Fig. 1Pancreatic tissue (upper and lower) with some small intestinal mucosa (middle) and fibrous extracellular components.
Fig. 2Acini are separated into lobules by connective tissue, and intercalated ducts are lined with simple low cuboidal epithelium. Pancreatic tissue including acini, ducts, and islets of Langerhans (A). Expression of chromogranin (B), synaptophysin (C), and neuron-specific enolase (D) in islets of Langerhans.
Table 1.Cases of heterotopic pancreatic tissue at the umbilicus reported in the English literature
No. |
Age/Sex |
Mass |
Discharge |
Size |
Site |
Reference |
1 |
12 yr/F |
N/A |
N/A |
N/A |
Umbilical subcutaneous tissue |
Wright (1900), cited by Harris and Wenzl [1] |
2 |
22 yr/M |
– |
+ |
N/A |
Umbilical cyst |
Trimingham (1943), cited by Harris and Wenzl [1] |
3 |
6 mo/M |
– |
N/A |
3-mm nodule |
Umbilical nodule |
Steck and Helwig (1964), cited by Avolio et al. [2] |
4 |
13 mo/M |
+ |
+ |
12 × 9 × 5 mm |
Umbilical mass |
Caberwal et al. (1977), cited by Avolio et al. [2] |
5 |
60 yr/M |
+ |
– |
N/A |
Umbilical polyp |
Kondoh et al. (1994), cited by Avolio et al. [2] |
6 |
8 mo/M |
+/– |
+ |
N/A |
Umbilical mass |
Avolio et al. [2] (1998) |
7 |
15 mo/M |
– |
+ |
N/A |
Umbilical mass |
Avolio et al. [2] (1998) |
8 |
6 mo/M |
– |
+ |
N/A |
Urachus |
Perez-Martinez et al. (1999), cited by Lee et al. [3] |
9 |
3 mo/M |
– |
+ |
1-cm cyst |
Umbilical cyst |
Tan et al. (2000), cited by Lee et al. [3] |
10 |
7 wk/M |
– |
+ |
N/A |
Umbilical cyst |
Tan et al. (2000), cited by Lee et al. [3] |
11 |
8 days/M |
+ |
+ |
26 × 20 × 7 mm |
Umbilical mass |
Lee et al. [3] (2005), |
12 |
18 mo/M |
+ |
+ |
N/A |
Umbilical mass |
Silva et al. (2010), cited by Sharma et al. [4] |
13 |
2 yr/M |
+ |
+ |
12 × 12 × 10 cm |
Umbilical mass |
Sharma et al. (2013), cited by Sharma et al. [4] |
14 |
3 mo/F |
– |
+ |
7 × 6 × 5 mm |
Umbilical cyst |
Present case |