | 1 | 0 | IIA | E | 47 | 96/82 | L | 84 | 17a |
26 | 84 | M | Ad | 1.7 | RUL | Posterior | 1b | 0 | 0 | IA | S | 58 | 105/91 | L | 31 | 19 |
27 | 71 | M | Ad | 4.8 | RLL | Lateral basal | 2a | 1 | 0 | IIA | S | 45 | 122/113 | L | 0 | 20 |
28 | 76 | M | SQ | 1.5 | RLL | Superior | 1a | 0 | 0 | IA | S | 50 | 76/83 | L | 0 | 21 |
29 | 76 | M | Ad | 2.2 | LLL | Superior | 1b | 2 | 0 | IIIA | S | 20 | 100/91 | L | 0 | 22 |
30 | 79 | M | SQ × 2 | 1.9, 0.4 | RLL | Superior | 2b | 0 | 0 | IIA | E | N/A | 96/75 | L | 65 | 26a |
31 | 65 | M | SQ | 2 | RLL | Lateral basal | 2a | 0 | 0 | IB | E | 38 | 90/85 | L | 0 | 29a |
32 | 73 | M | SQ | 3.1 | LLL | Posterior basal | 2a | 0 | 0 | IB | E | 50 | 92/86 | L | 0 | 29a |
33 | 70 | M | Pl | 3.3 | RLL | Superior | 2a | 0 | 0 | IB | S | N/A | 104/85 | L | 0 | 30 |
34 | 70 | M | Ad | 4.5 | RLL | Anterior basal | 2a | 0 | 0 | IB | N | 0 | 124/107 | L | 0 | 33 |
35 | 68 | M | SQ | 3 | RLL | Superior | 4 | 2 | 0 | IIIB | N/A | N/A | 102/88 | P | 8 | 38 |
36 | 54 | F | Ad | 3.5 | RLL | Anterior basal | 2a | 1 | 0 | IIA | N | 0 | 82/75 | L | 0 | 40 |
37 | 63 | M | SQ | 4 | LLL | Lateral basal | 2a | 0 | 0 | IB | S | 60 | 96/77 | L | 17 | 43a |
38 | 51 | F | Ad | 2.5 | RLL | Superior | 1b | 0 | 0 | IA | N | 0 | 87/71 | L | 0 | 53a |
39 | 64 | M | Ad | 1.8 | RUL | Anterior basal | 2a | 1 | 0 | IIA | E | 40 | 123/99 | L | 6 | 56 |
40 | 73 | M | Ad | 1 | RLL | Superior | 1a | 0 | 0 | IA | E | N/A | 79/81 | L | 0 | 63 |
41 | 71 | M | Ad | 2.8 | RLL | Superior | 1b | 1 | 0 | IIA | S | 60 | 95/103 | L | 0 | 82a |
42 | 60 | M | SQ | 3.5 | LUL | Anterior | 2a | 1 | 0 | IIA | E | 40 | 106/97 | L | 0 | 117 |
43 | 67 | M | SQ | 1.8 | LLL | Superior | 2a | 0 | 0 | IB | E | 40 | N/A | L | 0 | 160a |
SI, smoking index; py, packyears; PFT, pre-operative pulmonary function test; FEV1, forced expiratory volume at 1 second; FVC, forced vital capacity; CFP, cancer-free period; SP, survival period; M, male; SQ, squamous cell carcinoma; LLL, left lower lobe; S, current smoker; N/A, not available; P, pneumonectomy; E, ex-smoker; LCNE, large cell neuroendocrine carcinoma; RLL, right lower lobe; N, non-smoker; L, lobectomy; LUL, left upper lobe; Ad, adenocarcinoma; RUL, right upper lobe; LCC, large cell carcinoma; LCNE+SQ, combined large cell neuroendocrine carcinoma and squamous cell carcinoma; RML, right middle lobe; W, wedge resection; SCC, small cell carcinoma; NSCC, non-small cell carcinoma; ASQ, adenosquamous carcinoma; Pl, pleomorphic carcinoma; F, female.
a Censored.
Parameter | Value |
---|---|
No. of patients (surgical diagnosis:nonsurgical diagnosis) | 57:27 |
Mean age (yr) | 60 |
Sex (male:female) | 66:18 |
Smoking history (N:E:C) | 29:31:24 |
Mean survival period (mo)a | 39.83 (2-117) |
OR (95% CI) | p-value | |
---|---|---|
Smoking history (nonsmoking vs smoking) | 12.610 (1.293-123.016) | .029 |
Smoking index (≤ 30 py vs > 30 py) | 0.528 (0.065-4.321) | .552 |
FVC (> 86.5%a vs ≤ 86.5%) | 0.342 (0.090-1.308) | .117 |
Age (≤ 70a yr vs > 70 yr) | 0.222 (0.070-0.709) | .011 |
Stage (I vs II, III) | 0.310 (0.100-0.957) | .042 |
Procedure (W vs L, P) | 0.026 (0.002-0.399) | .009 |
CFP (≤ 2 mo vs > 2 mo) | 0.188 (0.062-0.567) | .003 |
OR (95% CI) | p-value | |
---|---|---|
Smoking history (nonsmoking vs smoking) | 1.557 (0.799-3.033) | .193 |
Smoking index (≤ 30 py vs > 30 py) | 0.913 (0.464-1.797) | .792 |
FVC (≤ 80.5%a vs > 80.5%) | 0.804 (0.480-1.347) | .408 |
Age (≤ 63a yr vs > 63 yr) | 0.699 (0.423-1.154) | .161 |
Cancer (UIP-only vs UIP with cancer) | 0.461 (0.262-0.810) | .007 |